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Protein

Rho GDP-dissociation inhibitor 3

Gene

ARHGDIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rho GDP-dissociation inhibitor activity Source: ProtInc

GO - Biological processi

  • negative regulation of cell adhesion Source: ProtInc
  • regulation of protein localization Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: ProtInc

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 3
Short name:
Rho GDI 3
Alternative name(s):
Rho-GDI gamma
Gene namesi
Name:ARHGDIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000242173.8
HGNCiHGNC:680 ARHGDIG
MIMi602844 gene
neXtProtiNX_Q99819

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi398
OpenTargetsiENSG00000242173
PharmGKBiPA24965

Polymorphism and mutation databases

BioMutaiARHGDIG
DMDMi38258951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190181 – 225Rho GDP-dissociation inhibitor 3Add BLAST225

Proteomic databases

PaxDbiQ99819
PeptideAtlasiQ99819
PRIDEiQ99819
ProteomicsDBi78492

PTM databases

PhosphoSitePlusiQ99819

Expressioni

Tissue specificityi

Primarily expressed in pancreas and brain.

Gene expression databases

BgeeiENSG00000242173
CleanExiHS_ARHGDIG
ExpressionAtlasiQ99819 baseline and differential
GenevisibleiQ99819 HS

Organism-specific databases

HPAiHPA078260

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi106891, 11 interactors
IntActiQ99819, 5 interactors
STRINGi9606.ENSP00000219409

Structurei

3D structure databases

ProteinModelPortaliQ99819
SMRiQ99819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205 Eukaryota
ENOG4111K44 LUCA
GeneTreeiENSGT00390000006233
HOGENOMiHOG000175765
HOVERGENiHBG000206
InParanoidiQ99819
KOiK12462
OMAiSYPPKKE
OrthoDBiEOG091G0MBU
PhylomeDBiQ99819
TreeFamiTF105387

Family and domain databases

Gene3Di2.70.50.30, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf
PANTHERiPTHR10980 PTHR10980, 1 hit
PfamiView protein in Pfam
PF02115 Rho_GDI, 1 hit
PRINTSiPR00492 RHOGDI
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q99819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA
60 70 80 90 100
PGRKSLLEIR QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS
110 120 130 140 150
EQAPGPVVMD LTGDLAVLKD QVFVLKEGVD YRVKISFKVH REIVSGLKCL
160 170 180 190 200
HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV TPVEEAPRGA LVRGPYLVVS
210 220
LFTDDDRTHH LSWEWGLCIC QDWKD
Length:225
Mass (Da):25,098
Last modified:October 31, 2003 - v2
Checksum:iAFC4576E6BE0E9BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114D → N (PubMed:9113980).Curated1
Sequence conflicti114D → N (PubMed:9787082).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82532 mRNA Translation: AAC33138.1
AF080237 Genomic DNA Translation: AAC72354.1
AB127078 mRNA Translation: BAE48733.1
AF498928 mRNA Translation: AAM21076.1
AE006463 Genomic DNA Translation: AAK61222.1
Z69667 Genomic DNA Translation: CAI95584.1
BC047699 mRNA Translation: AAH47699.1
CCDSiCCDS10404.1
RefSeqiNP_001167.2, NM_001176.3
UniGeneiHs.647388

Genome annotation databases

EnsembliENST00000219409; ENSP00000219409; ENSG00000242173
GeneIDi398
KEGGihsa:398
UCSCiuc002cgm.2 human

Similar proteinsi

Entry informationi

Entry nameiGDIR3_HUMAN
AccessioniPrimary (citable) accession number: Q99819
Secondary accession number(s): Q4TT69, Q96S29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 31, 2003
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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