UniProtKB - Q99816 (TS101_HUMAN)
Tumor susceptibility gene 101 protein
TSG101
Functioni
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).
7 PublicationsGO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- DNA binding Source: ProtInc
- nuclear receptor coactivator activity Source: Ensembl
- protein-containing complex binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- transcription corepressor activity Source: ProtInc
- ubiquitin binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- virion binding Source: UniProtKB
GO - Biological processi
- autophagosome maturation Source: ParkinsonsUK-UCL
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- endosome to lysosome transport Source: Ensembl
- exosomal secretion Source: Ensembl
- extracellular transport Source: UniProtKB
- keratinocyte differentiation Source: Ensembl
- macroautophagy Source: ParkinsonsUK-UCL
- multivesicular body assembly Source: ParkinsonsUK-UCL
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- negative regulation of epidermal growth factor receptor signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of exosomal secretion Source: UniProtKB
- positive regulation of ubiquitin-dependent endocytosis Source: Ensembl
- positive regulation of viral budding via host ESCRT complex Source: UniProtKB
- protein monoubiquitination Source: Ensembl
- protein transport Source: UniProtKB-KW
- regulation of cell cycle Source: Ensembl
- regulation of cell growth Source: Ensembl
- regulation of extracellular exosome assembly Source: UniProtKB
- regulation of MAP kinase activity Source: UniProtKB
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: HGNC-UCL
- viral budding Source: UniProtKB
- viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
- viral release from host cell Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Growth regulation, Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q99816 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-174490, Membrane binding and targetting of GAG proteins R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-9610379, HCMV Late Events R-HSA-9615710, Late endosomal microautophagy |
SignaLinki | Q99816 |
Protein family/group databases
MoonDBi | Q99816, Curated |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor susceptibility gene 101 proteinAlternative name(s): ESCRT-I complex subunit TSG101 |
Gene namesi | Name:TSG101 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15971, TSG101 |
MIMi | 601387, gene |
neXtProti | NX_Q99816 |
VEuPathDBi | HostDB:ENSG00000074319 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome 1 Publication
Endosome
- Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
- Late endosome membrane 2 Publications; Peripheral membrane protein
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Midbody ring 2 Publications
Note: Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis.2 Publications
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
- endosome membrane Source: Reactome
- ESCRT I complex Source: UniProtKB
- late endosome Source: BHF-UCL
- late endosome membrane Source: UniProtKB-SubCell
- multivesicular body Source: HGNC-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- Flemming body Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | V → A: Reduces interaction with ubiquitin; inhibits down-regulation of EGFR. 1 Publication | 1 | |
Mutagenesisi | 45 | N → A: Reduces interaction with ubiquitin. No effect on MGRN1-binding. 3 Publications | 1 | |
Mutagenesisi | 46 | D → A: Reduces interaction with ubiquitin. 1 Publication | 1 | |
Mutagenesisi | 63 | Y → A: Reduces interaction with HIV-1 p6; impairs HIV-1 budding. 1 Publication | 1 | |
Mutagenesisi | 88 | F → A: Reduces interaction with ubiquitin; no effect on in interaction with HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 89 | V → A: No change in interaction with p6; no effect on HIV-1 budding. 1 Publication | 1 | |
Mutagenesisi | 95 | M → A: Reduces interaction with VPS37B and HIV-1 p6; abolishes interaction with PDCD6IP; impairs HIV-1 budding; inhibits down-regulation of EGFR. Abolishes MGRN1-binding. Loss of interaction with ARRDC1. 6 Publications | 1 | |
Mutagenesisi | 141 | V → A: Reduces interaction with HIV-1 p6. 1 Publication | 1 | |
Mutagenesisi | 158 – 162 | Missing : Abolishes interaction with CEP55 and midbody localization; no effect on interaction with ESCRT-I proteins, PDCD6IP and viral proteins. 1 Publication | 5 | |
Mutagenesisi | 158 – 160 | PPN → AAA: Abolishes interaction with CEP55. 1 Publication | 3 | |
Mutagenesisi | 368 – 371 | RKQF → AAAA: Loss of interaction with VPS28. No effect on interaction with VPS37C. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 7251 |
OpenTargetsi | ENSG00000074319 |
PharmGKBi | PA38068 |
Miscellaneous databases
Pharosi | Q99816, Tbio |
Chemistry databases
ChEMBLi | CHEMBL6157 |
Genetic variation databases
BioMutai | TSG101 |
DMDMi | 9789790 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000082606 | 2 – 390 | Tumor susceptibility gene 101 proteinAdd BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 220 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99816 |
jPOSTi | Q99816 |
MassIVEi | Q99816 |
MaxQBi | Q99816 |
PaxDbi | Q99816 |
PeptideAtlasi | Q99816 |
PRIDEi | Q99816 |
ProteomicsDBi | 78490 [Q99816-1] 78491 [Q99816-2] |
PTM databases
GlyGeni | Q99816, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99816 |
PhosphoSitePlusi | Q99816 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000074319, Expressed in oocyte and 244 other tissues |
ExpressionAtlasi | Q99816, baseline and differential |
Genevisiblei | Q99816, HS |
Organism-specific databases
HPAi | ENSG00000074319, Low tissue specificity |
Interactioni
Subunit structurei
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry (PubMed:18005716).
Interacts with VPS37A, VPS37B and VPS37C (PubMed:15218037, PubMed:15509564).
Interacts with DMAP1 (PubMed:10888872).
Interacts with ubiquitin (PubMed:11595185).
Interacts with stathmin, GMCL and AATF (By similarity).
Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry (PubMed:21757351).
Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex.
Interacts with GGA1 and GGA3 (PubMed:15143060, PubMed:15039775).
Interacts (via UEV domain) with PDCD6IP/AIP1 (PubMed:14505570, PubMed:14519844).
Interacts with VPS28, SNF8 and VPS36 (PubMed:14505570). Self-associates (PubMed:14505570, PubMed:14519844).
Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex.
Interacts with VPS37D.
Interacts with LRSAM1.
Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding (PubMed:17853893).
Interacts with PDCD6 (PubMed:18256029).
Interacts with LITAF (PubMed:23166352).
Interacts with MGRN1 (PubMed:17229889).
Interacts with ARRDC1; recruits TSG101 to the plasma membrane (PubMed:21191027, PubMed:22315426).
By similarity19 Publications(Microbial infection) Interacts with HIV-1 p6.
5 Publications(Microbial infection) Interacts with human spumavirus Gag.
1 Publication(Microbial infection) Interacts with HTLV-1 Gag.
1 Publication(Microbial infection) Interacts with Ebola virus VP40.
1 Publication(Microbial infection) Interacts with EIAV p9; the interaction has been shown in vitro.
1 Publication(Microbial infection) Interacts with Lassa virus protein Z.
1 Publication(Microbial infection) Interacts with hepatitis E virus protein ORF3.
1 PublicationBinary interactionsi
Q99816
Isoform 1 [Q99816-1]
With | #Exp. | IntAct |
---|---|---|
HGS [O14964] | 2 | EBI-15891993,EBI-740220 |
p6-gag (PRO_0000038598) from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2). | 3 | EBI-15891993,EBI-10634977 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- ubiquitin binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113102, 243 interactors |
CORUMi | Q99816 |
DIPi | DIP-31809N |
ELMi | Q99816 |
IntActi | Q99816, 144 interactors |
MINTi | Q99816 |
STRINGi | 9606.ENSP00000251968 |
Chemistry databases
BindingDBi | Q99816 |
Miscellaneous databases
RNActi | Q99816, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q99816 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99816 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 145 | UEVPROSITE-ProRule annotationAdd BLAST | 144 | |
Domaini | 322 – 390 | SBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 162 | Interaction with CEP55 | 5 | |
Regioni | 198 – 220 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 235 – 316 | Sequence analysisAdd BLAST | 82 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 320 – 323 | PTAP motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 199 – 220 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2391, Eukaryota |
GeneTreei | ENSGT00940000153903 |
HOGENOMi | CLU_017548_1_1_1 |
InParanoidi | Q99816 |
OMAi | IWVPHAY |
OrthoDBi | 1435538at2759 |
PhylomeDBi | Q99816 |
TreeFami | TF312917 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR017916, SB_dom IPR016135, UBQ-conjugating_enzyme/RWD IPR008883, UEV_N |
Pfami | View protein in Pfam PF05743, UEV, 1 hit PF09454, Vps23_core, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS51312, SB, 1 hit PS51322, UEV, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR
60 70 80 90 100
ELMNLTGTIP VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG
110 120 130 140 150
KHVDANGKIY LPYLHEWKHP QSDLLGLIQV MIVVFGDEPP VFSRPISASY
160 170 180 190 200
PPYQATGPPN TSYMPGMPGG ISPYPSGYPP NPSGYPGCPY PPGGPYPATT
210 220 230 240 250
SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW RMKEEMDRAQ
260 270 280 290 300
AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS
310 320 330 340 350
ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR
360 370 380 390
RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H442 | F5H442_HUMAN | Tumor susceptibility gene 101 prote... | TSG101 | 365 | Annotation score: | ||
J3QKS4 | J3QKS4_HUMAN | Tumor susceptibility gene 101 prote... | TSG101 | 77 | Annotation score: | ||
J3QRU6 | J3QRU6_HUMAN | Tumor susceptibility gene 101 prote... | TSG101 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 343 | F → L in AAH02487 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034572 | 167 | M → I. Corresponds to variant dbSNP:rs34385327Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004440 | 15 – 119 | Missing in isoform 2. CuratedAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82130 mRNA Translation: AAC52083.1 BC002487 mRNA Translation: AAH02487.1 |
CCDSi | CCDS7842.1 [Q99816-1] |
RefSeqi | NP_006283.1, NM_006292.3 [Q99816-1] |
Genome annotation databases
Ensembli | ENST00000251968; ENSP00000251968; ENSG00000074319 |
GeneIDi | 7251 |
KEGGi | hsa:7251 |
MANE-Selecti | ENST00000251968.4; ENSP00000251968.3; NM_006292.4; NP_006283.1 |
UCSCi | uc001mor.4, human [Q99816-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82130 mRNA Translation: AAC52083.1 BC002487 mRNA Translation: AAH02487.1 |
CCDSi | CCDS7842.1 [Q99816-1] |
RefSeqi | NP_006283.1, NM_006292.3 [Q99816-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KPP | NMR | - | A | 1-145 | [»] | |
1KPQ | NMR | - | A | 1-145 | [»] | |
1M4P | NMR | - | A | 1-145 | [»] | |
1M4Q | NMR | - | A | 1-145 | [»] | |
1S1Q | X-ray | 2.00 | A/C | 1-145 | [»] | |
2F0R | X-ray | 2.26 | A/B | 1-145 | [»] | |
3IV1 | X-ray | 2.50 | A/B/C/D/E/F/G/H | 229-304 | [»] | |
3OBQ | X-ray | 1.40 | A | 2-145 | [»] | |
3OBS | X-ray | 1.50 | A | 2-145 | [»] | |
3OBU | X-ray | 1.60 | A | 2-145 | [»] | |
3OBX | X-ray | 1.60 | A | 2-145 | [»] | |
3P9G | X-ray | 1.80 | A | 2-145 | [»] | |
3P9H | X-ray | 1.80 | A | 2-145 | [»] | |
4EJE | X-ray | 2.20 | A/B | 1-145 | [»] | |
4YC1 | X-ray | 2.00 | A/B/C | 1-145 | [»] | |
4ZNY | X-ray | 2.40 | A | 4-145 | [»] | |
5VKG | NMR | - | A | 2-145 | [»] | |
6UD0 | NMR | - | C | 1-145 | [»] | |
6VME | X-ray | 2.19 | B/F/G/H/I/J | 308-388 | [»] | |
SMRi | Q99816 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113102, 243 interactors |
CORUMi | Q99816 |
DIPi | DIP-31809N |
ELMi | Q99816 |
IntActi | Q99816, 144 interactors |
MINTi | Q99816 |
STRINGi | 9606.ENSP00000251968 |
Chemistry databases
BindingDBi | Q99816 |
ChEMBLi | CHEMBL6157 |
Protein family/group databases
MoonDBi | Q99816, Curated |
PTM databases
GlyGeni | Q99816, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99816 |
PhosphoSitePlusi | Q99816 |
Genetic variation databases
BioMutai | TSG101 |
DMDMi | 9789790 |
Proteomic databases
EPDi | Q99816 |
jPOSTi | Q99816 |
MassIVEi | Q99816 |
MaxQBi | Q99816 |
PaxDbi | Q99816 |
PeptideAtlasi | Q99816 |
PRIDEi | Q99816 |
ProteomicsDBi | 78490 [Q99816-1] 78491 [Q99816-2] |
Protocols and materials databases
Antibodypediai | 1752, 485 antibodies from 39 providers |
DNASUi | 7251 |
Genome annotation databases
Ensembli | ENST00000251968; ENSP00000251968; ENSG00000074319 |
GeneIDi | 7251 |
KEGGi | hsa:7251 |
MANE-Selecti | ENST00000251968.4; ENSP00000251968.3; NM_006292.4; NP_006283.1 |
UCSCi | uc001mor.4, human [Q99816-1] |
Organism-specific databases
CTDi | 7251 |
DisGeNETi | 7251 |
GeneCardsi | TSG101 |
HGNCi | HGNC:15971, TSG101 |
HPAi | ENSG00000074319, Low tissue specificity |
MIMi | 601387, gene |
neXtProti | NX_Q99816 |
OpenTargetsi | ENSG00000074319 |
PharmGKBi | PA38068 |
VEuPathDBi | HostDB:ENSG00000074319 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2391, Eukaryota |
GeneTreei | ENSGT00940000153903 |
HOGENOMi | CLU_017548_1_1_1 |
InParanoidi | Q99816 |
OMAi | IWVPHAY |
OrthoDBi | 1435538at2759 |
PhylomeDBi | Q99816 |
TreeFami | TF312917 |
Enzyme and pathway databases
PathwayCommonsi | Q99816 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-174490, Membrane binding and targetting of GAG proteins R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-9610379, HCMV Late Events R-HSA-9615710, Late endosomal microautophagy |
SignaLinki | Q99816 |
Miscellaneous databases
BioGRID-ORCSi | 7251, 742 hits in 1065 CRISPR screens |
ChiTaRSi | TSG101, human |
EvolutionaryTracei | Q99816 |
GeneWikii | TSG101 |
GenomeRNAii | 7251 |
Pharosi | Q99816, Tbio |
PROi | PR:Q99816 |
RNActi | Q99816, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000074319, Expressed in oocyte and 244 other tissues |
ExpressionAtlasi | Q99816, baseline and differential |
Genevisiblei | Q99816, HS |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR017916, SB_dom IPR016135, UBQ-conjugating_enzyme/RWD IPR008883, UEV_N |
Pfami | View protein in Pfam PF05743, UEV, 1 hit PF09454, Vps23_core, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS51312, SB, 1 hit PS51322, UEV, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TS101_HUMAN | |
Accessioni | Q99816Primary (citable) accession number: Q99816 Secondary accession number(s): Q9BUM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 230 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families