UniProtKB - Q99811 (PRRX2_HUMAN)
Protein
Paired mesoderm homeobox protein 2
Gene
PRRX2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 104 – 163 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99811 |
Names & Taxonomyi
Protein namesi | Recommended name: Paired mesoderm homeobox protein 2Alternative name(s): Paired-related homeobox protein 2 Short name: PRX-2 |
Gene namesi | Name:PRRX2 Synonyms:PMX2, PRX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167157.10 |
HGNCi | HGNC:21338, PRRX2 |
MIMi | 604675, gene |
neXtProti | NX_Q99811 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51450 |
OpenTargetsi | ENSG00000167157 |
PharmGKBi | PA134871679 |
Miscellaneous databases
Pharosi | Q99811, Tbio |
Polymorphism and mutation databases
BioMutai | PRRX2 |
DMDMi | 12644475 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049255 | 1 – 253 | Paired mesoderm homeobox protein 2Add BLAST | 253 |
Proteomic databases
jPOSTi | Q99811 |
MassIVEi | Q99811 |
PaxDbi | Q99811 |
PeptideAtlasi | Q99811 |
PRIDEi | Q99811 |
ProteomicsDBi | 78488 |
PTM databases
iPTMneti | Q99811 |
PhosphoSitePlusi | Q99811 |
Expressioni
Tissue specificityi
In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.1 Publication
Developmental stagei
Higher expression in fetus than in adult.1 Publication
Gene expression databases
Bgeei | ENSG00000167157, Expressed in left coronary artery and 178 other tissues |
ExpressionAtlasi | Q99811, baseline and differential |
Genevisiblei | Q99811, HS |
Organism-specific databases
HPAi | ENSG00000167157, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119548, 1 interactor |
CORUMi | Q99811 |
STRINGi | 9606.ENSP00000361547 |
Miscellaneous databases
RNActi | Q99811, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 230 – 243 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000161643 |
HOGENOMi | CLU_087323_0_0_1 |
InParanoidi | Q99811 |
OMAi | YLSWTST |
OrthoDBi | 1413050at2759 |
PhylomeDBi | Q99811 |
TreeFami | TF351612 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q99811-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA
60 70 80 90 100
AAGRLAARPG ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR
110 120 130 140 150
KKKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREELARR VNLSEARVQV
160 170 180 190 200
WFQNRRAKFR RNERAMLASR SASLLKSYSQ EAAIEQPVAP RPTALSPDYL
210 220 230 240 250
SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK EFSLHHSQVP
TVN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | P → S in AAB39864 (PubMed:9665387).Curated | 1 | |
Sequence conflicti | 96 – 98 | SAA → RPP in AAB39864 (PubMed:9665387).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061970 mRNA Translation: AAF17708.1 AL590369 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87901.1 BC014645 mRNA Translation: AAH14645.1 U81600 mRNA Translation: AAB39864.1 |
CCDSi | CCDS6926.1 |
RefSeqi | NP_057391.1, NM_016307.3 |
Genome annotation databases
Ensembli | ENST00000372469; ENSP00000361547; ENSG00000167157 |
GeneIDi | 51450 |
KEGGi | hsa:51450 |
UCSCi | uc004byh.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061970 mRNA Translation: AAF17708.1 AL590369 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87901.1 BC014645 mRNA Translation: AAH14645.1 U81600 mRNA Translation: AAB39864.1 |
CCDSi | CCDS6926.1 |
RefSeqi | NP_057391.1, NM_016307.3 |
3D structure databases
SMRi | Q99811 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119548, 1 interactor |
CORUMi | Q99811 |
STRINGi | 9606.ENSP00000361547 |
PTM databases
iPTMneti | Q99811 |
PhosphoSitePlusi | Q99811 |
Polymorphism and mutation databases
BioMutai | PRRX2 |
DMDMi | 12644475 |
Proteomic databases
jPOSTi | Q99811 |
MassIVEi | Q99811 |
PaxDbi | Q99811 |
PeptideAtlasi | Q99811 |
PRIDEi | Q99811 |
ProteomicsDBi | 78488 |
Protocols and materials databases
Antibodypediai | 31430, 152 antibodies |
Genome annotation databases
Ensembli | ENST00000372469; ENSP00000361547; ENSG00000167157 |
GeneIDi | 51450 |
KEGGi | hsa:51450 |
UCSCi | uc004byh.4, human |
Organism-specific databases
CTDi | 51450 |
DisGeNETi | 51450 |
EuPathDBi | HostDB:ENSG00000167157.10 |
GeneCardsi | PRRX2 |
HGNCi | HGNC:21338, PRRX2 |
HPAi | ENSG00000167157, Low tissue specificity |
MIMi | 604675, gene |
neXtProti | NX_Q99811 |
OpenTargetsi | ENSG00000167157 |
PharmGKBi | PA134871679 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000161643 |
HOGENOMi | CLU_087323_0_0_1 |
InParanoidi | Q99811 |
OMAi | YLSWTST |
OrthoDBi | 1413050at2759 |
PhylomeDBi | Q99811 |
TreeFami | TF351612 |
Enzyme and pathway databases
PathwayCommonsi | Q99811 |
Miscellaneous databases
BioGRID-ORCSi | 51450, 6 hits in 868 CRISPR screens |
ChiTaRSi | PRRX2, human |
GeneWikii | PRRX2 |
GenomeRNAii | 51450 |
Pharosi | Q99811, Tbio |
PROi | PR:Q99811 |
RNActi | Q99811, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167157, Expressed in left coronary artery and 178 other tissues |
ExpressionAtlasi | Q99811, baseline and differential |
Genevisiblei | Q99811, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRRX2_HUMAN | |
Accessioni | Q99811Primary (citable) accession number: Q99811 Secondary accession number(s): Q5SZB5, Q9UIB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 11, 2001 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families