Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Equilibrative nucleoside transporter 1

Gene

SLC29A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.
  1. KM=0.62 mM for adenosine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • nucleoside transmembrane transporter activity Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.57.1.1 the equilibrative nucleoside transporter (ent) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 1
    Alternative name(s):
    Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-sensitive nucleoside transporter
    Nucleoside transporter, es-type
    Solute carrier family 29 member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC29A1
    Synonyms:ENT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000112759.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11003 SLC29A1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602193 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q99808

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 29HelicalSequence analysisAdd BLAST17
    Topological domaini30 – 82ExtracellularSequence analysisAdd BLAST53
    Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
    Topological domaini108 – 111CytoplasmicSequence analysis4
    Transmembranei112 – 130HelicalSequence analysisAdd BLAST19
    Topological domaini131 – 138ExtracellularSequence analysis8
    Transmembranei139 – 157HelicalSequence analysisAdd BLAST19
    Topological domaini158 – 174CytoplasmicSequence analysisAdd BLAST17
    Transmembranei175 – 199HelicalSequence analysisAdd BLAST25
    Topological domaini200 – 206ExtracellularSequence analysis7
    Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
    Topological domaini228 – 291CytoplasmicSequence analysisAdd BLAST64
    Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
    Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
    Transmembranei324 – 342HelicalSequence analysisAdd BLAST19
    Topological domaini343 – 359CytoplasmicSequence analysisAdd BLAST17
    Transmembranei360 – 378HelicalSequence analysisAdd BLAST19
    Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
    Transmembranei394 – 413HelicalSequence analysisAdd BLAST20
    Topological domaini414 – 431CytoplasmicSequence analysisAdd BLAST18
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
    Topological domaini453 – 456ExtracellularSequence analysis4

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi453 – 456Missing : No effect on subcellular localization and inosine transport. 1 Publication4
    Mutagenesisi453R → A: No effect on subcellular localization and inosine transport. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2030

    Open Targets

    More...
    OpenTargetsi
    ENSG00000112759

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA154

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1997

    Drug and drug target database

    More...
    DrugBanki
    DB00987 Cytarabine
    DB00900 Didanosine
    DB00898 Ethanol
    DB01073 Fludarabine
    DB00544 Fluorouracil
    DB00441 Gemcitabine
    DB01033 Mercaptopurine
    DB00642 Pemetrexed
    DB00811 Ribavirin
    DB00197 Troglitazone
    DB02745 Uridine
    DB00943 Zalcitabine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1117

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC29A1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    9296956

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002093372 – 456Equilibrative nucleoside transporter 1Add BLAST455

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei254PhosphoserineCombined sources1
    Modified residuei269PhosphoserineCombined sources1
    Modified residuei273PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q99808

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q99808

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q99808

    PeptideAtlas

    More...
    PeptideAtlasi
    Q99808

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q99808

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    78487

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1219

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q99808

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q99808

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q99808

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000112759 Expressed in 190 organ(s), highest expression level in lower esophagus

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_SLC29A1

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q99808 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA012384

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Identified in a complex with STOM.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    108344, 32 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q99808, 8 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q99808

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000360773

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q99808

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q99808

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q99808

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1479 Eukaryota
    ENOG410Y3MT LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153848

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000007684

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG074626

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q99808

    KEGG Orthology (KO)

    More...
    KOi
    K15014

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MTPWNFF

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G09WB

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q99808

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313950

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR030195 ENT1
    IPR034764 ENT1/ENT2
    IPR002259 Eqnu_transpt
    IPR036259 MFS_trans_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10332 PTHR10332, 1 hit
    PTHR10332:SF9 PTHR10332:SF9, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01733 Nucleoside_tran, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF016379 ENT, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01130 DERENTRNSPRT

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00939 2a57, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q99808-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS
    60 70 80 90 100
    LVTAELSKDA QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS
    110 120 130 140 150
    FLHQRIPQSV RILGSLVAIL LVFLITAILV KVQLDALPFF VITMIKIVLI
    160 170 180 190 200
    NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ GLAGFFASVA MICAIASGSE
    210 220 230 240 250
    LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL EGPGEQETKL
    260 270 280 290 300
    DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF
    310 320 330 340 350
    TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV
    360 370 380 390 400
    FMWPGKDSRW LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM
    410 420 430 440 450
    AAFAFSNGYL ASLCMCFGPK KVKPAEAETA GAIMAFFLCL GLALGAVFSF

    LFRAIV
    Length:456
    Mass (Da):50,219
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF18535A95DEBC95D
    GO
    Isoform 2 (identifier: Q99808-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRRERTRGPQ...PGKTENTITM

    Note: No experimental confirmation available.
    Show »
    Length:535
    Mass (Da):58,963
    Checksum:iE58D6674A3C519D7
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2R8Y6D1A0A2R8Y6D1_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    248Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2U3TZJ7A0A2U3TZJ7_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    229Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2U3TZM6A0A2U3TZM6_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    210Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2U3TZM5A0A2U3TZM5_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    177Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YEH8A0A2R8YEH8_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    83Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YFI6A0A2R8YFI6_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    169Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y854A0A2R8Y854_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    164Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y801A0A2R8Y801_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    110Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YFB9A0A2R8YFB9_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    136Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y567A0A2R8Y567_HUMAN
    Equilibrative nucleoside transporte...
    SLC29A1
    78Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053668216I → T. Corresponds to variant dbSNP:rs45573936Ensembl.1
    Natural variantiVAR_036221293A → T in a colorectal cancer sample; somatic mutation. 1 Publication1
    Natural variantiVAR_053669391E → K. Corresponds to variant dbSNP:rs45458701Ensembl.1
    Natural variantiVAR_036222455I → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767108156Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565791M → MRRERTRGPQAWEFPSPTKS GCSLQSLSRDLRELREGEKP EDQAETEESWQGLARKTPGK ACAPEGGSCQPGKTENTITM in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U81375 mRNA Translation: AAC51103.1
    AF190884 Genomic DNA Translation: AAF02777.1
    AF079117 mRNA Translation: AAC62495.1
    AF495730 Genomic DNA Translation: AAM11785.1
    AK090491 mRNA Translation: BAG52169.1
    AK090615 mRNA Translation: BAG52197.1
    AL139392 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04255.1
    BC001382 mRNA Translation: AAH01382.1
    BC008954 mRNA Translation: AAH08954.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4908.1 [Q99808-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001071643.1, NM_001078175.2 [Q99808-1]
    NP_001071645.1, NM_001078177.1 [Q99808-1]
    NP_001291391.1, NM_001304462.1 [Q99808-2]
    NP_001291392.1, NM_001304463.1
    NP_001291394.1, NM_001304465.1
    NP_001291395.1, NM_001304466.1
    XP_005248935.1, XM_005248878.3 [Q99808-1]
    XP_005248936.1, XM_005248879.3 [Q99808-1]
    XP_005248937.1, XM_005248880.3 [Q99808-1]
    XP_005248938.1, XM_005248881.3 [Q99808-1]
    XP_005248939.1, XM_005248882.3 [Q99808-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.25450

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000371708; ENSP00000360773; ENSG00000112759 [Q99808-1]
    ENST00000371713; ENSP00000360778; ENSG00000112759 [Q99808-1]
    ENST00000371724; ENSP00000360789; ENSG00000112759 [Q99808-1]
    ENST00000371755; ENSP00000360820; ENSG00000112759 [Q99808-1]
    ENST00000393844; ENSP00000377427; ENSG00000112759 [Q99808-1]
    ENST00000427851; ENSP00000392668; ENSG00000112759 [Q99808-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2030

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2030

    UCSC genome browser

    More...
    UCSCi
    uc003owu.2 human [Q99808-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U81375 mRNA Translation: AAC51103.1
    AF190884 Genomic DNA Translation: AAF02777.1
    AF079117 mRNA Translation: AAC62495.1
    AF495730 Genomic DNA Translation: AAM11785.1
    AK090491 mRNA Translation: BAG52169.1
    AK090615 mRNA Translation: BAG52197.1
    AL139392 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04255.1
    BC001382 mRNA Translation: AAH01382.1
    BC008954 mRNA Translation: AAH08954.1
    CCDSiCCDS4908.1 [Q99808-1]
    RefSeqiNP_001071643.1, NM_001078175.2 [Q99808-1]
    NP_001071645.1, NM_001078177.1 [Q99808-1]
    NP_001291391.1, NM_001304462.1 [Q99808-2]
    NP_001291392.1, NM_001304463.1
    NP_001291394.1, NM_001304465.1
    NP_001291395.1, NM_001304466.1
    XP_005248935.1, XM_005248878.3 [Q99808-1]
    XP_005248936.1, XM_005248879.3 [Q99808-1]
    XP_005248937.1, XM_005248880.3 [Q99808-1]
    XP_005248938.1, XM_005248881.3 [Q99808-1]
    XP_005248939.1, XM_005248882.3 [Q99808-1]
    UniGeneiHs.25450

    3D structure databases

    ProteinModelPortaliQ99808
    SMRiQ99808
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi108344, 32 interactors
    IntActiQ99808, 8 interactors
    MINTiQ99808
    STRINGi9606.ENSP00000360773

    Chemistry databases

    BindingDBiQ99808
    ChEMBLiCHEMBL1997
    DrugBankiDB00987 Cytarabine
    DB00900 Didanosine
    DB00898 Ethanol
    DB01073 Fludarabine
    DB00544 Fluorouracil
    DB00441 Gemcitabine
    DB01033 Mercaptopurine
    DB00642 Pemetrexed
    DB00811 Ribavirin
    DB00197 Troglitazone
    DB02745 Uridine
    DB00943 Zalcitabine
    GuidetoPHARMACOLOGYi1117

    Protein family/group databases

    TCDBi2.A.57.1.1 the equilibrative nucleoside transporter (ent) family

    PTM databases

    GlyConnecti1219
    iPTMnetiQ99808
    PhosphoSitePlusiQ99808
    SwissPalmiQ99808

    Polymorphism and mutation databases

    BioMutaiSLC29A1
    DMDMi9296956

    Proteomic databases

    EPDiQ99808
    MaxQBiQ99808
    PaxDbiQ99808
    PeptideAtlasiQ99808
    PRIDEiQ99808
    ProteomicsDBi78487

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    2030
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000371708; ENSP00000360773; ENSG00000112759 [Q99808-1]
    ENST00000371713; ENSP00000360778; ENSG00000112759 [Q99808-1]
    ENST00000371724; ENSP00000360789; ENSG00000112759 [Q99808-1]
    ENST00000371755; ENSP00000360820; ENSG00000112759 [Q99808-1]
    ENST00000393844; ENSP00000377427; ENSG00000112759 [Q99808-1]
    ENST00000427851; ENSP00000392668; ENSG00000112759 [Q99808-1]
    GeneIDi2030
    KEGGihsa:2030
    UCSCiuc003owu.2 human [Q99808-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2030
    DisGeNETi2030
    EuPathDBiHostDB:ENSG00000112759.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC29A1
    HGNCiHGNC:11003 SLC29A1
    HPAiHPA012384
    MIMi602193 gene
    neXtProtiNX_Q99808
    OpenTargetsiENSG00000112759
    PharmGKBiPA154

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1479 Eukaryota
    ENOG410Y3MT LUCA
    GeneTreeiENSGT00940000153848
    HOGENOMiHOG000007684
    HOVERGENiHBG074626
    InParanoidiQ99808
    KOiK15014
    OMAiMTPWNFF
    OrthoDBiEOG091G09WB
    PhylomeDBiQ99808
    TreeFamiTF313950

    Enzyme and pathway databases

    ReactomeiR-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC29A1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Equilibrative_nucleoside_transporter_1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2030

    Protein Ontology

    More...
    PROi
    PR:Q99808

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000112759 Expressed in 190 organ(s), highest expression level in lower esophagus
    CleanExiHS_SLC29A1
    GenevisibleiQ99808 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR030195 ENT1
    IPR034764 ENT1/ENT2
    IPR002259 Eqnu_transpt
    IPR036259 MFS_trans_sf
    PANTHERiPTHR10332 PTHR10332, 1 hit
    PTHR10332:SF9 PTHR10332:SF9, 1 hit
    PfamiView protein in Pfam
    PF01733 Nucleoside_tran, 1 hit
    PIRSFiPIRSF016379 ENT, 1 hit
    PRINTSiPR01130 DERENTRNSPRT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00939 2a57, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS29A1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99808
    Secondary accession number(s): B3KQV7
    , B3KQY5, Q5T9W9, Q9UJY2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: December 5, 2018
    This is version 172 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again