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Protein

Transmembrane 9 superfamily member 2

Gene

TM9SF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.

GO - Biological processi

  • protein localization to membrane Source: GO_Central

Protein family/group databases

TCDBi8.A.68.1.6 the endomembrane protein-70 (emp70) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Alternative name(s):
p76
Gene namesi
Name:TM9SF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000125304.8
HGNCiHGNC:11865 TM9SF2
MIMi604678 gene
neXtProtiNX_Q99805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 300LumenalSequence analysisAdd BLAST272
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398LumenalSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 466LumenalSequence analysis8
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 554LumenalSequence analysisAdd BLAST11
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 591CytoplasmicSequence analysisAdd BLAST16
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 631LumenalSequence analysisAdd BLAST19
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9375
OpenTargetsiENSG00000125304
PharmGKBiPA36566

Polymorphism and mutation databases

DMDMi13878805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436529 – 663Transmembrane 9 superfamily member 2Add BLAST635

Proteomic databases

EPDiQ99805
MaxQBiQ99805
PaxDbiQ99805
PeptideAtlasiQ99805
PRIDEiQ99805
ProteomicsDBi78484

PTM databases

iPTMnetiQ99805
PhosphoSitePlusiQ99805
SwissPalmiQ99805

Expressioni

Tissue specificityi

Ubiquitously expressed. Especially abundant in pancreas, highly expressed in kidney, lower levels in heart, brain, skeletal muscle and placenta. Lowest expression in lung and liver.

Gene expression databases

BgeeiENSG00000125304 Expressed in 242 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_TM9SF2
ExpressionAtlasiQ99805 baseline and differential
GenevisibleiQ99805 HS

Organism-specific databases

HPAiHPA005657

Interactioni

Protein-protein interaction databases

BioGridi114776, 16 interactors
IntActiQ99805, 13 interactors
MINTiQ99805
STRINGi9606.ENSP00000365567

Structurei

3D structure databases

ProteinModelPortaliQ99805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216679
HOVERGENiHBG054197
InParanoidiQ99805
KOiK17086
OMAiGFLFLCY
OrthoDBiEOG091G03BD
PhylomeDBiQ99805
TreeFamiTF300394

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARLPVLSP PRWPRLLLLS LLLLGAVPGP RRSGAFYLPG LAPVNFCDEE
60 70 80 90 100
KKSDECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKKETC KLVCTKTYHT EKAEDKQKLE FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYDVEDG QRFCNPGFPI GCYITDKGHA KDACVISSDF
210 220 230 240 250
HERDTFYIFN HVDIKIYYHV VETGSMGARL VAAKLEPKSF KHTHIDKPDC
260 270 280 290 300
SGPPMDISNK ASGEIKIAYT YSVSFEEDDK IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLIYAVHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,776
Last modified:May 1, 1997 - v1
Checksum:iC21A4D224534734D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y4S7A0A2R8Y4S7_HUMAN
Transmembrane 9 superfamily member ...
TM9SF2
13Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81006 mRNA Translation: AAB38973.1
AK290514 mRNA Translation: BAF83203.1
AL139035 Genomic DNA No translation available.
BC110656 mRNA Translation: AAI10657.1
BC130293 mRNA Translation: AAI30294.1
CCDSiCCDS9493.1
RefSeqiNP_004791.1, NM_004800.2
UniGeneiHs.607896

Genome annotation databases

EnsembliENST00000376387; ENSP00000365567; ENSG00000125304
ENST00000642475; ENSP00000493515; ENSG00000125304
GeneIDi9375
KEGGihsa:9375
UCSCiuc001voj.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81006 mRNA Translation: AAB38973.1
AK290514 mRNA Translation: BAF83203.1
AL139035 Genomic DNA No translation available.
BC110656 mRNA Translation: AAI10657.1
BC130293 mRNA Translation: AAI30294.1
CCDSiCCDS9493.1
RefSeqiNP_004791.1, NM_004800.2
UniGeneiHs.607896

3D structure databases

ProteinModelPortaliQ99805
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114776, 16 interactors
IntActiQ99805, 13 interactors
MINTiQ99805
STRINGi9606.ENSP00000365567

Protein family/group databases

TCDBi8.A.68.1.6 the endomembrane protein-70 (emp70) family

PTM databases

iPTMnetiQ99805
PhosphoSitePlusiQ99805
SwissPalmiQ99805

Polymorphism and mutation databases

DMDMi13878805

Proteomic databases

EPDiQ99805
MaxQBiQ99805
PaxDbiQ99805
PeptideAtlasiQ99805
PRIDEiQ99805
ProteomicsDBi78484

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376387; ENSP00000365567; ENSG00000125304
ENST00000642475; ENSP00000493515; ENSG00000125304
GeneIDi9375
KEGGihsa:9375
UCSCiuc001voj.3 human

Organism-specific databases

CTDi9375
DisGeNETi9375
EuPathDBiHostDB:ENSG00000125304.8
GeneCardsiTM9SF2
HGNCiHGNC:11865 TM9SF2
HPAiHPA005657
MIMi604678 gene
neXtProtiNX_Q99805
OpenTargetsiENSG00000125304
PharmGKBiPA36566
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216679
HOVERGENiHBG054197
InParanoidiQ99805
KOiK17086
OMAiGFLFLCY
OrthoDBiEOG091G03BD
PhylomeDBiQ99805
TreeFamiTF300394

Miscellaneous databases

ChiTaRSiTM9SF2 human
GeneWikiiTM9SF2
GenomeRNAii9375
PROiPR:Q99805
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125304 Expressed in 242 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_TM9SF2
ExpressionAtlasiQ99805 baseline and differential
GenevisibleiQ99805 HS

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S2_HUMAN
AccessioniPrimary (citable) accession number: Q99805
Secondary accession number(s): A8K399, Q2TAY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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