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Protein

Chemokine-like receptor 1

Gene

CMKLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).4 Publications

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc
  • G protein-coupled receptor activity Source: GO_Central
  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)

Protein family/group databases

TCDBi9.A.14.13.15 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001606

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
Gene namesi
Name:CMKLR1
Synonyms:CHEMR23, DEZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000174600.13
HGNCiHGNC:2121 CMKLR1
MIMi602351 gene
neXtProtiNX_Q99788

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 64Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini65 – 75CytoplasmicSequence analysisAdd BLAST11
Transmembranei76 – 97Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini98 – 114ExtracellularSequence analysisAdd BLAST17
Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 224ExtracellularSequence analysisAdd BLAST48
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini246 – 261CytoplasmicSequence analysisAdd BLAST16
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 300ExtracellularSequence analysisAdd BLAST18
Transmembranei301 – 320Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini321 – 373CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1240
OpenTargetsiENSG00000174600
PharmGKBiPA26640

Chemistry databases

ChEMBLiCHEMBL3540
GuidetoPHARMACOLOGYi79

Polymorphism and mutation databases

BioMutaiCMKLR1
DMDMi17380487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693071 – 373Chemokine-like receptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 189PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei339PhosphoserineBy similarity1
Modified residuei342PhosphothreonineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ99788
PeptideAtlasiQ99788
PRIDEiQ99788
ProteomicsDBi78474
78475 [Q99788-2]

PTM databases

iPTMnetiQ99788
PhosphoSitePlusiQ99788

Expressioni

Tissue specificityi

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.6 Publications

Developmental stagei

Expressed during bone development.

Inductioni

Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.3 Publications

Gene expression databases

BgeeiENSG00000174600 Expressed in 137 organ(s), highest expression level in tendon
CleanExiHS_CMKLR1
ExpressionAtlasiQ99788 baseline and differential
GenevisibleiQ99788 HS

Organism-specific databases

HPAiHPA047865

Interactioni

Protein-protein interaction databases

BioGridi107644, 79 interactors
STRINGi9606.ENSP00000311733

Chemistry databases

BindingDBiQ99788

Structurei

3D structure databases

ProteinModelPortaliQ99788
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiQ99788
KOiK04245
OMAiCKLRRNR
OrthoDBiEOG091G0AR8
PhylomeDBiQ99788
TreeFamiTF330976

Family and domain databases

CDDicd15116 7tmA_CMKLR1, 1 hit
InterProiView protein in InterPro
IPR002258 DEZorph_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR45356 PTHR45356, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01126 DEZORPHANR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q99788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV
60 70 80 90 100
CFLGILGNGL VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA
110 120 130 140 150
MDYHWVFGTA MCKISNFLLI HNMFTSVFLL TIISSDRCIS VLLPVWSQNH
160 170 180 190 200
RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT ANLHGKISCF NNFSLSTPGS
210 220 230 240 250
SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY LTIVCKLQRN
260 270 280 290 300
RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL
310 320 330 340 350
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH
360 370
RSFTKMSSMN ERTSMNERET GML
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:373
Mass (Da):42,322
Last modified:November 16, 2001 - v2
Checksum:i5244B9738EC93834
GO
Isoform B (identifier: Q99788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:371
Mass (Da):42,035
Checksum:i9A4E7AB541FB2898
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VYN7F8VYN7_HUMAN
Chemokine-like receptor 1
CMKLR1
147Annotation score:
F8VSC8F8VSC8_HUMAN
Chemokine-like receptor 1
CMKLR1
143Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248Q → H in AAC51258 (PubMed:9603476).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0019851 – 2Missing in isoform B. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79526 mRNA Translation: AAC51258.1
U79527 mRNA Translation: AAC51259.1
Y14838 Genomic DNA Translation: CAA75112.1
AB065871 Genomic DNA Translation: BAC06089.1
AY497547 mRNA Translation: AAR90850.1
AK291800 mRNA Translation: BAF84489.1
BT019556 mRNA Translation: AAV38363.1
BT019557 mRNA Translation: AAV38364.1
AC009729 Genomic DNA No translation available.
AC063957 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97810.1
CH471054 Genomic DNA Translation: EAW97811.1
BC106927 mRNA Translation: AAI06928.1
BC106928 mRNA Translation: AAI06929.1
CCDSiCCDS41829.1 [Q99788-2]
CCDS44965.1 [Q99788-1]
RefSeqiNP_001135815.1, NM_001142343.1 [Q99788-1]
NP_001135816.1, NM_001142344.1 [Q99788-1]
NP_001135817.1, NM_001142345.1 [Q99788-1]
NP_004063.1, NM_004072.2 [Q99788-2]
XP_016874309.1, XM_017018820.1 [Q99788-2]
UniGeneiHs.197143

Genome annotation databases

EnsembliENST00000312143; ENSP00000311733; ENSG00000174600 [Q99788-1]
ENST00000412676; ENSP00000401293; ENSG00000174600 [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600 [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600 [Q99788-2]
GeneIDi1240
KEGGihsa:1240
UCSCiuc001tmv.4 human [Q99788-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79526 mRNA Translation: AAC51258.1
U79527 mRNA Translation: AAC51259.1
Y14838 Genomic DNA Translation: CAA75112.1
AB065871 Genomic DNA Translation: BAC06089.1
AY497547 mRNA Translation: AAR90850.1
AK291800 mRNA Translation: BAF84489.1
BT019556 mRNA Translation: AAV38363.1
BT019557 mRNA Translation: AAV38364.1
AC009729 Genomic DNA No translation available.
AC063957 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97810.1
CH471054 Genomic DNA Translation: EAW97811.1
BC106927 mRNA Translation: AAI06928.1
BC106928 mRNA Translation: AAI06929.1
CCDSiCCDS41829.1 [Q99788-2]
CCDS44965.1 [Q99788-1]
RefSeqiNP_001135815.1, NM_001142343.1 [Q99788-1]
NP_001135816.1, NM_001142344.1 [Q99788-1]
NP_001135817.1, NM_001142345.1 [Q99788-1]
NP_004063.1, NM_004072.2 [Q99788-2]
XP_016874309.1, XM_017018820.1 [Q99788-2]
UniGeneiHs.197143

3D structure databases

ProteinModelPortaliQ99788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107644, 79 interactors
STRINGi9606.ENSP00000311733

Chemistry databases

BindingDBiQ99788
ChEMBLiCHEMBL3540
GuidetoPHARMACOLOGYi79
SwissLipidsiSLP:000001606

Protein family/group databases

TCDBi9.A.14.13.15 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ99788
PhosphoSitePlusiQ99788

Polymorphism and mutation databases

BioMutaiCMKLR1
DMDMi17380487

Proteomic databases

PaxDbiQ99788
PeptideAtlasiQ99788
PRIDEiQ99788
ProteomicsDBi78474
78475 [Q99788-2]

Protocols and materials databases

DNASUi1240
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312143; ENSP00000311733; ENSG00000174600 [Q99788-1]
ENST00000412676; ENSP00000401293; ENSG00000174600 [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600 [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600 [Q99788-2]
GeneIDi1240
KEGGihsa:1240
UCSCiuc001tmv.4 human [Q99788-1]

Organism-specific databases

CTDi1240
DisGeNETi1240
EuPathDBiHostDB:ENSG00000174600.13
GeneCardsiCMKLR1
HGNCiHGNC:2121 CMKLR1
HPAiHPA047865
MIMi602351 gene
neXtProtiNX_Q99788
OpenTargetsiENSG00000174600
PharmGKBiPA26640
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiQ99788
KOiK04245
OMAiCKLRRNR
OrthoDBiEOG091G0AR8
PhylomeDBiQ99788
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)

Miscellaneous databases

ChiTaRSiCMKLR1 human
GeneWikiiCMKLR1
GenomeRNAii1240
PROiPR:Q99788
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174600 Expressed in 137 organ(s), highest expression level in tendon
CleanExiHS_CMKLR1
ExpressionAtlasiQ99788 baseline and differential
GenevisibleiQ99788 HS

Family and domain databases

CDDicd15116 7tmA_CMKLR1, 1 hit
InterProiView protein in InterPro
IPR002258 DEZorph_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR45356 PTHR45356, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01126 DEZORPHANR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCML1_HUMAN
AccessioniPrimary (citable) accession number: Q99788
Secondary accession number(s): A8K6Y5
, O75748, Q3KP37, Q5U0H0, Q99789
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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