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UniProtKB - Q99788 (CML1_HUMAN)

Entry version 166 (10 Apr 2019)
Sequence version 2 (16 Nov 2001)
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Protein

Chemokine-like receptor 1

Gene

CMKLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373076 Class A/1 (Rhodopsin-like receptors)

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.13.15 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001606

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMKLR1
Synonyms:CHEMR23, DEZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000174600.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:2121 CMKLR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602351 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99788

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 64Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini65 – 75CytoplasmicSequence analysisAdd BLAST11
Transmembranei76 – 97Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini98 – 114ExtracellularSequence analysisAdd BLAST17
Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 224ExtracellularSequence analysisAdd BLAST48
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini246 – 261CytoplasmicSequence analysisAdd BLAST16
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 300ExtracellularSequence analysisAdd BLAST18
Transmembranei301 – 320Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini321 – 373CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1240

Open Targets

More...OpenTargetsi		ENSG00000174600

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26640

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3540

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		79

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CMKLR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		17380487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693071 – 373Chemokine-like receptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi112 ↔ 189PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei339PhosphoserineBy similarity1
Modified residuei342PhosphothreonineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99788

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99788

PeptideAtlas

More...PeptideAtlasi		Q99788

PRoteomics IDEntifications database

More...PRIDEi		Q99788

ProteomicsDB human proteome resource

More...ProteomicsDBi		78474
78475 [Q99788-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99788

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99788

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during bone development.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174600 Expressed in 137 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99788 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99788 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA047865

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107644, 79 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311733

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q99788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q99788

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410II0H Eukaryota
ENOG410YB48 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107927

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99788

KEGG Orthology (KO)

More...KOi		K04245

Identification of Orthologs from Complete Genome Data

More...OMAi		CKLRRNR

Database of Orthologous Groups

More...OrthoDBi		910274at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99788

TreeFam database of animal gene trees

More...TreeFami		TF330976

Family and domain databases

Conserved Domains Database

More...CDDi		cd15116 7tmA_CMKLR1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002258 DEZorph_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR45356 PTHR45356, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01126 DEZORPHANR
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q99788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV 
        60         70         80         90        100
CFLGILGNGL VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA 
       110        120        130        140        150
MDYHWVFGTA MCKISNFLLI HNMFTSVFLL TIISSDRCIS VLLPVWSQNH 
       160        170        180        190        200
RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT ANLHGKISCF NNFSLSTPGS 
       210        220        230        240        250
SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY LTIVCKLQRN 
       260        270        280        290        300
RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL 
       310        320        330        340        350
ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH 
       360        370 
RSFTKMSSMN ERTSMNERET GML
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:373
Mass (Da):42,322
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5244B9738EC93834
GO
Isoform B (identifier: Q99788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:371
Mass (Da):42,035
Checksum:i9A4E7AB541FB2898
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VSC8F8VSC8_HUMAN
Chemokine-like receptor 1
CMKLR1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYN7F8VYN7_HUMAN
Chemokine-like receptor 1
CMKLR1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248Q → H in AAC51258 (PubMed:9603476).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0019851 – 2Missing in isoform B. 3 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U79526 mRNA Translation: AAC51258.1
U79527 mRNA Translation: AAC51259.1
Y14838 Genomic DNA Translation: CAA75112.1
AB065871 Genomic DNA Translation: BAC06089.1
AY497547 mRNA Translation: AAR90850.1
AK291800 mRNA Translation: BAF84489.1
BT019556 mRNA Translation: AAV38363.1
BT019557 mRNA Translation: AAV38364.1
AC009729 Genomic DNA No translation available.
AC063957 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97810.1
CH471054 Genomic DNA Translation: EAW97811.1
BC106927 mRNA Translation: AAI06928.1
BC106928 mRNA Translation: AAI06929.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41829.1 [Q99788-2]
CCDS44965.1 [Q99788-1]

NCBI Reference Sequences

More...RefSeqi		NP_001135815.1, NM_001142343.1 [Q99788-1]
NP_001135816.1, NM_001142344.1 [Q99788-1]
NP_001135817.1, NM_001142345.1 [Q99788-1]
NP_004063.1, NM_004072.2 [Q99788-2]
XP_016874309.1, XM_017018820.1 [Q99788-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.197143

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312143; ENSP00000311733; ENSG00000174600 [Q99788-1]
ENST00000412676; ENSP00000401293; ENSG00000174600 [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600 [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600 [Q99788-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1240

UCSC genome browser

More...UCSCi		uc001tmv.4 human [Q99788-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79526 mRNA Translation: AAC51258.1
U79527 mRNA Translation: AAC51259.1
Y14838 Genomic DNA Translation: CAA75112.1
AB065871 Genomic DNA Translation: BAC06089.1
AY497547 mRNA Translation: AAR90850.1
AK291800 mRNA Translation: BAF84489.1
BT019556 mRNA Translation: AAV38363.1
BT019557 mRNA Translation: AAV38364.1
AC009729 Genomic DNA No translation available.
AC063957 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97810.1
CH471054 Genomic DNA Translation: EAW97811.1
BC106927 mRNA Translation: AAI06928.1
BC106928 mRNA Translation: AAI06929.1
CCDSiCCDS41829.1 [Q99788-2]
CCDS44965.1 [Q99788-1]
RefSeqiNP_001135815.1, NM_001142343.1 [Q99788-1]
NP_001135816.1, NM_001142344.1 [Q99788-1]
NP_001135817.1, NM_001142345.1 [Q99788-1]
NP_004063.1, NM_004072.2 [Q99788-2]
XP_016874309.1, XM_017018820.1 [Q99788-2]
UniGeneiHs.197143

3D structure databases

ProteinModelPortaliQ99788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107644, 79 interactors
STRINGi9606.ENSP00000311733

Chemistry databases

BindingDBiQ99788
ChEMBLiCHEMBL3540
GuidetoPHARMACOLOGYi79
SwissLipidsiSLP:000001606

Protein family/group databases

TCDBi9.A.14.13.15 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ99788
PhosphoSitePlusiQ99788

Polymorphism and mutation databases

BioMutaiCMKLR1
DMDMi17380487

Proteomic databases

jPOSTiQ99788
PaxDbiQ99788
PeptideAtlasiQ99788
PRIDEiQ99788
ProteomicsDBi78474
78475 [Q99788-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1240
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312143; ENSP00000311733; ENSG00000174600 [Q99788-1]
ENST00000412676; ENSP00000401293; ENSG00000174600 [Q99788-1]
ENST00000550402; ENSP00000449716; ENSG00000174600 [Q99788-1]
ENST00000552995; ENSP00000447579; ENSG00000174600 [Q99788-2]
GeneIDi1240
KEGGihsa:1240
UCSCiuc001tmv.4 human [Q99788-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1240
DisGeNETi1240
EuPathDBiHostDB:ENSG00000174600.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CMKLR1
HGNCiHGNC:2121 CMKLR1
HPAiHPA047865
MIMi602351 gene
neXtProtiNX_Q99788
OpenTargetsiENSG00000174600
PharmGKBiPA26640

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00950000182647
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiQ99788
KOiK04245
OMAiCKLRRNR
OrthoDBi910274at2759
PhylomeDBiQ99788
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CMKLR1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CMKLR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1240

Protein Ontology

More...PROi		PR:Q99788

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174600 Expressed in 137 organ(s), highest expression level in tendon
ExpressionAtlasiQ99788 baseline and differential
GenevisibleiQ99788 HS

Family and domain databases

CDDicd15116 7tmA_CMKLR1, 1 hit
InterProiView protein in InterPro
IPR002258 DEZorph_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR45356 PTHR45356, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01126 DEZORPHANR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCML1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99788
Secondary accession number(s): A8K6Y5
, O75748, Q3KP37, Q5U0H0, Q99789
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: April 10, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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