Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q99766 (ATP5S_HUMAN)

Entry version 158 (02 Dec 2020)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

ATP synthase subunit s, mitochondrial

Gene

DMAC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.By similarity

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi74Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi108MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99766

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrialCurated
Alternative name(s):
ATP synthase-coupling factor B
Short name:
FB
Distal membrane arm assembly complex 2-like proteinImported
Mitochondrial ATP synthase regulatory component factor B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMAC2LImported
Synonyms:ATP5SImported, ATPW
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000125375.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:18799, DMAC2L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618579, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99766

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27109

Open Targets

More...OpenTargetsi		ENSG00000125375

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99766, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP5S

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104249

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 40MitochondrionBy similarityAdd BLAST40
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000253841 – 215ATP synthase subunit s, mitochondrialAdd BLAST175

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99766

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99766

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99766

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99766

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99766

PeptideAtlas

More...PeptideAtlasi		Q99766

PRoteomics IDEntifications database

More...PRIDEi		Q99766

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78466 [Q99766-1]
78467 [Q99766-2]
78468 [Q99766-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99766

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99766

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125375, Expressed in biceps brachii and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99766, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99766, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125375, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Associates with ATP synthase.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118006, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q99766, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000308334

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99766, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99766

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 102LRR 1By similarityAdd BLAST26
Repeati103 – 131LRR 2By similarityAdd BLAST29
Repeati132 – 156LRR 3By similarityAdd BLAST25
Repeati157 – 188LRR 4By similarityAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 76N-terminal domainBy similarityAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3864, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1969785_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99766

Identification of Orthologs from Complete Genome Data

More...OMAi		RHFWGWL

Database of Orthologous Groups

More...OrthoDBi		1395428at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99766

TreeFam database of animal gene trees

More...TreeFami		TF315274

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026063, ATP5S/ATP5SL
IPR032675, LRR_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13382:SF10, PTHR13382:SF10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCCAVSEQRL TCADQMMPFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN 
        60         70         80         90        100
KVDYDRIRDV GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY 
       110        120        130        140        150
KIQAIDATDS CIMSIGFDHM EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN 
       160        170        180        190        200
LQKTILEMEI ISCGNITDKG IIALRHLRNL KYLLLSDLPG VREKENLVQA 
       210 
FKTALPSLEL KLQLK
Length:215
Mass (Da):24,866
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFDCDE6D81E5DC62
GO
Isoform 2 (identifier: Q99766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-136: EGLEHVEKIRLCKCHY → GNYPIVLLIENADDLQ
     137-215: Missing.

Show »
Length:136
Mass (Da):15,685
Checksum:iC69A8CD2A7720FCC
GO
Isoform 3 (identifier: Q99766-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-127: GLEHVE → TSNICC
     128-215: Missing.

Show »
Length:127
Mass (Da):14,667
Checksum:i7C0681D95BD6EABB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDJ1A0A2R8YDJ1_HUMAN
ATP synthase subunit s, mitochondri...
DMAC2L
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ2A0A5F9ZGZ2_HUMAN
ATP synthase subunit s, mitochondri...
DMAC2L
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW60A0A5K1VW60_HUMAN
ATP synthase subunit s, mitochondri...
DMAC2L
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V467G3V467_HUMAN
ATP synthase subunit s, mitochondri...
DMAC2L
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW82A0A5K1VW82_HUMAN
ATP synthase subunit s, mitochondri...
DMAC2L
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06029618P → L5 PublicationsCorresponds to variant dbSNP:rs2275592Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040059121 – 136EGLEH…CKCHY → GNYPIVLLIENADDLQ in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040060122 – 127GLEHVE → TSNICC in isoform 3. 1 Publication6
Alternative sequenceiVSP_040061128 – 215Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_040062137 – 215Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U79253 mRNA Translation: AAB50202.1
AY052377 mRNA Translation: AAL13058.1
AK290008 mRNA Translation: BAF82697.1
AL359397 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65718.1
CH471078 Genomic DNA Translation: EAW65722.1
BC011549 mRNA Translation: AAH11549.1

NCBI Reference Sequences

More...RefSeqi		NP_001003803.1, NM_001003803.2
NP_001003805.1, NM_001003805.2
NP_056499.2, NM_015684.3
XP_011534958.1, XM_011536656.2 [Q99766-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000245448; ENSP00000245448; ENSG00000125375 [Q99766-3]
ENST00000554204; ENSP00000451583; ENSG00000125375 [Q99766-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27109

UCSC genome browser

More...UCSCi		uc001wxv.4, human [Q99766-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79253 mRNA Translation: AAB50202.1
AY052377 mRNA Translation: AAL13058.1
AK290008 mRNA Translation: BAF82697.1
AL359397 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65718.1
CH471078 Genomic DNA Translation: EAW65722.1
BC011549 mRNA Translation: AAH11549.1
RefSeqiNP_001003803.1, NM_001003803.2
NP_001003805.1, NM_001003805.2
NP_056499.2, NM_015684.3
XP_011534958.1, XM_011536656.2 [Q99766-2]

3D structure databases

SMRiQ99766
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118006, 17 interactors
IntActiQ99766, 18 interactors
STRINGi9606.ENSP00000308334

PTM databases

iPTMnetiQ99766
PhosphoSitePlusiQ99766

Polymorphism and mutation databases

BioMutaiATP5S
DMDMi313104249

Proteomic databases

EPDiQ99766
jPOSTiQ99766
MassIVEiQ99766
MaxQBiQ99766
PaxDbiQ99766
PeptideAtlasiQ99766
PRIDEiQ99766
ProteomicsDBi78466 [Q99766-1]
78467 [Q99766-2]
78468 [Q99766-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		56666, 141 antibodies

Genome annotation databases

EnsembliENST00000245448; ENSP00000245448; ENSG00000125375 [Q99766-3]
ENST00000554204; ENSP00000451583; ENSG00000125375 [Q99766-1]
GeneIDi27109
KEGGihsa:27109
UCSCiuc001wxv.4, human [Q99766-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27109
DisGeNETi27109
EuPathDBiHostDB:ENSG00000125375.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		DMAC2L
HGNCiHGNC:18799, DMAC2L
HPAiENSG00000125375, Low tissue specificity
MIMi618579, gene
neXtProtiNX_Q99766
OpenTargetsiENSG00000125375

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3864, Eukaryota
GeneTreeiENSGT00940000156502
HOGENOMiCLU_1969785_0_0_1
InParanoidiQ99766
OMAiRHFWGWL
OrthoDBi1395428at2759
PhylomeDBiQ99766
TreeFamiTF315274

Enzyme and pathway databases

PathwayCommonsiQ99766
ReactomeiR-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27109, 6 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP5S, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP5S

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27109
PharosiQ99766, Tdark

Protein Ontology

More...PROi		PR:Q99766
RNActiQ99766, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125375, Expressed in biceps brachii and 247 other tissues
ExpressionAtlasiQ99766, baseline and differential
GenevisibleiQ99766, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026063, ATP5S/ATP5SL
IPR032675, LRR_dom_sf
PANTHERiPTHR13382:SF10, PTHR13382:SF10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP5S_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99766
Secondary accession number(s): A8K1U3
, D9N156, Q8WWX3, Q96F77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: December 2, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again