UniProtKB - Q99766 (ATP5S_HUMAN)
Protein
ATP synthase subunit s, mitochondrial
Gene
DMAC2L
Organism
Homo sapiens (Human)
Status
Functioni
Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.By similarity
Caution
It is uncertain whether Met-1 or Met-16 is the initiator.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 74 | Magnesium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 108 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- proton transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- ATP biosynthetic process Source: Reactome
- cristae formation Source: Reactome
- mitochondrial ATP synthesis coupled proton transport Source: Reactome
- proton transmembrane transport Source: UniProtKB
Keywordsi
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99766 |
Reactomei | R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit s, mitochondrialCuratedAlternative name(s): ATP synthase-coupling factor B Short name: FB Distal membrane arm assembly complex 2-like proteinImported Mitochondrial ATP synthase regulatory component factor B |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125375.14 |
HGNCi | HGNC:18799, DMAC2L |
MIMi | 618579, gene |
neXtProti | NX_Q99766 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
- Mitochondrion inner membrane By similarity
Mitochondrion
- mitochondrial inner membrane Source: Reactome
Other locations
- proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Keywords - Cellular componenti
CF(0), Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 27109 |
OpenTargetsi | ENSG00000125375 |
Miscellaneous databases
Pharosi | Q99766, Tdark |
Polymorphism and mutation databases
BioMutai | ATP5S |
DMDMi | 313104249 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 40 | MitochondrionBy similarityAdd BLAST | 40 | |
ChainiPRO_0000002538 | 41 – 215 | ATP synthase subunit s, mitochondrialAdd BLAST | 175 |
Proteomic databases
EPDi | Q99766 |
jPOSTi | Q99766 |
MassIVEi | Q99766 |
MaxQBi | Q99766 |
PaxDbi | Q99766 |
PeptideAtlasi | Q99766 |
PRIDEi | Q99766 |
ProteomicsDBi | 78466 [Q99766-1] 78467 [Q99766-2] 78468 [Q99766-3] |
PTM databases
iPTMneti | Q99766 |
PhosphoSitePlusi | Q99766 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125375, Expressed in biceps brachii and 247 other tissues |
ExpressionAtlasi | Q99766, baseline and differential |
Genevisiblei | Q99766, HS |
Organism-specific databases
HPAi | ENSG00000125375, Low tissue specificity |
Interactioni
Subunit structurei
Homotetramer. Associates with ATP synthase.
By similarityBinary interactionsi
Hide detailsIsoform 3 [Q99766-3]
With | #Exp. | IntAct |
---|---|---|
EVX2 [Q03828] | 3 | EBI-13309711,EBI-17280301 |
KLHL38 [Q2WGJ6] | 3 | EBI-13309711,EBI-6426443 |
Protein-protein interaction databases
BioGRIDi | 118006, 17 interactors |
IntActi | Q99766, 18 interactors |
STRINGi | 9606.ENSP00000308334 |
Miscellaneous databases
RNActi | Q99766, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 77 – 102 | LRR 1By similarityAdd BLAST | 26 | |
Repeati | 103 – 131 | LRR 2By similarityAdd BLAST | 29 | |
Repeati | 132 – 156 | LRR 3By similarityAdd BLAST | 25 | |
Repeati | 157 – 188 | LRR 4By similarityAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 16 – 76 | N-terminal domainBy similarityAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the ATP synthase subunit s family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Transit peptidePhylogenomic databases
eggNOGi | KOG3864, Eukaryota |
GeneTreei | ENSGT00940000156502 |
HOGENOMi | CLU_1969785_0_0_1 |
InParanoidi | Q99766 |
OMAi | RHFWGWL |
OrthoDBi | 1395428at2759 |
PhylomeDBi | Q99766 |
TreeFami | TF315274 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR026063, ATP5S/ATP5SL IPR032675, LRR_dom_sf |
PANTHERi | PTHR13382:SF10, PTHR13382:SF10, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99766-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCCAVSEQRL TCADQMMPFG KISQQLCGVK KLPWSCDSRY FWGWLNAVFN
60 70 80 90 100
KVDYDRIRDV GPDRAASEWL LRCGAMVRYH GQERWQKDYN HLPTGPLDKY
110 120 130 140 150
KIQAIDATDS CIMSIGFDHM EGLEHVEKIR LCKCHYIEDD CLLRLSQLEN
160 170 180 190 200
LQKTILEMEI ISCGNITDKG IIALRHLRNL KYLLLSDLPG VREKENLVQA
210
FKTALPSLEL KLQLK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YDJ1 | A0A2R8YDJ1_HUMAN | ATP synthase subunit s, mitochondri... | DMAC2L | 185 | Annotation score: | ||
A0A5F9ZGZ2 | A0A5F9ZGZ2_HUMAN | ATP synthase subunit s, mitochondri... | DMAC2L | 112 | Annotation score: | ||
A0A5K1VW60 | A0A5K1VW60_HUMAN | ATP synthase subunit s, mitochondri... | DMAC2L | 200 | Annotation score: | ||
G3V467 | G3V467_HUMAN | ATP synthase subunit s, mitochondri... | DMAC2L | 219 | Annotation score: | ||
A0A5K1VW82 | A0A5K1VW82_HUMAN | ATP synthase subunit s, mitochondri... | DMAC2L | 121 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060296 | 18 | P → L5 PublicationsCorresponds to variant dbSNP:rs2275592Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040059 | 121 – 136 | EGLEH…CKCHY → GNYPIVLLIENADDLQ in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_040060 | 122 – 127 | GLEHVE → TSNICC in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_040061 | 128 – 215 | Missing in isoform 3. 1 PublicationAdd BLAST | 88 | |
Alternative sequenceiVSP_040062 | 137 – 215 | Missing in isoform 2. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U79253 mRNA Translation: AAB50202.1 AY052377 mRNA Translation: AAL13058.1 AK290008 mRNA Translation: BAF82697.1 AL359397 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65718.1 CH471078 Genomic DNA Translation: EAW65722.1 BC011549 mRNA Translation: AAH11549.1 |
RefSeqi | NP_001003803.1, NM_001003803.2 NP_001003805.1, NM_001003805.2 NP_056499.2, NM_015684.3 XP_011534958.1, XM_011536656.2 [Q99766-2] |
Genome annotation databases
Ensembli | ENST00000245448; ENSP00000245448; ENSG00000125375 [Q99766-3] ENST00000554204; ENSP00000451583; ENSG00000125375 [Q99766-1] |
GeneIDi | 27109 |
KEGGi | hsa:27109 |
UCSCi | uc001wxv.4, human [Q99766-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U79253 mRNA Translation: AAB50202.1 AY052377 mRNA Translation: AAL13058.1 AK290008 mRNA Translation: BAF82697.1 AL359397 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65718.1 CH471078 Genomic DNA Translation: EAW65722.1 BC011549 mRNA Translation: AAH11549.1 |
RefSeqi | NP_001003803.1, NM_001003803.2 NP_001003805.1, NM_001003805.2 NP_056499.2, NM_015684.3 XP_011534958.1, XM_011536656.2 [Q99766-2] |
3D structure databases
SMRi | Q99766 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118006, 17 interactors |
IntActi | Q99766, 18 interactors |
STRINGi | 9606.ENSP00000308334 |
PTM databases
iPTMneti | Q99766 |
PhosphoSitePlusi | Q99766 |
Polymorphism and mutation databases
BioMutai | ATP5S |
DMDMi | 313104249 |
Proteomic databases
EPDi | Q99766 |
jPOSTi | Q99766 |
MassIVEi | Q99766 |
MaxQBi | Q99766 |
PaxDbi | Q99766 |
PeptideAtlasi | Q99766 |
PRIDEi | Q99766 |
ProteomicsDBi | 78466 [Q99766-1] 78467 [Q99766-2] 78468 [Q99766-3] |
Protocols and materials databases
Antibodypediai | 56666, 141 antibodies |
Genome annotation databases
Ensembli | ENST00000245448; ENSP00000245448; ENSG00000125375 [Q99766-3] ENST00000554204; ENSP00000451583; ENSG00000125375 [Q99766-1] |
GeneIDi | 27109 |
KEGGi | hsa:27109 |
UCSCi | uc001wxv.4, human [Q99766-1] |
Organism-specific databases
CTDi | 27109 |
DisGeNETi | 27109 |
EuPathDBi | HostDB:ENSG00000125375.14 |
GeneCardsi | DMAC2L |
HGNCi | HGNC:18799, DMAC2L |
HPAi | ENSG00000125375, Low tissue specificity |
MIMi | 618579, gene |
neXtProti | NX_Q99766 |
OpenTargetsi | ENSG00000125375 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3864, Eukaryota |
GeneTreei | ENSGT00940000156502 |
HOGENOMi | CLU_1969785_0_0_1 |
InParanoidi | Q99766 |
OMAi | RHFWGWL |
OrthoDBi | 1395428at2759 |
PhylomeDBi | Q99766 |
TreeFami | TF315274 |
Enzyme and pathway databases
PathwayCommonsi | Q99766 |
Reactomei | R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
Miscellaneous databases
BioGRID-ORCSi | 27109, 6 hits in 842 CRISPR screens |
ChiTaRSi | ATP5S, human |
GeneWikii | ATP5S |
GenomeRNAii | 27109 |
Pharosi | Q99766, Tdark |
PROi | PR:Q99766 |
RNActi | Q99766, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125375, Expressed in biceps brachii and 247 other tissues |
ExpressionAtlasi | Q99766, baseline and differential |
Genevisiblei | Q99766, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR026063, ATP5S/ATP5SL IPR032675, LRR_dom_sf |
PANTHERi | PTHR13382:SF10, PTHR13382:SF10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP5S_HUMAN | |
Accessioni | Q99766Primary (citable) accession number: Q99766 Secondary accession number(s): A8K1U3 Q96F77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations