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Entry version 179 (29 Sep 2021)
Sequence version 1 (01 May 1997)
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Protein

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Gene

PIP5K1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8955136, PubMed:21477596, PubMed:22942276).

PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631).

PIP5K1A-mediated phosphorylation of PtdIns4P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity).

Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276).

Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity).

Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity).

Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity).

Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393).

Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity).

Together with PIP5K1C has a role during embryogenesis (By similarity).

Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631).

Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197).

By similarity6 Publications

Caution

There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by diarachidonoyl phosphatidic acid (DAPA), when 1,2-dipalmitoyl-PI4P is used as a substrate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.3 µM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
  2. KM=2.8 µM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
  3. KM=16 µM for 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS07047-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.1.68, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q99755

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q99755

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99755

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000553 [Q99755-3]
SLP:000000554

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha1 Publication (EC:2.7.1.683 Publications)
Short name:
PIP5K1-alpha2 Publications
Short name:
PtdIns(4)P-5-kinase 1 alpha1 Publication
Alternative name(s):
68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha1 Publication
Phosphatidylinositol 4-phosphate 5-kinase type I alpha1 Publication
Short name:
PIP5KIalpha2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP5K1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:8994, PIP5K1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603275, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99755

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000143398

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi215L → I: Decreased 1-phosphatidylinositol-4-phosphate 5-kinase activity with 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate (arachidonate-PtdIns4P) as substrate. Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). No change in enzyme activation by 1-stearoyl-2-oleoyl phosphatidic acid (SOPA) or 1-stearoyl-2-arachidonoyl phosphatidic acid (SAPA). 2 Publications1
Mutagenesisi223L → I: Decreased 1-phosphatidylinositol-4-phosphate 5-kinase activity with 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate (arachidonate-PtdIns4P) as substrate. Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). No change in enzyme activation by 1-stearoyl-2-oleoyl phosphatidic acid (SOPA) or 1-stearoyl-2-arachidonoyl phosphatidic acid (SAPA). 1 Publication1
Mutagenesisi322D → A: Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). 1 Publication1
Mutagenesisi322D → N: Does not affect targeting of RAC1 to the plasma membrane; when associated with Q-440. 1 Publication1
Mutagenesisi440R → Q: Does not affect targeting of RAC1 to the plasma membrane; when associated with N-322. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8394

Open Targets

More...
OpenTargetsi
ENSG00000143398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33327

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q99755, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5969

DrugCentral

More...
DrugCentrali
Q99755

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PIP5K1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752158

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854561 – 562Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei486PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99755

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99755

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q99755

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99755

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99755

PeptideAtlas

More...
PeptideAtlasi
Q99755

PRoteomics IDEntifications database

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PRIDEi
Q99755

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78458 [Q99755-1]
78459 [Q99755-2]
78460 [Q99755-3]
78461 [Q99755-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99755

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99755

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q99755

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143398, Expressed in esophagogastric junction muscularis propria and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99755, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99755, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143398, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAC1 (By similarity).

Interacts with TUT1 (PubMed:18288197).

Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (PubMed:18288197).

Found in a ternary complex with IRS1 and DGKZ in the absence of insulin stimulation (By similarity).

Interacts with DGKZ (PubMed:15157668).

Interacts with PIP4K2C; the interaction inhibits PIP5K1A kinase activity (PubMed:31091439).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113983, 78 interactors

Database of interacting proteins

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DIPi
DIP-60649N

Protein interaction database and analysis system

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IntActi
Q99755, 38 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357883

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q99755

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q99755, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99755

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 449PIPKPROSITE-ProRule annotationAdd BLAST369

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni506 – 526DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0229, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154703

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004312_5_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99755

Identification of Orthologs from Complete Genome Data

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OMAi
GETLQMQ

Database of Orthologous Groups

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OrthoDBi
1562683at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99755

TreeFam database of animal gene trees

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TreeFami
TF319618

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N

The PANTHER Classification System

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PANTHERi
PTHR23086, PTHR23086, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01504, PIP5K, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00330, PIPKc, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51455, PIPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99755-1) [UniParc]FASTAAdd to basket
Also known as: PIP5KIalpha21 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI
60 70 80 90 100
SLVPYASGMP IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL
110 120 130 140 150
STKPERDVLM QDFYVVESIF FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF
160 170 180 190 200
RELFGIRPDD YLYSLCSEPL IELCSSGASG SLFYVSSDDE FIIKTVQHKE
210 220 230 240 250
AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR IVVMNNLLPR
260 270 280 290 300
SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
310 320 330 340 350
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT
360 370 380 390 400
RRPAPQKALY STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI
410 420 430 440 450
GIIDILQSYR FVKKLEHSWK ALVHDGDTVS VHRPGFYAER FQRFMCNTVF
460 470 480 490 500
KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC ITYQPSVSGE HKAQVTTKAE
510 520 530 540 550
VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET LQMLTTSTTL
560
EKLEVAESEF TH
Length:562
Mass (Da):62,633
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8F7988EB73506A0
GO
Isoform 2 (identifier: Q99755-2) [UniParc]FASTAAdd to basket
Also known as: PIP5KIalpha31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     30-52: ASGIKRPMASEVLEARQDSYISL → SGIKRPMASE
     455-504: LKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG → C

Show »
Length:500
Mass (Da):56,053
Checksum:i684F0C9C2DBE9EC4
GO
Isoform 3 (identifier: Q99755-3) [UniParc]FASTAAdd to basket
Also known as: PIP5KIalpha11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     30-52: ASGIKRPMASEVLEARQDSYISL → SGIKRPMASE

Show »
Length:549
Mass (Da):61,187
Checksum:i7CD48BFE175564A0
GO
Isoform 4 (identifier: Q99755-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-52: Missing.
     382-410: HMGGIPARNSKGERLLLYIGIIDILQSYR → Q

Show »
Length:522
Mass (Da):58,119
Checksum:i693CE47DBFC72B5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PW57A6PW57_HUMAN
Phosphatidylinositol 4-phosphate 5-...
PIP5K1A
550Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSF8E9PSF8_HUMAN
Phosphatidylinositol 4-phosphate 5-...
PIP5K1A
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW58A6PW58_HUMAN
Phosphatidylinositol 4-phosphate 5-...
PIP5K1A
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A5X0A2A5X0_HUMAN
Phosphatidylinositol 4-phosphate 5-...
PIP5K1A
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW56A6PW56_HUMAN
Phosphatidylinositol 4-phosphate 5-...
PIP5K1A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti257K → E in BAG58542 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01600730 – 52ASGIK…SYISL → SGIKRPMASE in isoform 2 and isoform 3. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_04191241 – 52Missing in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_041913382 – 410HMGGI…LQSYR → Q in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_016008455 – 504LKPSP…EVEPG → C in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U78575 mRNA Translation: AAC50910.1
U78576 mRNA Translation: AAC50911.1
U78577 mRNA Translation: AAC50912.1
AK291015 mRNA Translation: BAF83704.1
AK295691 mRNA Translation: BAG58542.1
AL592424 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53461.1
BC007833 mRNA Translation: AAH07833.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44219.1 [Q99755-1]
CCDS44220.1 [Q99755-4]
CCDS44221.1 [Q99755-2]
CCDS990.1 [Q99755-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001129108.1, NM_001135636.1 [Q99755-4]
NP_001129109.1, NM_001135637.1 [Q99755-2]
NP_001129110.1, NM_001135638.1 [Q99755-1]
NP_001317618.1, NM_001330689.1
NP_003548.1, NM_003557.2 [Q99755-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3]
ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1]
ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2]
ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8394

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8394

UCSC genome browser

More...
UCSCi
uc001exi.4, human [Q99755-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78575 mRNA Translation: AAC50910.1
U78576 mRNA Translation: AAC50911.1
U78577 mRNA Translation: AAC50912.1
AK291015 mRNA Translation: BAF83704.1
AK295691 mRNA Translation: BAG58542.1
AL592424 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53461.1
BC007833 mRNA Translation: AAH07833.1
CCDSiCCDS44219.1 [Q99755-1]
CCDS44220.1 [Q99755-4]
CCDS44221.1 [Q99755-2]
CCDS990.1 [Q99755-3]
RefSeqiNP_001129108.1, NM_001135636.1 [Q99755-4]
NP_001129109.1, NM_001135637.1 [Q99755-2]
NP_001129110.1, NM_001135638.1 [Q99755-1]
NP_001317618.1, NM_001330689.1
NP_003548.1, NM_003557.2 [Q99755-3]

3D structure databases

SMRiQ99755
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113983, 78 interactors
DIPiDIP-60649N
IntActiQ99755, 38 interactors
STRINGi9606.ENSP00000357883

Chemistry databases

BindingDBiQ99755
ChEMBLiCHEMBL5969
DrugCentraliQ99755
SwissLipidsiSLP:000000553 [Q99755-3]
SLP:000000554

PTM databases

iPTMnetiQ99755
PhosphoSitePlusiQ99755
SwissPalmiQ99755

Genetic variation databases

BioMutaiPIP5K1A
DMDMi74752158

Proteomic databases

EPDiQ99755
jPOSTiQ99755
MassIVEiQ99755
MaxQBiQ99755
PaxDbiQ99755
PeptideAtlasiQ99755
PRIDEiQ99755
ProteomicsDBi78458 [Q99755-1]
78459 [Q99755-2]
78460 [Q99755-3]
78461 [Q99755-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34058, 192 antibodies

The DNASU plasmid repository

More...
DNASUi
8394

Genome annotation databases

EnsembliENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3]
ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1]
ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2]
ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4]
GeneIDi8394
KEGGihsa:8394
UCSCiuc001exi.4, human [Q99755-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8394
DisGeNETi8394

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIP5K1A
HGNCiHGNC:8994, PIP5K1A
HPAiENSG00000143398, Low tissue specificity
MIMi603275, gene
neXtProtiNX_Q99755
OpenTargetsiENSG00000143398
PharmGKBiPA33327
VEuPathDBiHostDB:ENSG00000143398

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0229, Eukaryota
GeneTreeiENSGT00940000154703
HOGENOMiCLU_004312_5_1_1
InParanoidiQ99755
OMAiGETLQMQ
OrthoDBi1562683at2759
PhylomeDBiQ99755
TreeFamiTF319618

Enzyme and pathway databases

BioCyciMetaCyc:HS07047-MONOMER
BRENDAi2.7.1.68, 2681
PathwayCommonsiQ99755
ReactomeiR-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiQ99755
SIGNORiQ99755

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8394, 104 hits in 1026 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIP5K1A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PIP5K1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8394
PharosiQ99755, Tbio

Protein Ontology

More...
PROi
PR:Q99755
RNActiQ99755, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143398, Expressed in esophagogastric junction muscularis propria and 236 other tissues
ExpressionAtlasiQ99755, baseline and differential
GenevisibleiQ99755, HS

Family and domain databases

Gene3Di3.30.800.10, 1 hit
InterProiView protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N
PANTHERiPTHR23086, PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504, PIP5K, 1 hit
SMARTiView protein in SMART
SM00330, PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455, PIPK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI51A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99755
Secondary accession number(s): A8K4Q0
, B4DIN0, Q99754, Q99756
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 1997
Last modified: September 29, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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