PIP5K1A

Functionⁱ

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197, PubMed:19158393, PubMed:20660631). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity).By similarity3 Publications

Caution

There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Curated

Catalytic activityⁱ

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functionⁱ

1-phosphatidylinositol-3-phosphate 4-kinase activity Source: Reactome
1-phosphatidylinositol-3-phosphate 5-kinase activity Source: Reactome
1-phosphatidylinositol-4-phosphate 5-kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15157668
1-phosphatidylinositol-5-kinase activity Source: Reactome
ATP binding Source: UniProtKB-KW
kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15157668
phosphatidylinositol-3,4-bisphosphate 5-kinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
activation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
cell chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
cell migration
Source: UniProtKB
Non-traceable author statementⁱ
- 15157668
fibroblast migration Source: Ensembl
focal adhesion assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
glycerophospholipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8955136
keratinocyte differentiation
Source: UniProtKB
Traceable author statementⁱ
- 19889969
phagocytosis
Source: UniProtKB
Traceable author statementⁱ
- 19889969
phosphatidylinositol biosynthetic process Source: Reactome
phospholipid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15157668
positive regulation of glucose import in response to insulin stimulus Source: UniProtKB
protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
ruffle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20660631
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8955136

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07047-MONOMER
BRENDAⁱ	2.7.1.68 2681
Reactomeⁱ	R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q99755
SIGNORⁱ	Q99755

Chemistry databases

SwissLipidsⁱ	SLP:000000553 [Q99755-3] SLP:000000554

SwissLipidsⁱ

SLP:000000553 [Q99755-3]
SLP:000000554

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (EC:2.7.1.68) Short name: PIP5K1-alpha Short name: PtdIns(4)P-5-kinase 1 alpha Alternative name(s): 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha Phosphatidylinositol 4-phosphate 5-kinase type I alpha Short name: PIP5KIalpha
Gene namesⁱ	Name:PIP5K1A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143398.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8994 PIP5K1A
MIMⁱ	603275 gene
neXtProtⁱ	NX_Q99755

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	322	D → N: Does not affect targeting of RAC1 to the plasma membrane; when associated with Q-440. 1 Publication		1
Mutagenesisⁱ	440	R → Q: Does not affect targeting of RAC1 to the plasma membrane; when associated with N-322. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8394
Open Targets More...OpenTargetsⁱ	ENSG00000143398
PharmGKBⁱ	PA33327

Chemistry databases

ChEMBLⁱ	CHEMBL5969

ChEMBLⁱ

CHEMBL5969

Polymorphism and mutation databases

BioMutaⁱ	PIP5K1A
DMDMⁱ	74752158

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185456	1 – 562	Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaAdd BLAST		562

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	103	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residueⁱ	486	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99755
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99755
PaxDbⁱ	Q99755
PeptideAtlas More...PeptideAtlasⁱ	Q99755
PRIDEⁱ	Q99755
ProteomicsDBⁱ	78458 78459 [Q99755-2] 78460 [Q99755-3] 78461 [Q99755-4]

PTM databases

iPTMnetⁱ	Q99755
PhosphoSitePlusⁱ	Q99755
SwissPalmⁱ	Q99755

Miscellaneous databases

PMAP-CutDBⁱ	Q99755

PMAP-CutDBⁱ

Q99755

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.

Gene expression databases

Bgeeⁱ	ENSG00000143398 Expressed in 224 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_PIP5K1A
ExpressionAtlasⁱ	Q99755 baseline and differential
Genevisibleⁱ	Q99755 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029366

HPAⁱ

HPA029366

Interactionⁱ

Subunit structureⁱ

Interacts with RAC1 (By similarity). Interacts with TUT1. Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (PubMed:18288197, PubMed:19158393). Found in a ternary complex with IRS1 and DGKZ in the absence of insulin stimulation (By similarity). Interacts with DGKZ (PubMed:15157668).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TUT1	Q9H6E5	3	EBI-726414,EBI-2511680

With

Entry

#Exp.

IntAct

Notes

TUT1

Q9H6E5

3

EBI-726414,EBI-2511680

GO - Molecular functionⁱ

kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15157668

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113983, 58 interactors
Database of interacting proteins More...DIPⁱ	DIP-60649N
IntActⁱ	Q99755, 9 interactors
STRINGⁱ	9606.ENSP00000357883

Chemistry databases

BindingDBⁱ

Q99755

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99755
SMRⁱ	Q99755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	81 – 449	PIPKPROSITE-ProRule annotationAdd BLAST		369

Phylogenomic databases

eggNOGⁱ	KOG0229 Eukaryota COG5253 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119184
HOGENOMⁱ	HOG000193876
HOVERGENⁱ	HBG052818
InParanoidⁱ	Q99755
KEGG Orthology (KO) More...KOⁱ	K00889
OMAⁱ	MQDIPDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A6L
PhylomeDBⁱ	Q99755
TreeFamⁱ	TF319618

Family and domain databases

Gene3Dⁱ	3.30.800.10, 1 hit 3.30.810.10, 2 hits
InterProⁱ	View protein in InterPro IPR023610 PInositol-4-P-5-kinase IPR027483 PInositol-4-P-5-kinase_C IPR002498 PInositol-4-P-5-kinase_core IPR027484 PInositol-4-P-5-kinase_N
PANTHERⁱ	PTHR23086 PTHR23086, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01504 PIP5K, 1 hit
SMARTⁱ	View protein in SMART SM00330 PIPKc, 1 hit
PROSITEⁱ	View protein in PROSITE PS51455 PIPK, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q99755-1) [UniParc]FASTA Add to basket

Also known as: PIP5KIalpha2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI 
        60         70         80         90        100
SLVPYASGMP IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL 
       110        120        130        140        150
STKPERDVLM QDFYVVESIF FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF 
       160        170        180        190        200
RELFGIRPDD YLYSLCSEPL IELCSSGASG SLFYVSSDDE FIIKTVQHKE 
       210        220        230        240        250
AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR IVVMNNLLPR 
       260        270        280        290        300
SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM 
       310        320        330        340        350
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT 
       360        370        380        390        400
RRPAPQKALY STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI 
       410        420        430        440        450
GIIDILQSYR FVKKLEHSWK ALVHDGDTVS VHRPGFYAER FQRFMCNTVF 
       460        470        480        490        500
KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC ITYQPSVSGE HKAQVTTKAE 
       510        520        530        540        550
VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET LQMLTTSTTL 
       560 
EKLEVAESEF TH

Length:562

Mass (Da):62,633

Last modified:May 1, 1997 - v1

Checksum:ⁱA8F7988EB73506A0

GO

Isoform 2 (identifier: Q99755-2) [UniParc]FASTA Add to basket

Also known as: PIP5KIalpha3

The sequence of this isoform differs from the canonical sequence as follows:
30-52: ASGIKRPMASEVLEARQDSYISL → SGIKRPMASE
455-504: LKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG → C

« Hide

        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAS GIKRPMASEV PYASGMPIKK 
        60         70         80         90        100
IGHRSVDSSG ETTYKKTTSS ALKGAIQLGI THTVGSLSTK PERDVLMQDF 
       110        120        130        140        150
YVVESIFFPS EGSNLTPAHH YNDFRFKTYA PVAFRYFREL FGIRPDDYLY 
       160        170        180        190        200
SLCSEPLIEL CSSGASGSLF YVSSDDEFII KTVQHKEAEF LQKLLPGYYM 
       210        220        230        240        250
NLNQNPRTLL PKFYGLYCVQ AGGKNIRIVV MNNLLPRSVK MHIKYDLKGS 
       260        270        280        290        300
TYKRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADMYNA LCKTLQRDCL 
       310        320        330        340        350
VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP APQKALYSTA 
       360        370        380        390        400
MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK 
       410        420        430        440        450
KLEHSWKALV HDGDTVSVHR PGFYAERFQR FMCNTVFKKI PCVHLGRPDV 
       460        470        480        490        500
LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK LEVAESEFTH

Show »

Length:500

Mass (Da):56,053

Checksum:ⁱ684F0C9C2DBE9EC4

GO

Isoform 3 (identifier: Q99755-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
30-52: ASGIKRPMASEVLEARQDSYISL → SGIKRPMASE

« Hide

        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAS GIKRPMASEV PYASGMPIKK 
        60         70         80         90        100
IGHRSVDSSG ETTYKKTTSS ALKGAIQLGI THTVGSLSTK PERDVLMQDF 
       110        120        130        140        150
YVVESIFFPS EGSNLTPAHH YNDFRFKTYA PVAFRYFREL FGIRPDDYLY 
       160        170        180        190        200
SLCSEPLIEL CSSGASGSLF YVSSDDEFII KTVQHKEAEF LQKLLPGYYM 
       210        220        230        240        250
NLNQNPRTLL PKFYGLYCVQ AGGKNIRIVV MNNLLPRSVK MHIKYDLKGS 
       260        270        280        290        300
TYKRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADMYNA LCKTLQRDCL 
       310        320        330        340        350
VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP APQKALYSTA 
       360        370        380        390        400
MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK 
       410        420        430        440        450
KLEHSWKALV HDGDTVSVHR PGFYAERFQR FMCNTVFKKI PLKPSPSKKF 
       460        470        480        490        500
RSGSSFSRRA GSSGNSCITY QPSVSGEHKA QVTTKAEVEP GVHLGRPDVL 
       510        520        530        540 
PQTPPLEEIS EGSPIPDPSF SPLVGETLQM LTTSTTLEKL EVAESEFTH

Show »

Length:549

Mass (Da):61,187

Checksum:ⁱ7CD48BFE175564A0

GO

Isoform 4 (identifier: Q99755-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
41-52: Missing.
382-410: HMGGIPARNSKGERLLLYIGIIDILQSYR → Q

« Hide

        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VPYASGMPIK 
        60         70         80         90        100
KIGHRSVDSS GETTYKKTTS SALKGAIQLG ITHTVGSLST KPERDVLMQD 
       110        120        130        140        150
FYVVESIFFP SEGSNLTPAH HYNDFRFKTY APVAFRYFRE LFGIRPDDYL 
       160        170        180        190        200
YSLCSEPLIE LCSSGASGSL FYVSSDDEFI IKTVQHKEAE FLQKLLPGYY 
       210        220        230        240        250
MNLNQNPRTL LPKFYGLYCV QAGGKNIRIV VMNNLLPRSV KMHIKYDLKG 
       260        270        280        290        300
STYKRRASQK EREKPLPTFK DLDFLQDIPD GLFLDADMYN ALCKTLQRDC 
       310        320        330        340        350
LVLQSFKIMD YSLLMSIHNI DHAQREPLSS ETQYSVDTRR PAPQKALYST 
       360        370        380        390        400
AMESIQGEAR RGGTMETDDQ FVKKLEHSWK ALVHDGDTVS VHRPGFYAER 
       410        420        430        440        450
FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC ITYQPSVSGE 
       460        470        480        490        500
HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET 
       510        520 
LQMLTTSTTL EKLEVAESEF TH

Show »

Length:522

Mass (Da):58,119

Checksum:ⁱ693CE47DBFC72B5F

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6PW57	A6PW57_HUMAN	Phosphatidylinositol 4-phosphate 5-... Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	PIP5K1A	550	Annotation score:
A6PW58	A6PW58_HUMAN	Phosphatidylinositol 4-phosphate 5-... Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	PIP5K1A	86	Annotation score:
A2A5X0	A2A5X0_HUMAN	Phosphatidylinositol 4-phosphate 5-... Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	PIP5K1A	101	Annotation score:
A6PW56	A6PW56_HUMAN	Phosphatidylinositol 4-phosphate 5-... Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	PIP5K1A	41	Annotation score:
E9PSF8	E9PSF8_HUMAN	Phosphatidylinositol 4-phosphate 5-... Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	PIP5K1A	39	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	257	K → E in BAG58542 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016007	30 – 52	ASGIK…SYISL → SGIKRPMASE in isoform 2 and isoform 3. 3 PublicationsAdd BLAST	23
Alternative sequenceⁱVSP_041912	41 – 52	Missing in isoform 4. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_041913	382 – 410	HMGGI…LQSYR → Q in isoform 4. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_016008	455 – 504	LKPSP…EVEPG → C in isoform 2. 2 PublicationsAdd BLAST	50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78575 mRNA Translation: AAC50910.1 U78576 mRNA Translation: AAC50911.1 U78577 mRNA Translation: AAC50912.1 AK291015 mRNA Translation: BAF83704.1 AK295691 mRNA Translation: BAG58542.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53461.1 BC007833 mRNA Translation: AAH07833.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44219.1 [Q99755-1] CCDS44220.1 [Q99755-4] CCDS44221.1 [Q99755-2] CCDS990.1 [Q99755-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001129108.1, NM_001135636.1 [Q99755-4] NP_001129109.1, NM_001135637.1 [Q99755-2] NP_001129110.1, NM_001135638.1 [Q99755-1] NP_001317618.1, NM_001330689.1 NP_003548.1, NM_003557.2 [Q99755-3]
UniGeneⁱ	Hs.655131 Hs.661888

Genome annotation databases

Ensemblⁱ	ENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3] ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1] ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2] ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4]
GeneIDⁱ	8394
KEGGⁱ	hsa:8394
UCSC genome browser More...UCSCⁱ	uc001exi.4 human [Q99755-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99755	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3		Enhydra lutris kenyoni		582	UniRef90_Q99755
Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (Fragment)		NEOVI		336
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1		ODORO		582
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha		FELCA		576
Uncharacterized protein		PIG		565
+184
Q99755-2	Uncharacterized protein		NOMLE		591	UniRef90_Q99755-2
Uncharacterized protein		PANPA		500
PIP5K1A isoform 4		PANTR		500
PIP5K1A isoform 4		PONAB		500
Uncharacterized protein		NOMLE		534
+3
Q99755-4	Uncharacterized protein		PROCO		558	UniRef90_Q99755-4
PIP5K1A isoform 5		PANTR		522
PIP5K1A isoform 5		PONAB		522
Uncharacterized protein		PAPAN		522
Uncharacterized protein		NOMLE		522
+20

Protein	Similar proteins		Species	Score	Length	Source
Q99755	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1		ODORO		582	UniRef50_Q99755
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3		Enhydra lutris kenyoni		582
Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (Fragment)		NEOVI		336
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha		FELCA		576
Uncharacterized protein		PIG		565
+373
Q99755-2	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha		MOUSE		546	UniRef50_Q99755-2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha		RAT		546
Uncharacterized protein		NOMLE		591
PIP5K1A isoform 4		PANTR		500
PIP5K1A isoform 4		PONAB		500
+190
Q99755-4	Uncharacterized protein		PROCO		558	UniRef50_Q99755-4
Uncharacterized protein		PAPAN		522
Uncharacterized protein		PANPA		522
Uncharacterized protein		MACNE		522
Uncharacterized protein		CALJA		522
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78575 mRNA Translation: AAC50910.1 U78576 mRNA Translation: AAC50911.1 U78577 mRNA Translation: AAC50912.1 AK291015 mRNA Translation: BAF83704.1 AK295691 mRNA Translation: BAG58542.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53461.1 BC007833 mRNA Translation: AAH07833.1
CCDSⁱ	CCDS44219.1 [Q99755-1] CCDS44220.1 [Q99755-4] CCDS44221.1 [Q99755-2] CCDS990.1 [Q99755-3]
RefSeqⁱ	NP_001129108.1, NM_001135636.1 [Q99755-4] NP_001129109.1, NM_001135637.1 [Q99755-2] NP_001129110.1, NM_001135638.1 [Q99755-1] NP_001317618.1, NM_001330689.1 NP_003548.1, NM_003557.2 [Q99755-3]
UniGeneⁱ	Hs.655131 Hs.661888

3D structure databases

ProteinModelPortalⁱ	Q99755
SMRⁱ	Q99755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113983, 58 interactors
DIPⁱ	DIP-60649N
IntActⁱ	Q99755, 9 interactors
STRINGⁱ	9606.ENSP00000357883

Chemistry databases

BindingDBⁱ	Q99755
ChEMBLⁱ	CHEMBL5969
SwissLipidsⁱ	SLP:000000553 [Q99755-3] SLP:000000554

PTM databases

iPTMnetⁱ	Q99755
PhosphoSitePlusⁱ	Q99755
SwissPalmⁱ	Q99755

Polymorphism and mutation databases

BioMutaⁱ	PIP5K1A
DMDMⁱ	74752158

Proteomic databases

EPDⁱ	Q99755
MaxQBⁱ	Q99755
PaxDbⁱ	Q99755
PeptideAtlasⁱ	Q99755
PRIDEⁱ	Q99755
ProteomicsDBⁱ	78458 78459 [Q99755-2] 78460 [Q99755-3] 78461 [Q99755-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8394
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3] ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1] ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2] ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4]
GeneIDⁱ	8394
KEGGⁱ	hsa:8394
UCSCⁱ	uc001exi.4 human [Q99755-1]

Organism-specific databases

CTDⁱ	8394
DisGeNETⁱ	8394
EuPathDBⁱ	HostDB:ENSG00000143398.19
GeneCardsⁱ	PIP5K1A
HGNCⁱ	HGNC:8994 PIP5K1A
HPAⁱ	HPA029366
MIMⁱ	603275 gene
neXtProtⁱ	NX_Q99755
OpenTargetsⁱ	ENSG00000143398
PharmGKBⁱ	PA33327
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0229 Eukaryota COG5253 LUCA
GeneTreeⁱ	ENSGT00760000119184
HOGENOMⁱ	HOG000193876
HOVERGENⁱ	HBG052818
InParanoidⁱ	Q99755
KOⁱ	K00889
OMAⁱ	MQDIPDG
OrthoDBⁱ	EOG091G0A6L
PhylomeDBⁱ	Q99755
TreeFamⁱ	TF319618

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07047-MONOMER
BRENDAⁱ	2.7.1.68 2681
Reactomeⁱ	R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q99755
SIGNORⁱ	Q99755

Miscellaneous databases

ChiTaRSⁱ	PIP5K1A human
GeneWikiⁱ	PIP5K1A
GenomeRNAiⁱ	8394
PMAP-CutDBⁱ	Q99755
Protein Ontology More...PROⁱ	PR:Q99755
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143398 Expressed in 224 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_PIP5K1A
ExpressionAtlasⁱ	Q99755 baseline and differential
Genevisibleⁱ	Q99755 HS

Family and domain databases

Gene3Dⁱ	3.30.800.10, 1 hit 3.30.810.10, 2 hits
InterProⁱ	View protein in InterPro IPR023610 PInositol-4-P-5-kinase IPR027483 PInositol-4-P-5-kinase_C IPR002498 PInositol-4-P-5-kinase_core IPR027484 PInositol-4-P-5-kinase_N
PANTHERⁱ	PTHR23086 PTHR23086, 1 hit
Pfamⁱ	View protein in Pfam PF01504 PIP5K, 1 hit
SMARTⁱ	View protein in SMART SM00330 PIPKc, 1 hit
PROSITEⁱ	View protein in PROSITE PS51455 PIPK, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PI51A_HUMAN
Accessionⁱ	Q99755Primary (citable) accession number: Q99755 Secondary accession number(s): A8K4Q0 , B4DIN0, Q99754, Q99756
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q99755 (PI51A_HUMAN)

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Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ