UniProtKB - Q99755 (PI51A_HUMAN)
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1A
Functioni
Caution
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+4 PublicationsEC:2.7.1.684 PublicationsThis reaction proceeds in the forward4 Publications direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Kineticsi
- KM=0.3 µM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
- KM=2.8 µM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
- KM=16 µM for 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
GO - Molecular functioni
- 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- kinase binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- activation of GTPase activity Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cell migration Source: UniProtKB
- fibroblast migration Source: Ensembl
- focal adhesion assembly Source: UniProtKB
- glycerophospholipid metabolic process Source: ProtInc
- keratinocyte differentiation Source: UniProtKB
- phagocytosis Source: UniProtKB
- phosphatidylinositol biosynthetic process Source: Reactome
- phospholipid biosynthetic process Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
- ruffle assembly Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07047-MONOMER |
BRENDAi | 2.7.1.68, 2681 |
PathwayCommonsi | Q99755 |
Reactomei | R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q99755 |
SIGNORi | Q99755 |
Chemistry databases
SwissLipidsi | SLP:000000553 [Q99755-3] SLP:000000554 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha1 Publication (EC:2.7.1.683 Publications)Short name: PIP5K1-alpha2 Publications Short name: PtdIns(4)P-5-kinase 1 alpha1 Publication Alternative name(s): 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha1 Publication Phosphatidylinositol 4-phosphate 5-kinase type I alpha1 Publication Short name: PIP5KIalpha2 Publications |
Gene namesi | Name:PIP5K1AImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8994, PIP5K1A |
MIMi | 603275, gene |
neXtProti | NX_Q99755 |
VEuPathDBi | HostDB:ENSG00000143398.19 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus speckle 1 Publication
Plasma membrane
- Cell membrane By similarity
Other locations
- Cytoplasm By similarity
- ruffle 1 Publication
- lamellipodium 1 Publication
Note: Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197).2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- ruffle membrane Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
- lamellipodium Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 215 | L → I: Decreased 1-phosphatidylinositol-4-phosphate 5-kinase activity with 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate (arachidonate-PtdIns4P) as substrate. Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). No change in enzyme activation by 1-stearoyl-2-oleoyl phosphatidic acid (SOPA) or 1-stearoyl-2-arachidonoyl phosphatidic acid (SAPA). 2 Publications | 1 | |
Mutagenesisi | 223 | L → I: Decreased 1-phosphatidylinositol-4-phosphate 5-kinase activity with 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate (arachidonate-PtdIns4P) as substrate. Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). No change in enzyme activation by 1-stearoyl-2-oleoyl phosphatidic acid (SOPA) or 1-stearoyl-2-arachidonoyl phosphatidic acid (SAPA). 1 Publication | 1 | |
Mutagenesisi | 322 | D → A: Increased enzyme activation by diarachidonoyl phosphatidic acid (DAPA). 1 Publication | 1 | |
Mutagenesisi | 322 | D → N: Does not affect targeting of RAC1 to the plasma membrane; when associated with Q-440. 1 Publication | 1 | |
Mutagenesisi | 440 | R → Q: Does not affect targeting of RAC1 to the plasma membrane; when associated with N-322. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8394 |
OpenTargetsi | ENSG00000143398 |
PharmGKBi | PA33327 |
Miscellaneous databases
Pharosi | Q99755, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5969 |
DrugCentrali | Q99755 |
Genetic variation databases
BioMutai | PIP5K1A |
DMDMi | 74752158 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185456 | 1 – 562 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaAdd BLAST | 562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 103 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 486 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99755 |
jPOSTi | Q99755 |
MassIVEi | Q99755 |
MaxQBi | Q99755 |
PaxDbi | Q99755 |
PeptideAtlasi | Q99755 |
PRIDEi | Q99755 |
ProteomicsDBi | 78458 [Q99755-1] 78459 [Q99755-2] 78460 [Q99755-3] 78461 [Q99755-4] |
PTM databases
iPTMneti | Q99755 |
PhosphoSitePlusi | Q99755 |
SwissPalmi | Q99755 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000143398, Expressed in esophagogastric junction muscularis propria and 236 other tissues |
ExpressionAtlasi | Q99755, baseline and differential |
Genevisiblei | Q99755, HS |
Organism-specific databases
HPAi | ENSG00000143398, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RAC1 (By similarity).
Interacts with TUT1 (PubMed:18288197).
Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (PubMed:18288197).
Found in a ternary complex with IRS1 and DGKZ in the absence of insulin stimulation (By similarity).
Interacts with DGKZ (PubMed:15157668).
Interacts with PIP4K2C; the interaction inhibits PIP5K1A kinase activity (PubMed:31091439).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ99755
With | #Exp. | IntAct |
---|---|---|
TUT1 [Q9H6E5] | 3 | EBI-726414,EBI-2511680 |
Isoform 1 [Q99755-1]
With | #Exp. | IntAct |
---|---|---|
TUT1 [Q9H6E5] | 2 | EBI-15687389,EBI-2511680 |
GO - Molecular functioni
- kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113983, 76 interactors |
DIPi | DIP-60649N |
IntActi | Q99755, 37 interactors |
STRINGi | 9606.ENSP00000357883 |
Chemistry databases
BindingDBi | Q99755 |
Miscellaneous databases
RNActi | Q99755, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 449 | PIPKPROSITE-ProRule annotationAdd BLAST | 369 |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000154703 |
HOGENOMi | CLU_004312_5_1_1 |
InParanoidi | Q99755 |
OMAi | IGHRRID |
OrthoDBi | 1562683at2759 |
PhylomeDBi | Q99755 |
TreeFami | TF319618 |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR027483, PInositol-4-P-5-kinase_C IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI
60 70 80 90 100
SLVPYASGMP IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL
110 120 130 140 150
STKPERDVLM QDFYVVESIF FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF
160 170 180 190 200
RELFGIRPDD YLYSLCSEPL IELCSSGASG SLFYVSSDDE FIIKTVQHKE
210 220 230 240 250
AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR IVVMNNLLPR
260 270 280 290 300
SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
310 320 330 340 350
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT
360 370 380 390 400
RRPAPQKALY STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI
410 420 430 440 450
GIIDILQSYR FVKKLEHSWK ALVHDGDTVS VHRPGFYAER FQRFMCNTVF
460 470 480 490 500
KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC ITYQPSVSGE HKAQVTTKAE
510 520 530 540 550
VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET LQMLTTSTTL
560
EKLEVAESEF TH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6PW57 | A6PW57_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1A | 550 | Annotation score: | ||
E9PSF8 | E9PSF8_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1A | 39 | Annotation score: | ||
A6PW58 | A6PW58_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1A | 86 | Annotation score: | ||
A2A5X0 | A2A5X0_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1A | 101 | Annotation score: | ||
A6PW56 | A6PW56_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1A | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 257 | K → E in BAG58542 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016007 | 30 – 52 | ASGIK…SYISL → SGIKRPMASE in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_041912 | 41 – 52 | Missing in isoform 4. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_041913 | 382 – 410 | HMGGI…LQSYR → Q in isoform 4. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_016008 | 455 – 504 | LKPSP…EVEPG → C in isoform 2. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78575 mRNA Translation: AAC50910.1 U78576 mRNA Translation: AAC50911.1 U78577 mRNA Translation: AAC50912.1 AK291015 mRNA Translation: BAF83704.1 AK295691 mRNA Translation: BAG58542.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53461.1 BC007833 mRNA Translation: AAH07833.1 |
CCDSi | CCDS44219.1 [Q99755-1] CCDS44220.1 [Q99755-4] CCDS44221.1 [Q99755-2] CCDS990.1 [Q99755-3] |
RefSeqi | NP_001129108.1, NM_001135636.1 [Q99755-4] NP_001129109.1, NM_001135637.1 [Q99755-2] NP_001129110.1, NM_001135638.1 [Q99755-1] NP_001317618.1, NM_001330689.1 NP_003548.1, NM_003557.2 [Q99755-3] |
Genome annotation databases
Ensembli | ENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3] ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1] ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2] ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4] |
GeneIDi | 8394 |
KEGGi | hsa:8394 |
UCSCi | uc001exi.4, human [Q99755-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78575 mRNA Translation: AAC50910.1 U78576 mRNA Translation: AAC50911.1 U78577 mRNA Translation: AAC50912.1 AK291015 mRNA Translation: BAF83704.1 AK295691 mRNA Translation: BAG58542.1 AL592424 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53461.1 BC007833 mRNA Translation: AAH07833.1 |
CCDSi | CCDS44219.1 [Q99755-1] CCDS44220.1 [Q99755-4] CCDS44221.1 [Q99755-2] CCDS990.1 [Q99755-3] |
RefSeqi | NP_001129108.1, NM_001135636.1 [Q99755-4] NP_001129109.1, NM_001135637.1 [Q99755-2] NP_001129110.1, NM_001135638.1 [Q99755-1] NP_001317618.1, NM_001330689.1 NP_003548.1, NM_003557.2 [Q99755-3] |
3D structure databases
SMRi | Q99755 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113983, 76 interactors |
DIPi | DIP-60649N |
IntActi | Q99755, 37 interactors |
STRINGi | 9606.ENSP00000357883 |
Chemistry databases
BindingDBi | Q99755 |
ChEMBLi | CHEMBL5969 |
DrugCentrali | Q99755 |
SwissLipidsi | SLP:000000553 [Q99755-3] SLP:000000554 |
PTM databases
iPTMneti | Q99755 |
PhosphoSitePlusi | Q99755 |
SwissPalmi | Q99755 |
Genetic variation databases
BioMutai | PIP5K1A |
DMDMi | 74752158 |
Proteomic databases
EPDi | Q99755 |
jPOSTi | Q99755 |
MassIVEi | Q99755 |
MaxQBi | Q99755 |
PaxDbi | Q99755 |
PeptideAtlasi | Q99755 |
PRIDEi | Q99755 |
ProteomicsDBi | 78458 [Q99755-1] 78459 [Q99755-2] 78460 [Q99755-3] 78461 [Q99755-4] |
Protocols and materials databases
Antibodypediai | 34058, 180 antibodies |
DNASUi | 8394 |
Genome annotation databases
Ensembli | ENST00000349792; ENSP00000271663; ENSG00000143398 [Q99755-3] ENST00000368888; ENSP00000357883; ENSG00000143398 [Q99755-1] ENST00000368890; ENSP00000357885; ENSG00000143398 [Q99755-2] ENST00000441902; ENSP00000415648; ENSG00000143398 [Q99755-4] |
GeneIDi | 8394 |
KEGGi | hsa:8394 |
UCSCi | uc001exi.4, human [Q99755-1] |
Organism-specific databases
CTDi | 8394 |
DisGeNETi | 8394 |
GeneCardsi | PIP5K1A |
HGNCi | HGNC:8994, PIP5K1A |
HPAi | ENSG00000143398, Low tissue specificity |
MIMi | 603275, gene |
neXtProti | NX_Q99755 |
OpenTargetsi | ENSG00000143398 |
PharmGKBi | PA33327 |
VEuPathDBi | HostDB:ENSG00000143398.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000154703 |
HOGENOMi | CLU_004312_5_1_1 |
InParanoidi | Q99755 |
OMAi | IGHRRID |
OrthoDBi | 1562683at2759 |
PhylomeDBi | Q99755 |
TreeFami | TF319618 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07047-MONOMER |
BRENDAi | 2.7.1.68, 2681 |
PathwayCommonsi | Q99755 |
Reactomei | R-HSA-1660499, Synthesis of PIPs at the plasma membrane R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q99755 |
SIGNORi | Q99755 |
Miscellaneous databases
BioGRID-ORCSi | 8394, 95 hits in 882 CRISPR screens |
ChiTaRSi | PIP5K1A, human |
GeneWikii | PIP5K1A |
GenomeRNAii | 8394 |
Pharosi | Q99755, Tbio |
PROi | PR:Q99755 |
RNActi | Q99755, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143398, Expressed in esophagogastric junction muscularis propria and 236 other tissues |
ExpressionAtlasi | Q99755, baseline and differential |
Genevisiblei | Q99755, HS |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR027483, PInositol-4-P-5-kinase_C IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PI51A_HUMAN | |
Accessioni | Q99755Primary (citable) accession number: Q99755 Secondary accession number(s): A8K4Q0 Q99756 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM