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Protein

MyoD family inhibitor

Gene

MDFI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription factor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99750

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MyoD family inhibitor
Alternative name(s):
Myogenic repressor I-mf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDFI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000112559.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6967 MDFI

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604971 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q99750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000112559

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30713

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MDFI

Domain mapping of disease mutations (DMDM)

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DMDMi
25090674

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963241 – 246MyoD family inhibitorAdd BLAST246

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99750

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99750

PeptideAtlas

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PeptideAtlasi
Q99750

PRoteomics IDEntifications database

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PRIDEi
Q99750

ProteomicsDB human proteome resource

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ProteomicsDBi
78457

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112559 Expressed in 156 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

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CleanExi
HS_MDFI

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99750 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99750 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The C-terminus interacts with AXIN1 and LEF1 (By similarity). Interacts with CCNT2 (PubMed:17289077).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-724076,EBI-724076
Q5BKY63EBI-724076,EBI-10243533
Q5W1505EBI-724076,EBI-10248148
Q5XG855EBI-724076,EBI-10248413
AANATQ166136EBI-724076,EBI-7451846
ABCF3A0A0S2Z6453EBI-724076,EBI-16432404
ADAMTSL3P829875EBI-724076,EBI-10221726
AKAP17AQ02040-33EBI-724076,EBI-10222656
AQP1P299726EBI-724076,EBI-745213
AQP5P550643EBI-724076,EBI-746103
ARHGAP32A7KAX93EBI-724076,EBI-308663
ARID5AQ039894EBI-724076,EBI-948603
AVPI1Q5T6866EBI-724076,EBI-8640233
AXIN1A0A0S2Z4M13EBI-724076,EBI-16429430
AXIN1O151693EBI-724076,EBI-710484
BAHD1Q8TBE06EBI-724076,EBI-742750
BANPA0A0S2Z5G43EBI-724076,EBI-16429704
BANPB4DE543EBI-724076,EBI-16429313
BANPQ8N9N5-25EBI-724076,EBI-11524452
BANPQ8N9N5-73EBI-724076,EBI-16429296
BBS2Q9BXC95EBI-724076,EBI-748297
BEX1Q9HBH75EBI-724076,EBI-7162175
C10orf62Q5T6817EBI-724076,EBI-744052
C22orf39Q6P5X53EBI-724076,EBI-7317823
C8orf33Q9H7E94EBI-724076,EBI-715389
C8orf48Q96LL45EBI-724076,EBI-751596
CATSPER1Q8NEC53EBI-724076,EBI-744545
CBFA2T2O434394EBI-724076,EBI-748628
CBX2Q147813EBI-724076,EBI-745934
CC2D1BQ5T0F93EBI-724076,EBI-10245204
CCDC116Q8IYX34EBI-724076,EBI-744311
CCDC185Q8N7153EBI-724076,EBI-740814
CCDC198Q9NVL83EBI-724076,EBI-10238351
CDCA7LQ96GN55EBI-724076,EBI-5278764
CDKL3Q8IVW43EBI-724076,EBI-3919850
CEP57L1Q8IYX85EBI-724076,EBI-1104570
CHRNGP07510-25EBI-724076,EBI-11979451
CNNM3Q8NE015EBI-724076,EBI-741032
CREB5Q02930-37EBI-724076,EBI-10192698
DAAM2Q6DCB03EBI-724076,EBI-10249414
DCAF8Q5TAQ96EBI-724076,EBI-740686
DCANP1Q8TF635EBI-724076,EBI-10275670
DHRS1Q96LJ73EBI-724076,EBI-746300
DKK1O949073EBI-724076,EBI-742864
DMRT3Q9NQL95EBI-724076,EBI-9679045
DOCK2Q926085EBI-724076,EBI-448771
EIF4A2Q14240-23EBI-724076,EBI-10232522
ELOAQ142415EBI-724076,EBI-742350
ENKD1Q9H0I27EBI-724076,EBI-744099
ESR2Q92731-33EBI-724076,EBI-12259414
FAAP100Q0VG06-33EBI-724076,EBI-10226932
FAM124BQ9H5Z64EBI-724076,EBI-741626
FAM161AQ3B8205EBI-724076,EBI-719941
FAM27E3Q08E935EBI-724076,EBI-2602739
FBXL18Q96D165EBI-724076,EBI-744419
FBXO34Q9NWN33EBI-724076,EBI-719816
FNDC11Q9BVV23EBI-724076,EBI-744935
FOXD4L6Q3SYB35EBI-724076,EBI-6425864
GATA1P15976-25EBI-724076,EBI-9090198
GATA2P237693EBI-724076,EBI-2806671
GDF15Q999884EBI-724076,EBI-2116863
GNAI2P048995EBI-724076,EBI-353997
GNG5P632183EBI-724076,EBI-10220734
GPATCH2LQ9NWQ43EBI-724076,EBI-5666657
GTF3C5Q9Y5Q83EBI-724076,EBI-1045409
hCG_20425B4DNA45EBI-724076,EBI-7399002
HEYLQ9NQ876EBI-724076,EBI-751092
HNRNPLLQ8WVV94EBI-724076,EBI-535849
HOXA1P496393EBI-724076,EBI-740785
Hoxa1P090223EBI-724076,EBI-3957603From Mus musculus.
HOXB9P174825EBI-724076,EBI-745290
HTR1BP282226EBI-724076,EBI-1056863
KAT5Q929933EBI-724076,EBI-399080
KIAA0040A0A024R9355EBI-724076,EBI-20764875
KPNA2P522923EBI-724076,EBI-349938
LAMB3A0A0S2Z3Z33EBI-724076,EBI-16435132
LASP1Q148473EBI-724076,EBI-742828
LCE1BQ5T7P33EBI-724076,EBI-10245913
LCE3EQ5T5B05EBI-724076,EBI-10245456
LCE4AQ5TA785EBI-724076,EBI-10246358
LIMS2Q7Z4I7-53EBI-724076,EBI-10257651
LRCH4O754273EBI-724076,EBI-718707
MAGED1Q9Y5V35EBI-724076,EBI-716006
MAGEF1Q9HAY23EBI-724076,EBI-5525855
MAPKBP1O603365EBI-724076,EBI-947402
METTL17Q9H7H04EBI-724076,EBI-749353
METTL17Q9H7H0-25EBI-724076,EBI-11098807
NECTIN2Q926924EBI-724076,EBI-718419
NEU4Q8WWR84EBI-724076,EBI-746964
NPDC1Q9NQX57EBI-724076,EBI-748927
NR1H2F1D8P75EBI-724076,EBI-10177172
NR1H2P550553EBI-724076,EBI-745354
NR1H3Q131333EBI-724076,EBI-781356
NR1H3Q13133-23EBI-724076,EBI-12699353
ODAPHQ17RF55EBI-724076,EBI-10239029
OLIG3Q7RTU35EBI-724076,EBI-10225049
OTX1P322427EBI-724076,EBI-740446
PDIA5Q145543EBI-724076,EBI-953879
PHLDA1Q8WV243EBI-724076,EBI-738731
PID1Q7Z2X43EBI-724076,EBI-10256685
PIDD1Q9HB753EBI-724076,EBI-520427
PIH1D2Q8WWB55EBI-724076,EBI-10232538
PIN1Q135266EBI-724076,EBI-714158
PITX1P783373EBI-724076,EBI-748265
PLEKHG4Q58EX73EBI-724076,EBI-949255
PRKAB2O437417EBI-724076,EBI-1053424
PRPF31Q8WWY35EBI-724076,EBI-1567797
PTPMT1Q8WUK06EBI-724076,EBI-7199479
RABL6Q3YEC72EBI-724076,EBI-742029
REG3AQ061413EBI-724076,EBI-10223932
REX1BDQ96EN95EBI-724076,EBI-745810
RIPPLY1Q0D2K35EBI-724076,EBI-10226430
RNF6A0A0S2Z4G93EBI-724076,EBI-16428950
RTP5Q14D335EBI-724076,EBI-10217913
RYDENQ9NUL53EBI-724076,EBI-10313866
SIX1Q154752EBI-724076,EBI-743675
SLC25A10Q9UBX37EBI-724076,EBI-750394
SLC25A10Q9UBX3-23EBI-724076,EBI-12056597
SPATA8Q6RVD65EBI-724076,EBI-8635958
SPG7Q9UQ906EBI-724076,EBI-717201
SPRY1O436095EBI-724076,EBI-3866665
SPRY2O435973EBI-724076,EBI-742487
TEAD4A0A0S2Z4E53EBI-724076,EBI-16432288
TEAD4A0A0S2Z4F23EBI-724076,EBI-16429215
TGIF1Q155834EBI-724076,EBI-714215
THEGQ9P2T03EBI-724076,EBI-751020
TNNI1P192373EBI-724076,EBI-746692
TNP2Q4VB563EBI-724076,EBI-10241829
TRIB3Q96RU73EBI-724076,EBI-492476
TTC23Q5W5X93EBI-724076,EBI-6447954
TTLL10Q6ZVT03EBI-724076,EBI-7844656
TUSC2O758965EBI-724076,EBI-1052725
TYMSOSQ8TAI16EBI-724076,EBI-742060
TYRO3Q064183EBI-724076,EBI-3951628
USP20Q9Y2K63EBI-724076,EBI-2511991
VHLP403373EBI-724076,EBI-301246
VHLP40337-23EBI-724076,EBI-12157263
VPS72Q159064EBI-724076,EBI-399189
WNT11O960145EBI-724076,EBI-8058160
ZBTB24O431678EBI-724076,EBI-744471
ZBTB25P242782EBI-724076,EBI-739899
ZBTB9Q96C005EBI-724076,EBI-395708
ZFABQ9Y2604EBI-724076,EBI-750052
ZFYVE26Q68DK2-55EBI-724076,EBI-8656416
ZNF101Q8IZC75EBI-724076,EBI-5278328
ZNF124Q159735EBI-724076,EBI-2555767
ZNF136P527379EBI-724076,EBI-749129
ZNF138P52744-23EBI-724076,EBI-10213071
ZNF155Q12901-23EBI-724076,EBI-10227379
ZNF223Q9UK115EBI-724076,EBI-10322867
ZNF230Q9UIE03EBI-724076,EBI-1105361
ZNF264Q14C613EBI-724076,EBI-2826570
ZNF266Q145845EBI-724076,EBI-7115319
ZNF408Q9H9D45EBI-724076,EBI-347633
ZNF417Q8TAU36EBI-724076,EBI-740727
ZNF433Q8N7K03EBI-724076,EBI-10267553
ZNF439Q8NDP47EBI-724076,EBI-747580
ZNF440Q8IYI89EBI-724076,EBI-726439
ZNF490Q9ULM26EBI-724076,EBI-1105370
ZNF559Q9BR846EBI-724076,EBI-746605
ZNF564Q8TBZ85EBI-724076,EBI-10273713
ZNF578Q3MI943EBI-724076,EBI-10241108
ZNF581Q9P0T46EBI-724076,EBI-745520
ZNF587Q96SQ55EBI-724076,EBI-6427977
ZNF607Q96SK34EBI-724076,EBI-747175
ZNF646O150153EBI-724076,EBI-745608
ZNF670Q9BS344EBI-724076,EBI-745276
ZNF679Q8IYX03EBI-724076,EBI-745567
ZNF688A0A0S2Z5X43EBI-724076,EBI-16429014
ZNF707Q96C284EBI-724076,EBI-748111
ZNF764Q96H863EBI-724076,EBI-745775
ZNF79Q159373EBI-724076,EBI-10237274
ZNF844Q08AG55EBI-724076,EBI-10225757

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110353, 238 interactors

Protein interaction database and analysis system

More...
IntActi
Q99750, 410 interactors

Molecular INTeraction database

More...
MINTi
Q99750

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230321

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99750

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99750

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 246MDFIAdd BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 243Cys-richAdd BLAST81

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MDFI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IYH9 Eukaryota
ENOG410YK34 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160187

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000001577

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG031704

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99750

Identification of Orthologs from Complete Genome Data

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OMAi
HCDAPHG

Database of Orthologous Groups

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OrthoDBi
1487193at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99750

TreeFam database of animal gene trees

More...
TreeFami
TF332113

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026134 MDFI/MDFIC

The PANTHER Classification System

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PANTHERi
PTHR15304 PTHR15304, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15316 MDFI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q99750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYQVSGQRPS GCDAPYGAPS AAPGPAQTLS LLPGLEVVTG STHPAEAAPE
60 70 80 90 100
EGSLEEAATP MPQGNGPGIP QGLDSTDLDV PTEAVTCQPQ GNPLGCTPLL
110 120 130 140 150
PNDSGHPSEL GGTRRAGNGA LGGPKAHRKL QTHPSLASQG SKKSKSSSKS
160 170 180 190 200
TTSQIPLQAQ EDCCVHCILS CLFCEFLTLC NIVLDCATCG SCSSEDSCLC
210 220 230 240
CCCCGSGECA DCDLPCDLDC GILDACCESA DCLEICMECC GLCFSS
Length:246
Mass (Da):25,029
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9330E52141B79E5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKB6B1AKB6_HUMAN
MyoD family inhibitor
MDFI
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKB8B1AKB8_HUMAN
MyoD family inhibitor
MDFI
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKB7B1AKB7_HUMAN
MyoD family inhibitor
MDFI
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKB9B1AKB9_HUMAN
MyoD family inhibitor
MDFI
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKC0B1AKC0_HUMAN
MyoD family inhibitor
MDFI
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKC1B1AKC1_HUMAN
MyoD family inhibitor
MDFI
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U78313 mRNA Translation: AAB39748.1
AL035588 Genomic DNA No translation available.
BC007836 mRNA Translation: AAH07836.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4857.1

NCBI Reference Sequences

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RefSeqi
NP_001287733.1, NM_001300804.1
NP_001287734.1, NM_001300805.1
NP_001287735.1, NM_001300806.1
NP_005577.1, NM_005586.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.520119

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230321; ENSP00000230321; ENSG00000112559
ENST00000373051; ENSP00000362142; ENSG00000112559

Database of genes from NCBI RefSeq genomes

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GeneIDi
4188

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4188

UCSC genome browser

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UCSCi
uc003oqq.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78313 mRNA Translation: AAB39748.1
AL035588 Genomic DNA No translation available.
BC007836 mRNA Translation: AAH07836.1
CCDSiCCDS4857.1
RefSeqiNP_001287733.1, NM_001300804.1
NP_001287734.1, NM_001300805.1
NP_001287735.1, NM_001300806.1
NP_005577.1, NM_005586.3
UniGeneiHs.520119

3D structure databases

ProteinModelPortaliQ99750
SMRiQ99750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110353, 238 interactors
IntActiQ99750, 410 interactors
MINTiQ99750
STRINGi9606.ENSP00000230321

PTM databases

iPTMnetiQ99750
PhosphoSitePlusiQ99750

Polymorphism and mutation databases

BioMutaiMDFI
DMDMi25090674

Proteomic databases

MaxQBiQ99750
PaxDbiQ99750
PeptideAtlasiQ99750
PRIDEiQ99750
ProteomicsDBi78457

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4188
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230321; ENSP00000230321; ENSG00000112559
ENST00000373051; ENSP00000362142; ENSG00000112559
GeneIDi4188
KEGGihsa:4188
UCSCiuc003oqq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4188
EuPathDBiHostDB:ENSG00000112559.13

GeneCards: human genes, protein and diseases

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GeneCardsi
MDFI
HGNCiHGNC:6967 MDFI
HPAiHPA049973
MIMi604971 gene
neXtProtiNX_Q99750
OpenTargetsiENSG00000112559
PharmGKBiPA30713

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYH9 Eukaryota
ENOG410YK34 LUCA
GeneTreeiENSGT00940000160187
HOGENOMiHOG000001577
HOVERGENiHBG031704
InParanoidiQ99750
OMAiHCDAPHG
OrthoDBi1487193at2759
PhylomeDBiQ99750
TreeFamiTF332113

Enzyme and pathway databases

SIGNORiQ99750

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MDFI human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MDFI

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4188

Protein Ontology

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PROi
PR:Q99750

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112559 Expressed in 156 organ(s), highest expression level in ectocervix
CleanExiHS_MDFI
ExpressionAtlasiQ99750 baseline and differential
GenevisibleiQ99750 HS

Family and domain databases

InterProiView protein in InterPro
IPR026134 MDFI/MDFIC
PANTHERiPTHR15304 PTHR15304, 1 hit
PfamiView protein in Pfam
PF15316 MDFI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDFI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99750
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1997
Last modified: January 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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