UniProtKB - Q99747 (SNAG_HUMAN)
Protein
Gamma-soluble NSF attachment protein
Gene
NAPG
Organism
Homo sapiens (Human)
Status
Functioni
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
GO - Molecular functioni
- soluble NSF attachment protein activity Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: ProtInc
- membrane fusion Source: ProtInc
- protein-containing complex assembly Source: UniProtKB
- protein stabilization Source: UniProtKB
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q99747 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-soluble NSF attachment proteinShort name: SNAP-gamma Alternative name(s): N-ethylmaleimide-sensitive factor attachment protein gamma |
Gene namesi | Name:NAPG Synonyms:SNAPG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7642, NAPG |
MIMi | 603216, gene |
neXtProti | NX_Q99747 |
VEuPathDBi | HostDB:ENSG00000134265.12 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- SNARE complex Source: GO_Central
- synapse Source: Ensembl
- vacuolar membrane Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8774 |
OpenTargetsi | ENSG00000134265 |
PharmGKBi | PA31445 |
Miscellaneous databases
Pharosi | Q99747, Tbio |
Genetic variation databases
BioMutai | NAPG |
DMDMi | 3024632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219063 | 1 – 312 | Gamma-soluble NSF attachment proteinAdd BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 284 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 308 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99747 |
jPOSTi | Q99747 |
MassIVEi | Q99747 |
MaxQBi | Q99747 |
PaxDbi | Q99747 |
PeptideAtlasi | Q99747 |
PRIDEi | Q99747 |
ProteomicsDBi | 4024 78455 [Q99747-1] |
2D gel databases
OGPi | Q99747 |
PTM databases
iPTMneti | Q99747 |
PhosphoSitePlusi | Q99747 |
SwissPalmi | Q99747 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134265, Expressed in corpus callosum and 232 other tissues |
ExpressionAtlasi | Q99747, baseline and differential |
Genevisiblei | Q99747, HS |
Organism-specific databases
HPAi | ENSG00000134265, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binds RIP11.
Interacts with VTI1A (By similarity).
By similarityGO - Molecular functioni
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114304, 45 interactors |
CORUMi | Q99747 |
IntActi | Q99747, 32 interactors |
STRINGi | 9606.ENSP00000324628 |
Miscellaneous databases
RNActi | Q99747, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SNAP family.Curated
Phylogenomic databases
eggNOGi | KOG1585, Eukaryota |
GeneTreei | ENSGT00390000005826 |
HOGENOMi | CLU_063974_1_0_1 |
InParanoidi | Q99747 |
OMAi | PYEQAGM |
OrthoDBi | 1540214at2759 |
PhylomeDBi | Q99747 |
TreeFami | TF312872 |
Family and domain databases
CDDi | cd15832, SNAP, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR000744, NSF_attach IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13768, PTHR13768, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99747-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ
60 70 80 90 100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK
110 120 130 140 150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL
160 170 180 190 200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ
210 220 230 240 250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV
260 270 280 290 300
SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA
310
DEEEDEYSGG LC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KTJ6 | J3KTJ6_HUMAN | Gamma-soluble NSF attachment protei... | NAPG | 177 | Annotation score: | ||
J3QKW4 | J3QKW4_HUMAN | Gamma-soluble NSF attachment protei... | NAPG | 22 | Annotation score: | ||
J3QS28 | J3QS28_HUMAN | Gamma-soluble NSF attachment protei... | NAPG | 18 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 147 | E → D in AAH01889 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052027 | 92 | P → S. Corresponds to variant dbSNP:rs2228300Ensembl. | 1 | |
Natural variantiVAR_020129 | 281 | K → N. Corresponds to variant dbSNP:rs2305370Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056355 | 1 – 82 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78107 mRNA Translation: AAB69753.1 AK294038 mRNA Translation: BAG57390.1 AP001099 Genomic DNA No translation available. BC001889 mRNA Translation: AAH01889.1 |
CCDSi | CCDS45827.1 [Q99747-1] |
RefSeqi | NP_003817.1, NM_003826.2 [Q99747-1] XP_011524058.1, XM_011525756.2 [Q99747-2] |
Genome annotation databases
Ensembli | ENST00000322897; ENSP00000324628; ENSG00000134265 [Q99747-1] |
GeneIDi | 8774 |
KEGGi | hsa:8774 |
UCSCi | uc002kon.4, human [Q99747-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78107 mRNA Translation: AAB69753.1 AK294038 mRNA Translation: BAG57390.1 AP001099 Genomic DNA No translation available. BC001889 mRNA Translation: AAH01889.1 |
CCDSi | CCDS45827.1 [Q99747-1] |
RefSeqi | NP_003817.1, NM_003826.2 [Q99747-1] XP_011524058.1, XM_011525756.2 [Q99747-2] |
3D structure databases
SMRi | Q99747 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114304, 45 interactors |
CORUMi | Q99747 |
IntActi | Q99747, 32 interactors |
STRINGi | 9606.ENSP00000324628 |
PTM databases
iPTMneti | Q99747 |
PhosphoSitePlusi | Q99747 |
SwissPalmi | Q99747 |
Genetic variation databases
BioMutai | NAPG |
DMDMi | 3024632 |
2D gel databases
OGPi | Q99747 |
Proteomic databases
EPDi | Q99747 |
jPOSTi | Q99747 |
MassIVEi | Q99747 |
MaxQBi | Q99747 |
PaxDbi | Q99747 |
PeptideAtlasi | Q99747 |
PRIDEi | Q99747 |
ProteomicsDBi | 4024 78455 [Q99747-1] |
Protocols and materials databases
Antibodypediai | 2189, 177 antibodies |
DNASUi | 8774 |
Genome annotation databases
Ensembli | ENST00000322897; ENSP00000324628; ENSG00000134265 [Q99747-1] |
GeneIDi | 8774 |
KEGGi | hsa:8774 |
UCSCi | uc002kon.4, human [Q99747-1] |
Organism-specific databases
CTDi | 8774 |
DisGeNETi | 8774 |
GeneCardsi | NAPG |
HGNCi | HGNC:7642, NAPG |
HPAi | ENSG00000134265, Tissue enhanced (brain) |
MIMi | 603216, gene |
neXtProti | NX_Q99747 |
OpenTargetsi | ENSG00000134265 |
PharmGKBi | PA31445 |
VEuPathDBi | HostDB:ENSG00000134265.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1585, Eukaryota |
GeneTreei | ENSGT00390000005826 |
HOGENOMi | CLU_063974_1_0_1 |
InParanoidi | Q99747 |
OMAi | PYEQAGM |
OrthoDBi | 1540214at2759 |
PhylomeDBi | Q99747 |
TreeFami | TF312872 |
Enzyme and pathway databases
PathwayCommonsi | Q99747 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 8774, 472 hits in 876 CRISPR screens |
ChiTaRSi | NAPG, human |
GeneWikii | NAPG |
GenomeRNAii | 8774 |
Pharosi | Q99747, Tbio |
PROi | PR:Q99747 |
RNActi | Q99747, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134265, Expressed in corpus callosum and 232 other tissues |
ExpressionAtlasi | Q99747, baseline and differential |
Genevisiblei | Q99747, HS |
Family and domain databases
CDDi | cd15832, SNAP, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR000744, NSF_attach IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13768, PTHR13768, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAG_HUMAN | |
Accessioni | Q99747Primary (citable) accession number: Q99747 Secondary accession number(s): B4DFC9, Q9BUV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants