NAPG

Functionⁱ

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functionⁱ

soluble NSF attachment protein activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intra-Golgi vesicle-mediated transport
Source: ProtInc
Traceable author statementⁱ
- 8455721
membrane fusion
Source: ProtInc
Traceable author statementⁱ
- 8455721
protein-containing complex assembly
Source: UniProtKB
Non-traceable author statementⁱ
- 11278501
protein stabilization
Source: UniProtKB
Non-traceable author statementⁱ
- 11278501

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Protein transport, Transport

Biological process

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438 Intra-Golgi traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gamma-soluble NSF attachment protein Short name: SNAP-gamma Alternative name(s): N-ethylmaleimide-sensitive factor attachment protein gamma
Gene namesⁱ	Name:NAPG Synonyms:SNAPG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134265.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7642 NAPG
MIMⁱ	603216 gene
neXtProtⁱ	NX_Q99747

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8774
Open Targets More...OpenTargetsⁱ	ENSG00000134265
PharmGKBⁱ	PA31445

Polymorphism and mutation databases

BioMutaⁱ	NAPG
DMDMⁱ	3024632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219063	1 – 312	Gamma-soluble NSF attachment proteinAdd BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	284	PhosphoserineBy similarity	1
Modified residueⁱ	287	PhosphothreonineBy similarity	1
Modified residueⁱ	308	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q99747
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99747
PaxDbⁱ	Q99747
PeptideAtlas More...PeptideAtlasⁱ	Q99747
PRIDEⁱ	Q99747
ProteomicsDBⁱ	78455

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q99747

OGPⁱ

Q99747

PTM databases

iPTMnetⁱ	Q99747
PhosphoSitePlusⁱ	Q99747
SwissPalmⁱ	Q99747

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134265 Expressed in 222 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_NAPG
ExpressionAtlasⁱ	Q99747 baseline and differential
Genevisibleⁱ	Q99747 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008208 HPA011389

HPAⁱ

HPA008208
HPA011389

Interactionⁱ

Subunit structureⁱ

Binds RIP11. Interacts with VTI1A (By similarity).By similarity

GO - Molecular functionⁱ

soluble NSF attachment protein activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114304, 40 interactors
CORUMⁱ	Q99747
IntActⁱ	Q99747, 6 interactors
STRINGⁱ	9606.ENSP00000324628

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99747
SMRⁱ	Q99747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1585 Eukaryota ENOG410ZYD7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010109
HOGENOMⁱ	HOG000007747
HOVERGENⁱ	HBG001648
InParanoidⁱ	Q99747
KEGG Orthology (KO) More...KOⁱ	K21198
OMAⁱ	PYEQAGM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GNK
PhylomeDBⁱ	Q99747
TreeFamⁱ	TF312872

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15832 SNAP, 1 hit
Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000744 NSF_attach IPR011990 TPR-like_helical_dom_sf
PANTHERⁱ	PTHR13768 PTHR13768, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q99747-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ 
        60         70         80         90        100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK 
       110        120        130        140        150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL 
       160        170        180        190        200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ 
       210        220        230        240        250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV 
       260        270        280        290        300
SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA 
       310 
DEEEDEYSGG LC

Length:312

Mass (Da):34,746

Last modified:May 1, 1997 - v1

Checksum:ⁱC37D73C1AEFD48C8

GO

Isoform 2 (identifier: Q99747-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-82: Missing.

« Hide

        10         20         30         40         50
MMLKEMQKLP EAVQLIEKAS MMYLENGTPD TAAMALERAG KLIENVDPEK 
        60         70         80         90        100
AVQLYQQTAN VFENEERLRQ AVELLGKASR LLVRGRRFDE AALSIQKEKN 
       110        120        130        140        150
IYKEIENYPT CYKKTIAQVL VHLHRNDYVA AERCVRESYS IPGFNGSEDC 
       160        170        180        190        200
AALEQLLEGY DQQDQDQVSD VCNSPLFKYM DNDYAKLGLS LVVPGGGIKK 
       210        220        230
KSPATPQAKP DGVTATAADE EEDEYSGGLC

Note: No experimental confirmation available.

Show »

Length:230

Mass (Da):25,662

Checksum:ⁱ1243534338B3B8D2

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KTJ6	J3KTJ6_HUMAN	Gamma-soluble NSF attachment protei... Gamma-soluble NSF attachment protein	NAPG	177	Annotation score:
J3QKW4	J3QKW4_HUMAN	Gamma-soluble NSF attachment protei... Gamma-soluble NSF attachment protein	NAPG	22	Annotation score:
J3QS28	J3QS28_HUMAN	Gamma-soluble NSF attachment protei... Gamma-soluble NSF attachment protein	NAPG	18	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	147	E → D in AAH01889 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052027	92	P → S. Corresponds to variant dbSNP:rs2228300Ensembl.		1
Natural variantⁱVAR_020129	281	K → N. Corresponds to variant dbSNP:rs2305370Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056355	1 – 82	Missing in isoform 2. 1 PublicationAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78107 mRNA Translation: AAB69753.1 AK294038 mRNA Translation: BAG57390.1 AP001099 Genomic DNA No translation available. BC001889 mRNA Translation: AAH01889.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45827.1 [Q99747-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003817.1, NM_003826.2 [Q99747-1] XP_011524058.1, XM_011525756.2 [Q99747-2]
UniGeneⁱ	Hs.464622

Genome annotation databases

Ensemblⁱ	ENST00000322897; ENSP00000324628; ENSG00000134265 [Q99747-1]
GeneIDⁱ	8774
KEGGⁱ	hsa:8774
UCSC genome browser More...UCSCⁱ	uc002kon.4 human [Q99747-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99747	N-ethylmaleimide-sensitive factor attachment protein, gamma, isoform CRA_b		HUMAN		312	UniRef100_Q99747
N-ethylmaleimide-sensitive factor attachment protein, gamma		PANTR		312
Gamma-soluble NSF attachment protein		CALJA		312
NAPG isoform 3		PONAB		312
NSF attachment protein gamma		SAIBB		312
+8

Protein	Similar proteins		Species	Score	Length	Source
Q99747	Gamma-soluble NSF attachment protein		MOUSE		312	UniRef90_Q99747
N-ethylmaleimide-sensitive factor attachment protein, gamma, isoform CRA_b		HUMAN		312
N-ethylmaleimide-sensitive factor attachment protein, gamma		PANTR		312
Gamma-soluble NSF attachment protein		CALJA		312
NAPG isoform 3		PONAB		312
+109

Protein	Similar proteins		Species	Score	Length	Source
Q99747	Gamma-soluble NSF attachment protein		MOUSE		312	UniRef50_Q99747
Gamma-soluble NSF attachment protein		BOVIN		312
N-ethylmaleimide-sensitive factor attachment protein, gamma, isoform CRA_b		HUMAN		312
N-ethylmaleimide-sensitive factor attachment protein, gamma		PANTR		312
Gamma-soluble NSF attachment protein		CALJA		312
+249

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78107 mRNA Translation: AAB69753.1 AK294038 mRNA Translation: BAG57390.1 AP001099 Genomic DNA No translation available. BC001889 mRNA Translation: AAH01889.1
CCDSⁱ	CCDS45827.1 [Q99747-1]
RefSeqⁱ	NP_003817.1, NM_003826.2 [Q99747-1] XP_011524058.1, XM_011525756.2 [Q99747-2]
UniGeneⁱ	Hs.464622

3D structure databases

ProteinModelPortalⁱ	Q99747
SMRⁱ	Q99747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114304, 40 interactors
CORUMⁱ	Q99747
IntActⁱ	Q99747, 6 interactors
STRINGⁱ	9606.ENSP00000324628

PTM databases

iPTMnetⁱ	Q99747
PhosphoSitePlusⁱ	Q99747
SwissPalmⁱ	Q99747

Polymorphism and mutation databases

BioMutaⁱ	NAPG
DMDMⁱ	3024632

2D gel databases

OGPⁱ	Q99747

OGPⁱ

Q99747

Proteomic databases

EPDⁱ	Q99747
MaxQBⁱ	Q99747
PaxDbⁱ	Q99747
PeptideAtlasⁱ	Q99747
PRIDEⁱ	Q99747
ProteomicsDBⁱ	78455

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8774
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000322897; ENSP00000324628; ENSG00000134265 [Q99747-1]
GeneIDⁱ	8774
KEGGⁱ	hsa:8774
UCSCⁱ	uc002kon.4 human [Q99747-1]

Organism-specific databases

CTDⁱ	8774
DisGeNETⁱ	8774
EuPathDBⁱ	HostDB:ENSG00000134265.12
GeneCardsⁱ	NAPG
HGNCⁱ	HGNC:7642 NAPG
HPAⁱ	HPA008208 HPA011389
MIMⁱ	603216 gene
neXtProtⁱ	NX_Q99747
OpenTargetsⁱ	ENSG00000134265
PharmGKBⁱ	PA31445
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1585 Eukaryota ENOG410ZYD7 LUCA
GeneTreeⁱ	ENSGT00390000010109
HOGENOMⁱ	HOG000007747
HOVERGENⁱ	HBG001648
InParanoidⁱ	Q99747
KOⁱ	K21198
OMAⁱ	PYEQAGM
OrthoDBⁱ	EOG091G0GNK
PhylomeDBⁱ	Q99747
TreeFamⁱ	TF312872

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438 Intra-Golgi traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSⁱ	NAPG human
GeneWikiⁱ	NAPG
GenomeRNAiⁱ	8774
Protein Ontology More...PROⁱ	PR:Q99747
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134265 Expressed in 222 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_NAPG
ExpressionAtlasⁱ	Q99747 baseline and differential
Genevisibleⁱ	Q99747 HS

Family and domain databases

CDDⁱ	cd15832 SNAP, 1 hit
Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000744 NSF_attach IPR011990 TPR-like_helical_dom_sf
PANTHERⁱ	PTHR13768 PTHR13768, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNAG_HUMAN
Accessionⁱ	Q99747Primary (citable) accession number: Q99747 Secondary accession number(s): B4DFC9, Q9BUV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

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UniProtKB - Q99747 (SNAG_HUMAN)

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Gamma-soluble NSF attachment protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Lysosome

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ