Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (07 Oct 2020)
Sequence version 1 (01 May 1997)
Previous versions | rss
Add a publicationFeedback
Protein

Microsomal glutathione S-transferase 2

Gene

MGST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Each monomer can bind on GSH molecule but only one subunit is catalytically active.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.6 sec(-1) for leukotriene A4 as substrate (PubMed:23409838). kcat is 14.3 sec(-1) for 1-chloro-2,4-dinitrobenzene as substrate (PubMed:23409838). kcat is 0.1 sec(-1) for 5-HPETE as substrate (PubMed:23409838).1 Publication
  1. KM=7 µM for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate (5-HPETE)2 Publications
  2. KM=28 µM for leukotriene A41 Publication
  3. KM=40 µM for leukotriene A41 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase, Oxidoreductase, Transferase
    Biological processLeukotriene biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q99735

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-156590, Glutathione conjugation
    R-HSA-5423646, Aflatoxin activation and detoxification

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001464

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 2 (EC:2.5.1.183 Publications)
    Short name:
    Microsomal GST-2
    Alternative name(s):
    Glutathione peroxidase MGST2Curated (EC:1.11.1.-2 Publications)
    Leukotriene C4 synthase MGST2Curated (EC:4.4.1.204 Publications)
    Microsomal glutathione S-transferase II1 Publication
    Short name:
    Microsomal GST-II1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MGST2
    Synonyms:GST2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000085871.8

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7063, MGST2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    601733, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q99735

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
    Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
    Transmembranei111 – 131HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4258

    Open Targets

    More...
    OpenTargetsi
    ENSG00000085871

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30792

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q99735, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1743185

    Drug and drug target database

    More...
    DrugBanki
    DB01008, Busulfan
    DB00143, Glutathione

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MGST2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    2842764

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002177401 – 147Microsomal glutathione S-transferase 2Add BLAST147

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q99735

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q99735

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q99735

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q99735

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q99735

    PeptideAtlas

    More...
    PeptideAtlasi
    Q99735

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q99735

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    13587
    78451 [Q99735-1]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q99735-1 [Q99735-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q99735

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q99735

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876).2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Upon ER stress with brefeldin A or with tunicamycin, MGST2 is down-regulated, in several non-haematopoietic cell types, during the early, protective phase of the unfolded protein response (UPR), and up-regulated at the late, death-promoting phase of the unfolded protein response (UPR).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000085871, Expressed in right lobe of liver and 236 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q99735, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000085871, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    110414, 29 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q99735, 25 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q99735

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000482639

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q99735, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502S082, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160288

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_110291_3_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q99735

    KEGG Orthology (KO)

    More...
    KOi
    K00799

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HKYFWGY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1609516at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q99735

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105328

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.120.550, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001446, 5_LipOase_AP
    IPR018295, FLAP/GST2/LTC4S_CS
    IPR023352, MAPEG-like_dom_sf
    IPR001129, Membr-assoc_MAPEG

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01124, MAPEG, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00488, 5LPOXGNASEAP

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF161084, SSF161084, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01297, FLAP_GST2_LTC4S, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q99735-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF
    60 70 80 90 100
    RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA
    110 120 130 140
    AKKRITGFRL SLGILALLTL LGALGIANSF LDEYLDLNIA KKLRRQF
    Length:147
    Mass (Da):16,621
    Last modified:May 1, 1997 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0E89B46885D16EF
    GO
    Isoform 2 (identifier: Q99735-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-147: QQNCVEFYPI...NIAKKLRRQF → HFCYLSGSGVHIWPSPILLGIFRSC

    Show »
    Length:77
    Mass (Da):8,359
    Checksum:iCABF1D4ECFAD2B79
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019997101A → V1 PublicationCorresponds to variant dbSNP:rs8192111Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04453853 – 147QQNCV…LRRQF → HFCYLSGSGVHIWPSPILLG IFRSC in isoform 2. 1 PublicationAdd BLAST95

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U77604 mRNA Translation: AAC51768.1
    CR407640 mRNA Translation: CAG28568.1
    AY341028 Genomic DNA Translation: AAP88934.1 Sequence problems.
    AC108053 Genomic DNA No translation available.
    AC112236 Genomic DNA No translation available.
    BC025416 mRNA Translation: AAH25416.1
    BG519599 mRNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS3749.1 [Q99735-1]
    CCDS56339.1 [Q99735-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001191295.1, NM_001204366.1 [Q99735-1]
    NP_001191297.1, NM_001204368.1 [Q99735-2]
    NP_002404.1, NM_002413.4 [Q99735-1]
    XP_016863700.1, XM_017008211.1 [Q99735-1]
    XP_016863701.1, XM_017008212.1 [Q99735-1]
    XP_016863702.1, XM_017008213.1 [Q99735-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000265498; ENSP00000265498; ENSG00000085871 [Q99735-1]
    ENST00000503816; ENSP00000423008; ENSG00000085871 [Q99735-1]
    ENST00000506797; ENSP00000424278; ENSG00000085871 [Q99735-2]
    ENST00000616265; ENSP00000482639; ENSG00000085871 [Q99735-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4258

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4258

    UCSC genome browser

    More...
    UCSCi
    uc003ihy.4, human [Q99735-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U77604 mRNA Translation: AAC51768.1
    CR407640 mRNA Translation: CAG28568.1
    AY341028 Genomic DNA Translation: AAP88934.1 Sequence problems.
    AC108053 Genomic DNA No translation available.
    AC112236 Genomic DNA No translation available.
    BC025416 mRNA Translation: AAH25416.1
    BG519599 mRNA No translation available.
    CCDSiCCDS3749.1 [Q99735-1]
    CCDS56339.1 [Q99735-2]
    RefSeqiNP_001191295.1, NM_001204366.1 [Q99735-1]
    NP_001191297.1, NM_001204368.1 [Q99735-2]
    NP_002404.1, NM_002413.4 [Q99735-1]
    XP_016863700.1, XM_017008211.1 [Q99735-1]
    XP_016863701.1, XM_017008212.1 [Q99735-1]
    XP_016863702.1, XM_017008213.1 [Q99735-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi110414, 29 interactors
    IntActiQ99735, 25 interactors
    MINTiQ99735
    STRINGi9606.ENSP00000482639

    Chemistry databases

    ChEMBLiCHEMBL1743185
    DrugBankiDB01008, Busulfan
    DB00143, Glutathione
    SwissLipidsiSLP:000001464

    PTM databases

    iPTMnetiQ99735
    PhosphoSitePlusiQ99735

    Polymorphism and mutation databases

    BioMutaiMGST2
    DMDMi2842764

    Proteomic databases

    EPDiQ99735
    jPOSTiQ99735
    MassIVEiQ99735
    MaxQBiQ99735
    PaxDbiQ99735
    PeptideAtlasiQ99735
    PRIDEiQ99735
    ProteomicsDBi13587
    78451 [Q99735-1]
    TopDownProteomicsiQ99735-1 [Q99735-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    2759, 166 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    4258

    Genome annotation databases

    EnsembliENST00000265498; ENSP00000265498; ENSG00000085871 [Q99735-1]
    ENST00000503816; ENSP00000423008; ENSG00000085871 [Q99735-1]
    ENST00000506797; ENSP00000424278; ENSG00000085871 [Q99735-2]
    ENST00000616265; ENSP00000482639; ENSG00000085871 [Q99735-1]
    GeneIDi4258
    KEGGihsa:4258
    UCSCiuc003ihy.4, human [Q99735-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4258
    DisGeNETi4258
    EuPathDBiHostDB:ENSG00000085871.8

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MGST2
    HGNCiHGNC:7063, MGST2
    HPAiENSG00000085871, Low tissue specificity
    MIMi601733, gene
    neXtProtiNX_Q99735
    OpenTargetsiENSG00000085871
    PharmGKBiPA30792

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG502S082, Eukaryota
    GeneTreeiENSGT00940000160288
    HOGENOMiCLU_110291_3_0_1
    InParanoidiQ99735
    KOiK00799
    OMAiHKYFWGY
    OrthoDBi1609516at2759
    PhylomeDBiQ99735
    TreeFamiTF105328

    Enzyme and pathway databases

    PathwayCommonsiQ99735
    ReactomeiR-HSA-156590, Glutathione conjugation
    R-HSA-5423646, Aflatoxin activation and detoxification

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    4258, 4 hits in 875 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    MGST2, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MGST2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4258
    PharosiQ99735, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q99735
    RNActiQ99735, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000085871, Expressed in right lobe of liver and 236 other tissues
    GenevisibleiQ99735, HS

    Family and domain databases

    Gene3Di1.20.120.550, 1 hit
    InterProiView protein in InterPro
    IPR001446, 5_LipOase_AP
    IPR018295, FLAP/GST2/LTC4S_CS
    IPR023352, MAPEG-like_dom_sf
    IPR001129, Membr-assoc_MAPEG
    PfamiView protein in Pfam
    PF01124, MAPEG, 1 hit
    PRINTSiPR00488, 5LPOXGNASEAP
    SUPFAMiSSF161084, SSF161084, 1 hit
    PROSITEiView protein in PROSITE
    PS01297, FLAP_GST2_LTC4S, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGST2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99735
    Secondary accession number(s): D6RBB5, Q7Z5B8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 7, 2020
    This is version 176 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again