Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleosome assembly protein 1-like 4

Gene

NAP1L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as histone chaperone in nucleosome assembly.1 Publication

GO - Molecular functioni

  • nucleosome binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • unfolded protein binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Alternative name(s):
Nucleosome assembly protein 21 Publication
Short name:
NAP-21 Publication
Gene namesi
Name:NAP1L4Imported
Synonyms:NAP21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000205531.12
HGNCiHGNC:7640 NAP1L4
MIMi601651 gene
neXtProtiNX_Q99733

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4676
OpenTargetsiENSG00000205531
PharmGKBiPA31442

Chemistry databases

ChEMBLiCHEMBL3886061

Polymorphism and mutation databases

BioMutaiNAP1L4
DMDMi2498672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001856582 – 375Nucleosome assembly protein 1-like 4Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei58PhosphothreonineCombined sources1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei304PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.1 Publication
Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).By similarityCurated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99733
MaxQBiQ99733
PaxDbiQ99733
PeptideAtlasiQ99733
PRIDEiQ99733
ProteomicsDBi78450

PTM databases

iPTMnetiQ99733
PhosphoSitePlusiQ99733
SwissPalmiQ99733

Miscellaneous databases

PMAP-CutDBiQ99733

Expressioni

Tissue specificityi

Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000205531 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_NAP1L4
ExpressionAtlasiQ99733 baseline and differential
GenevisibleiQ99733 HS

Organism-specific databases

HPAiCAB011567

Interactioni

Subunit structurei

Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046083EBI-2255116,EBI-6164389From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110757, 84 interactors
IntActiQ99733, 38 interactors
MINTiQ99733
STRINGi9606.ENSP00000369915

Structurei

3D structure databases

ProteinModelPortaliQ99733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 271Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 131Poly-Glu6
Compositional biasi301 – 310Asp/Glu-rich (acidic)10
Compositional biasi347 – 370Asp/Glu-rich (acidic)Add BLAST24

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ99733
KOiK11282
OMAiSQPSECK
OrthoDBiEOG091G0HVV
PhylomeDBiQ99733
TreeFamiTF314349

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99733-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SEWHSENEEE EKLAGDMKSK VVVTEKAAAT
160 170 180 190 200
AEEPDPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370
EGEEEELEGD EEGEDEDDAE INPKV
Length:375
Mass (Da):42,823
Last modified:May 1, 1997 - v1
Checksum:i788E1F9F5BC8FD45
GO
Isoform 2 (identifier: Q99733-2) [UniParc]FASTAAdd to basket
Also known as: NAP1L4b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     375-375: V → KEPSQPAECKQQ

Show »
Length:386
Mass (Da):44,079
Checksum:i4B758A68C22F9D9E
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZI7C9JZI7_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
278Annotation score:
A8MXH2A8MXH2_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
156Annotation score:
E9PS34E9PS34_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
133Annotation score:
C9J6D1C9J6D1_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
178Annotation score:
E9PP22E9PP22_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
154Annotation score:
H0YCI4H0YCI4_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
204Annotation score:
E9PNJ7E9PNJ7_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
140Annotation score:
E9PNW0E9PNW0_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
107Annotation score:
E9PJJ2E9PJJ2_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
128Annotation score:
E9PKI2E9PKI2_HUMAN
Nucleosome assembly protein 1-like ...
NAP1L4
78Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107R → K in BAG35491 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053910375V → KEPSQPAECKQQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77456 mRNA Translation: AAC50870.1
AB500094 mRNA Translation: BAH95827.1
AK312599 mRNA Translation: BAG35491.1
AC131971 Genomic DNA No translation available.
BC022090 mRNA Translation: AAH22090.1
CCDSiCCDS41599.1 [Q99733-1]
RefSeqiNP_005960.1, NM_005969.3 [Q99733-1]
UniGeneiHs.731784

Genome annotation databases

EnsembliENST00000380542; ENSP00000369915; ENSG00000205531 [Q99733-1]
ENST00000526115; ENSP00000436397; ENSG00000205531 [Q99733-2]
ENST00000616696; ENSP00000478654; ENSG00000273562 [Q99733-2]
ENST00000619695; ENSP00000483728; ENSG00000273562 [Q99733-1]
ENST00000620138; ENSP00000481412; ENSG00000205531 [Q99733-2]
ENST00000632791; ENSP00000487984; ENSG00000273562 [Q99733-2]
GeneIDi4676
KEGGihsa:4676
UCSCiuc001lxc.4 human [Q99733-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77456 mRNA Translation: AAC50870.1
AB500094 mRNA Translation: BAH95827.1
AK312599 mRNA Translation: BAG35491.1
AC131971 Genomic DNA No translation available.
BC022090 mRNA Translation: AAH22090.1
CCDSiCCDS41599.1 [Q99733-1]
RefSeqiNP_005960.1, NM_005969.3 [Q99733-1]
UniGeneiHs.731784

3D structure databases

ProteinModelPortaliQ99733
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110757, 84 interactors
IntActiQ99733, 38 interactors
MINTiQ99733
STRINGi9606.ENSP00000369915

Chemistry databases

ChEMBLiCHEMBL3886061

PTM databases

iPTMnetiQ99733
PhosphoSitePlusiQ99733
SwissPalmiQ99733

Polymorphism and mutation databases

BioMutaiNAP1L4
DMDMi2498672

Proteomic databases

EPDiQ99733
MaxQBiQ99733
PaxDbiQ99733
PeptideAtlasiQ99733
PRIDEiQ99733
ProteomicsDBi78450

Protocols and materials databases

DNASUi4676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380542; ENSP00000369915; ENSG00000205531 [Q99733-1]
ENST00000526115; ENSP00000436397; ENSG00000205531 [Q99733-2]
ENST00000616696; ENSP00000478654; ENSG00000273562 [Q99733-2]
ENST00000619695; ENSP00000483728; ENSG00000273562 [Q99733-1]
ENST00000620138; ENSP00000481412; ENSG00000205531 [Q99733-2]
ENST00000632791; ENSP00000487984; ENSG00000273562 [Q99733-2]
GeneIDi4676
KEGGihsa:4676
UCSCiuc001lxc.4 human [Q99733-1]

Organism-specific databases

CTDi4676
DisGeNETi4676
EuPathDBiHostDB:ENSG00000205531.12
GeneCardsiNAP1L4
HGNCiHGNC:7640 NAP1L4
HPAiCAB011567
MIMi601651 gene
neXtProtiNX_Q99733
OpenTargetsiENSG00000205531
PharmGKBiPA31442
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ99733
KOiK11282
OMAiSQPSECK
OrthoDBiEOG091G0HVV
PhylomeDBiQ99733
TreeFamiTF314349

Miscellaneous databases

ChiTaRSiNAP1L4 human
GeneWikiiNAP1L4
GenomeRNAii4676
PMAP-CutDBiQ99733
PROiPR:Q99733
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205531 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_NAP1L4
ExpressionAtlasiQ99733 baseline and differential
GenevisibleiQ99733 HS

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNP1L4_HUMAN
AccessioniPrimary (citable) accession number: Q99733
Secondary accession number(s): B2R6J4, F5HFY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again