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Protein

C-C motif chemokine 19

Gene

CCL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.1 Publication

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Beta-chemokine exodus-3
CK beta-11
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Macrophage inflammatory protein 3 beta
Short name:
MIP-3-beta
Small-inducible cytokine A19
Gene namesi
Name:CCL19
Synonyms:ELC, MIP3B, SCYA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000172724.11
HGNCiHGNC:10617 CCL19
MIMi602227 gene
neXtProtiNX_Q99731

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6363
OpenTargetsiENSG00000172724
PharmGKBiPA35550

Polymorphism and mutation databases

BioMutaiCCL19
DMDMi2842763

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000000521422 – 98C-C motif chemokine 19Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 55By similarity
Disulfide bondi30 ↔ 71By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ99731
PeptideAtlasiQ99731
PRIDEiQ99731
ProteomicsDBi78447

PTM databases

PhosphoSitePlusiQ99731

Expressioni

Tissue specificityi

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Gene expression databases

BgeeiENSG00000172724
CleanExiHS_CCL19
ExpressionAtlasiQ99731 baseline and differential
GenevisibleiQ99731 HS

Organism-specific databases

HPAiHPA067758

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFAIP6P980662EBI-11711510,EBI-11700693

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112266, 2 interactors
DIPiDIP-5857N
IntActiQ99731, 2 interactors
STRINGi9606.ENSP00000308815

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 29Combined sources4
Beta strandi42 – 49Combined sources8
Turni51 – 53Combined sources3
Beta strandi59 – 64Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi74 – 76Combined sources3
Helixi77 – 90Combined sources14

3D structure databases

ProteinModelPortaliQ99731
SMRiQ99731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4UG Eukaryota
ENOG410ZG6G LUCA
GeneTreeiENSGT00730000111353
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ99731
KOiK05512
PhylomeDBiQ99731
TreeFamiTF334888

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL
60 70 80 90
IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS
Length:98
Mass (Da):10,993
Last modified:May 1, 1997 - v1
Checksum:i0D2516DB2EB1C81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77180 mRNA Translation: AAC50944.1
AB000887 mRNA Translation: BAA20383.1
U88321 mRNA Translation: AAC23905.1
AJ223410 Genomic DNA Translation: CAA11307.1
BC027968 mRNA Translation: AAH27968.1
CCDSiCCDS6570.1
RefSeqiNP_006265.1, NM_006274.2
UniGeneiHs.50002

Genome annotation databases

EnsembliENST00000311925; ENSP00000308815; ENSG00000172724
GeneIDi6363
KEGGihsa:6363
UCSCiuc003zvn.4 human

Similar proteinsi

Entry informationi

Entry nameiCCL19_HUMAN
AccessioniPrimary (citable) accession number: Q99731
Secondary accession number(s): O00697, O00736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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