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Protein

Heterogeneous nuclear ribonucleoprotein A/B

Gene

HNRNPAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: GO_Central
  • sequence-specific double-stranded DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A/B
Short name:
hnRNP A/B
Alternative name(s):
APOBEC1-binding protein 1
Short name:
ABBP-1
Gene namesi
Name:HNRNPAB
Synonyms:ABBP1, HNRPAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000197451.10
HGNCiHGNC:5034 HNRNPAB
MIMi602688 gene
neXtProtiNX_Q99729

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3182
OpenTargetsiENSG00000197451
PharmGKBiPA162391196

Polymorphism and mutation databases

BioMutaiHNRNPAB
DMDMi158523286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814921 – 332Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineCombined sources1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei215N6-acetyllysineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei245Dimethylated arginine; alternate1 Publication1
Modified residuei245Omega-N-methylarginine; alternate1 Publication1
Modified residuei250Omega-N-methylarginineBy similarity1
Modified residuei253Omega-N-methylarginineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei322Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei322Dimethylated arginine; alternateCombined sources1
Modified residuei322Omega-N-methylarginine; alternateCombined sources1
Isoform 3 (identifier: Q99729-3)
Modified residuei250Omega-N-methylarginineCombined sources1
Modified residuei253Omega-N-methylarginineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei271N6-acetyllysineCombined sources1
Isoform 4 (identifier: Q99729-4)
Modified residuei251Omega-N-methylarginineCombined sourcesCurated1
Modified residuei254Omega-N-methylarginineCombined sourcesCurated1
Modified residuei256PhosphoserineCombined sourcesCurated1
Modified residuei272N6-acetyllysineCombined sourcesCurated1

Post-translational modificationi

Dimethylation at Arg-322 is probably asymmetric.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99729
PaxDbiQ99729
PeptideAtlasiQ99729
PRIDEiQ99729
ProteomicsDBi78443
78444 [Q99729-2]
78445 [Q99729-3]
78446 [Q99729-4]

2D gel databases

SWISS-2DPAGEiQ99729

PTM databases

GlyConnecti1313 [Q99729-2]
iPTMnetiQ99729
PhosphoSitePlusiQ99729
SwissPalmiQ99729

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000197451 Expressed in 231 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_HNRNPAB
ExpressionAtlasiQ99729 baseline and differential
GenevisibleiQ99729 HS

Organism-specific databases

HPAiHPA046688

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156374EBI-1044873,EBI-744603

Protein-protein interaction databases

BioGridi109423, 108 interactors
ComplexPortaliCPX-1097 C-to-U editosome complex
DIPiDIP-50394N
IntActiQ99729, 62 interactors
MINTiQ99729
STRINGi9606.ENSP00000351108

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99729
SMRiQ99729
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99729

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 154RRM 1PROSITE-ProRule annotationAdd BLAST86
Domaini153 – 233RRM 2PROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 324Gly-richAdd BLAST84

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ99729
KOiK13044
OMAiFKEPGSV
OrthoDBiEOG091G1CPI
PhylomeDBiQ99729
TreeFamiTF314808

Family and domain databases

CDDicd12757 RRM1_hnRNPAB, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956 CARG-binding_factor_N
IPR034846 hnRNPAB_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF08143 CBFNT, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99729-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN
60 70 80 90 100
QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI
110 120 130 140 150
KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD
160 170 180 190 200
PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI
210 220 230 240 250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR
260 270 280 290 300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY
310 320 330
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
Length:332
Mass (Da):36,225
Last modified:September 11, 2007 - v2
Checksum:iF824A7E08D15268A
GO
Isoform 2 (identifier: Q99729-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A

Show »
Length:332
Mass (Da):35,968
Checksum:iF710B690D495500D
GO
Isoform 3 (identifier: Q99729-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A
     264-310: Missing.

Show »
Length:285
Mass (Da):30,588
Checksum:i3E4F386C2F5B9705
GO
Isoform 4 (identifier: Q99729-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     264-310: Missing.

Show »
Length:286
Mass (Da):30,701
Checksum:iAA24BA3F6A0BAD62
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBZ0D6RBZ0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
327Annotation score:
D6R9P3D6R9P3_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
280Annotation score:
D6RD18D6RD18_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
283Annotation score:

Sequence cautioni

Isoform 4 : The sequence AAA36575 differs from that shown. Reason: Frameshift at several positions.Combined sourcesCurated
The sequence AAC50956 differs from that shown. Reason: Frameshift at positions 296, 307 and 330.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00782626 – 32ASRGRGW → GESPAGAG in isoform 2, isoform 3 and isoform 4. 3 Publications7
Alternative sequenceiVSP_007828164 – 165SP → A in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_007829264 – 310Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65028 mRNA Translation: AAA36575.1 Frameshift.
U76713 mRNA Translation: AAC50956.1 Frameshift.
AK054600 mRNA Translation: BAG51397.1
AK097657 mRNA Translation: BAC05134.1
CH471165 Genomic DNA Translation: EAW53843.1
CH471165 Genomic DNA Translation: EAW53844.1
CH471165 Genomic DNA Translation: EAW53845.1
BC001616 mRNA Translation: AAH01616.1
BC002625 mRNA Translation: AAH02625.1
BC004561 mRNA Translation: AAH04561.1
BC009359 mRNA Translation: AAH09359.1
BC036708 mRNA Translation: AAH36708.1
CCDSiCCDS34309.1 [Q99729-2]
CCDS34310.1 [Q99729-3]
PIRiS17563
RefSeqiNP_004490.2, NM_004499.3 [Q99729-3]
NP_112556.2, NM_031266.2 [Q99729-2]
UniGeneiHs.591731
Hs.715055

Genome annotation databases

EnsembliENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]
GeneIDi3182
KEGGihsa:3182
UCSCiuc003miu.4 human [Q99729-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65028 mRNA Translation: AAA36575.1 Frameshift.
U76713 mRNA Translation: AAC50956.1 Frameshift.
AK054600 mRNA Translation: BAG51397.1
AK097657 mRNA Translation: BAC05134.1
CH471165 Genomic DNA Translation: EAW53843.1
CH471165 Genomic DNA Translation: EAW53844.1
CH471165 Genomic DNA Translation: EAW53845.1
BC001616 mRNA Translation: AAH01616.1
BC002625 mRNA Translation: AAH02625.1
BC004561 mRNA Translation: AAH04561.1
BC009359 mRNA Translation: AAH09359.1
BC036708 mRNA Translation: AAH36708.1
CCDSiCCDS34309.1 [Q99729-2]
CCDS34310.1 [Q99729-3]
PIRiS17563
RefSeqiNP_004490.2, NM_004499.3 [Q99729-3]
NP_112556.2, NM_031266.2 [Q99729-2]
UniGeneiHs.591731
Hs.715055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S7RX-ray2.15A/B59-144[»]
ProteinModelPortaliQ99729
SMRiQ99729
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109423, 108 interactors
ComplexPortaliCPX-1097 C-to-U editosome complex
DIPiDIP-50394N
IntActiQ99729, 62 interactors
MINTiQ99729
STRINGi9606.ENSP00000351108

PTM databases

GlyConnecti1313 [Q99729-2]
iPTMnetiQ99729
PhosphoSitePlusiQ99729
SwissPalmiQ99729

Polymorphism and mutation databases

BioMutaiHNRNPAB
DMDMi158523286

2D gel databases

SWISS-2DPAGEiQ99729

Proteomic databases

MaxQBiQ99729
PaxDbiQ99729
PeptideAtlasiQ99729
PRIDEiQ99729
ProteomicsDBi78443
78444 [Q99729-2]
78445 [Q99729-3]
78446 [Q99729-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]
GeneIDi3182
KEGGihsa:3182
UCSCiuc003miu.4 human [Q99729-1]

Organism-specific databases

CTDi3182
DisGeNETi3182
EuPathDBiHostDB:ENSG00000197451.10
GeneCardsiHNRNPAB
HGNCiHGNC:5034 HNRNPAB
HPAiHPA046688
MIMi602688 gene
neXtProtiNX_Q99729
OpenTargetsiENSG00000197451
PharmGKBiPA162391196
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ99729
KOiK13044
OMAiFKEPGSV
OrthoDBiEOG091G1CPI
PhylomeDBiQ99729
TreeFamiTF314808

Miscellaneous databases

ChiTaRSiHNRNPAB human
EvolutionaryTraceiQ99729
GeneWikiiHNRPAB
GenomeRNAii3182
PROiPR:Q99729
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197451 Expressed in 231 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_HNRNPAB
ExpressionAtlasiQ99729 baseline and differential
GenevisibleiQ99729 HS

Family and domain databases

CDDicd12757 RRM1_hnRNPAB, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956 CARG-binding_factor_N
IPR034846 hnRNPAB_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF08143 CBFNT, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiROAA_HUMAN
AccessioniPrimary (citable) accession number: Q99729
Secondary accession number(s): B3KNN5
, D3DWP7, Q04150, Q8N7U3, Q9BQ99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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