HNRNPAB

Functionⁱ

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

GO - Molecular functionⁱ

mRNA binding
Source: ProtInc
Traceable author statementⁱ
- 8999813
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epithelial to mesenchymal transition Source: HGNC
positive regulation of transcription, DNA-templated Source: HGNC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heterogeneous nuclear ribonucleoprotein A/B Short name: hnRNP A/B Alternative name(s): APOBEC1-binding protein 1 Short name: ABBP-1
Gene namesⁱ	Name:HNRNPAB Synonyms:ABBP1, HNRPAB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197451.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5034 HNRNPAB
MIMⁱ	602688 gene
neXtProtⁱ	NX_Q99729

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3182
Open Targets More...OpenTargetsⁱ	ENSG00000197451
PharmGKBⁱ	PA162391196

Polymorphism and mutation databases

BioMutaⁱ	HNRNPAB
DMDMⁱ	158523286

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081492	1 – 332	Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST		332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	81	PhosphoserineCombined sources	1
Cross-linkⁱ	130	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	203	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	215	N6-acetyllysineBy similarity	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	245	Dimethylated arginine; alternate1 Publication	1
Modified residueⁱ	245	Omega-N-methylarginine; alternate1 Publication	1
Modified residueⁱ	250	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	253	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	318	N6-acetyllysineBy similarity	1
Modified residueⁱ	322	Asymmetric dimethylarginine; alternateBy similarity	1
Modified residueⁱ	322	Dimethylated arginine; alternateCombined sources	1
Modified residueⁱ	322	Omega-N-methylarginine; alternateCombined sources	1
Isoform 3 (identifier: Q99729-3)
Modified residueⁱ	250	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	253	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	255	PhosphoserineCombined sources	1
Modified residueⁱ	271	N6-acetyllysineCombined sources	1
Isoform 4 (identifier: Q99729-4)
Modified residueⁱ	251	Omega-N-methylarginineCombined sourcesCurated	1
Modified residueⁱ	254	Omega-N-methylarginineCombined sourcesCurated	1
Modified residueⁱ	256	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	272	N6-acetyllysineCombined sourcesCurated	1

Post-translational modificationⁱ

Dimethylation at Arg-322 is probably asymmetric.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99729
PaxDbⁱ	Q99729
PeptideAtlas More...PeptideAtlasⁱ	Q99729
PRIDEⁱ	Q99729
ProteomicsDBⁱ	78443 78444 [Q99729-2] 78445 [Q99729-3] 78446 [Q99729-4]

2D gel databases

SWISS-2DPAGEⁱ	Q99729

SWISS-2DPAGEⁱ

Q99729

PTM databases

GlyConnectⁱ	1313 [Q99729-2]
iPTMnetⁱ	Q99729
PhosphoSitePlusⁱ	Q99729
SwissPalmⁱ	Q99729

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000197451 Expressed in 231 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_HNRNPAB
ExpressionAtlasⁱ	Q99729 baseline and differential
Genevisibleⁱ	Q99729 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046688

HPAⁱ

HPA046688

Interactionⁱ

Subunit structureⁱ

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SF1	Q15637	4	EBI-1044873,EBI-744603

With

Entry

#Exp.

IntAct

Notes

SF1

Q15637

4

EBI-1044873,EBI-744603

Protein-protein interaction databases

BioGridⁱ	109423, 108 interactors
ComplexPortalⁱ	CPX-1097 C-to-U editosome complex
Database of interacting proteins More...DIPⁱ	DIP-50394N
IntActⁱ	Q99729, 62 interactors
Molecular INTeraction database More...MINTⁱ	Q99729
STRINGⁱ	9606.ENSP00000351108

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	70 – 74	Combined sources	5
Helixⁱ	82 – 89	Combined sources	8
Turnⁱ	90 – 92	Combined sources	3
Beta strandⁱ	95 – 102	Combined sources	8
Turnⁱ	104 – 106	Combined sources	3
Beta strandⁱ	109 – 119	Combined sources	11
Helixⁱ	121 – 128	Combined sources	8
Beta strandⁱ	132 – 134	Combined sources	3
Beta strandⁱ	137 – 143	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99729
SMRⁱ	Q99729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99729

EvolutionaryTraceⁱ

Q99729

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	69 – 154	RRM 1PROSITE-ProRule annotationAdd BLAST		86
Domainⁱ	153 – 233	RRM 2PROSITE-ProRule annotationAdd BLAST		81

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	241 – 324	Gly-richAdd BLAST		84

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota COG0724 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140835
HOGENOMⁱ	HOG000234441
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q99729
KEGG Orthology (KO) More...KOⁱ	K13044
OMAⁱ	FKEPGSV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1CPI
PhylomeDBⁱ	Q99729
TreeFamⁱ	TF314808

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12757 RRM1_hnRNPAB, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012956 CARG-binding_factor_N IPR034846 hnRNPAB_RRM1 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08143 CBFNT, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 2 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q99729-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN 
        60         70         80         90        100
QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI 
       110        120        130        140        150
KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD 
       160        170        180        190        200
PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI 
       210        220        230        240        250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR 
       260        270        280        290        300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY 
       310        320        330 
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY

Length:332

Mass (Da):36,225

Last modified:September 11, 2007 - v2

Checksum:ⁱF824A7E08D15268A

GO

Isoform 2 (identifier: Q99729-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
26-32: ASRGRGW → GESPAGAG
164-165: SP → A

« Hide

        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEGESPA GAGTGAAAGA GGATAAPPSG 
        60         70         80         90        100
NQNGAEGDQI NASKNEEDAG KMFVGGLSWD TSKKDLKDYF TKFGEVVDCT 
       110        120        130        140        150
IKMDPNTGRS RGFGFILFKD AASVEKVLDQ KEHRLDGRVI DPKKAMAMKK 
       160        170        180        190        200
DPVKKIFVGG LNPEATEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI 
       210        220        230        240        250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR 
       260        270        280        290        300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY 
       310        320        330 
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY

Show »

Length:332

Mass (Da):35,968

Checksum:ⁱF710B690D495500D

GO

Isoform 3 (identifier: Q99729-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A
     264-310: Missing.

« Hide

        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEGESPA GAGTGAAAGA GGATAAPPSG 
        60         70         80         90        100
NQNGAEGDQI NASKNEEDAG KMFVGGLSWD TSKKDLKDYF TKFGEVVDCT 
       110        120        130        140        150
IKMDPNTGRS RGFGFILFKD AASVEKVLDQ KEHRLDGRVI DPKKAMAMKK 
       160        170        180        190        200
DPVKKIFVGG LNPEATEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI 
       210        220        230        240        250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR 
       260        270        280 
GNRGSGGGGG GGGQGSTNYG KSQRRGGHQN NYKPY

Show »

Length:285

Mass (Da):30,588

Checksum:ⁱ3E4F386C2F5B9705

GO

Isoform 4 (identifier: Q99729-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
26-32: ASRGRGW → GESPAGAG
264-310: Missing.

« Hide

        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEGESPA GAGTGAAAGA GGATAAPPSG 
        60         70         80         90        100
NQNGAEGDQI NASKNEEDAG KMFVGGLSWD TSKKDLKDYF TKFGEVVDCT 
       110        120        130        140        150
IKMDPNTGRS RGFGFILFKD AASVEKVLDQ KEHRLDGRVI DPKKAMAMKK 
       160        170        180        190        200
DPVKKIFVGG LNPESPTEEK IREYFGEFGE IEAIELPMDP KLNKRRGFVF 
       210        220        230        240        250
ITFKEEEPVK KVLEKKFHTV SGSKCEIKVA QPKEVYQQQQ YGSGGRGNRN 
       260        270        280 
RGNRGSGGGG GGGGQGSTNY GKSQRRGGHQ NNYKPY

Show »

Length:286

Mass (Da):30,701

Checksum:ⁱAA24BA3F6A0BAD62

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBZ0	D6RBZ0_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein A/B	HNRNPAB	327	Annotation score:
D6R9P3	D6R9P3_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein A/B	HNRNPAB	280	Annotation score:
D6RD18	D6RD18_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein A/B	HNRNPAB	283	Annotation score:

Sequence cautionⁱ

Isoform 4 : The sequence AAA36575 differs from that shown. Reason: Frameshift at several positions.Combined sourcesCurated

The sequence AAC50956 differs from that shown. Reason: Frameshift at positions 296, 307 and 330.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_007826	26 – 32	ASRGRGW → GESPAGAG in isoform 2, isoform 3 and isoform 4. 3 Publications	7
Alternative sequenceⁱVSP_007828	164 – 165	SP → A in isoform 2 and isoform 3. 2 Publications	2
Alternative sequenceⁱVSP_007829	264 – 310	Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST	47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65028 mRNA Translation: AAA36575.1 Frameshift. U76713 mRNA Translation: AAC50956.1 Frameshift. AK054600 mRNA Translation: BAG51397.1 AK097657 mRNA Translation: BAC05134.1 CH471165 Genomic DNA Translation: EAW53843.1 CH471165 Genomic DNA Translation: EAW53844.1 CH471165 Genomic DNA Translation: EAW53845.1 BC001616 mRNA Translation: AAH01616.1 BC002625 mRNA Translation: AAH02625.1 BC004561 mRNA Translation: AAH04561.1 BC009359 mRNA Translation: AAH09359.1 BC036708 mRNA Translation: AAH36708.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34309.1 [Q99729-2] CCDS34310.1 [Q99729-3]
PIRⁱ	S17563
NCBI Reference Sequences More...RefSeqⁱ	NP_004490.2, NM_004499.3 [Q99729-3] NP_112556.2, NM_031266.2 [Q99729-2]
UniGeneⁱ	Hs.591731 Hs.715055

Genome annotation databases

Ensemblⁱ	ENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3] ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2] ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2] ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]
GeneIDⁱ	3182
KEGGⁱ	hsa:3182
UCSC genome browser More...UCSCⁱ	uc003miu.4 human [Q99729-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99729	Uncharacterized protein		PIG		345	UniRef90_Q99729
Heterogeneous nuclear ribonucleoprotein A/B (Fragment)		ESCRO		263
Uncharacterized protein		MYOLU		334
Heterogeneous nuclear ribonucleoprotein A/B		MYOBR		263
heterogeneous nuclear ribonucleoprotein A/B isoform X1		DIPOR		334
+97
Q99729-2	Uncharacterized protein		FELCA		332	UniRef90_M3X5X9
heterogeneous nuclear ribonucleoprotein A/B isoform X1		TURTR		386
heterogeneous nuclear ribonucleoprotein A/B isoform X1		PHYCD		335
heterogeneous nuclear ribonucleoprotein A/B isoform X1		DELLE		335
heterogeneous nuclear ribonucleoprotein A/B isoform X1		LIPVE		335
+83

Protein	Similar proteins		Species	Score	Length	Source
Q99729	Uncharacterized protein		PIG		345	UniRef50_Q99729
Heterogeneous nuclear ribonucleoprotein A/B (Fragment)		ESCRO		263
heterogeneous nuclear ribonucleoprotein A/B isoform X1		DIPOR		334
Uncharacterized protein		MYOLU		334
Heterogeneous nuclear ribonucleoprotein A/B		MYOBR		263
+280
Q99729-2	Uncharacterized protein		CHICK		324	UniRef50_F6QGM9
Heterogeneous nuclear ribonucleoprotein D		MELGA		258
heterogeneous nuclear ribonucleoprotein D0 isoform X2		MESAU		333
Uncharacterized protein		CALSU		325
Uncharacterized protein		COLVI		322
+246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65028 mRNA Translation: AAA36575.1 Frameshift. U76713 mRNA Translation: AAC50956.1 Frameshift. AK054600 mRNA Translation: BAG51397.1 AK097657 mRNA Translation: BAC05134.1 CH471165 Genomic DNA Translation: EAW53843.1 CH471165 Genomic DNA Translation: EAW53844.1 CH471165 Genomic DNA Translation: EAW53845.1 BC001616 mRNA Translation: AAH01616.1 BC002625 mRNA Translation: AAH02625.1 BC004561 mRNA Translation: AAH04561.1 BC009359 mRNA Translation: AAH09359.1 BC036708 mRNA Translation: AAH36708.1
CCDSⁱ	CCDS34309.1 [Q99729-2] CCDS34310.1 [Q99729-3]
PIRⁱ	S17563
RefSeqⁱ	NP_004490.2, NM_004499.3 [Q99729-3] NP_112556.2, NM_031266.2 [Q99729-2]
UniGeneⁱ	Hs.591731 Hs.715055

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S7R	X-ray	2.15	A/B	59-144	[»]
ProteinModelPortalⁱ	Q99729
SMRⁱ	Q99729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109423, 108 interactors
ComplexPortalⁱ	CPX-1097 C-to-U editosome complex
DIPⁱ	DIP-50394N
IntActⁱ	Q99729, 62 interactors
MINTⁱ	Q99729
STRINGⁱ	9606.ENSP00000351108

PTM databases

GlyConnectⁱ	1313 [Q99729-2]
iPTMnetⁱ	Q99729
PhosphoSitePlusⁱ	Q99729
SwissPalmⁱ	Q99729

Polymorphism and mutation databases

BioMutaⁱ	HNRNPAB
DMDMⁱ	158523286

2D gel databases

SWISS-2DPAGEⁱ	Q99729

SWISS-2DPAGEⁱ

Q99729

Proteomic databases

MaxQBⁱ	Q99729
PaxDbⁱ	Q99729
PeptideAtlasⁱ	Q99729
PRIDEⁱ	Q99729
ProteomicsDBⁱ	78443 78444 [Q99729-2] 78445 [Q99729-3] 78446 [Q99729-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3] ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2] ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2] ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]
GeneIDⁱ	3182
KEGGⁱ	hsa:3182
UCSCⁱ	uc003miu.4 human [Q99729-1]

Organism-specific databases

CTDⁱ	3182
DisGeNETⁱ	3182
EuPathDBⁱ	HostDB:ENSG00000197451.10
GeneCardsⁱ	HNRNPAB
HGNCⁱ	HGNC:5034 HNRNPAB
HPAⁱ	HPA046688
MIMⁱ	602688 gene
neXtProtⁱ	NX_Q99729
OpenTargetsⁱ	ENSG00000197451
PharmGKBⁱ	PA162391196
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0118 Eukaryota COG0724 LUCA
GeneTreeⁱ	ENSGT00900000140835
HOGENOMⁱ	HOG000234441
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q99729
KOⁱ	K13044
OMAⁱ	FKEPGSV
OrthoDBⁱ	EOG091G1CPI
PhylomeDBⁱ	Q99729
TreeFamⁱ	TF314808

Miscellaneous databases

ChiTaRSⁱ	HNRNPAB human
EvolutionaryTraceⁱ	Q99729
GeneWikiⁱ	HNRPAB
GenomeRNAiⁱ	3182
Protein Ontology More...PROⁱ	PR:Q99729
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197451 Expressed in 231 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_HNRNPAB
ExpressionAtlasⁱ	Q99729 baseline and differential
Genevisibleⁱ	Q99729 HS

Family and domain databases

CDDⁱ	cd12757 RRM1_hnRNPAB, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012956 CARG-binding_factor_N IPR034846 hnRNPAB_RRM1 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF08143 CBFNT, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 2 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ROAA_HUMAN
Accessionⁱ	Q99729Primary (citable) accession number: Q99729 Secondary accession number(s): B3KNN5 , D3DWP7, Q04150, Q8N7U3, Q9BQ99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	September 11, 2007
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

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Help

UniRef

Proteomes

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Supporting data

UniProtKB - Q99729 (ROAA_HUMAN)

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Heterogeneous nuclear ribonucleoprotein A/B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ