UniProtKB - Q99729 (ROAA_HUMAN)
Protein
Heterogeneous nuclear ribonucleoprotein A/B
Gene
HNRNPAB
Organism
Homo sapiens (Human)
Status
Functioni
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
GO - Molecular functioni
- mRNA binding Source: ProtInc
- RNA binding Source: UniProtKB
- sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: GO_Central
GO - Biological processi
- epithelial to mesenchymal transition Source: HGNC-UCL
- positive regulation of transcription, DNA-templated Source: HGNC-UCL
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99729 |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein A/BShort name: hnRNP A/B Alternative name(s): APOBEC1-binding protein 1 Short name: ABBP-1 |
Gene namesi | Name:HNRNPAB Synonyms:ABBP1, HNRPAB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5034, HNRNPAB |
MIMi | 602688, gene |
neXtProti | NX_Q99729 |
VEuPathDBi | HostDB:ENSG00000197451.10 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: HGNC-UCL
Other locations
- cytoplasm Source: HGNC-UCL
- ribonucleoprotein complex Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3182 |
OpenTargetsi | ENSG00000197451 |
PharmGKBi | PA162391196 |
Miscellaneous databases
Pharosi | Q99729, Tbio |
Genetic variation databases
BioMutai | HNRNPAB |
DMDMi | 158523286 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081492 | 1 – 332 | Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 81 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 130 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 203 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 215 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 242 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 245 | Dimethylated arginine; alternate1 Publication | 1 | ||
Modified residuei | 245 | Omega-N-methylarginine; alternate1 Publication | 1 | ||
Modified residuei | 250 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 253 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 318 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 322 | Asymmetric dimethylarginine; alternateBy similarity | 1 | ||
Modified residuei | 322 | Dimethylated arginine; alternateCombined sources | 1 | ||
Modified residuei | 322 | Omega-N-methylarginine; alternateCombined sources | 1 | ||
Isoform 3 (identifier: Q99729-3) | |||||
Modified residuei | 250 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 253 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 255 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 271 | N6-acetyllysineCombined sources | 1 | ||
Isoform 4 (identifier: Q99729-4) | |||||
Modified residuei | 251 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 254 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 256 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 272 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Dimethylation at Arg-322 is probably asymmetric.
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q99729 |
MassIVEi | Q99729 |
MaxQBi | Q99729 |
PaxDbi | Q99729 |
PeptideAtlasi | Q99729 |
PRIDEi | Q99729 |
ProteomicsDBi | 78443 [Q99729-1] 78444 [Q99729-2] 78445 [Q99729-3] 78446 [Q99729-4] |
2D gel databases
SWISS-2DPAGEi | Q99729 |
PTM databases
GlyConnecti | 1313, 2 N-Linked glycans (1 site) [Q99729-2] |
iPTMneti | Q99729 |
MetOSitei | Q99729 |
PhosphoSitePlusi | Q99729 |
SwissPalmi | Q99729 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000197451, Expressed in layer of synovial tissue and 243 other tissues |
ExpressionAtlasi | Q99729, baseline and differential |
Genevisiblei | Q99729, HS |
Organism-specific databases
HPAi | ENSG00000197451, Low tissue specificity |
Interactioni
Subunit structurei
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with APOBEC1.
1 PublicationBinary interactionsi
Hide detailsQ99729
With | #Exp. | IntAct |
---|---|---|
SF1 [Q15637] | 4 | EBI-1044873,EBI-744603 |
TP63 [Q9H3D4] | 3 | EBI-1044873,EBI-2337775 |
TP63 - isoform 1 [Q9H3D4-1] | 2 | EBI-1044873,EBI-2400586 |
TP63 - isoform 2 [Q9H3D4-2] | 2 | EBI-1044873,EBI-6481107 |
Protein-protein interaction databases
BioGRIDi | 109423, 175 interactors |
ComplexPortali | CPX-1097, C-to-U editosome complex |
DIPi | DIP-50394N |
IntActi | Q99729, 95 interactors |
MINTi | Q99729 |
STRINGi | 9606.ENSP00000351108 |
Miscellaneous databases
RNActi | Q99729, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99729 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99729 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 154 | RRM 1PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 153 – 233 | RRM 2PROSITE-ProRule annotationAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 241 – 324 | Gly-richAdd BLAST | 84 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00940000154735 |
HOGENOMi | CLU_012062_1_1_1 |
InParanoidi | Q99729 |
OMAi | GAQSQNW |
OrthoDBi | 1202220at2759 |
PhylomeDBi | Q99729 |
TreeFami | TF314808 |
Family and domain databases
CDDi | cd12757, RRM1_hnRNPAB, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012956, CARG-binding_factor_N IPR034846, hnRNPAB_RRM1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08143, CBFNT, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99729-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN
60 70 80 90 100
QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI
110 120 130 140 150
KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD
160 170 180 190 200
PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI
210 220 230 240 250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR
260 270 280 290 300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY
310 320 330
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBZ0 | D6RBZ0_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPAB | 327 | Annotation score: | ||
D6R9P3 | D6R9P3_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPAB | 280 | Annotation score: | ||
D6RD18 | D6RD18_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPAB | 283 | Annotation score: |
Sequence cautioni
The sequence AAC50956 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007826 | 26 – 32 | ASRGRGW → GESPAGAG in isoform 2, isoform 3 and isoform 4. 3 Publications | 7 | |
Alternative sequenceiVSP_007828 | 164 – 165 | SP → A in isoform 2 and isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_007829 | 264 – 310 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65028 mRNA Translation: AAA36575.1 Frameshift. U76713 mRNA Translation: AAC50956.1 Frameshift. AK054600 mRNA Translation: BAG51397.1 AK097657 mRNA Translation: BAC05134.1 CH471165 Genomic DNA Translation: EAW53843.1 CH471165 Genomic DNA Translation: EAW53844.1 CH471165 Genomic DNA Translation: EAW53845.1 BC001616 mRNA Translation: AAH01616.1 BC002625 mRNA Translation: AAH02625.1 BC004561 mRNA Translation: AAH04561.1 BC009359 mRNA Translation: AAH09359.1 BC036708 mRNA Translation: AAH36708.1 |
CCDSi | CCDS34309.1 [Q99729-2] CCDS34310.1 [Q99729-3] |
PIRi | S17563 |
RefSeqi | NP_004490.2, NM_004499.3 [Q99729-3] NP_112556.2, NM_031266.2 [Q99729-2] |
Genome annotation databases
Ensembli | ENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3] ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2] ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2] ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3] |
GeneIDi | 3182 |
KEGGi | hsa:3182 |
UCSCi | uc003miu.4, human [Q99729-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65028 mRNA Translation: AAA36575.1 Frameshift. U76713 mRNA Translation: AAC50956.1 Frameshift. AK054600 mRNA Translation: BAG51397.1 AK097657 mRNA Translation: BAC05134.1 CH471165 Genomic DNA Translation: EAW53843.1 CH471165 Genomic DNA Translation: EAW53844.1 CH471165 Genomic DNA Translation: EAW53845.1 BC001616 mRNA Translation: AAH01616.1 BC002625 mRNA Translation: AAH02625.1 BC004561 mRNA Translation: AAH04561.1 BC009359 mRNA Translation: AAH09359.1 BC036708 mRNA Translation: AAH36708.1 |
CCDSi | CCDS34309.1 [Q99729-2] CCDS34310.1 [Q99729-3] |
PIRi | S17563 |
RefSeqi | NP_004490.2, NM_004499.3 [Q99729-3] NP_112556.2, NM_031266.2 [Q99729-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3S7R | X-ray | 2.15 | A/B | 59-144 | [»] | |
SMRi | Q99729 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109423, 175 interactors |
ComplexPortali | CPX-1097, C-to-U editosome complex |
DIPi | DIP-50394N |
IntActi | Q99729, 95 interactors |
MINTi | Q99729 |
STRINGi | 9606.ENSP00000351108 |
PTM databases
GlyConnecti | 1313, 2 N-Linked glycans (1 site) [Q99729-2] |
iPTMneti | Q99729 |
MetOSitei | Q99729 |
PhosphoSitePlusi | Q99729 |
SwissPalmi | Q99729 |
Genetic variation databases
BioMutai | HNRNPAB |
DMDMi | 158523286 |
2D gel databases
SWISS-2DPAGEi | Q99729 |
Proteomic databases
jPOSTi | Q99729 |
MassIVEi | Q99729 |
MaxQBi | Q99729 |
PaxDbi | Q99729 |
PeptideAtlasi | Q99729 |
PRIDEi | Q99729 |
ProteomicsDBi | 78443 [Q99729-1] 78444 [Q99729-2] 78445 [Q99729-3] 78446 [Q99729-4] |
Protocols and materials databases
Antibodypediai | 17556, 146 antibodies |
Genome annotation databases
Ensembli | ENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3] ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2] ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2] ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3] |
GeneIDi | 3182 |
KEGGi | hsa:3182 |
UCSCi | uc003miu.4, human [Q99729-1] |
Organism-specific databases
CTDi | 3182 |
DisGeNETi | 3182 |
GeneCardsi | HNRNPAB |
HGNCi | HGNC:5034, HNRNPAB |
HPAi | ENSG00000197451, Low tissue specificity |
MIMi | 602688, gene |
neXtProti | NX_Q99729 |
OpenTargetsi | ENSG00000197451 |
PharmGKBi | PA162391196 |
VEuPathDBi | HostDB:ENSG00000197451.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00940000154735 |
HOGENOMi | CLU_012062_1_1_1 |
InParanoidi | Q99729 |
OMAi | GAQSQNW |
OrthoDBi | 1202220at2759 |
PhylomeDBi | Q99729 |
TreeFami | TF314808 |
Enzyme and pathway databases
PathwayCommonsi | Q99729 |
Miscellaneous databases
BioGRID-ORCSi | 3182, 9 hits in 880 CRISPR screens |
ChiTaRSi | HNRNPAB, human |
EvolutionaryTracei | Q99729 |
GeneWikii | HNRPAB |
GenomeRNAii | 3182 |
Pharosi | Q99729, Tbio |
PROi | PR:Q99729 |
RNActi | Q99729, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197451, Expressed in layer of synovial tissue and 243 other tissues |
ExpressionAtlasi | Q99729, baseline and differential |
Genevisiblei | Q99729, HS |
Family and domain databases
CDDi | cd12757, RRM1_hnRNPAB, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012956, CARG-binding_factor_N IPR034846, hnRNPAB_RRM1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08143, CBFNT, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROAA_HUMAN | |
Accessioni | Q99729Primary (citable) accession number: Q99729 Secondary accession number(s): B3KNN5 Q9BQ99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM