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UniProtKB - Q99729 (ROAA_HUMAN)

Entry version 195 (02 Jun 2021)
Sequence version 2 (11 Sep 2007)
Previous versions | rss
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Protein

Heterogeneous nuclear ribonucleoprotein A/B

Gene

HNRNPAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99729

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A/B
Short name:
hnRNP A/B
Alternative name(s):
APOBEC1-binding protein 1
Short name:
ABBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPAB
Synonyms:ABBP1, HNRPAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5034, HNRNPAB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602688, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99729

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197451.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3182

Open Targets

More...OpenTargetsi		ENSG00000197451

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391196

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99729, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPAB

Domain mapping of disease mutations (DMDM)

More...DMDMi		158523286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000814921 – 332Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei215N6-acetyllysineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei245Dimethylated arginine; alternate1 Publication1
Modified residuei245Omega-N-methylarginine; alternate1 Publication1
Modified residuei250Omega-N-methylarginineBy similarity1
Modified residuei253Omega-N-methylarginineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei322Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei322Dimethylated arginine; alternateCombined sources1
Modified residuei322Omega-N-methylarginine; alternateCombined sources1
Isoform 3 (identifier: Q99729-3)
Modified residuei250Omega-N-methylarginineCombined sources1
Modified residuei253Omega-N-methylarginineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei271N6-acetyllysineCombined sources1
Isoform 4 (identifier: Q99729-4)
Modified residuei251Omega-N-methylarginineCombined sources1
Modified residuei254Omega-N-methylarginineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei272N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Dimethylation at Arg-322 is probably asymmetric.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99729

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99729

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99729

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99729

PeptideAtlas

More...PeptideAtlasi		Q99729

PRoteomics IDEntifications database

More...PRIDEi		Q99729

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78443 [Q99729-1]
78444 [Q99729-2]
78445 [Q99729-3]
78446 [Q99729-4]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q99729

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1313, 2 N-Linked glycans (1 site) [Q99729-2]

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99729

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q99729

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99729

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99729

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197451, Expressed in layer of synovial tissue and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99729, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99729, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197451, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Interacts with APOBEC1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109423, 229 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1097, C-to-U editosome complex

Database of interacting proteins

More...DIPi		DIP-50394N

Protein interaction database and analysis system

More...IntActi		Q99729, 108 interactors

Molecular INTeraction database

More...MINTi		Q99729

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000351108

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99729, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99729

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99729

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 154RRM 1PROSITE-ProRule annotationAdd BLAST86
Domaini153 – 233RRM 2PROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni235 – 268DisorderedSequence analysisAdd BLAST34
Regioni311 – 332DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Polar residuesSequence analysisAdd BLAST15
Compositional biasi45 – 59Polar residuesSequence analysisAdd BLAST15
Compositional biasi235 – 249Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0118, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012062_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99729

Identification of Orthologs from Complete Genome Data

More...OMAi		GAQSQNW

Database of Orthologous Groups

More...OrthoDBi		1202220at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99729

TreeFam database of animal gene trees

More...TreeFami		TF314808

Family and domain databases

Conserved Domains Database

More...CDDi		cd12757, RRM1_hnRNPAB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012956, CARG-binding_factor_N
IPR034846, hnRNPAB_RRM1
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08143, CBFNT, 1 hit
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99729-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN 
        60         70         80         90        100
QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI 
       110        120        130        140        150
KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD 
       160        170        180        190        200
PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI 
       210        220        230        240        250
TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR 
       260        270        280        290        300
GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY 
       310        320        330 
YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
Length:332
Mass (Da):36,225
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF824A7E08D15268A
GO
Isoform 2 (identifier: Q99729-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A

Show »
Length:332
Mass (Da):35,968
Checksum:iF710B690D495500D
GO
Isoform 3 (identifier: Q99729-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     164-165: SP → A
     264-310: Missing.

Show »
Length:285
Mass (Da):30,588
Checksum:i3E4F386C2F5B9705
GO
Isoform 4 (identifier: Q99729-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-32: ASRGRGW → GESPAGAG
     264-310: Missing.

Show »
Length:286
Mass (Da):30,701
Checksum:iAA24BA3F6A0BAD62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBZ0D6RBZ0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
327Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9P3D6R9P3_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD18D6RD18_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPAB
283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36575 differs from that shown. Reason: Frameshift.Curated
The sequence AAC50956 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00782626 – 32ASRGRGW → GESPAGAG in isoform 2, isoform 3 and isoform 4. 3 Publications7
Alternative sequenceiVSP_007828164 – 165SP → A in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_007829264 – 310Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M65028 mRNA Translation: AAA36575.1 Frameshift.
U76713 mRNA Translation: AAC50956.1 Frameshift.
AK054600 mRNA Translation: BAG51397.1
AK097657 mRNA Translation: BAC05134.1
CH471165 Genomic DNA Translation: EAW53843.1
CH471165 Genomic DNA Translation: EAW53844.1
CH471165 Genomic DNA Translation: EAW53845.1
BC001616 mRNA Translation: AAH01616.1
BC002625 mRNA Translation: AAH02625.1
BC004561 mRNA Translation: AAH04561.1
BC009359 mRNA Translation: AAH09359.1
BC036708 mRNA Translation: AAH36708.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34309.1 [Q99729-2]
CCDS34310.1 [Q99729-3]

Protein sequence database of the Protein Information Resource

More...PIRi		S17563

NCBI Reference Sequences

More...RefSeqi		NP_004490.2, NM_004499.3 [Q99729-3]
NP_112556.2, NM_031266.2 [Q99729-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3182

UCSC genome browser

More...UCSCi		uc003miu.4, human [Q99729-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65028 mRNA Translation: AAA36575.1 Frameshift.
U76713 mRNA Translation: AAC50956.1 Frameshift.
AK054600 mRNA Translation: BAG51397.1
AK097657 mRNA Translation: BAC05134.1
CH471165 Genomic DNA Translation: EAW53843.1
CH471165 Genomic DNA Translation: EAW53844.1
CH471165 Genomic DNA Translation: EAW53845.1
BC001616 mRNA Translation: AAH01616.1
BC002625 mRNA Translation: AAH02625.1
BC004561 mRNA Translation: AAH04561.1
BC009359 mRNA Translation: AAH09359.1
BC036708 mRNA Translation: AAH36708.1
CCDSiCCDS34309.1 [Q99729-2]
CCDS34310.1 [Q99729-3]
PIRiS17563
RefSeqiNP_004490.2, NM_004499.3 [Q99729-3]
NP_112556.2, NM_031266.2 [Q99729-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S7RX-ray2.15A/B59-144[»]
SMRiQ99729
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109423, 229 interactors
ComplexPortaliCPX-1097, C-to-U editosome complex
DIPiDIP-50394N
IntActiQ99729, 108 interactors
MINTiQ99729
STRINGi9606.ENSP00000351108

PTM databases

GlyConnecti1313, 2 N-Linked glycans (1 site) [Q99729-2]
iPTMnetiQ99729
MetOSiteiQ99729
PhosphoSitePlusiQ99729
SwissPalmiQ99729

Genetic variation databases

BioMutaiHNRNPAB
DMDMi158523286

2D gel databases

SWISS-2DPAGEiQ99729

Proteomic databases

jPOSTiQ99729
MassIVEiQ99729
MaxQBiQ99729
PaxDbiQ99729
PeptideAtlasiQ99729
PRIDEiQ99729
ProteomicsDBi78443 [Q99729-1]
78444 [Q99729-2]
78445 [Q99729-3]
78446 [Q99729-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17556, 155 antibodies

The DNASU plasmid repository

More...DNASUi		3182

Genome annotation databases

EnsembliENST00000355836; ENSP00000348093; ENSG00000197451 [Q99729-3]
ENST00000358344; ENSP00000351108; ENSG00000197451 [Q99729-2]
ENST00000504898; ENSP00000425031; ENSG00000197451 [Q99729-2]
ENST00000506259; ENSP00000427465; ENSG00000197451 [Q99729-3]
GeneIDi3182
KEGGihsa:3182
UCSCiuc003miu.4, human [Q99729-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3182
DisGeNETi3182

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPAB
HGNCiHGNC:5034, HNRNPAB
HPAiENSG00000197451, Low tissue specificity
MIMi602688, gene
neXtProtiNX_Q99729
OpenTargetsiENSG00000197451
PharmGKBiPA162391196
VEuPathDBiHostDB:ENSG00000197451.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0118, Eukaryota
GeneTreeiENSGT00940000154735
HOGENOMiCLU_012062_1_1_1
InParanoidiQ99729
OMAiGAQSQNW
OrthoDBi1202220at2759
PhylomeDBiQ99729
TreeFamiTF314808

Enzyme and pathway databases

PathwayCommonsiQ99729

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3182, 15 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HNRNPAB, human
EvolutionaryTraceiQ99729

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HNRPAB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3182
PharosiQ99729, Tbio

Protein Ontology

More...PROi		PR:Q99729
RNActiQ99729, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197451, Expressed in layer of synovial tissue and 244 other tissues
ExpressionAtlasiQ99729, baseline and differential
GenevisibleiQ99729, HS

Family and domain databases

CDDicd12757, RRM1_hnRNPAB, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956, CARG-binding_factor_N
IPR034846, hnRNPAB_RRM1
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF08143, CBFNT, 1 hit
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROAA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99729
Secondary accession number(s): B3KNN5
, D3DWP7, Q04150, Q8N7U3, Q9BQ99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: September 11, 2007
Last modified: June 2, 2021
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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