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Protein

BRCA1-associated RING domain protein 1

Gene

BARD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.3 Publications

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 87RING-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

  • kinase binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: MGI
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5689603 UCH proteinases
R-HSA-5689901 Metalloprotease DUBs
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SignaLinkiQ99728
SIGNORiQ99728
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA1-associated RING domain protein 1 (EC:2.3.2.272 Publications)
Short name:
BARD-1
Alternative name(s):
RING-type E3 ubiquitin transferase BARD1Curated
Gene namesi
Name:BARD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138376.10
HGNCiHGNC:952 BARD1
MIMi601593 gene
neXtProtiNX_Q99728

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi580
MalaCardsiBARD1
OpenTargetsiENSG00000138376
Orphaneti145 Hereditary breast and ovarian cancer syndrome
PharmGKBiPA25256

Polymorphism and mutation databases

BioMutaiBARD1
DMDMi116241265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558191 – 777BRCA1-associated RING domain protein 1Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei186PhosphoserineCombined sources1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei394PhosphothreonineCombined sources1
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki548Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99728
MaxQBiQ99728
PaxDbiQ99728
PeptideAtlasiQ99728
PRIDEiQ99728
ProteomicsDBi78442

PTM databases

iPTMnetiQ99728
PhosphoSitePlusiQ99728

Expressioni

Gene expression databases

BgeeiENSG00000138376 Expressed in 210 organ(s), highest expression level in secondary oocyte
CleanExiHS_BARD1
ExpressionAtlasiQ99728 baseline and differential
GenevisibleiQ99728 HS

Organism-specific databases

HPAiCAB034106
HPA035354
HPA044864

Interactioni

Subunit structurei

Homo- and heterodimer. Heterodimer (RING-type zinc finger) with BRCA1. Heterodimer (via ANK repeats and BRCT domains) with CSTF1/CSTF-50. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts with UBXN1.7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107056, 272 interactors
ComplexPortaliCPX-955 BRCC ubiquitin ligase complex
CORUMiQ99728
DIPiDIP-5972N
IntActiQ99728, 47 interactors
MINTiQ99728
STRINGi9606.ENSP00000260947

Chemistry databases

BindingDBiQ99728

Structurei

Secondary structure

1777
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99728
SMRiQ99728
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99728

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati427 – 459ANK 1Add BLAST33
Repeati460 – 492ANK 2Add BLAST33
Repeati493 – 525ANK 3Add BLAST33
Repeati526 – 546ANK 4; degenerateAdd BLAST21
Domaini560 – 653BRCT 1PROSITE-ProRule annotationAdd BLAST94
Domaini667 – 777BRCT 2PROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 119Interaction with BRCA1Add BLAST94
Regioni554 – 558Flexible linker5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi400 – 403Poly-Ser4
Compositional biasi542 – 545Poly-Leu4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 87RING-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4362 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000237306
HOVERGENiHBG050662
InParanoidiQ99728
KOiK10683
OMAiCYFYLGG
OrthoDBiEOG091G0JNZ
PhylomeDBiQ99728
TreeFamiTF326440

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00027 BRCT, 2 hits
cd16496 RING-HC_BARD1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR033097 BARD1
IPR039503 BARD1_Znf-RING
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR24171:SF8 PTHR24171:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14835 zf-RING_6, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00292 BRCT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50172 BRCT, 2 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99728-1) [UniParc]FASTAAdd to basket
Also known as: FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC
60 70 80 90 100
SRCTNILREP VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ
110 120 130 140 150
LDSMIQLCSK LRNLLHDNEL SDLKEDKPRK SLFNDAGNKK NSIKMWFSPR
160 170 180 190 200
SKKVRYVVSK ASVQTQPAIK KDASAQQDSY EFVSPSPPAD VSERAKKASA
210 220 230 240 250
RSGKKQKKKT LAEINQKWNL EAEKEDGEFD SKEESKQKLV SFCSQPSVIS
260 270 280 290 300
SPQINGEIDL LASGSLTESE CFGSLTEVSL PLAEQIESPD TKSRNEVVTP
310 320 330 340 350
EKVCKNYLTS KKSLPLENNG KRGHHNRLSS PISKRCRTSI LSTSGDFVKQ
360 370 380 390 400
TVPSENIPLP ECSSPPSCKR KVGGTSGRKN SNMSDEFISL SPGTPPSTLS
410 420 430 440 450
SSSYRRVMSS PSAMKLLPNM AVKRNHRGET LLHIASIKGD IPSVEYLLQN
460 470 480 490 500
GSDPNVKDHA GWTPLHEACN HGHLKVVELL LQHKALVNTT GYQNDSPLHD
510 520 530 540 550
AAKNGHVDIV KLLLSYGASR NAVNIFGLRP VDYTDDESMK SLLLLPEKNE
560 570 580 590 600
SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV ILKAKKYTEF
610 620 630 640 650
DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK
660 670 680 690 700
YEIPEGPRRS RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG
710 720 730 740 750
QILSRKPKPD SDVTQTINTV AYHARPDSDQ RFCTQYIIYE DLCNYHPERV
760 770
RQGKVWKAPS SWFIDCVMSF ELLPLDS
Length:777
Mass (Da):86,648
Last modified:October 17, 2006 - v2
Checksum:i95E2D904046B5646
GO
Isoform alpha (identifier: Q99728-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-72: Missing.

Show »
Length:758
Mass (Da):84,574
Checksum:iF45B73AF6EDB602D
GO
Isoform beta (identifier: Q99728-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MPDNRQPRNRQPRIRSGNEPRSAP → MVAVPGPTVAPRSTAWRSCCAARV
     25-121: Missing.

Show »
Length:680
Mass (Da):75,474
Checksum:iD710F909D260F2F3
GO
Isoform gamma (identifier: Q99728-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-127: DLKEDK → GRHTFC
     128-777: Missing.

Show »
Length:127
Mass (Da):14,362
Checksum:iFEA9852C92F33975
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2H0A0A087X2H0_HUMAN
BRCA1-associated RING domain protei...
BARD1
326Annotation score:
F6MDI1F6MDI1_HUMAN
BRCA1 associated RING domain 1 isof...
BARD1
307Annotation score:
C9IYG1C9IYG1_HUMAN
BRCA1-associated RING domain protei...
BARD1
216Annotation score:
A0A087WZ19A0A087WZ19_HUMAN
BRCA1-associated RING domain protei...
BARD1
264Annotation score:
A0A087X0C6A0A087X0C6_HUMAN
BRCA1-associated RING domain protei...
BARD1
167Annotation score:
C9J6M1C9J6M1_HUMAN
BRCA1-associated RING domain protei...
BARD1
44Annotation score:
F8WCG2F8WCG2_HUMAN
BRCA1-associated RING domain protei...
BARD1
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85V → A in AEF57473 (PubMed:18089818).Curated1
Sequence conflicti406R → Q in AAB38316 (PubMed:8944023).Curated1
Sequence conflicti406R → Q in AEF57471 (PubMed:18089818).Curated1
Sequence conflicti406R → Q in AEF57472 (PubMed:18089818).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01035424P → S Common polymorphism in Caucasians; less frequent in Africans. 1 PublicationCorresponds to variant dbSNP:rs1048108EnsemblClinVar.1
Natural variantiVAR_010355153K → E1 PublicationCorresponds to variant dbSNP:rs753377280Ensembl.1
Natural variantiVAR_038371186S → G. Corresponds to variant dbSNP:rs16852741EnsemblClinVar.1
Natural variantiVAR_020109241S → C. Corresponds to variant dbSNP:rs3738885EnsemblClinVar.1
Natural variantiVAR_024611378R → S1 PublicationCorresponds to variant dbSNP:rs2229571EnsemblClinVar.1
Natural variantiVAR_010356507V → M1 PublicationCorresponds to variant dbSNP:rs2070094EnsemblClinVar.1
Natural variantiVAR_010357557C → S Rare polymorphism in Caucasians. 1 PublicationCorresponds to variant dbSNP:rs28997576EnsemblClinVar.1
Natural variantiVAR_010358564Q → H in an ovarian clear cell adenocarcinoma. 1 Publication1
Natural variantiVAR_038372645C → R. Corresponds to variant dbSNP:rs2228456EnsemblClinVar.1
Natural variantiVAR_010359658R → C Rare polymorphism in Caucasians; absent in Africans. 1 PublicationCorresponds to variant dbSNP:rs3738888EnsemblClinVar.1
Natural variantiVAR_010360695V → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs111367604Ensembl.1
Natural variantiVAR_028309728S → F. Corresponds to variant dbSNP:rs13389423EnsemblClinVar.1
Natural variantiVAR_010361761S → N in an uterine cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142155101EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558741 – 24MPDNR…PRSAP → MVAVPGPTVAPRSTAWRSCC AARV in isoform beta. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_05587525 – 121Missing in isoform beta. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_05587654 – 72Missing in isoform alpha. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_055877122 – 127DLKEDK → GRHTFC in isoform gamma. 1 Publication6
Alternative sequenceiVSP_055878128 – 777Missing in isoform gamma. 1 PublicationAdd BLAST650

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76638 mRNA Translation: AAB38316.1
AF038042
, AF038034, AF038035, AF038036, AF038037, AF038038, AF038039, AF038040, AF038041 Genomic DNA Translation: AAB99978.1
JF790280 mRNA Translation: AEF57471.1
JF790281 mRNA Translation: AEF57472.1
JF790282 mRNA Translation: AEF57473.1
AC016708 Genomic DNA Translation: AAX93130.1
BC126426 mRNA Translation: AAI26427.1
CCDSiCCDS2397.1 [Q99728-1]
CCDS74646.1 [Q99728-2]
RefSeqiNP_000456.2, NM_000465.3 [Q99728-1]
NP_001269472.1, NM_001282543.1 [Q99728-2]
UniGeneiHs.591642
Hs.597413

Genome annotation databases

EnsembliENST00000260947; ENSP00000260947; ENSG00000138376 [Q99728-1]
ENST00000617164; ENSP00000480470; ENSG00000138376 [Q99728-2]
ENST00000620057; ENSP00000481988; ENSG00000138376 [Q99728-4]
GeneIDi580
KEGGihsa:580
UCSCiuc002veu.4 human [Q99728-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76638 mRNA Translation: AAB38316.1
AF038042
, AF038034, AF038035, AF038036, AF038037, AF038038, AF038039, AF038040, AF038041 Genomic DNA Translation: AAB99978.1
JF790280 mRNA Translation: AEF57471.1
JF790281 mRNA Translation: AEF57472.1
JF790282 mRNA Translation: AEF57473.1
AC016708 Genomic DNA Translation: AAX93130.1
BC126426 mRNA Translation: AAI26427.1
CCDSiCCDS2397.1 [Q99728-1]
CCDS74646.1 [Q99728-2]
RefSeqiNP_000456.2, NM_000465.3 [Q99728-1]
NP_001269472.1, NM_001282543.1 [Q99728-2]
UniGeneiHs.591642
Hs.597413

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JM7NMR-B26-140[»]
2NTEX-ray1.90A/B568-777[»]
2R1ZX-ray2.10A/B569-777[»]
3C5RX-ray2.00A/B425-555[»]
3FA2X-ray2.20A/B566-777[»]
ProteinModelPortaliQ99728
SMRiQ99728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107056, 272 interactors
ComplexPortaliCPX-955 BRCC ubiquitin ligase complex
CORUMiQ99728
DIPiDIP-5972N
IntActiQ99728, 47 interactors
MINTiQ99728
STRINGi9606.ENSP00000260947

Chemistry databases

BindingDBiQ99728

PTM databases

iPTMnetiQ99728
PhosphoSitePlusiQ99728

Polymorphism and mutation databases

BioMutaiBARD1
DMDMi116241265

Proteomic databases

EPDiQ99728
MaxQBiQ99728
PaxDbiQ99728
PeptideAtlasiQ99728
PRIDEiQ99728
ProteomicsDBi78442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260947; ENSP00000260947; ENSG00000138376 [Q99728-1]
ENST00000617164; ENSP00000480470; ENSG00000138376 [Q99728-2]
ENST00000620057; ENSP00000481988; ENSG00000138376 [Q99728-4]
GeneIDi580
KEGGihsa:580
UCSCiuc002veu.4 human [Q99728-1]

Organism-specific databases

CTDi580
DisGeNETi580
EuPathDBiHostDB:ENSG00000138376.10
GeneCardsiBARD1
H-InvDBiHIX0030010
HGNCiHGNC:952 BARD1
HPAiCAB034106
HPA035354
HPA044864
MalaCardsiBARD1
MIMi601593 gene
neXtProtiNX_Q99728
OpenTargetsiENSG00000138376
Orphaneti145 Hereditary breast and ovarian cancer syndrome
PharmGKBiPA25256
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4362 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000237306
HOVERGENiHBG050662
InParanoidiQ99728
KOiK10683
OMAiCYFYLGG
OrthoDBiEOG091G0JNZ
PhylomeDBiQ99728
TreeFamiTF326440

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5689603 UCH proteinases
R-HSA-5689901 Metalloprotease DUBs
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SignaLinkiQ99728
SIGNORiQ99728

Miscellaneous databases

ChiTaRSiBARD1 human
EvolutionaryTraceiQ99728
GeneWikiiBARD1
GenomeRNAii580
PROiPR:Q99728
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138376 Expressed in 210 organ(s), highest expression level in secondary oocyte
CleanExiHS_BARD1
ExpressionAtlasiQ99728 baseline and differential
GenevisibleiQ99728 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00027 BRCT, 2 hits
cd16496 RING-HC_BARD1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR033097 BARD1
IPR039503 BARD1_Znf-RING
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR24171:SF8 PTHR24171:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14835 zf-RING_6, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00292 BRCT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52113 SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50172 BRCT, 2 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBARD1_HUMAN
AccessioniPrimary (citable) accession number: Q99728
Secondary accession number(s): F6MDH7
, F6MDH8, F6MDH9, O43574, Q53SS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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