UniProtKB - Q99726 (ZNT3_HUMAN)
Protein
Zinc transporter 3
Gene
SLC30A3
Organism
Homo sapiens (Human)
Status
Functioni
Involved in accumulation of zinc in synaptic vesicles.By similarity
GO - Molecular functioni
- ATPase-coupled zinc transmembrane transporter activity Source: ProtInc
- zinc ion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- positive regulation of transport Source: Ensembl
- regulation of sequestering of zinc ion Source: BHF-UCL
- response to zinc ion Source: GO_Central
- zinc ion import into synaptic vesicle Source: Ensembl
- zinc ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q99726 |
Reactomei | R-HSA-435368, Zinc efflux and compartmentalization by the SLC30 family |
Protein family/group databases
TCDBi | 2.A.4.3.2, the cation diffusion facilitator (cdf) family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc transporter 3Short name: ZnT-3 Alternative name(s): Solute carrier family 30 member 3 |
Gene namesi | Name:SLC30A3 Synonyms:ZNT3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000115194.10 |
HGNCi | HGNC:11014, SLC30A3 |
MIMi | 602878, gene |
neXtProti | NX_Q99726 |
Subcellular locationi
Lysosome
- Lysosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endosome
- Late endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
- synaptosome By similarity
- synaptic vesicle 1 Publication
Endosome
- endosome Source: ProtInc
- late endosome Source: BHF-UCL
- late endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: BHF-UCL
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- membrane Source: ProtInc
- neuron projection Source: UniProtKB
- synaptic vesicle Source: UniProtKB
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 105 | VacuolarSequence analysis | 9 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 145 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 167 – 177 | VacuolarSequence analysisAdd BLAST | 11 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 235 | CytoplasmicSequence analysisAdd BLAST | 37 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 264 | VacuolarSequence analysis | 8 | |
Transmembranei | 265 – 285 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 286 – 388 | CytoplasmicSequence analysisAdd BLAST | 103 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, SynaptosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 7781 |
OpenTargetsi | ENSG00000115194 |
PharmGKBi | PA35884 |
Miscellaneous databases
Pharosi | Q99726, Tbio |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Polymorphism and mutation databases
BioMutai | SLC30A3 |
DMDMi | 215273923 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206096 | 1 – 388 | Zinc transporter 3Add BLAST | 388 |
Proteomic databases
MassIVEi | Q99726 |
MaxQBi | Q99726 |
PaxDbi | Q99726 |
PeptideAtlasi | Q99726 |
PRIDEi | Q99726 |
ProteomicsDBi | 78440 |
PTM databases
iPTMneti | Q99726 |
PhosphoSitePlusi | Q99726 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115194, Expressed in right testis and 154 other tissues |
ExpressionAtlasi | Q99726, baseline and differential |
Genevisiblei | Q99726, HS |
Organism-specific databases
HPAi | ENSG00000115194, Group enriched (brain, epididymis, testis) |
Interactioni
Binary interactionsi
Hide detailsQ99726
Protein-protein interaction databases
BioGRIDi | 113562, 31 interactors |
IntActi | Q99726, 29 interactors |
STRINGi | 9606.ENSP00000233535 |
Miscellaneous databases
RNActi | Q99726, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1482, Eukaryota |
GeneTreei | ENSGT00940000161480 |
InParanoidi | Q99726 |
OMAi | RTWGWAR |
OrthoDBi | 973492at2759 |
PhylomeDBi | Q99726 |
TreeFami | TF313382 |
Family and domain databases
Gene3Di | 1.20.1510.10, 1 hit |
InterProi | View protein in InterPro IPR002524, Cation_efflux IPR036837, Cation_efflux_CTD_sf IPR027469, Cation_efflux_TMD_sf |
Pfami | View protein in Pfam PF01545, Cation_efflux, 1 hit |
SUPFAMi | SSF160240, SSF160240, 1 hit SSF161111, SSF161111, 1 hit |
TIGRFAMsi | TIGR01297, CDF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q99726-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM
60 70 80 90 100
PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV
310 320 330 340 350
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZ83 | H7BZ83_HUMAN | Zinc transporter 3 | SLC30A3 | 302 | Annotation score: | ||
C9JM13 | C9JM13_HUMAN | Zinc transporter 3 | SLC30A3 | 240 | Annotation score: | ||
C9JHX4 | C9JHX4_HUMAN | Zinc transporter 3 | SLC30A3 | 170 | Annotation score: | ||
C9JV68 | C9JV68_HUMAN | Zinc transporter 3 | SLC30A3 | 230 | Annotation score: | ||
C9J1K4 | C9J1K4_HUMAN | Zinc transporter 3 | SLC30A3 | 98 | Annotation score: | ||
C9JHZ9 | C9JHZ9_HUMAN | Zinc transporter 3 | SLC30A3 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | E → Q in AAB39732 (PubMed:8962159).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077209 | 298 | R → C Rare polymorphism; may be associated with increased risk for febrile seizures; the mutant has decreased localization to synaptic vesicles. 1 PublicationCorresponds to variant dbSNP:rs146572471Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76010 mRNA Translation: AAB39732.1 AK313600 mRNA Translation: BAG36366.1 AC013413 Genomic DNA Translation: AAY24294.1 BC028358 mRNA Translation: AAH28358.1 |
CCDSi | CCDS1743.1 |
RefSeqi | NP_001305878.1, NM_001318949.1 NP_001305879.1, NM_001318950.1 NP_001305880.1, NM_001318951.1 NP_003450.2, NM_003459.4 |
Genome annotation databases
Ensembli | ENST00000233535; ENSP00000233535; ENSG00000115194 |
GeneIDi | 7781 |
KEGGi | hsa:7781 |
UCSCi | uc002rjk.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U76010 mRNA Translation: AAB39732.1 AK313600 mRNA Translation: BAG36366.1 AC013413 Genomic DNA Translation: AAY24294.1 BC028358 mRNA Translation: AAH28358.1 |
CCDSi | CCDS1743.1 |
RefSeqi | NP_001305878.1, NM_001318949.1 NP_001305879.1, NM_001318950.1 NP_001305880.1, NM_001318951.1 NP_003450.2, NM_003459.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113562, 31 interactors |
IntActi | Q99726, 29 interactors |
STRINGi | 9606.ENSP00000233535 |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
TCDBi | 2.A.4.3.2, the cation diffusion facilitator (cdf) family |
PTM databases
iPTMneti | Q99726 |
PhosphoSitePlusi | Q99726 |
Polymorphism and mutation databases
BioMutai | SLC30A3 |
DMDMi | 215273923 |
Proteomic databases
MassIVEi | Q99726 |
MaxQBi | Q99726 |
PaxDbi | Q99726 |
PeptideAtlasi | Q99726 |
PRIDEi | Q99726 |
ProteomicsDBi | 78440 |
Protocols and materials databases
Antibodypediai | 47345, 133 antibodies |
DNASUi | 7781 |
Genome annotation databases
Ensembli | ENST00000233535; ENSP00000233535; ENSG00000115194 |
GeneIDi | 7781 |
KEGGi | hsa:7781 |
UCSCi | uc002rjk.4, human |
Organism-specific databases
CTDi | 7781 |
DisGeNETi | 7781 |
EuPathDBi | HostDB:ENSG00000115194.10 |
GeneCardsi | SLC30A3 |
HGNCi | HGNC:11014, SLC30A3 |
HPAi | ENSG00000115194, Group enriched (brain, epididymis, testis) |
MIMi | 602878, gene |
neXtProti | NX_Q99726 |
OpenTargetsi | ENSG00000115194 |
PharmGKBi | PA35884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1482, Eukaryota |
GeneTreei | ENSGT00940000161480 |
InParanoidi | Q99726 |
OMAi | RTWGWAR |
OrthoDBi | 973492at2759 |
PhylomeDBi | Q99726 |
TreeFami | TF313382 |
Enzyme and pathway databases
PathwayCommonsi | Q99726 |
Reactomei | R-HSA-435368, Zinc efflux and compartmentalization by the SLC30 family |
Miscellaneous databases
BioGRID-ORCSi | 7781, 2 hits in 839 CRISPR screens |
GeneWikii | SLC30A3 |
GenomeRNAii | 7781 |
Pharosi | Q99726, Tbio |
PROi | PR:Q99726 |
RNActi | Q99726, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115194, Expressed in right testis and 154 other tissues |
ExpressionAtlasi | Q99726, baseline and differential |
Genevisiblei | Q99726, HS |
Family and domain databases
Gene3Di | 1.20.1510.10, 1 hit |
InterProi | View protein in InterPro IPR002524, Cation_efflux IPR036837, Cation_efflux_CTD_sf IPR027469, Cation_efflux_TMD_sf |
Pfami | View protein in Pfam PF01545, Cation_efflux, 1 hit |
SUPFAMi | SSF160240, SSF160240, 1 hit SSF161111, SSF161111, 1 hit |
TIGRFAMsi | TIGR01297, CDF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNT3_HUMAN | |
Accessioni | Q99726Primary (citable) accession number: Q99726 Secondary accession number(s): Q8TC03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations