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Protein

Zinc transporter 3

Gene

SLC30A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.By similarity

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: GO_Central
  • zinc-transporting ATPase activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Protein family/group databases

TCDBi2.A.4.3.2 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:SLC30A3
Synonyms:ZNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115194.10
HGNCiHGNC:11014 SLC30A3
MIMi602878 gene
neXtProtiNX_Q99726

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 105VacuolarSequence analysis9
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 177VacuolarSequence analysisAdd BLAST11
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 235CytoplasmicSequence analysisAdd BLAST37
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 264VacuolarSequence analysis8
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 388CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7781
OpenTargetsiENSG00000115194
PharmGKBiPA35884

Polymorphism and mutation databases

BioMutaiSLC30A3
DMDMi215273923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060961 – 388Zinc transporter 3Add BLAST388

Proteomic databases

EPDiQ99726
MaxQBiQ99726
PaxDbiQ99726
PeptideAtlasiQ99726
PRIDEiQ99726
ProteomicsDBi78440

PTM databases

iPTMnetiQ99726
PhosphoSitePlusiQ99726

Expressioni

Gene expression databases

BgeeiENSG00000115194 Expressed in 127 organ(s), highest expression level in right testis
CleanExiHS_SLC30A3
ExpressionAtlasiQ99726 baseline and differential
GenevisibleiQ99726 HS

Organism-specific databases

HPAiCAB079044
HPA060505
HPA067637

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113562, 3 interactors
IntActiQ99726, 22 interactors
STRINGi9606.ENSP00000233535

Structurei

3D structure databases

ProteinModelPortaliQ99726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiQ99726
KOiK14690
OMAiHSRFGFS
OrthoDBiEOG091G07UN
PhylomeDBiQ99726
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q99726-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM
60 70 80 90 100
PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV
310 320 330 340 350
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA
Length:388
Mass (Da):41,945
Last modified:November 25, 2008 - v2
Checksum:iD73DE65F46860FD8
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JM13C9JM13_HUMAN
Zinc transporter 3
SLC30A3
240Annotation score:
C9JV68C9JV68_HUMAN
Zinc transporter 3
SLC30A3
230Annotation score:
C9JHX4C9JHX4_HUMAN
Zinc transporter 3
SLC30A3
170Annotation score:
H7BZ83H7BZ83_HUMAN
Zinc transporter 3
SLC30A3
302Annotation score:
C9J1K4C9J1K4_HUMAN
Zinc transporter 3
SLC30A3
98Annotation score:
C9JHZ9C9JHZ9_HUMAN
Zinc transporter 3
SLC30A3
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223E → Q in AAB39732 (PubMed:8962159).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077209298R → C Rare polymorphism; may be associated with increased risk for febrile seizures; the mutant has decreased localization to synaptic vesicles. 1 PublicationCorresponds to variant dbSNP:rs146572471Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76010 mRNA Translation: AAB39732.1
AK313600 mRNA Translation: BAG36366.1
AC013413 Genomic DNA Translation: AAY24294.1
BC028358 mRNA Translation: AAH28358.1
CCDSiCCDS1743.1
RefSeqiNP_001305878.1, NM_001318949.1
NP_001305879.1, NM_001318950.1
NP_001305880.1, NM_001318951.1
NP_003450.2, NM_003459.4
UniGeneiHs.467981

Genome annotation databases

EnsembliENST00000233535; ENSP00000233535; ENSG00000115194
GeneIDi7781
KEGGihsa:7781
UCSCiuc002rjk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76010 mRNA Translation: AAB39732.1
AK313600 mRNA Translation: BAG36366.1
AC013413 Genomic DNA Translation: AAY24294.1
BC028358 mRNA Translation: AAH28358.1
CCDSiCCDS1743.1
RefSeqiNP_001305878.1, NM_001318949.1
NP_001305879.1, NM_001318950.1
NP_001305880.1, NM_001318951.1
NP_003450.2, NM_003459.4
UniGeneiHs.467981

3D structure databases

ProteinModelPortaliQ99726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113562, 3 interactors
IntActiQ99726, 22 interactors
STRINGi9606.ENSP00000233535

Protein family/group databases

TCDBi2.A.4.3.2 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ99726
PhosphoSitePlusiQ99726

Polymorphism and mutation databases

BioMutaiSLC30A3
DMDMi215273923

Proteomic databases

EPDiQ99726
MaxQBiQ99726
PaxDbiQ99726
PeptideAtlasiQ99726
PRIDEiQ99726
ProteomicsDBi78440

Protocols and materials databases

DNASUi7781
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233535; ENSP00000233535; ENSG00000115194
GeneIDi7781
KEGGihsa:7781
UCSCiuc002rjk.4 human

Organism-specific databases

CTDi7781
DisGeNETi7781
EuPathDBiHostDB:ENSG00000115194.10
GeneCardsiSLC30A3
H-InvDBiHIX0001914
HGNCiHGNC:11014 SLC30A3
HPAiCAB079044
HPA060505
HPA067637
MIMi602878 gene
neXtProtiNX_Q99726
OpenTargetsiENSG00000115194
PharmGKBiPA35884
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiQ99726
KOiK14690
OMAiHSRFGFS
OrthoDBiEOG091G07UN
PhylomeDBiQ99726
TreeFamiTF313382

Enzyme and pathway databases

ReactomeiR-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Miscellaneous databases

ChiTaRSiSLC30A3 human
GeneWikiiSLC30A3
GenomeRNAii7781
PROiPR:Q99726
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115194 Expressed in 127 organ(s), highest expression level in right testis
CleanExiHS_SLC30A3
ExpressionAtlasiQ99726 baseline and differential
GenevisibleiQ99726 HS

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNT3_HUMAN
AccessioniPrimary (citable) accession number: Q99726
Secondary accession number(s): Q8TC03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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