UniProtKB - Q99726 (ZNT3_HUMAN)

BLAST

>sp|Q99726|ZNT3_HUMAN Zinc transporter 3 OS=Homo sapiens OX=9606 GN=SLC30A3 PE=1 SV=2
MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPL
PPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSL
FSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAM
LLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVL
GDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNV
GFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRF
GFSSCTLQVEQYQPEMAQCLRCQEPPQA

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History
Entry version 159 (07 Nov 2018)
Sequence version 2 (25 Nov 2008)
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Protein

Zinc transporter 3

Gene

SLC30A3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in accumulation of zinc in synaptic vesicles.By similarity

GO - Molecular functionⁱ

zinc ion transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc-transporting ATPase activity
Source: ProtInc
Traceable author statementⁱ
- 8962159

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transport Source: Ensembl
regulation of sequestering of zinc ion
Source: BHF-UCL
Inferred from direct assayⁱ
- 17349999
response to zinc ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion import into synaptic vesicle Source: Ensembl
zinc ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Transport, Zinc transport
Ligand	Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Reactomeⁱ

R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Protein family/group databases

TCDBⁱ	2.A.4.3.2 the cation diffusion facilitator (cdf) family

TCDBⁱ

2.A.4.3.2 the cation diffusion facilitator (cdf) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc transporter 3 Short name: ZnT-3 Alternative name(s): Solute carrier family 30 member 3
Gene namesⁱ	Name:SLC30A3 Synonyms:ZNT3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115194.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11014 SLC30A3
MIMⁱ	602878 gene
neXtProtⁱ	NX_Q99726

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 75	CytoplasmicSequence analysisAdd BLAST	75
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	97 – 105	VacuolarSequence analysis	9
Transmembraneⁱ	106 – 126	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	127 – 145	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	146 – 166	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	167 – 177	VacuolarSequence analysisAdd BLAST	11
Transmembraneⁱ	178 – 198	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	199 – 235	CytoplasmicSequence analysisAdd BLAST	37
Transmembraneⁱ	236 – 256	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	257 – 264	VacuolarSequence analysis	8
Transmembraneⁱ	265 – 285	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	286 – 388	CytoplasmicSequence analysisAdd BLAST	103

Keywords - Cellular componentⁱ

Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7781
Open Targets More...OpenTargetsⁱ	ENSG00000115194
PharmGKBⁱ	PA35884

Polymorphism and mutation databases

BioMutaⁱ	SLC30A3
DMDMⁱ	215273923

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206096	1 – 388	Zinc transporter 3Add BLAST		388

Proteomic databases

EPDⁱ	Q99726
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99726
PaxDbⁱ	Q99726
PeptideAtlas More...PeptideAtlasⁱ	Q99726
PRIDEⁱ	Q99726
ProteomicsDBⁱ	78440

PTM databases

iPTMnetⁱ	Q99726
PhosphoSitePlusⁱ	Q99726

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000115194 Expressed in 127 organ(s), highest expression level in right testis
CleanExⁱ	HS_SLC30A3
ExpressionAtlasⁱ	Q99726 baseline and differential
Genevisibleⁱ	Q99726 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB079044 HPA060505 HPA067637

HPAⁱ

CAB079044
HPA060505
HPA067637

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
NAALADL2	Q58DX5	3	EBI-10294651,EBI-10178964
SLC30A10	Q6XR72	3	EBI-10294651,EBI-13917996
SLC30A2	Q9BRI3	7	EBI-10294651,EBI-8644112
SLC30A4	O14863	8	EBI-10294651,EBI-13918058

Protein-protein interaction databases

BioGridⁱ	113562, 3 interactors
IntActⁱ	Q99726, 22 interactors
STRINGⁱ	9606.ENSP00000233535

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99726
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1482 Eukaryota COG1230 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074381
HOGENOMⁱ	HOG000079023
HOVERGENⁱ	HBG003345
InParanoidⁱ	Q99726
KEGG Orthology (KO) More...KOⁱ	K14690
OMAⁱ	HSRFGFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07UN
PhylomeDBⁱ	Q99726
TreeFamⁱ	TF313382

Family and domain databases

Gene3Dⁱ	1.20.1510.10, 1 hit
InterProⁱ	View protein in InterPro IPR002524 Cation_efflux IPR036837 Cation_efflux_CTD_sf IPR027469 Cation_efflux_TMD_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01545 Cation_efflux, 1 hit
SUPFAMⁱ	SSF160240 SSF160240, 1 hit SSF161111 SSF161111, 1 hit
TIGRFAMsⁱ	TIGR01297 CDF, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q99726-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM 
        60         70         80         90        100
PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL 
       110        120        130        140        150
AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV 
       160        170        180        190        200
VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ 
       210        220        230        240        250
AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL 
       260        270        280        290        300
AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV 
       310        320        330        340        350
GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA 
       360        370        380 
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA

Length:388

Mass (Da):41,945

Last modified:November 25, 2008 - v2

Checksum:ⁱD73DE65F46860FD8

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JM13	C9JM13_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	240	Annotation score:
C9JV68	C9JV68_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	230	Annotation score:
C9JHX4	C9JHX4_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	170	Annotation score:
H7BZ83	H7BZ83_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	302	Annotation score:
C9J1K4	C9J1K4_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	98	Annotation score:
C9JHZ9	C9JHZ9_HUMAN	Zinc transporter 3 Zinc transporter 3	SLC30A3	110	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	223	E → Q in AAB39732 (PubMed:8962159).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077209	298	R → C Rare polymorphism; may be associated with increased risk for febrile seizures; the mutant has decreased localization to synaptic vesicles. 1 PublicationCorresponds to variant dbSNP:rs146572471Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76010 mRNA Translation: AAB39732.1 AK313600 mRNA Translation: BAG36366.1 AC013413 Genomic DNA Translation: AAY24294.1 BC028358 mRNA Translation: AAH28358.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1743.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305878.1, NM_001318949.1 NP_001305879.1, NM_001318950.1 NP_001305880.1, NM_001318951.1 NP_003450.2, NM_003459.4
UniGeneⁱ	Hs.467981

Genome annotation databases

Ensemblⁱ	ENST00000233535; ENSP00000233535; ENSG00000115194
GeneIDⁱ	7781
KEGGⁱ	hsa:7781
UCSC genome browser More...UCSCⁱ	uc002rjk.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99726	SLC30A3 isoform 7		PANTR		339	UniRef100_Q99726
Zinc transporter 3 (Fragment)		HUMAN		240
SLC30A3 isoform 9 (Fragment)		PONAB		111
Solute carrier family 30 member 3		GORGO		388
Zinc transporter 3 (Fragment)		HUMAN		110
+8

Protein	Similar proteins		Species	Score	Length	Source
Q99726	SLC30A3 isoform 7		PANTR		339	UniRef90_Q99726
Zinc transporter 3 (Fragment)		HUMAN		240
SLC30A3 isoform 9 (Fragment)		PONAB		111
Solute carrier family 30 member 3		GORGO		388
Uncharacterized protein		NOMLE		388
+14

Protein	Similar proteins		Species	Score	Length	Source
Q99726	SLC30A3 isoform 7		PANTR		339	UniRef50_Q99726
Zinc transporter 3 (Fragment)		HUMAN		240
SLC30A3 isoform 9 (Fragment)		PONAB		111
Solute carrier family 30 member 3		GORGO		388
Uncharacterized protein		NOMLE		388
+66

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76010 mRNA Translation: AAB39732.1 AK313600 mRNA Translation: BAG36366.1 AC013413 Genomic DNA Translation: AAY24294.1 BC028358 mRNA Translation: AAH28358.1
CCDSⁱ	CCDS1743.1
RefSeqⁱ	NP_001305878.1, NM_001318949.1 NP_001305879.1, NM_001318950.1 NP_001305880.1, NM_001318951.1 NP_003450.2, NM_003459.4
UniGeneⁱ	Hs.467981

3D structure databases

ProteinModelPortalⁱ	Q99726
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113562, 3 interactors
IntActⁱ	Q99726, 22 interactors
STRINGⁱ	9606.ENSP00000233535

Protein family/group databases

TCDBⁱ	2.A.4.3.2 the cation diffusion facilitator (cdf) family

TCDBⁱ

2.A.4.3.2 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetⁱ	Q99726
PhosphoSitePlusⁱ	Q99726

Polymorphism and mutation databases

BioMutaⁱ	SLC30A3
DMDMⁱ	215273923

Proteomic databases

EPDⁱ	Q99726
MaxQBⁱ	Q99726
PaxDbⁱ	Q99726
PeptideAtlasⁱ	Q99726
PRIDEⁱ	Q99726
ProteomicsDBⁱ	78440

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7781
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000233535; ENSP00000233535; ENSG00000115194
GeneIDⁱ	7781
KEGGⁱ	hsa:7781
UCSCⁱ	uc002rjk.4 human

Organism-specific databases

CTDⁱ	7781
DisGeNETⁱ	7781
EuPathDBⁱ	HostDB:ENSG00000115194.10
GeneCardsⁱ	SLC30A3
H-InvDBⁱ	HIX0001914
HGNCⁱ	HGNC:11014 SLC30A3
HPAⁱ	CAB079044 HPA060505 HPA067637
MIMⁱ	602878 gene
neXtProtⁱ	NX_Q99726
OpenTargetsⁱ	ENSG00000115194
PharmGKBⁱ	PA35884
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1482 Eukaryota COG1230 LUCA
GeneTreeⁱ	ENSGT00550000074381
HOGENOMⁱ	HOG000079023
HOVERGENⁱ	HBG003345
InParanoidⁱ	Q99726
KOⁱ	K14690
OMAⁱ	HSRFGFS
OrthoDBⁱ	EOG091G07UN
PhylomeDBⁱ	Q99726
TreeFamⁱ	TF313382

Enzyme and pathway databases

Reactomeⁱ	R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Reactomeⁱ

R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Miscellaneous databases

ChiTaRSⁱ	SLC30A3 human
GeneWikiⁱ	SLC30A3
GenomeRNAiⁱ	7781
Protein Ontology More...PROⁱ	PR:Q99726
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115194 Expressed in 127 organ(s), highest expression level in right testis
CleanExⁱ	HS_SLC30A3
ExpressionAtlasⁱ	Q99726 baseline and differential
Genevisibleⁱ	Q99726 HS

Family and domain databases

Gene3Dⁱ	1.20.1510.10, 1 hit
InterProⁱ	View protein in InterPro IPR002524 Cation_efflux IPR036837 Cation_efflux_CTD_sf IPR027469 Cation_efflux_TMD_sf
Pfamⁱ	View protein in Pfam PF01545 Cation_efflux, 1 hit
SUPFAMⁱ	SSF160240 SSF160240, 1 hit SSF161111 SSF161111, 1 hit
TIGRFAMsⁱ	TIGR01297 CDF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNT3_HUMAN
Accessionⁱ	Q99726Primary (citable) accession number: Q99726 Secondary accession number(s): Q8TC03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99726 (ZNT3_HUMAN)

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Zinc transporter 3

SLC30A3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Lysosome

Other locations

Endosome

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ