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Protein

Sigma non-opioid intracellular receptor 1

Gene

SIGMAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).By similarity2 Publications

Miscellaneous

Depletion by RNAi inhibits growth and survival signaling cascades and induces cell death. The antagonist rimcazole produces the same effect.
Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.1 Publication

Caution

The NMR solution structure identifies a second transmembrane helix starting with Gly-91 (PubMed:25647032). The X-ray structure clearly shows that this region is not helical and not in the membrane; instead it is part of two beta-strands (PubMed:27042935).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126Important for ligand binding1 Publication1
Sitei172Important for ligand binding1 Publication1

GO - Molecular functioni

  • drug binding Source: ProtInc
  • identical protein binding Source: IntAct
  • opioid receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Enzyme and pathway databases

SIGNORiQ99720

Protein family/group databases

TCDBi8.A.63.1.1 the sigma non-opioid intracellular recpetor, (s1r) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma non-opioid intracellular receptor 1
Alternative name(s):
Aging-associated gene 8 protein
SR31747-binding protein
Short name:
SR-BP
Sigma 1-type opioid receptor
Short name:
SIG-1R
Short name:
Sigma1-receptor
Short name:
Sigma1R
Short name:
hSigmaR1
Gene namesi
Name:SIGMAR1
Synonyms:OPRS1, SRBP
ORF Names:AAG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147955.16
HGNCiHGNC:8157 SIGMAR1
MIMi601978 gene
neXtProtiNX_Q99720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Lumenal1 Publication9
Transmembranei10 – 30Helical1 PublicationAdd BLAST21
Topological domaini31 – 223Cytoplasmic1 PublicationAdd BLAST193

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 16, juvenile (ALS16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
See also OMIM:614373
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067311102E → Q in ALS16; the mutation decreases the viability of motor neurons; the mutant protein is shifted to lower density membranes and forms detergent-resistant complexes; there is an almost 2-fold increase in apoptosis in response to stress compared to controls. 1 PublicationCorresponds to variant dbSNP:rs387906829EnsemblClinVar.1
Distal spinal muscular atrophy, autosomal recessive, 2 (DSMA2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neuromuscular disorder characterized by onset of distal muscle weakness and wasting affecting the lower and upper limbs in the first decade. There is no sensory involvement.
See also OMIM:605726
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07881665L → Q in DSMA2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140376902Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi123E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi126D → G: Reduces ligand-binding. No effect on subcellular localization. 1 Publication1
Mutagenesisi138E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi144E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi150E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi158E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi163E → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi172E → G: Reduces ligand-binding. No effect on subcellular localization. 1 Publication1
Mutagenesisi188D → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi195D → G: No effect on ligand-binding. 1 Publication1
Mutagenesisi213E → G: No effect on ligand-binding. 1 Publication1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi10280
MalaCardsiSIGMAR1
MIMi605726 phenotype
614373 phenotype
OpenTargetsiENSG00000147955
Orphaneti300605 Juvenile amyotrophic lateral sclerosis
PharmGKBiPA164725706

Chemistry databases

ChEMBLiCHEMBL287
DrugBankiDB00321 Amitriptyline
DB09014 Captodiame
DB00514 Dextromethorphan
DB01488 Dimethyltryptamine
DB00540 Nortriptyline
DB00652 Pentazocine
DB03575 Phencyclidine
DB01708 Prasterone
DB00409 Remoxipride
GuidetoPHARMACOLOGYi2552

Polymorphism and mutation databases

DMDMi74752153

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686521 – 223Sigma non-opioid intracellular receptor 1Add BLAST223

Proteomic databases

EPDiQ99720
MaxQBiQ99720
PaxDbiQ99720
PeptideAtlasiQ99720
PRIDEiQ99720
ProteomicsDBi78435
78436 [Q99720-2]
78437 [Q99720-3]
78438 [Q99720-4]
78439 [Q99720-5]
TopDownProteomicsiQ99720-1 [Q99720-1]
Q99720-2 [Q99720-2]
Q99720-3 [Q99720-3]
Q99720-4 [Q99720-4]
Q99720-5 [Q99720-5]

PTM databases

iPTMnetiQ99720
PhosphoSitePlusiQ99720

Expressioni

Tissue specificityi

Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020).4 Publications

Gene expression databases

BgeeiENSG00000147955 Expressed in 223 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ99720 baseline and differential
GenevisibleiQ99720 HS

Organism-specific databases

HPAiCAB013470
HPA018002
HPA024071

Interactioni

Subunit structurei

Homotrimer (PubMed:27042935). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4. Interacts with KCNA2; cocaine consumption leads to increased interaction. Interacts with RNF112 in an oxidative stress-regulated manner (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115569, 15 interactors
CORUMiQ99720
DIPiDIP-61974N
ELMiQ99720
IntActiQ99720, 5 interactors
STRINGi9606.ENSP00000277010

Chemistry databases

BindingDBiQ99720

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99720
SMRiQ99720
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 8Targeting to endoplasmic reticulum-associated lipid dropletsBy similarity7
Regioni99 – 106Important for ligand-bindingBy similarity8
Regioni177 – 223C-terminal hydrophobic region1 PublicationAdd BLAST47

Domaini

The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.1 Publication

Sequence similaritiesi

Belongs to the ERG2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4143 Eukaryota
ENOG410XP0Z LUCA
GeneTreeiENSGT00390000012082
HOVERGENiHBG058220
InParanoidiQ99720
KOiK20719
OMAiWKEGTTK
OrthoDBiEOG091G0KD7
PhylomeDBiQ99720
TreeFamiTF300106

Family and domain databases

InterProiView protein in InterPro
IPR006716 ERG2_sigma1_rcpt-like
PANTHERiPTHR10868 PTHR10868, 1 hit
PfamiView protein in Pfam
PF04622 ERG2_Sigma1R, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99720-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA
60 70 80 90 100
GLDHELAFSR LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL
110 120 130 140 150
SEYVLLFGTA LGSRGHSGRY WAEISDTIIS GTFHQWREGT TKSEVFYPGE
160 170 180 190 200
TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLAFALADTV FSTQDFLTLF
210 220
YTLRSYARGL RLELTTYLFG QDP
Length:223
Mass (Da):25,128
Last modified:May 1, 1997 - v1
Checksum:i0C498636BEB1C443
GO
Isoform 2 (identifier: Q99720-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-50: Missing.

Show »
Length:203
Mass (Da):22,803
Checksum:i755BFC0F9182D947
GO
Isoform 3 (identifier: Q99720-3) [UniParc]FASTAAdd to basket
Also known as: Sigma-R1A

The sequence of this isoform differs from the canonical sequence as follows:
     118-148: Missing.

Show »
Length:192
Mass (Da):21,483
Checksum:i9E0C6A120A89126F
GO
Isoform 4 (identifier: Q99720-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-106: YVLL → ALLG
     107-223: Missing.

Show »
Length:106
Mass (Da):11,992
Checksum:i8A4FDBFAFF6DAEEE
GO
Isoform 5 (identifier: Q99720-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-52: Missing.
     63-76: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,013
Checksum:iE50731B80FB98FBF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1J1Q5T1J1_HUMAN
HCG20471, isoform CRA_c
SIGMAR1 hCG_20471
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → A in AAF64280 (Ref. 4) Curated1
Sequence conflicti168T → A in ABG29111 (Ref. 6) Curated1
Sequence conflicti208R → W in AAV33304 (Ref. 5) Curated1
Sequence conflicti218L → I in ABG29111 (Ref. 6) Curated1
Sequence conflicti219F → S in BAD96619 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0297502Q → P1 PublicationCorresponds to variant dbSNP:rs1800866Ensembl.1
Natural variantiVAR_07881665L → Q in DSMA2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs140376902Ensembl.1
Natural variantiVAR_067311102E → Q in ALS16; the mutation decreases the viability of motor neurons; the mutant protein is shifted to lower density membranes and forms detergent-resistant complexes; there is an almost 2-fold increase in apoptosis in response to stress compared to controls. 1 PublicationCorresponds to variant dbSNP:rs387906829EnsemblClinVar.1
Natural variantiVAR_029751211R → Q1 PublicationCorresponds to variant dbSNP:rs192644838Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02198131 – 52Missing in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_02198231 – 50Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02198363 – 76Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021984103 – 106YVLL → ALLG in isoform 4. 2 Publications4
Alternative sequenceiVSP_021985107 – 223Missing in isoform 4. 2 PublicationsAdd BLAST117
Alternative sequenceiVSP_021986118 – 148Missing in isoform 3. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75283 mRNA Translation: AAB50402.1
U79528 mRNA Translation: AAB51238.1
AF001977, AF001976 Genomic DNA Translation: AAC04507.1
AF226604 mRNA Translation: AAF64280.1
AY633611 mRNA Translation: AAV33304.1
DQ644568 mRNA Translation: ABG29111.1
DQ647702 mRNA Translation: ABG36559.1
DQ656583 mRNA Translation: ABG46369.1
AK098451 mRNA Translation: BAC05307.1
CR457075 mRNA Translation: CAG33356.1
AK222899 mRNA Translation: BAD96619.1
AL450283 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58431.1
CH471071 Genomic DNA Translation: EAW58434.1
BC004899 mRNA Translation: AAH04899.1
BC007839 mRNA Translation: AAH07839.1
CCDSiCCDS6562.1 [Q99720-1]
CCDS6563.1 [Q99720-3]
PIRiJC5266
RefSeqiNP_001269134.1, NM_001282205.1
NP_001269135.1, NM_001282206.1
NP_001269136.1, NM_001282207.1 [Q99720-2]
NP_001269137.1, NM_001282208.1
NP_001269138.1, NM_001282209.1
NP_005857.1, NM_005866.3 [Q99720-1]
NP_671513.1, NM_147157.2 [Q99720-3]
UniGeneiHs.522087

Genome annotation databases

EnsembliENST00000277010; ENSP00000277010; ENSG00000147955 [Q99720-1]
ENST00000353468; ENSP00000434453; ENSG00000147955 [Q99720-4]
ENST00000477726; ENSP00000420022; ENSG00000147955 [Q99720-3]
GeneIDi10280
KEGGihsa:10280
UCSCiuc003zvb.5 human [Q99720-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Sigma-1 receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75283 mRNA Translation: AAB50402.1
U79528 mRNA Translation: AAB51238.1
AF001977, AF001976 Genomic DNA Translation: AAC04507.1
AF226604 mRNA Translation: AAF64280.1
AY633611 mRNA Translation: AAV33304.1
DQ644568 mRNA Translation: ABG29111.1
DQ647702 mRNA Translation: ABG36559.1
DQ656583 mRNA Translation: ABG46369.1
AK098451 mRNA Translation: BAC05307.1
CR457075 mRNA Translation: CAG33356.1
AK222899 mRNA Translation: BAD96619.1
AL450283 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58431.1
CH471071 Genomic DNA Translation: EAW58434.1
BC004899 mRNA Translation: AAH04899.1
BC007839 mRNA Translation: AAH07839.1
CCDSiCCDS6562.1 [Q99720-1]
CCDS6563.1 [Q99720-3]
PIRiJC5266
RefSeqiNP_001269134.1, NM_001282205.1
NP_001269135.1, NM_001282206.1
NP_001269136.1, NM_001282207.1 [Q99720-2]
NP_001269137.1, NM_001282208.1
NP_001269138.1, NM_001282209.1
NP_005857.1, NM_005866.3 [Q99720-1]
NP_671513.1, NM_147157.2 [Q99720-3]
UniGeneiHs.522087

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HK1X-ray2.51A/B/C1-223[»]
5HK2X-ray3.20A/B/C1-223[»]
ProteinModelPortaliQ99720
SMRiQ99720
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115569, 15 interactors
CORUMiQ99720
DIPiDIP-61974N
ELMiQ99720
IntActiQ99720, 5 interactors
STRINGi9606.ENSP00000277010

Chemistry databases

BindingDBiQ99720
ChEMBLiCHEMBL287
DrugBankiDB00321 Amitriptyline
DB09014 Captodiame
DB00514 Dextromethorphan
DB01488 Dimethyltryptamine
DB00540 Nortriptyline
DB00652 Pentazocine
DB03575 Phencyclidine
DB01708 Prasterone
DB00409 Remoxipride
GuidetoPHARMACOLOGYi2552

Protein family/group databases

TCDBi8.A.63.1.1 the sigma non-opioid intracellular recpetor, (s1r) family

PTM databases

iPTMnetiQ99720
PhosphoSitePlusiQ99720

Polymorphism and mutation databases

DMDMi74752153

Proteomic databases

EPDiQ99720
MaxQBiQ99720
PaxDbiQ99720
PeptideAtlasiQ99720
PRIDEiQ99720
ProteomicsDBi78435
78436 [Q99720-2]
78437 [Q99720-3]
78438 [Q99720-4]
78439 [Q99720-5]
TopDownProteomicsiQ99720-1 [Q99720-1]
Q99720-2 [Q99720-2]
Q99720-3 [Q99720-3]
Q99720-4 [Q99720-4]
Q99720-5 [Q99720-5]

Protocols and materials databases

DNASUi10280
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277010; ENSP00000277010; ENSG00000147955 [Q99720-1]
ENST00000353468; ENSP00000434453; ENSG00000147955 [Q99720-4]
ENST00000477726; ENSP00000420022; ENSG00000147955 [Q99720-3]
GeneIDi10280
KEGGihsa:10280
UCSCiuc003zvb.5 human [Q99720-1]

Organism-specific databases

CTDi10280
DisGeNETi10280
EuPathDBiHostDB:ENSG00000147955.16
GeneCardsiSIGMAR1
H-InvDBiHIX0008000
HIX0169361
HGNCiHGNC:8157 SIGMAR1
HPAiCAB013470
HPA018002
HPA024071
MalaCardsiSIGMAR1
MIMi601978 gene
605726 phenotype
614373 phenotype
neXtProtiNX_Q99720
OpenTargetsiENSG00000147955
Orphaneti300605 Juvenile amyotrophic lateral sclerosis
PharmGKBiPA164725706
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4143 Eukaryota
ENOG410XP0Z LUCA
GeneTreeiENSGT00390000012082
HOVERGENiHBG058220
InParanoidiQ99720
KOiK20719
OMAiWKEGTTK
OrthoDBiEOG091G0KD7
PhylomeDBiQ99720
TreeFamiTF300106

Enzyme and pathway databases

SIGNORiQ99720

Miscellaneous databases

ChiTaRSiSIGMAR1 human
GeneWikiiSigma-1_receptor
GenomeRNAii10280
PROiPR:Q99720
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147955 Expressed in 223 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ99720 baseline and differential
GenevisibleiQ99720 HS

Family and domain databases

InterProiView protein in InterPro
IPR006716 ERG2_sigma1_rcpt-like
PANTHERiPTHR10868 PTHR10868, 1 hit
PfamiView protein in Pfam
PF04622 ERG2_Sigma1R, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGMR1_HUMAN
AccessioniPrimary (citable) accession number: Q99720
Secondary accession number(s): D3DRM7
, O00673, O00725, Q0Z9W6, Q153Z1, Q2TSD1, Q53GN2, Q7Z653, Q8N7H3, Q9NYX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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