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Protein

Septin-5

Gene

SEPT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Miscellaneous

In a heterologous system, SEPT5 overexpression has been shown to exert dopamine-dependent neurotoxicity. As wild-type PRKN, but not familial-linked PRKN mutants, ubiquitinates mouse SEPT5 and promotes its degradation, it has been suggested that a deficiency in SEPT5 degradation may contribute to the development of early onset Parkinson disease 2 (PARK2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85GTPBy similarity1
Binding sitei111GTP; via amide nitrogenBy similarity1
Binding sitei248GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei263GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi190 – 198GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex scaffold activity Source: GO_Central
  • structural molecule activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:SEPT5
Synonyms:PNUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184702.17
HGNCiHGNC:9164 SEPT5
MIMi602724 gene
neXtProtiNX_Q99719

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi5413
OpenTargetsiENSG00000184702
PharmGKBiPA33486

Polymorphism and mutation databases

BioMutaiSEPT5
DMDMi6685760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735211 – 369Septin-5Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineBy similarity1
Modified residuei168Omega-N-methylarginineBy similarity1
Modified residuei225PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei336PhosphothreonineBy similarity1

Post-translational modificationi

In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ99719
PaxDbiQ99719
PeptideAtlasiQ99719
PRIDEiQ99719
ProteomicsDBi78433
78434 [Q99719-2]

2D gel databases

UCD-2DPAGEiQ99719

PTM databases

iPTMnetiQ99719
PhosphoSitePlusiQ99719
SwissPalmiQ99719

Expressioni

Tissue specificityi

Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000184702 Expressed in 182 organ(s), highest expression level in right frontal lobe
CleanExiHS_SEPT5
ExpressionAtlasiQ99719 baseline and differential
GenevisibleiQ99719 HS

Organism-specific databases

HPAiCAB016120
HPA029095
HPA063885

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PRKN. This interaction leads to SEPT5 ubiquitination and degradation (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111414, 26 interactors
DIPiDIP-31201N
IntActiQ99719, 19 interactors
MINTiQ99719
STRINGi9606.ENSP00000391311

Structurei

3D structure databases

ProteinModelPortaliQ99719
SMRiQ99719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 314Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni108 – 111G3 motifPROSITE-ProRule annotation4
Regioni189 – 192G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 369Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ99719
KOiK04557
PhylomeDBiQ99719
TreeFamiTF101079

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030647 SEPT5
IPR016491 Septin
PANTHERiPTHR18884:SF68 PTHR18884:SF68, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99719-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RISQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNTE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKERIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE
360
ELRRMQEMLQ RMKQQMQDQ
Length:369
Mass (Da):42,777
Last modified:May 1, 1997 - v1
Checksum:i47054765DEA10D33
GO
Isoform 2 (identifier: Q99719-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSTGLRYKSKLATPEDKQ → MDSLAAPQDRLVEQLLSPRTQAQRRLK
     272-369: VENQAHCDFV...QRMKQQMQDQ → GALRLREAAQ...PAAAHPGRRD

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):39,332
Checksum:i380EACD6A7BFE814
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAH0G3XAH0_HUMAN
HCG2002594, isoform CRA_c
SEPT5 hCG_2002594
378Annotation score:
B4DJ62B4DJ62_HUMAN
HCG2002594, isoform CRA_a
hCG_2002594
322Annotation score:
E7EQM7E7EQM7_HUMAN
Septin-5
SEPT5
248Annotation score:
C9JM82C9JM82_HUMAN
Septin-5
SEPT5
301Annotation score:
E7EPG2E7EPG2_HUMAN
Septin-5
SEPT5
304Annotation score:
E7EX32E7EX32_HUMAN
Septin-5
SEPT5
337Annotation score:
F8W9E5F8W9E5_HUMAN
Septin-5
SEPT5
180Annotation score:
H7C299H7C299_HUMAN
Septin-5
SEPT5
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224D → N in CAA72332 (PubMed:9385360).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426891 – 18MSTGL…PEDKQ → MDSLAAPQDRLVEQLLSPRT QAQRRLK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042690272 – 369VENQA…QMQDQ → GALRLREAAQHAHPHAYARP QGRDVRRALRELPRALHPAD DQQTDPGQPHGEPHPDPAAA HPGRRD in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74628 mRNA Translation: AAB93438.1
Y11593 mRNA Translation: CAA72332.1
AF006988 Genomic DNA Translation: AAC39779.1
CR456545 mRNA Translation: CAG30431.1
AK056273 mRNA Translation: BAB71133.1
AC000093 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03032.1
BC025261 mRNA Translation: AAH25261.1
CCDSiCCDS13764.1 [Q99719-1]
CCDS56224.1 [Q99719-2]
RefSeqiNP_001009939.1, NM_001009939.2 [Q99719-2]
NP_002679.2, NM_002688.5 [Q99719-1]
UniGeneiHs.728762

Genome annotation databases

EnsembliENST00000438754; ENSP00000394541; ENSG00000184702 [Q99719-2]
ENST00000455784; ENSP00000391311; ENSG00000184702 [Q99719-1]
GeneIDi5413
KEGGihsa:5413
UCSCiuc002zpw.2 human [Q99719-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74628 mRNA Translation: AAB93438.1
Y11593 mRNA Translation: CAA72332.1
AF006988 Genomic DNA Translation: AAC39779.1
CR456545 mRNA Translation: CAG30431.1
AK056273 mRNA Translation: BAB71133.1
AC000093 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03032.1
BC025261 mRNA Translation: AAH25261.1
CCDSiCCDS13764.1 [Q99719-1]
CCDS56224.1 [Q99719-2]
RefSeqiNP_001009939.1, NM_001009939.2 [Q99719-2]
NP_002679.2, NM_002688.5 [Q99719-1]
UniGeneiHs.728762

3D structure databases

ProteinModelPortaliQ99719
SMRiQ99719
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111414, 26 interactors
DIPiDIP-31201N
IntActiQ99719, 19 interactors
MINTiQ99719
STRINGi9606.ENSP00000391311

PTM databases

iPTMnetiQ99719
PhosphoSitePlusiQ99719
SwissPalmiQ99719

Polymorphism and mutation databases

BioMutaiSEPT5
DMDMi6685760

2D gel databases

UCD-2DPAGEiQ99719

Proteomic databases

EPDiQ99719
PaxDbiQ99719
PeptideAtlasiQ99719
PRIDEiQ99719
ProteomicsDBi78433
78434 [Q99719-2]

Protocols and materials databases

DNASUi5413
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438754; ENSP00000394541; ENSG00000184702 [Q99719-2]
ENST00000455784; ENSP00000391311; ENSG00000184702 [Q99719-1]
GeneIDi5413
KEGGihsa:5413
UCSCiuc002zpw.2 human [Q99719-1]

Organism-specific databases

CTDi5413
DisGeNETi5413
EuPathDBiHostDB:ENSG00000184702.17
GeneCardsiSEPT5
H-InvDBiHIX0016241
HGNCiHGNC:9164 SEPT5
HPAiCAB016120
HPA029095
HPA063885
MIMi602724 gene
neXtProtiNX_Q99719
OpenTargetsiENSG00000184702
PharmGKBiPA33486
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ99719
KOiK04557
PhylomeDBiQ99719
TreeFamiTF101079

Miscellaneous databases

ChiTaRSiSEPT5 human
GeneWikiiSEPT5
GenomeRNAii5413
PROiPR:Q99719
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184702 Expressed in 182 organ(s), highest expression level in right frontal lobe
CleanExiHS_SEPT5
ExpressionAtlasiQ99719 baseline and differential
GenevisibleiQ99719 HS

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030647 SEPT5
IPR016491 Septin
PANTHERiPTHR18884:SF68 PTHR18884:SF68, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT5_HUMAN
AccessioniPrimary (citable) accession number: Q99719
Secondary accession number(s): O15251, Q96MY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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