UniProtKB - Q99717 (SMAD5_HUMAN)

BLAST

>sp|Q99717|SMAD5_HUMAN Mothers against decapentaplegic homolog 5 OS=Homo sapiens OX=9606 GN=SMAD5 PE=1 SV=1
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP
MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS

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History
Entry version 193 (07 Nov 2018)
Sequence version 1 (01 May 1997)
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Protein

Mothers against decapentaplegic homolog 5

Gene

SMAD5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	65	ZincBy similarity	1
Metal bindingⁱ	110	ZincBy similarity	1
Metal bindingⁱ	122	ZincBy similarity	1
Metal bindingⁱ	127	ZincBy similarity	1

GO - Molecular functionⁱ

DEAD/H-box RNA helicase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18548003
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Source: BHF-UCL
Traceable author statementⁱ
- 19018011
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11278251

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway Source: UniProtKB
bone development Source: Ensembl
cardiac muscle contraction Source: Ensembl
cartilage development Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
embryonic pattern specification Source: UniProtKB
erythrocyte differentiation Source: Ensembl
germ cell development Source: Ensembl
Mullerian duct regression Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
osteoblast fate commitment Source: Ensembl
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10708949
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
protein phosphorylation Source: Ensembl
signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 9759503
SMAD protein signal transduction Source: BHF-UCL
transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 10708948
ureteric bud development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201451 Signaling by BMP
SignaLinkⁱ	Q99717
SIGNORⁱ	Q99717

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homolog 5 Short name: MAD homolog 5 Short name: Mothers against DPP homolog 5 Alternative name(s): JV5-1 SMAD family member 5 Short name: SMAD 5 Short name: Smad5 Short name: hSmad5
Gene namesⁱ	Name:SMAD5 Synonyms:MADH5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113658.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6771 SMAD5
MIMⁱ	603110 gene
neXtProtⁱ	NX_Q99717

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	419	G → S: Loss of phosphorylation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4090
Open Targets More...OpenTargetsⁱ	ENSG00000113658
PharmGKBⁱ	PA30528

Polymorphism and mutation databases

BioMutaⁱ	SMAD5
DMDMⁱ	13959566

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000090865	2 – 465	Mothers against decapentaplegic homolog 5Add BLAST		464

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineCombined sources1 Publication	1
Modified residueⁱ	463	PhosphoserineCombined sources	1
Modified residueⁱ	465	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q99717
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99717
PaxDbⁱ	Q99717
PeptideAtlas More...PeptideAtlasⁱ	Q99717
PRIDEⁱ	Q99717
ProteomicsDBⁱ	78432

PTM databases

iPTMnetⁱ	Q99717
PhosphoSitePlusⁱ	Q99717

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000113658 Expressed in 231 organ(s), highest expression level in female gonad
CleanExⁱ	HS_SMAD5
ExpressionAtlasⁱ	Q99717 baseline and differential
Genevisibleⁱ	Q99717 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058931

HPAⁱ

HPA058931

Interactionⁱ

Subunit structureⁱ

May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (PubMed:25755279).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DDX5	P17844	3	EBI-6391136,EBI-351962

With

Entry

#Exp.

IntAct

Notes

DDX5

P17844

EBI-6391136,EBI-351962

GO - Molecular functionⁱ

DEAD/H-box RNA helicase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18548003
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11278251

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110265, 62 interactors
Database of interacting proteins More...DIPⁱ	DIP-57571N
IntActⁱ	Q99717, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q99717
STRINGⁱ	9606.ENSP00000441954

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99717
SMRⁱ	Q99717
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 137	MH1PROSITE-ProRule annotationAdd BLAST		125
Domainⁱ	271 – 465	MH2PROSITE-ProRule annotationAdd BLAST		195

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	40 – 46	Poly-Lys		7

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119091
HOVERGENⁱ	HBG053353
InParanoidⁱ	Q99717
KEGG Orthology (KO) More...KOⁱ	K16790
OMAⁱ	DVQPVEY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082C
PhylomeDBⁱ	Q99717

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q99717-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME 
        60         70         80         90        100
ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS 
       110        120        130        140        150
HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ 
       160        170        180        190        200
HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS 
       210        220        230        240        250
TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ 
       260        270        280        290        300
IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
       310        320        330        340        350
DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD 
       360        370        380        390        400
SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF 
       410        420        430        440        450
EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV 
       460 
LTQMGSPLNP ISSVS

Length:465

Mass (Da):52,258

Last modified:May 1, 1997 - v1

Checksum:ⁱ4A1FD7EC7BD06728

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBB4	D6RBB4_HUMAN	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog 5	SMAD5	134	Annotation score:
D6RIZ9	D6RIZ9_HUMAN	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog 5	SMAD5	128	Annotation score:
D6R9D4	D6R9D4_HUMAN	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog 5	SMAD5	80	Annotation score:
H0YAK7	H0YAK7_HUMAN	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog 5	SMAD5	174	Annotation score:
H0YAM3	H0YAM3_HUMAN	Mothers against decapentaplegic hom... Mothers against decapentaplegic homolog 5	SMAD5	60	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	175	D → H in AAC50791 (PubMed:8673135).Curated	1
Sequence conflictⁱ	237	N → P in AAC50791 (PubMed:8673135).Curated	1
Sequence conflictⁱ	293	S → R in AAC50791 (PubMed:8673135).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59913 mRNA Translation: AAC50791.1 AF010601 mRNA Translation: AAB66353.1 AF010607 AF010606 Genomic DNA Translation: AAB92396.1 U73825 mRNA Translation: AAB95090.1 AF009744 AF009743 Genomic DNA Translation: AAB82655.1 AF009678 mRNA Translation: AAB72180.1 BC009682 mRNA Translation: AAH09682.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS75308.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001001419.1, NM_001001419.2 NP_001001420.1, NM_001001420.2 NP_005894.3, NM_005903.6 XP_016864959.1, XM_017009470.1
UniGeneⁱ	Hs.167700

Genome annotation databases

Ensemblⁱ	ENST00000509297; ENSP00000426696; ENSG00000113658 ENST00000545279; ENSP00000441954; ENSG00000113658 ENST00000545620; ENSP00000446474; ENSG00000113658
GeneIDⁱ	4090
KEGGⁱ	hsa:4090
UCSC genome browser More...UCSCⁱ	uc032vlw.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99717	Mothers against decapentaplegic homolog 5		PONAB		465	UniRef100_Q99717
Mothers against decapentaplegic homolog (Fragment)		wild yak		468
Mothers against decapentaplegic homolog		HUMAN		465
Mothers against decapentaplegic homolog		PANTR		465
Mothers against decapentaplegic homolog		CALJA		465
+37

Protein	Similar proteins		Species	Score	Length	Source
Q99717	Mothers against decapentaplegic homolog 5		PONAB		465	UniRef90_Q99717
Mothers against decapentaplegic homolog 5		CHICK		465
Mothers against decapentaplegic homolog (Fragment)		wild yak		468
Mothers against decapentaplegic homolog		HUMAN		465
Mothers against decapentaplegic homolog		PANTR		465
+82

Protein	Similar proteins		Species	Score	Length	Source
Q99717	Mothers against decapentaplegic homolog 1	)	HUMAN		465	UniRef50_Q15797
Mothers against decapentaplegic homolog 1		DANRE		472
Mothers against decapentaplegic homolog 1		BOVIN		465
Mothers against decapentaplegic homolog 1	)	MOUSE		465
Mothers against decapentaplegic homolog 5		PONAB		465
+896

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59913 mRNA Translation: AAC50791.1 AF010601 mRNA Translation: AAB66353.1 AF010607 AF010606 Genomic DNA Translation: AAB92396.1 U73825 mRNA Translation: AAB95090.1 AF009744 AF009743 Genomic DNA Translation: AAB82655.1 AF009678 mRNA Translation: AAB72180.1 BC009682 mRNA Translation: AAH09682.1
CCDSⁱ	CCDS75308.1
RefSeqⁱ	NP_001001419.1, NM_001001419.2 NP_001001420.1, NM_001001420.2 NP_005894.3, NM_005903.6 XP_016864959.1, XM_017009470.1
UniGeneⁱ	Hs.167700

3D structure databases

ProteinModelPortalⁱ	Q99717
SMRⁱ	Q99717
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110265, 62 interactors
DIPⁱ	DIP-57571N
IntActⁱ	Q99717, 33 interactors
MINTⁱ	Q99717
STRINGⁱ	9606.ENSP00000441954

PTM databases

iPTMnetⁱ	Q99717
PhosphoSitePlusⁱ	Q99717

Polymorphism and mutation databases

BioMutaⁱ	SMAD5
DMDMⁱ	13959566

Proteomic databases

EPDⁱ	Q99717
MaxQBⁱ	Q99717
PaxDbⁱ	Q99717
PeptideAtlasⁱ	Q99717
PRIDEⁱ	Q99717
ProteomicsDBⁱ	78432

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4090
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000509297; ENSP00000426696; ENSG00000113658 ENST00000545279; ENSP00000441954; ENSG00000113658 ENST00000545620; ENSP00000446474; ENSG00000113658
GeneIDⁱ	4090
KEGGⁱ	hsa:4090
UCSCⁱ	uc032vlw.2 human

Organism-specific databases

CTDⁱ	4090
DisGeNETⁱ	4090
EuPathDBⁱ	HostDB:ENSG00000113658.16
GeneCardsⁱ	SMAD5
HGNCⁱ	HGNC:6771 SMAD5
HPAⁱ	HPA058931
MIMⁱ	603110 gene
neXtProtⁱ	NX_Q99717
OpenTargetsⁱ	ENSG00000113658
PharmGKBⁱ	PA30528
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3701 Eukaryota ENOG410XQKU LUCA
GeneTreeⁱ	ENSGT00760000119091
HOVERGENⁱ	HBG053353
InParanoidⁱ	Q99717
KOⁱ	K16790
OMAⁱ	DVQPVEY
OrthoDBⁱ	EOG091G082C
PhylomeDBⁱ	Q99717

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201451 Signaling by BMP
SignaLinkⁱ	Q99717
SIGNORⁱ	Q99717

Miscellaneous databases

ChiTaRSⁱ	SMAD5 human
GeneWikiⁱ	Mothers_against_decapentaplegic_homolog_5
GenomeRNAiⁱ	4090
Protein Ontology More...PROⁱ	PR:Q99717
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113658 Expressed in 231 organ(s), highest expression level in female gonad
CleanExⁱ	HS_SMAD5
ExpressionAtlasⁱ	Q99717 baseline and differential
Genevisibleⁱ	Q99717 HS

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790 Dwarfin IPR003619 MAD_homology1_Dwarfin-type IPR013019 MAD_homology_MH1 IPR017855 SMAD-like_dom_sf IPR001132 SMAD_dom_Dwarfin-type IPR008984 SMAD_FHA_dom_sf IPR036578 SMAD_MH1_sf
PANTHERⁱ	PTHR13703 PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165 MH1, 1 hit PF03166 MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit SM00524 DWB, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF56366 SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075 MH1, 1 hit PS51076 MH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMAD5_HUMAN
Accessionⁱ	Q99717Primary (citable) accession number: Q99717 Secondary accession number(s): O14688, Q15798, Q9UQA1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99717 (SMAD5_HUMAN)

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Mothers against decapentaplegic homolog 5

SMAD5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ