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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • potassium ion import Source: GO_Central
  • potassium ion transport Source: ProtInc
  • regulation of ion transmembrane transport Source: UniProtKB-KW

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:KCNJ15
Synonyms:KCNJ14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000157551.17
HGNCiHGNC:6261 KCNJ15
MIMi602106 gene
neXtProtiNX_Q99712

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicBy similarityAdd BLAST63
Transmembranei64 – 88Helical; Name=M1By similarityAdd BLAST25
Topological domaini89 – 113ExtracellularBy similarityAdd BLAST25
Intramembranei114 – 125Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei126 – 132Pore-formingBy similarity7
Topological domaini133 – 141ExtracellularBy similarity9
Transmembranei142 – 163Helical; Name=M2By similarityAdd BLAST22
Topological domaini164 – 375CytoplasmicBy similarityAdd BLAST212

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3772
OpenTargetsiENSG00000157551
PharmGKBiPA30046

Chemistry databases

DrugBankiDB01392 Yohimbine

Polymorphism and mutation databases

DMDMi77416869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549721 – 375ATP-sensitive inward rectifier potassium channel 15Add BLAST375

Proteomic databases

PaxDbiQ99712
PeptideAtlasiQ99712
PRIDEiQ99712
ProteomicsDBi78426

PTM databases

PhosphoSitePlusiQ99712

Expressioni

Gene expression databases

BgeeiENSG00000157551 Expressed in 169 organ(s), highest expression level in nephron tubule
CleanExiHS_KCNJ14
HS_KCNJ15
ExpressionAtlasiQ99712 baseline and differential
GenevisibleiQ99712 HS

Organism-specific databases

HPAiHPA016702

Interactioni

Subunit structurei

Interacts with PATJ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PatjQ63ZW74EBI-7082607,EBI-8366894From Mus musculus.

Protein-protein interaction databases

BioGridi109974, 1 interactor
IntActiQ99712, 3 interactors
MINTiQ99712
STRINGi9606.ENSP00000331698

Structurei

3D structure databases

ProteinModelPortaliQ99712
SMRiQ99712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiQ99712
KOiK05008
OMAiECPLAIF
OrthoDBiEOG091G08HC
PhylomeDBiQ99712
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003270 K_chnl_inward-rec_Kir1.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF20 PTHR11767:SF20, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01323 KIR13CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q99712-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP
110 120 130 140 150
ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ
360 370
LEEKYRQEDQ RERELRTLLL QQSNV
Length:375
Mass (Da):42,577
Last modified:October 11, 2005 - v2
Checksum:iCECCB4EDF827B24D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPG3E7EPG3_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
245Annotation score:
A8MVK1A8MVK1_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
156Annotation score:
E7EWV2E7EWV2_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
139Annotation score:
A8MTZ5A8MTZ5_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
61Annotation score:
C9JTX1C9JTX1_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
39Annotation score:
F8VX74F8VX74_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
48Annotation score:
F8VW46F8VW46_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
25Annotation score:
C9J0W5C9J0W5_HUMAN
ATP-sensitive inward rectifier pota...
KCNJ15
19Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235V → A in CAA71734 (PubMed:9299242).Curated1
Sequence conflicti245S → G in BAA13326 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02552330M → L. Corresponds to variant dbSNP:rs3746875Ensembl.1
Natural variantiVAR_03642771A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs199857043Ensembl.1
Natural variantiVAR_01972898G → D2 PublicationsCorresponds to variant dbSNP:rs2230033Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA Translation: CAA71734.1
U73191 mRNA Translation: AAC50922.1
D87291 mRNA Translation: BAA13326.1
AP001434 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09683.1
CH471079 Genomic DNA Translation: EAX09684.1
BC013327 mRNA Translation: AAH13327.1
CCDSiCCDS13656.1
RefSeqiNP_001263364.1, NM_001276435.1
NP_001263365.1, NM_001276436.1
NP_001263366.1, NM_001276437.1
NP_001263367.1, NM_001276438.1
NP_001263368.1, NM_001276439.1
NP_002234.2, NM_002243.4
NP_733932.1, NM_170736.2
NP_733933.1, NM_170737.2
XP_005261032.1, XM_005260975.2
XP_006724065.1, XM_006724002.2
XP_011527862.1, XM_011529560.2
XP_011527863.1, XM_011529561.2
XP_016883832.1, XM_017028343.1
XP_016883833.1, XM_017028344.1
XP_016883834.1, XM_017028345.1
UniGeneiHs.411299

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551
ENST00000398930; ENSP00000381904; ENSG00000157551
ENST00000398932; ENSP00000381905; ENSG00000157551
ENST00000398934; ENSP00000381907; ENSG00000157551
ENST00000398938; ENSP00000381911; ENSG00000157551
ENST00000612702; ENSP00000484960; ENSG00000157551
ENST00000613499; ENSP00000479100; ENSG00000157551
GeneIDi3772
KEGGihsa:3772
UCSCiuc002ywv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10745 mRNA Translation: CAA71734.1
U73191 mRNA Translation: AAC50922.1
D87291 mRNA Translation: BAA13326.1
AP001434 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09683.1
CH471079 Genomic DNA Translation: EAX09684.1
BC013327 mRNA Translation: AAH13327.1
CCDSiCCDS13656.1
RefSeqiNP_001263364.1, NM_001276435.1
NP_001263365.1, NM_001276436.1
NP_001263366.1, NM_001276437.1
NP_001263367.1, NM_001276438.1
NP_001263368.1, NM_001276439.1
NP_002234.2, NM_002243.4
NP_733932.1, NM_170736.2
NP_733933.1, NM_170737.2
XP_005261032.1, XM_005260975.2
XP_006724065.1, XM_006724002.2
XP_011527862.1, XM_011529560.2
XP_011527863.1, XM_011529561.2
XP_016883832.1, XM_017028343.1
XP_016883833.1, XM_017028344.1
XP_016883834.1, XM_017028345.1
UniGeneiHs.411299

3D structure databases

ProteinModelPortaliQ99712
SMRiQ99712
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109974, 1 interactor
IntActiQ99712, 3 interactors
MINTiQ99712
STRINGi9606.ENSP00000331698

Chemistry databases

DrugBankiDB01392 Yohimbine

PTM databases

PhosphoSitePlusiQ99712

Polymorphism and mutation databases

DMDMi77416869

Proteomic databases

PaxDbiQ99712
PeptideAtlasiQ99712
PRIDEiQ99712
ProteomicsDBi78426

Protocols and materials databases

DNASUi3772
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328656; ENSP00000331698; ENSG00000157551
ENST00000398930; ENSP00000381904; ENSG00000157551
ENST00000398932; ENSP00000381905; ENSG00000157551
ENST00000398934; ENSP00000381907; ENSG00000157551
ENST00000398938; ENSP00000381911; ENSG00000157551
ENST00000612702; ENSP00000484960; ENSG00000157551
ENST00000613499; ENSP00000479100; ENSG00000157551
GeneIDi3772
KEGGihsa:3772
UCSCiuc002ywv.5 human

Organism-specific databases

CTDi3772
DisGeNETi3772
EuPathDBiHostDB:ENSG00000157551.17
GeneCardsiKCNJ15
HGNCiHGNC:6261 KCNJ15
HPAiHPA016702
MIMi602106 gene
neXtProtiNX_Q99712
OpenTargetsiENSG00000157551
PharmGKBiPA30046
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiQ99712
KOiK05008
OMAiECPLAIF
OrthoDBiEOG091G08HC
PhylomeDBiQ99712
TreeFamiTF313676

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRSiKCNJ15 human
GeneWikiiKCNJ15
GenomeRNAii3772
PROiPR:Q99712
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157551 Expressed in 169 organ(s), highest expression level in nephron tubule
CleanExiHS_KCNJ14
HS_KCNJ15
ExpressionAtlasiQ99712 baseline and differential
GenevisibleiQ99712 HS

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003270 K_chnl_inward-rec_Kir1.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF20 PTHR11767:SF20, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01323 KIR13CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ15_HUMAN
AccessioniPrimary (citable) accession number: Q99712
Secondary accession number(s): D3DSH5
, O00564, Q96L28, Q99446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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