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Protein

Methionine synthase

Gene

MTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).By similarity

Miscellaneous

L-homocysteine is bound via the zinc atom.By similarity

Catalytic activityi

5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetH route).
Proteins known to be involved in this subpathway in this organism are:
  1. Methionine synthase (MTR), Methionine synthase, Methionine synthase (MTR), Methionine synthase (metH)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetH route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi260ZincPROSITE-ProRule annotation1
Metal bindingi323ZincPROSITE-ProRule annotation1
Metal bindingi324ZincPROSITE-ProRule annotation1
Binding sitei449SubstrateCombined sources1 Publication1
Binding sitei470SubstrateCombined sources1 Publication1
Binding sitei537SubstrateCombined sources1 Publication1
Binding sitei579SubstrateCombined sources1 Publication1
Binding sitei585SubstrateCombined sources1 Publication1
Binding sitei591SubstrateCombined sources1 Publication1
Metal bindingi785Cobalt (cobalamin axial ligand)By similarity1
Binding sitei830CobalaminBy similarity1
Binding sitei974S-adenosyl-L-methionineBy similarity1
Binding sitei1172S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei1176Cobalamin; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • cobalamin binding Source: UniProtKB-KW
  • methionine synthase activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

  • axon regeneration Source: BHF-UCL
  • cellular response to nitric oxide Source: BHF-UCL
  • cobalamin metabolic process Source: BHF-UCL
  • methionine biosynthetic process Source: BHF-UCL
  • nervous system development Source: ProtInc
  • pteridine-containing compound metabolic process Source: InterPro
  • response to axon injury Source: BHF-UCL

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandCobalamin, Cobalt, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS04076-MONOMER
ReactomeiR-HSA-156581 Methylation
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
R-HSA-3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
SIGNORiQ99707
UniPathwayi
UPA00051;UER00081

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine synthase (EC:2.1.1.13)
Alternative name(s):
5-methyltetrahydrofolate--homocysteine methyltransferase
Vitamin-B12 dependent methionine synthase
Short name:
MS
Gene namesi
Name:MTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116984.12
HGNCiHGNC:7468 MTR
MIMi156570 gene
neXtProtiNX_Q99707

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Homocystinuria-megaloblastic anemia, cblG complementation type (HMAG)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive inborn error of metabolism resulting from defects in the cobalamin-dependent pathway that converts homocysteine to methionine. It causes delayed psychomotor development, megaloblastic anemia, homocystinuria, and hypomethioninemia.
See also OMIM:250940
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004328881Missing in HMAG. 2 Publications1
Natural variantiVAR_004330920H → D in HMAG. 1 PublicationCorresponds to variant dbSNP:rs121913579EnsemblClinVar.1
Natural variantiVAR_0043311173P → L in HMAG. 1 PublicationCorresponds to variant dbSNP:rs121913578EnsemblClinVar.1
Neural tube defects, folate-sensitive (NTDFS)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe most common NTDs are open spina bifida (myelomeningocele) and anencephaly.
See also OMIM:601634

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi963D → E: Decreases binding to MTRR; when associated with N-1071. 1 Publication1
Mutagenesisi1071K → N: Decreases binding to MTRR; when associated with E-963. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4548
GeneReviewsiMTR
MalaCardsiMTR
MIMi250940 phenotype
601634 phenotype
603174 phenotype
OpenTargetsiENSG00000116984
Orphaneti2170 Methylcobalamin deficiency type cblG
PharmGKBiPA31272

Chemistry databases

ChEMBLiCHEMBL2150844
DrugBankiDB00115 Cyanocobalamin
DB00200 Hydroxocobalamin
DB00134 L-Methionine
DB00116 Tetrahydrofolic acid

Polymorphism and mutation databases

BioMutaiMTR
DMDMi2842762

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045301 – 1265Methionine synthaseAdd BLAST1265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1264PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99707
MaxQBiQ99707
PaxDbiQ99707
PeptideAtlasiQ99707
PRIDEiQ99707
ProteomicsDBi78423

PTM databases

iPTMnetiQ99707
PhosphoSitePlusiQ99707

Expressioni

Tissue specificityi

Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.

Gene expression databases

BgeeiENSG00000116984 Expressed in 237 organ(s), highest expression level in metanephros
CleanExiHS_MTR
ExpressionAtlasiQ99707 baseline and differential
GenevisibleiQ99707 HS

Organism-specific databases

HPAiHPA044474
HPA054915

Interactioni

Subunit structurei

Monomer (PubMed:17288554). Dimer (PubMed:17288554). Mainly monomer. Interacts with MTRR (PubMed:17288554).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MMACHCQ9Y4U13EBI-1045782,EBI-9775184

Protein-protein interaction databases

BioGridi110642, 31 interactors
DIPiDIP-40306N
IntActiQ99707, 10 interactors
STRINGi9606.ENSP00000355536

Chemistry databases

BindingDBiQ99707

Structurei

Secondary structure

11265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99707
SMRiQ99707
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99707

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 338Hcy-bindingPROSITE-ProRule annotationAdd BLAST320
Domaini371 – 632Pterin-bindingPROSITE-ProRule annotationAdd BLAST262
Domaini662 – 759B12-binding N-terminalPROSITE-ProRule annotationAdd BLAST98
Domaini772 – 907B12-bindingPROSITE-ProRule annotationAdd BLAST136
Domaini923 – 1265AdoMet activationPROSITE-ProRule annotationAdd BLAST343

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni382 – 384Substrate bindingCombined sources3
Regioni860 – 861Cobalamin-bindingBy similarity2
Regioni1227 – 1228S-adenosyl-L-methionine bindingBy similarity2

Domaini

Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1579 Eukaryota
COG0646 LUCA
COG1410 LUCA
GeneTreeiENSGT00420000029824
HOGENOMiHOG000251409
HOVERGENiHBG006347
InParanoidiQ99707
KOiK00548
OMAiKYPRPLN
OrthoDBiEOG091G00WU
PhylomeDBiQ99707
TreeFamiTF312829

Family and domain databases

CDDicd02069 methionine_synthase_B12_BD, 1 hit
Gene3Di1.10.1240.10, 1 hit
3.10.196.10, 3 hits
3.20.20.20, 1 hit
3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR003759 Cbl-bd_cap
IPR006158 Cobalamin-bd
IPR036724 Cobalamin-bd_sf
IPR011005 Dihydropteroate_synth-like
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
IPR033706 Met_synthase_B12-bd
IPR011822 MetH
IPR036594 Meth_synthase_dom
IPR000489 Pterin-binding_dom
IPR004223 VitB12-dep_Met_synth_activ_dom
IPR037010 VitB12-dep_Met_synth_activ_sf
PfamiView protein in Pfam
PF02310 B12-binding, 1 hit
PF02607 B12-binding_2, 1 hit
PF02965 Met_synt_B12, 1 hit
PF00809 Pterin_bind, 1 hit
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF000381 MetH, 1 hit
SMARTiView protein in SMART
SM01018 B12-binding_2, 1 hit
SUPFAMiSSF47644 SSF47644, 1 hit
SSF51717 SSF51717, 1 hit
SSF52242 SSF52242, 1 hit
SSF56507 SSF56507, 1 hit
SSF82282 SSF82282, 1 hit
TIGRFAMsiTIGR02082 metH, 1 hit
PROSITEiView protein in PROSITE
PS50974 ADOMET_ACTIVATION, 1 hit
PS51332 B12_BINDING, 1 hit
PS51337 B12_BINDING_NTER, 1 hit
PS50970 HCY, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99707-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPALQDLSQ PEGLKKTLRD EINAILQKRI MVLDGGMGTM IQREKLNEEH
60 70 80 90 100
FRGQEFKDHA RPLKGNNDIL SITQPDVIYQ IHKEYLLAGA DIIETNTFSS
110 120 130 140 150
TSIAQADYGL EHLAYRMNMC SAGVARKAAE EVTLQTGIKR FVAGALGPTN
160 170 180 190 200
KTLSVSPSVE RPDYRNITFD ELVEAYQEQA KGLLDGGVDI LLIETIFDTA
210 220 230 240 250
NAKAALFALQ NLFEEKYAPR PIFISGTIVD KSGRTLSGQT GEGFVISVSH
260 270 280 290 300
GEPLCIGLNC ALGAAEMRPF IEIIGKCTTA YVLCYPNAGL PNTFGDYDET
310 320 330 340 350
PSMMAKHLKD FAMDGLVNIV GGCCGSTPDH IREIAEAVKN CKPRVPPATA
360 370 380 390 400
FEGHMLLSGL EPFRIGPYTN FVNIGERCNV AGSRKFAKLI MAGNYEEALC
410 420 430 440 450
VAKVQVEMGA QVLDVNMDDG MLDGPSAMTR FCNLIASEPD IAKVPLCIDS
460 470 480 490 500
SNFAVIEAGL KCCQGKCIVN SISLKEGEDD FLEKARKIKK YGAAMVVMAF
510 520 530 540 550
DEEGQATETD TKIRVCTRAY HLLVKKLGFN PNDIIFDPNI LTIGTGMEEH
560 570 580 590 600
NLYAINFIHA TKVIKETLPG ARISGGLSNL SFSFRGMEAI REAMHGVFLY
610 620 630 640 650
HAIKSGMDMG IVNAGNLPVY DDIHKELLQL CEDLIWNKDP EATEKLLRYA
660 670 680 690 700
QTQGTGGKKV IQTDEWRNGP VEERLEYALV KGIEKHIIED TEEARLNQKK
710 720 730 740 750
YPRPLNIIEG PLMNGMKIVG DLFGAGKMFL PQVIKSARVM KKAVGHLIPF
760 770 780 790 800
MEKEREETRV LNGTVEEEDP YQGTIVLATV KGDVHDIGKN IVGVVLGCNN
810 820 830 840 850
FRVIDLGVMT PCDKILKAAL DHKADIIGLS GLITPSLDEM IFVAKEMERL
860 870 880 890 900
AIRIPLLIGG ATTSKTHTAV KIAPRYSAPV IHVLDASKSV VVCSQLLDEN
910 920 930 940 950
LKDEYFEEIM EEYEDIRQDH YESLKERRYL PLSQARKSGF QMDWLSEPHP
960 970 980 990 1000
VKPTFIGTQV FEDYDLQKLV DYIDWKPFFD VWQLRGKYPN RGFPKIFNDK
1010 1020 1030 1040 1050
TVGGEARKVY DDAHNMLNTL ISQKKLRARG VVGFWPAQSI QDDIHLYAEA
1060 1070 1080 1090 1100
AVPQAAEPIA TFYGLRQQAE KDSASTEPYY CLSDFIAPLH SGIRDYLGLF
1110 1120 1130 1140 1150
AVACFGVEEL SKAYEDDGDD YSSIMVKALG DRLAEAFAEE LHERVRRELW
1160 1170 1180 1190 1200
AYCGSEQLDV ADLRRLRYKG IRPAPGYPSQ PDHTEKLTMW RLADIEQSTG
1210 1220 1230 1240 1250
IRLTESLAMA PASAVSGLYF SNLKSKYFAV GKISKDQVED YALRKNISVA
1260
EVEKWLGPIL GYDTD
Length:1,265
Mass (Da):140,527
Last modified:July 1, 1997 - v2
Checksum:iB04C26BCBE9A57C2
GO
Isoform 2 (identifier: Q99707-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-732: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):134,793
Checksum:i2E568CD852B22E8C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ANE3B1ANE3_HUMAN
Methionine synthase
MTR
819Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05003352R → Q. Corresponds to variant dbSNP:rs12749581EnsemblClinVar.1
Natural variantiVAR_00432661R → K1 Publication1
Natural variantiVAR_004327255C → Y1 PublicationCorresponds to variant dbSNP:rs1140598Ensembl.1
Natural variantiVAR_061338314D → N. Corresponds to variant dbSNP:rs2229274EnsemblClinVar.1
Natural variantiVAR_004328881Missing in HMAG. 2 Publications1
Natural variantiVAR_004329919D → G4 PublicationsCorresponds to variant dbSNP:rs1805087EnsemblClinVar.1
Natural variantiVAR_004330920H → D in HMAG. 1 PublicationCorresponds to variant dbSNP:rs121913579EnsemblClinVar.1
Natural variantiVAR_0043311173P → L in HMAG. 1 PublicationCorresponds to variant dbSNP:rs121913578EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057283682 – 732Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71285 mRNA Translation: AAC51188.1
U75743 mRNA Translation: AAB58906.1
U73338 mRNA Translation: AAB39704.1
AL359185 Genomic DNA No translation available.
AL359259 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70066.1
BC130616 mRNA Translation: AAI30617.1
BC136440 mRNA Translation: AAI36441.1
BC144095 mRNA Translation: AAI44096.1
CCDSiCCDS1614.1 [Q99707-1]
CCDS73054.1 [Q99707-2]
RefSeqiNP_000245.2, NM_000254.2 [Q99707-1]
NP_001278868.1, NM_001291939.1 [Q99707-2]
NP_001278869.1, NM_001291940.1
UniGeneiHs.498187

Genome annotation databases

EnsembliENST00000366577; ENSP00000355536; ENSG00000116984 [Q99707-1]
ENST00000535889; ENSP00000441845; ENSG00000116984 [Q99707-2]
GeneIDi4548
KEGGihsa:4548
UCSCiuc001hyi.5 human [Q99707-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

5-methyltetrahydrofolate-homocysteine methyltransferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71285 mRNA Translation: AAC51188.1
U75743 mRNA Translation: AAB58906.1
U73338 mRNA Translation: AAB39704.1
AL359185 Genomic DNA No translation available.
AL359259 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70066.1
BC130616 mRNA Translation: AAI30617.1
BC136440 mRNA Translation: AAI36441.1
BC144095 mRNA Translation: AAI44096.1
CCDSiCCDS1614.1 [Q99707-1]
CCDS73054.1 [Q99707-2]
RefSeqiNP_000245.2, NM_000254.2 [Q99707-1]
NP_001278868.1, NM_001291939.1 [Q99707-2]
NP_001278869.1, NM_001291940.1
UniGeneiHs.498187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O2KX-ray1.60A/B925-1265[»]
4CCZX-ray2.70A16-657[»]
ProteinModelPortaliQ99707
SMRiQ99707
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110642, 31 interactors
DIPiDIP-40306N
IntActiQ99707, 10 interactors
STRINGi9606.ENSP00000355536

Chemistry databases

BindingDBiQ99707
ChEMBLiCHEMBL2150844
DrugBankiDB00115 Cyanocobalamin
DB00200 Hydroxocobalamin
DB00134 L-Methionine
DB00116 Tetrahydrofolic acid

PTM databases

iPTMnetiQ99707
PhosphoSitePlusiQ99707

Polymorphism and mutation databases

BioMutaiMTR
DMDMi2842762

Proteomic databases

EPDiQ99707
MaxQBiQ99707
PaxDbiQ99707
PeptideAtlasiQ99707
PRIDEiQ99707
ProteomicsDBi78423

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366577; ENSP00000355536; ENSG00000116984 [Q99707-1]
ENST00000535889; ENSP00000441845; ENSG00000116984 [Q99707-2]
GeneIDi4548
KEGGihsa:4548
UCSCiuc001hyi.5 human [Q99707-1]

Organism-specific databases

CTDi4548
DisGeNETi4548
EuPathDBiHostDB:ENSG00000116984.12
GeneCardsiMTR
GeneReviewsiMTR
HGNCiHGNC:7468 MTR
HPAiHPA044474
HPA054915
MalaCardsiMTR
MIMi156570 gene
250940 phenotype
601634 phenotype
603174 phenotype
neXtProtiNX_Q99707
OpenTargetsiENSG00000116984
Orphaneti2170 Methylcobalamin deficiency type cblG
PharmGKBiPA31272
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1579 Eukaryota
COG0646 LUCA
COG1410 LUCA
GeneTreeiENSGT00420000029824
HOGENOMiHOG000251409
HOVERGENiHBG006347
InParanoidiQ99707
KOiK00548
OMAiKYPRPLN
OrthoDBiEOG091G00WU
PhylomeDBiQ99707
TreeFamiTF312829

Enzyme and pathway databases

UniPathwayi
UPA00051;UER00081

BioCyciMetaCyc:HS04076-MONOMER
ReactomeiR-HSA-156581 Methylation
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
R-HSA-3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
SIGNORiQ99707

Miscellaneous databases

ChiTaRSiMTR human
EvolutionaryTraceiQ99707
GeneWikiiMethionine_synthase
GenomeRNAii4548
PROiPR:Q99707
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116984 Expressed in 237 organ(s), highest expression level in metanephros
CleanExiHS_MTR
ExpressionAtlasiQ99707 baseline and differential
GenevisibleiQ99707 HS

Family and domain databases

CDDicd02069 methionine_synthase_B12_BD, 1 hit
Gene3Di1.10.1240.10, 1 hit
3.10.196.10, 3 hits
3.20.20.20, 1 hit
3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR003759 Cbl-bd_cap
IPR006158 Cobalamin-bd
IPR036724 Cobalamin-bd_sf
IPR011005 Dihydropteroate_synth-like
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
IPR033706 Met_synthase_B12-bd
IPR011822 MetH
IPR036594 Meth_synthase_dom
IPR000489 Pterin-binding_dom
IPR004223 VitB12-dep_Met_synth_activ_dom
IPR037010 VitB12-dep_Met_synth_activ_sf
PfamiView protein in Pfam
PF02310 B12-binding, 1 hit
PF02607 B12-binding_2, 1 hit
PF02965 Met_synt_B12, 1 hit
PF00809 Pterin_bind, 1 hit
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF000381 MetH, 1 hit
SMARTiView protein in SMART
SM01018 B12-binding_2, 1 hit
SUPFAMiSSF47644 SSF47644, 1 hit
SSF51717 SSF51717, 1 hit
SSF52242 SSF52242, 1 hit
SSF56507 SSF56507, 1 hit
SSF82282 SSF82282, 1 hit
TIGRFAMsiTIGR02082 metH, 1 hit
PROSITEiView protein in PROSITE
PS50974 ADOMET_ACTIVATION, 1 hit
PS51332 B12_BINDING, 1 hit
PS51337 B12_BINDING_NTER, 1 hit
PS50970 HCY, 1 hit
PS50972 PTERIN_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMETH_HUMAN
AccessioniPrimary (citable) accession number: Q99707
Secondary accession number(s): A1L4N8
, A9Z1W4, B7ZLW7, B9EGF7, Q99713, Q99723
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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