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Protein

Killer cell immunoglobulin-like receptor 2DL4

Gene

KIR2DL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class Ib receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99706

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL4
Alternative name(s):
CD158 antigen-like family member D
G9P
Killer cell inhibitory receptor 103AS
Short name:
KIR-103AS
MHC class I NK cell receptor KIR103AS
CD_antigen: CD158d1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR2DL42 PublicationsImported
Synonyms:CD158D, KIR103AS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189013.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6332 KIR2DL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604945 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99706

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 242ExtracellularSequence analysisAdd BLAST221
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 377CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi246 – 247RY → GT: Does not affect targeting to the endosomal compartment. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
3805

Open Targets

More...
OpenTargetsi
ENSG00000189013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30117

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIR2DL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325511396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001508122 – 377Killer cell immunoglobulin-like receptor 2DL4Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 97By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 195By similarity
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99706

PeptideAtlas

More...
PeptideAtlasi
Q99706

PRoteomics IDEntifications database

More...
PRIDEi
Q99706

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78417
78418 [Q99706-2]
78419 [Q99706-3]
78420 [Q99706-4]
78421 [Q99706-5]
78422 [Q99706-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99706

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99706

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in decidual NK cells and innate lymphoid cell type I (ILC1) (PubMed:29262349). Expressed in a subset of peripheral NK cells (PubMed:19304799).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189013 Expressed in 51 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99706 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99706 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with peptide-bound HLA-G-B2M heterotrimeric complex (PubMed:10190900, PubMed:16366734). Interacts with ARRB2 (PubMed:18604210).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110006, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q99706, 6 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WYRX-ray2.80A/B24-218[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99706

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99706

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 104Ig-like C2-type 1Add BLAST61
Domaini139 – 202Ig-like C2-type 2Add BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234396

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074353

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99706

KEGG Orthology (KO)

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KOi
K07981

Database of Orthologous Groups

More...
OrthoDBi
1055520at2759

TreeFam database of animal gene trees

More...
TreeFami
TF352669

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047 ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 30 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99706-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR
60 70 80 90 100
CHYRRGFNIF TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF
110 120 130 140 150
HPHSPTEWSA PSNPLVIMVT GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS
160 170 180 190 200
SFDIYHLSRE GEAHELRLPA VPSINGTFQA DFPLGPATHG ETYRCFGSFH
210 220 230 240 250
GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH LHAVIRYSVA
260 270 280 290 300
IILFTILPFF LLHRWCSKKK DAAVMNQEPA GHRTVNREDS DEQDPQEVTY
310 320 330 340 350
AQLDHCIFTQ RKITGPSQRS KRPSTDTSVC IELPNAEPRA LSPAHEHHSQ
360 370
ALMGSSRETT ALSQTQLASS NVPAAGI
Length:377
Mass (Da):41,487
Last modified:March 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i888B3297332D6C59
GO
Isoform 2 (identifier: Q99706-2) [UniParc]FASTAAdd to basket
Also known as: AST

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.

Show »
Length:360
Mass (Da):39,699
Checksum:iA7E18C6F0DDBD526
GO
Isoform 3 (identifier: Q99706-3) [UniParc]FASTAAdd to basket
Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     236-270: Missing.

Show »
Length:342
Mass (Da):37,356
Checksum:i963B74BC0E5C7B64
GO
Isoform 4 (identifier: Q99706-4) [UniParc]FASTAAdd to basket
Also known as: ASD1

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.
     236-270: Missing.

Show »
Length:325
Mass (Da):35,568
Checksum:iA07C525E18C55C79
GO
Isoform 5 (identifier: Q99706-5) [UniParc]FASTAAdd to basket
Also known as: ASD2

The sequence of this isoform differs from the canonical sequence as follows:
     219-235: Missing.
     236-270: Missing.
     271-288: Missing.

Show »
Length:307
Mass (Da):33,591
Checksum:i360E7C2058E1788E
GO
Isoform 6 (identifier: Q99706-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-121: Missing.
     219-235: Missing.
     236-270: Missing.

Show »
Length:230
Mass (Da):24,917
Checksum:i0FCFE3EE13BACBB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 30 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86U48Q86U48_HUMAN
KIR2DL4
KIR2DL4 KIR-2DL4
377Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1S6A0A0B4J1S6_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MT18A8MT18_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7RE46K7RE46_HUMAN
KIR2DL4
KIR2DL4
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMD1A0A0G2JMD1_HUMAN
KIR2DL4 protein
KIR2DL4
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP28A0A0G2JP28_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNK6A0A0G2JNK6_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7QUT1K7QUT1_HUMAN
KIR2DL4
KIR2DL4
377Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMF5A0A0G2JMF5_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQ39A0A0G2JQ39_HUMAN
Killer cell immunoglobulin-like rec...
KIR2DL4
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47V → A in ABW73961 (PubMed:18082267).Curated1
Sequence conflicti229T → P in AAD24763 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01030753Y → C3 PublicationsCorresponds to variant dbSNP:rs618835Ensembl.1
Natural variantiVAR_01030887V → L3 Publications1
Natural variantiVAR_010309138A → T5 PublicationsCorresponds to variant dbSNP:rs1051454Ensembl.1
Natural variantiVAR_010310209P → A5 PublicationsCorresponds to variant dbSNP:rs1051456Ensembl.1
Natural variantiVAR_064649271 – 273DAA → MLL in allele KIR2DL4*0501. 3
Natural variantiVAR_010311271D → N4 Publications1
Natural variantiVAR_065101274 – 377Missing in allele KIR2DL4*0501. Add BLAST104
Natural variantiVAR_010312371N → H4 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00260827 – 121Missing in isoform 6. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_002609219 – 235Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_002610236 – 270Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_002611271 – 288Missing in isoform 5. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U71199 mRNA Translation: AAB49756.1
AF034771 mRNA Translation: AAB95164.1
AF034772 mRNA Translation: AAB95165.1
AF034773 mRNA Translation: AAB95166.1
U73394 mRNA Translation: AAC51146.1
AF003123
, AF003116, AF003117, AF003118, AF003119, AF003121, AF003122, AF003120 Genomic DNA Translation: AAB61926.1
AF002979 mRNA Translation: AAB71387.1
AF002980 mRNA Translation: AAB71388.1
AF002981 mRNA Translation: AAB71389.1
AF002982 mRNA Translation: AAB71390.1
EU194342 mRNA Translation: ABW73961.1
X97229 mRNA Translation: CAA65868.1
X99479 mRNA Translation: CAA67842.1
X99480 mRNA Translation: CAA67843.1
X99481 mRNA Translation: CAA67844.1
AF110035
, AF110032, AF110033, AF110034 Genomic DNA Translation: AAD24763.1
AC011501 Genomic DNA No translation available.
AL133414 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42619.1 [Q99706-3]

NCBI Reference Sequences

More...
RefSeqi
NP_002246.5, NM_002255.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.661219
Hs.743945

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345540; ENSP00000339634; ENSG00000189013 [Q99706-3]
ENST00000357494; ENSP00000350088; ENSG00000189013 [Q99706-4]
ENST00000396293; ENSP00000379588; ENSG00000189013 [Q99706-6]
ENST00000611022; ENSP00000484469; ENSG00000274232 [Q99706-3]
ENST00000612573; ENSP00000482206; ENSG00000275456
ENST00000612660; ENSP00000479179; ENSG00000275317
ENST00000613053; ENSP00000484389; ENSG00000277362
ENST00000614653; ENSP00000478362; ENSG00000277750
ENST00000614680; ENSP00000477984; ENSG00000273575 [Q99706-3]
ENST00000615232; ENSP00000479874; ENSG00000274232 [Q99706-6]
ENST00000615243; ENSP00000482454; ENSG00000274232 [Q99706-4]
ENST00000615970; ENSP00000477887; ENSG00000278271
ENST00000616354; ENSP00000483782; ENSG00000278430
ENST00000616384; ENSP00000479347; ENSG00000276044 [Q99706-3]
ENST00000618297; ENSP00000477886; ENSG00000278074
ENST00000618358; ENSP00000483101; ENSG00000274609
ENST00000618567; ENSP00000482383; ENSG00000276779
ENST00000619637; ENSP00000478491; ENSG00000274955
ENST00000619848; ENSP00000480801; ENSG00000277964
ENST00000620484; ENSP00000477601; ENSG00000275317
ENST00000620486; ENSP00000482452; ENSG00000278430
ENST00000621182; ENSP00000479175; ENSG00000275699 [Q99706-3]
ENST00000638231; ENSP00000492368; ENSG00000284460 [Q99706-6]
ENST00000638248; ENSP00000491734; ENSG00000284365 [Q99706-4]
ENST00000638297; ENSP00000492029; ENSG00000284365 [Q99706-6]
ENST00000638563; ENSP00000491532; ENSG00000284013 [Q99706-4]
ENST00000638897; ENSP00000492653; ENSG00000283961 [Q99706-4]
ENST00000639460; ENSP00000491648; ENSG00000283869 [Q99706-6]
ENST00000639533; ENSP00000491289; ENSG00000283961 [Q99706-6]
ENST00000639577; ENSP00000492722; ENSG00000284013 [Q99706-3]
ENST00000639740; ENSP00000492606; ENSG00000284509 [Q99706-6]
ENST00000639866; ENSP00000491202; ENSG00000283961 [Q99706-3]
ENST00000640163; ENSP00000491890; ENSG00000284013 [Q99706-6]
ENST00000640814; ENSP00000491623; ENSG00000284365 [Q99706-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3805

UCSC genome browser

More...
UCSCi
uc002qhg.5 human [Q99706-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71199 mRNA Translation: AAB49756.1
AF034771 mRNA Translation: AAB95164.1
AF034772 mRNA Translation: AAB95165.1
AF034773 mRNA Translation: AAB95166.1
U73394 mRNA Translation: AAC51146.1
AF003123
, AF003116, AF003117, AF003118, AF003119, AF003121, AF003122, AF003120 Genomic DNA Translation: AAB61926.1
AF002979 mRNA Translation: AAB71387.1
AF002980 mRNA Translation: AAB71388.1
AF002981 mRNA Translation: AAB71389.1
AF002982 mRNA Translation: AAB71390.1
EU194342 mRNA Translation: ABW73961.1
X97229 mRNA Translation: CAA65868.1
X99479 mRNA Translation: CAA67842.1
X99480 mRNA Translation: CAA67843.1
X99481 mRNA Translation: CAA67844.1
AF110035
, AF110032, AF110033, AF110034 Genomic DNA Translation: AAD24763.1
AC011501 Genomic DNA No translation available.
AL133414 Genomic DNA No translation available.
CCDSiCCDS42619.1 [Q99706-3]
RefSeqiNP_002246.5, NM_002255.5
UniGeneiHs.661219
Hs.743945

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WYRX-ray2.80A/B24-218[»]
ProteinModelPortaliQ99706
SMRiQ99706
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110006, 5 interactors
IntActiQ99706, 6 interactors

PTM databases

iPTMnetiQ99706
PhosphoSitePlusiQ99706

Polymorphism and mutation databases

BioMutaiKIR2DL4
DMDMi325511396

Proteomic databases

jPOSTiQ99706
PeptideAtlasiQ99706
PRIDEiQ99706
ProteomicsDBi78417
78418 [Q99706-2]
78419 [Q99706-3]
78420 [Q99706-4]
78421 [Q99706-5]
78422 [Q99706-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345540; ENSP00000339634; ENSG00000189013 [Q99706-3]
ENST00000357494; ENSP00000350088; ENSG00000189013 [Q99706-4]
ENST00000396293; ENSP00000379588; ENSG00000189013 [Q99706-6]
ENST00000611022; ENSP00000484469; ENSG00000274232 [Q99706-3]
ENST00000612573; ENSP00000482206; ENSG00000275456
ENST00000612660; ENSP00000479179; ENSG00000275317
ENST00000613053; ENSP00000484389; ENSG00000277362
ENST00000614653; ENSP00000478362; ENSG00000277750
ENST00000614680; ENSP00000477984; ENSG00000273575 [Q99706-3]
ENST00000615232; ENSP00000479874; ENSG00000274232 [Q99706-6]
ENST00000615243; ENSP00000482454; ENSG00000274232 [Q99706-4]
ENST00000615970; ENSP00000477887; ENSG00000278271
ENST00000616354; ENSP00000483782; ENSG00000278430
ENST00000616384; ENSP00000479347; ENSG00000276044 [Q99706-3]
ENST00000618297; ENSP00000477886; ENSG00000278074
ENST00000618358; ENSP00000483101; ENSG00000274609
ENST00000618567; ENSP00000482383; ENSG00000276779
ENST00000619637; ENSP00000478491; ENSG00000274955
ENST00000619848; ENSP00000480801; ENSG00000277964
ENST00000620484; ENSP00000477601; ENSG00000275317
ENST00000620486; ENSP00000482452; ENSG00000278430
ENST00000621182; ENSP00000479175; ENSG00000275699 [Q99706-3]
ENST00000638231; ENSP00000492368; ENSG00000284460 [Q99706-6]
ENST00000638248; ENSP00000491734; ENSG00000284365 [Q99706-4]
ENST00000638297; ENSP00000492029; ENSG00000284365 [Q99706-6]
ENST00000638563; ENSP00000491532; ENSG00000284013 [Q99706-4]
ENST00000638897; ENSP00000492653; ENSG00000283961 [Q99706-4]
ENST00000639460; ENSP00000491648; ENSG00000283869 [Q99706-6]
ENST00000639533; ENSP00000491289; ENSG00000283961 [Q99706-6]
ENST00000639577; ENSP00000492722; ENSG00000284013 [Q99706-3]
ENST00000639740; ENSP00000492606; ENSG00000284509 [Q99706-6]
ENST00000639866; ENSP00000491202; ENSG00000283961 [Q99706-3]
ENST00000640163; ENSP00000491890; ENSG00000284013 [Q99706-6]
ENST00000640814; ENSP00000491623; ENSG00000284365 [Q99706-3]
GeneIDi3805
KEGGihsa:3805
UCSCiuc002qhg.5 human [Q99706-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3805
DisGeNETi3805
EuPathDBiHostDB:ENSG00000189013.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIR2DL4
HGNCiHGNC:6332 KIR2DL4
MIMi604945 gene
neXtProtiNX_Q99706
OpenTargetsiENSG00000189013
PharmGKBiPA30117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153748
HOGENOMiHOG000234396
HOVERGENiHBG074353
InParanoidiQ99706
KOiK07981
OrthoDBi1055520at2759
TreeFamiTF352669

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiQ99706

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KIR2DL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3805

Protein Ontology

More...
PROi
PR:Q99706

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189013 Expressed in 51 organ(s), highest expression level in blood
ExpressionAtlasiQ99706 baseline and differential
GenevisibleiQ99706 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI2L4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99706
Secondary accession number(s): A8W795
, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q8N738, Q99559, Q99560, Q99561, Q99562, Q9UQJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 8, 2011
Last modified: January 16, 2019
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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