Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.1 Publication

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • hormone binding Source: Ensembl
  • melanin-concentrating hormone receptor activity Source: GO_Central
  • neuropeptide binding Source: GO_Central
  • neuropeptide receptor activity Source: ProtInc
  • protein C-terminus binding Source: Ensembl
  • signaling receptor binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99705

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.6 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCHR1
Synonyms:GPR24, SLC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128285.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4479 MCHR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601751 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99705

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 113ExtracellularSequence analysisAdd BLAST113
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei114 – 136Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini137 – 148CytoplasmicSequence analysisAdd BLAST12
Transmembranei149 – 171Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini172 – 185ExtracellularSequence analysisAdd BLAST14
Transmembranei186 – 208Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini209 – 227CytoplasmicSequence analysisAdd BLAST19
Transmembranei228 – 250Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 301Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini302 – 321CytoplasmicSequence analysisAdd BLAST20
Transmembranei322 – 344Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini345 – 358ExtracellularSequence analysisAdd BLAST14
Transmembranei359 – 381Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini382 – 422CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2847

Open Targets

More...
OpenTargetsi
ENSG00000128285

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28867

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL344

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
280

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCHR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33860175

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697341 – 422Melanin-concentrating hormone receptor 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99705

PeptideAtlas

More...
PeptideAtlasi
Q99705

PRoteomics IDEntifications database

More...
PRIDEi
Q99705

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78416

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99705

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99705

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128285 Expressed in 98 organ(s), highest expression level in middle temporal gyrus

CleanEx database of gene expression profiles

More...
CleanExi
HS_MCHR1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99705 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99705 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCDN.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000249016

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99705

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99705

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99705

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154272

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000704

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105726

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99705

KEGG Orthology (KO)

More...
KOi
K04320

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSTYILT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HEN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99705

TreeFam database of animal gene trees

More...
TreeFami
TF315737

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004047 MCH1_rcpt
IPR008361 MCH_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR44627 PTHR44627, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR01507 MCH1RECEPTOR
PR01783 MCHRECEPTOR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99705-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP
60 70 80 90 100
AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP
110 120 130 140 150
RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF
160 170 180 190 200
IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST
210 220 230 240 250
YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY
260 270 280 290 300
ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
310 320 330 340 350
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS
360 370 380 390 400
ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ
410 420
GQLRAVSNAQ TADEERTESK GT
Length:422
Mass (Da):45,963
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3986919A18183818
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6ZJ87A6ZJ87_HUMAN
Melanin-concentrating hormone recep...
MCHR1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC14587 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02665225T → M1 PublicationCorresponds to variant dbSNP:rs117372135Ensembl.1
Natural variantiVAR_02665328D → V1 PublicationCorresponds to variant dbSNP:rs112405400Ensembl.1
Natural variantiVAR_01622132N → D No significant functional differences. 7 PublicationsCorresponds to variant dbSNP:rs133072Ensembl.1
Natural variantiVAR_02665434G → R No changes in receptor binding or functional signaling. 1 Publication1
Natural variantiVAR_049417103G → R. Corresponds to variant dbSNP:rs11914085Ensembl.1
Natural variantiVAR_026655210R → H1 PublicationCorresponds to variant dbSNP:rs750210146Ensembl.1
Natural variantiVAR_026656250Y → H1 Publication1
Natural variantiVAR_026657305T → M1 PublicationCorresponds to variant dbSNP:rs550313335Ensembl.1
Natural variantiVAR_026658317R → Q2 PublicationsCorresponds to variant dbSNP:rs45439291Ensembl.1
Natural variantiVAR_026659377P → S1 PublicationCorresponds to variant dbSNP:rs539260735Ensembl.1
Natural variantiVAR_026660411T → M1 PublicationCorresponds to variant dbSNP:rs149604804Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB063174 mRNA Translation: BAB60890.1
AF490537 mRNA Translation: AAO14670.1
CR456497 mRNA Translation: CAG30383.1
BT006725 mRNA Translation: AAP35371.1
AY562945 mRNA Translation: AAS72373.1
AK314857 mRNA Translation: BAG37373.1
Z86090 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60388.1
BC001736 mRNA Translation: AAH01736.1
BC021146 mRNA Translation: AAH21146.1
U71092 Genomic DNA Translation: AAC14587.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14004.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7080

NCBI Reference Sequences

More...
RefSeqi
NP_005288.3, NM_005297.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.248122

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000249016; ENSP00000249016; ENSG00000128285

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2847

UCSC genome browser

More...
UCSCi
uc003ayz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063174 mRNA Translation: BAB60890.1
AF490537 mRNA Translation: AAO14670.1
CR456497 mRNA Translation: CAG30383.1
BT006725 mRNA Translation: AAP35371.1
AY562945 mRNA Translation: AAS72373.1
AK314857 mRNA Translation: BAG37373.1
Z86090 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60388.1
BC001736 mRNA Translation: AAH01736.1
BC021146 mRNA Translation: AAH21146.1
U71092 Genomic DNA Translation: AAC14587.1 Sequence problems.
CCDSiCCDS14004.1
PIRiJC7080
RefSeqiNP_005288.3, NM_005297.3
UniGeneiHs.248122

3D structure databases

ProteinModelPortaliQ99705
SMRiQ99705
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000249016

Chemistry databases

BindingDBiQ99705
ChEMBLiCHEMBL344
GuidetoPHARMACOLOGYi280

Protein family/group databases

TCDBi9.A.14.13.6 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ99705
PhosphoSitePlusiQ99705

Polymorphism and mutation databases

BioMutaiMCHR1
DMDMi33860175

Proteomic databases

PaxDbiQ99705
PeptideAtlasiQ99705
PRIDEiQ99705
ProteomicsDBi78416

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2847
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249016; ENSP00000249016; ENSG00000128285
GeneIDi2847
KEGGihsa:2847
UCSCiuc003ayz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2847
DisGeNETi2847
EuPathDBiHostDB:ENSG00000128285.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MCHR1
HGNCiHGNC:4479 MCHR1
MIMi601751 gene
neXtProtiNX_Q99705
OpenTargetsiENSG00000128285
PharmGKBiPA28867

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154272
HOGENOMiHOG000000704
HOVERGENiHBG105726
InParanoidiQ99705
KOiK04320
OMAiTSTYILT
OrthoDBiEOG091G0HEN
PhylomeDBiQ99705
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
SIGNORiQ99705

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Melanin-concentrating_hormone_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2847

Protein Ontology

More...
PROi
PR:Q99705

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128285 Expressed in 98 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_MCHR1
ExpressionAtlasiQ99705 baseline and differential
GenevisibleiQ99705 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004047 MCH1_rcpt
IPR008361 MCH_rcpt
PANTHERiPTHR44627 PTHR44627, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01507 MCH1RECEPTOR
PR01783 MCHRECEPTOR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCHR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99705
Secondary accession number(s): B2RBX6
, Q5R3J1, Q96S47, Q9BV08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: December 5, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again