UniProtKB - Q99697 (PITX2_HUMAN)
Pituitary homeobox 2
PITX2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 85 – 144 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphoprotein binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- ribonucleoprotein complex binding Source: BHF-UCL
- RNA polymerase II activating transcription factor binding Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- camera-type eye development Source: BHF-UCL
- cardiac neural crest cell migration involved in outflow tract morphogenesis Source: BHF-UCL
- cell proliferation involved in outflow tract morphogenesis Source: BHF-UCL
- deltoid tuberosity development Source: BHF-UCL
- determination of left/right symmetry Source: BHF-UCL
- hair cell differentiation Source: BHF-UCL
- iris morphogenesis Source: BHF-UCL
- left/right axis specification Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- odontogenesis Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- prolactin secreting cell differentiation Source: BHF-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: MGI
- somatotropin secreting cell differentiation Source: BHF-UCL
- spleen development Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99697 |
Reactomei | R-HSA-8866906, TFAP2 (AP-2) family regulates transcription of other transcription factors |
SignaLinki | Q99697 |
SIGNORi | Q99697 |
Names & Taxonomyi
Protein namesi | Recommended name: Pituitary homeobox 2CuratedAlternative name(s): ALL1-responsive protein ARP1 Homeobox protein PITX2 Paired-like homeodomain transcription factor 2 RIEG bicoid-related homeobox transcription factor Solurshin |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9005, PITX2 |
MIMi | 601542, gene |
neXtProti | NX_Q99697 |
VEuPathDBi | HostDB:ENSG00000164093.15 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Axenfeld-Rieger syndrome 1 (RIEG1)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003763 | 100 | L → Q in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893857Ensembl. | 1 | |
Natural variantiVAR_058735 | 110 | P → L in RIEG1. 2 PublicationsCorresponds to variant dbSNP:rs1057519484Ensembl. | 1 | |
Natural variantiVAR_058736 | 110 | P → R in RIEG1. 1 Publication | 1 | |
Natural variantiVAR_003764 | 114 | T → P in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893858Ensembl. | 1 | |
Natural variantiVAR_035028 | 128 – 134 | Missing in RIEG1; more than 100-fold reduction in DNA binding activity as well as no detectable transactivation activity. | 7 | |
Natural variantiVAR_035029 | 129 | V → L in RIEG1; more than 200% increase in transactivation activity. 1 PublicationCorresponds to variant dbSNP:rs121909249Ensembl. | 1 | |
Natural variantiVAR_058737 | 134 | K → E in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs387906810Ensembl. | 1 | |
Natural variantiVAR_058738 | 136 | R → C in RIEG1. 2 Publications | 1 | |
Natural variantiVAR_003766 | 137 | R → P in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893859Ensembl. | 1 | |
Natural variantiVAR_058739 | 151 | L → V in RIEG1. 1 Publication | 1 | |
Natural variantiVAR_058740 | 154 | N → T in RIEG1. 1 Publication | 1 |
Anterior segment dysgenesis 4 (ASGD4)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_003765 | 115 | R → H in ASGD4. 1 PublicationCorresponds to variant dbSNP:rs104893861Ensembl. | 1 | ||
Natural variantiVAR_003762 | 130 | R → W in ASGD4. 1 PublicationCorresponds to variant dbSNP:rs121909248Ensembl. | 1 | ||
Isoform PTX2A (identifier: Q99697-3) | |||||
Natural variantiVAR_082833 | 58 | F → L in ASGD4. 1 Publication | 1 |
Ring dermoid of cornea (RDC)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035027 | 108 | R → H in RDC; results in 25% loss of transactivation activity. 2 PublicationsCorresponds to variant dbSNP:rs104893862Ensembl. | 1 |
Keywords - Diseasei
Disease variant, Peters anomalyOrganism-specific databases
DisGeNETi | 5308 |
MalaCardsi | PITX2 |
MIMi | 137600, phenotype 180500, phenotype 180550, phenotype |
OpenTargetsi | ENSG00000164093 |
Orphaneti | 98978, Axenfeld anomaly 782, Axenfeld-Rieger syndrome 334, Familial atrial fibrillation 708, Peters anomaly 91483, Rieger anomaly 91481, Ring dermoid of cornea |
PharmGKBi | PA33339 |
Miscellaneous databases
Pharosi | Q99697, Tbio |
Genetic variation databases
BioMutai | PITX2 |
DMDMi | 6174907 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049223 | 1 – 317 | Pituitary homeobox 2Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 90 | Phosphothreonine; by PKB/AKT2By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q99697 |
MassIVEi | Q99697 |
MaxQBi | Q99697 |
PaxDbi | Q99697 |
PeptideAtlasi | Q99697 |
PRIDEi | Q99697 |
ProteomicsDBi | 78403 [Q99697-1] 78404 [Q99697-2] 78405 [Q99697-3] |
PTM databases
iPTMneti | Q99697 |
PhosphoSitePlusi | Q99697 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164093, Expressed in placenta and 148 other tissues |
ExpressionAtlasi | Q99697, baseline and differential |
Genevisiblei | Q99697, HS |
Organism-specific databases
HPAi | ENSG00000164093, Tissue enhanced (placenta, retina, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with PITX2.
1 PublicationBinary interactionsi
Hide detailsQ99697
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] | 2 | EBI-1175211,EBI-491549 |
YBX1 [P67809] | 3 | EBI-1175211,EBI-354065 |
Hoxa1 [P09022] from Mus musculus. | 3 | EBI-1175211,EBI-3957603 |
Isoform PTX2C [Q99697-2]
PITX2 - isoform PTX2A [Q99697-3]
With | #Exp. | IntAct |
---|---|---|
FOXC1 [Q12948] | 6 | EBI-1175243,EBI-1175253 |
MEF2A [Q02078] | 2 | EBI-1175243,EBI-2656305 |
itself | 5 | EBI-1175243,EBI-1175243 |
Pou1f1 [P10037] from Rattus norvegicus. | 2 | EBI-1175243,EBI-9825525 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphoprotein binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- RNA polymerase II activating transcription factor binding Source: BHF-UCL
- RNA polymerase II transcription factor binding Source: BHF-UCL
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111325, 51 interactors |
CORUMi | Q99697 |
IntActi | Q99697, 52 interactors |
MINTi | Q99697 |
STRINGi | 9606.ENSP00000304169 |
Miscellaneous databases
RNActi | Q99697, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q99697 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99697 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 279 – 292 | OARPROSITE-ProRule annotationAdd BLAST | 14 | |
Motifi | 285 – 289 | Nuclear localization signalSequence analysis | 5 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0486, Eukaryota |
GeneTreei | ENSGT00940000162789 |
HOGENOMi | CLU_030301_0_0_1 |
InParanoidi | Q99697 |
OMAi | YEDMYPS |
OrthoDBi | 1432356at2759 |
PhylomeDBi | Q99697 |
TreeFami | TF351940 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS
60 70 80 90 100
KFFPRQHPGA NEKDKSQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL
110 120 130 140 150
EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE
160 170 180 190 200
LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM
210 220 230 240 250
NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS
260 270 280 290 300
PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ
310
NPASNLSACQ YAVDRPV
The sequence of this isoform differs from the canonical sequence as follows:
1-61: METNCRKLVS...FFPRQHPGAN → MNCMKGPLHL...ISDTSSPEAA
The sequence of this isoform differs from the canonical sequence as follows:
16-61: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RFI4 | D6RFI4_HUMAN | Pituitary homeobox 2 | PITX2 | 290 | Annotation score: | ||
D6RBG8 | D6RBG8_HUMAN | Pituitary homeobox 2 | PITX2 | 118 | Annotation score: | ||
U3KQ81 | U3KQ81_HUMAN | Pituitary homeobox 2 | PITX2 | 264 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | V → L (PubMed:8944018).Curated | 1 | |
Sequence conflicti | 13 | V → L (Ref. 3) Curated | 1 | |
Sequence conflicti | 99 | E → Q in AAC16257 (PubMed:8944018).Curated | 1 | |
Sequence conflicti | 127 | A → T in BAF84280 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 301 | N → K (PubMed:8944018).Curated | 1 | |
Sequence conflicti | 301 | N → K (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_003763 | 100 | L → Q in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893857Ensembl. | 1 | ||
Natural variantiVAR_035027 | 108 | R → H in RDC; results in 25% loss of transactivation activity. 2 PublicationsCorresponds to variant dbSNP:rs104893862Ensembl. | 1 | ||
Natural variantiVAR_058735 | 110 | P → L in RIEG1. 2 PublicationsCorresponds to variant dbSNP:rs1057519484Ensembl. | 1 | ||
Natural variantiVAR_058736 | 110 | P → R in RIEG1. 1 Publication | 1 | ||
Natural variantiVAR_003764 | 114 | T → P in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893858Ensembl. | 1 | ||
Natural variantiVAR_003765 | 115 | R → H in ASGD4. 1 PublicationCorresponds to variant dbSNP:rs104893861Ensembl. | 1 | ||
Natural variantiVAR_035028 | 128 – 134 | Missing in RIEG1; more than 100-fold reduction in DNA binding activity as well as no detectable transactivation activity. | 7 | ||
Natural variantiVAR_035029 | 129 | V → L in RIEG1; more than 200% increase in transactivation activity. 1 PublicationCorresponds to variant dbSNP:rs121909249Ensembl. | 1 | ||
Natural variantiVAR_003762 | 130 | R → W in ASGD4. 1 PublicationCorresponds to variant dbSNP:rs121909248Ensembl. | 1 | ||
Natural variantiVAR_058737 | 134 | K → E in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs387906810Ensembl. | 1 | ||
Natural variantiVAR_058738 | 136 | R → C in RIEG1. 2 Publications | 1 | ||
Natural variantiVAR_003766 | 137 | R → P in RIEG1. 1 PublicationCorresponds to variant dbSNP:rs104893859Ensembl. | 1 | ||
Natural variantiVAR_058739 | 151 | L → V in RIEG1. 1 Publication | 1 | ||
Natural variantiVAR_058740 | 154 | N → T in RIEG1. 1 Publication | 1 | ||
Isoform PTX2A (identifier: Q99697-3) | |||||
Natural variantiVAR_082833 | 58 | F → L in ASGD4. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002260 | 1 – 61 | METNC…HPGAN → MNCMKGPLHLEHRAAGTKLS AVSSSSCHHPQPLAMASVLA PGQPRSLDSSKHRLEVHTIS DTSSPEAA in isoform PTX2C. 3 PublicationsAdd BLAST | 61 | |
Alternative sequenceiVSP_002261 | 16 – 61 | Missing in isoform PTX2A. 3 PublicationsAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69961 mRNA Translation: AAC16257.1 AF048720 mRNA Translation: AAC39716.1 AF048721 mRNA Translation: AAC39717.1 AF048722 mRNA Translation: AAC39718.1 AF238048 Genomic DNA Translation: AAK15048.1 AK127829 mRNA Translation: BAG54582.1 AK291591 mRNA Translation: BAF84280.1 AK313987 mRNA Translation: BAG36699.1 CH471057 Genomic DNA Translation: EAX06262.1 CH471057 Genomic DNA Translation: EAX06263.1 CH471057 Genomic DNA Translation: EAX06264.1 BC013998 mRNA Translation: AAH13998.1 BC106010 mRNA Translation: AAI06011.1 |
CCDSi | CCDS3692.1 [Q99697-1] CCDS3693.1 [Q99697-3] CCDS3694.1 [Q99697-2] |
RefSeqi | NP_000316.2, NM_000325.5 [Q99697-2] NP_001191326.1, NM_001204397.1 [Q99697-1] NP_001191327.1, NM_001204398.1 [Q99697-1] NP_001191328.1, NM_001204399.1 [Q99697-3] NP_700475.1, NM_153426.2 [Q99697-1] NP_700476.1, NM_153427.2 [Q99697-3] XP_011530329.1, XM_011532027.2 |
Genome annotation databases
Ensembli | ENST00000354925; ENSP00000347004; ENSG00000164093 [Q99697-1] ENST00000355080; ENSP00000347192; ENSG00000164093 [Q99697-3] ENST00000394595; ENSP00000378095; ENSG00000164093 [Q99697-1] ENST00000613094; ENSP00000484763; ENSG00000164093 [Q99697-1] ENST00000614423; ENSP00000481951; ENSG00000164093 [Q99697-1] ENST00000616641; ENSP00000484909; ENSG00000164093 [Q99697-3] ENST00000644743; ENSP00000495061; ENSG00000164093 [Q99697-2] |
GeneIDi | 5308 |
KEGGi | hsa:5308 |
UCSCi | uc003iac.4, human [Q99697-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69961 mRNA Translation: AAC16257.1 AF048720 mRNA Translation: AAC39716.1 AF048721 mRNA Translation: AAC39717.1 AF048722 mRNA Translation: AAC39718.1 AF238048 Genomic DNA Translation: AAK15048.1 AK127829 mRNA Translation: BAG54582.1 AK291591 mRNA Translation: BAF84280.1 AK313987 mRNA Translation: BAG36699.1 CH471057 Genomic DNA Translation: EAX06262.1 CH471057 Genomic DNA Translation: EAX06263.1 CH471057 Genomic DNA Translation: EAX06264.1 BC013998 mRNA Translation: AAH13998.1 BC106010 mRNA Translation: AAI06011.1 |
CCDSi | CCDS3692.1 [Q99697-1] CCDS3693.1 [Q99697-3] CCDS3694.1 [Q99697-2] |
RefSeqi | NP_000316.2, NM_000325.5 [Q99697-2] NP_001191326.1, NM_001204397.1 [Q99697-1] NP_001191327.1, NM_001204398.1 [Q99697-1] NP_001191328.1, NM_001204399.1 [Q99697-3] NP_700475.1, NM_153426.2 [Q99697-1] NP_700476.1, NM_153427.2 [Q99697-3] XP_011530329.1, XM_011532027.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L7F | NMR | - | P | 85-144 | [»] | |
2L7M | NMR | - | P | 85-144 | [»] | |
2LKX | NMR | - | A | 85-144 | [»] | |
SMRi | Q99697 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111325, 51 interactors |
CORUMi | Q99697 |
IntActi | Q99697, 52 interactors |
MINTi | Q99697 |
STRINGi | 9606.ENSP00000304169 |
PTM databases
iPTMneti | Q99697 |
PhosphoSitePlusi | Q99697 |
Genetic variation databases
BioMutai | PITX2 |
DMDMi | 6174907 |
Proteomic databases
jPOSTi | Q99697 |
MassIVEi | Q99697 |
MaxQBi | Q99697 |
PaxDbi | Q99697 |
PeptideAtlasi | Q99697 |
PRIDEi | Q99697 |
ProteomicsDBi | 78403 [Q99697-1] 78404 [Q99697-2] 78405 [Q99697-3] |
Protocols and materials databases
Antibodypediai | 15459, 284 antibodies |
DNASUi | 5308 |
Genome annotation databases
Organism-specific databases
CTDi | 5308 |
DisGeNETi | 5308 |
GeneCardsi | PITX2 |
HGNCi | HGNC:9005, PITX2 |
HPAi | ENSG00000164093, Tissue enhanced (placenta, retina, skeletal muscle) |
MalaCardsi | PITX2 |
MIMi | 137600, phenotype 180500, phenotype 180550, phenotype 601542, gene |
neXtProti | NX_Q99697 |
OpenTargetsi | ENSG00000164093 |
Orphaneti | 98978, Axenfeld anomaly 782, Axenfeld-Rieger syndrome 334, Familial atrial fibrillation 708, Peters anomaly 91483, Rieger anomaly 91481, Ring dermoid of cornea |
PharmGKBi | PA33339 |
VEuPathDBi | HostDB:ENSG00000164093.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0486, Eukaryota |
GeneTreei | ENSGT00940000162789 |
HOGENOMi | CLU_030301_0_0_1 |
InParanoidi | Q99697 |
OMAi | YEDMYPS |
OrthoDBi | 1432356at2759 |
PhylomeDBi | Q99697 |
TreeFami | TF351940 |
Enzyme and pathway databases
PathwayCommonsi | Q99697 |
Reactomei | R-HSA-8866906, TFAP2 (AP-2) family regulates transcription of other transcription factors |
SignaLinki | Q99697 |
SIGNORi | Q99697 |
Miscellaneous databases
BioGRID-ORCSi | 5308, 2 hits in 897 CRISPR screens |
ChiTaRSi | PITX2, human |
EvolutionaryTracei | Q99697 |
GeneWikii | PITX2 |
GenomeRNAii | 5308 |
Pharosi | Q99697, Tbio |
PROi | PR:Q99697 |
RNActi | Q99697, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164093, Expressed in placenta and 148 other tissues |
ExpressionAtlasi | Q99697, baseline and differential |
Genevisiblei | Q99697, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PITX2_HUMAN | |
Accessioni | Q99697Primary (citable) accession number: Q99697 Secondary accession number(s): A8K6C6 Q9BY17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families