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Entry version 163 (16 Oct 2019)
Sequence version 3 (15 Feb 2005)
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Protein

Homeobox protein Meis3

Gene

MEIS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi262 – 324Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Meis3
Alternative name(s):
Meis1-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEIS3
Synonyms:MRG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29537 MEIS3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99687

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000105419

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30742

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99687

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MEIS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59803105

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491101 – 375Homeobox protein Meis3Add BLAST375

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99687

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q99687

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99687

PeptideAtlas

More...
PeptideAtlasi
Q99687

PRoteomics IDEntifications database

More...
PRIDEi
Q99687

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78398 [Q99687-1]
78399 [Q99687-2]
78400 [Q99687-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99687

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99687

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105419 Expressed in 119 organ(s), highest expression level in myometrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99687 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99687 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046699

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121245, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q99687, 24 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99687

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi210 – 249Ser/Thr-richAdd BLAST40
Compositional biasi252 – 259Asp/Glu-rich (acidic)8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000161057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253923

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99687

KEGG Orthology (KO)

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KOi
K16671

Identification of Orthologs from Complete Genome Data

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OMAi
SGCREDL

Database of Orthologous Groups

More...
OrthoDBi
1126341at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99687

TreeFam database of animal gene trees

More...
TreeFami
TF318093

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS
60 70 80 90 100
DGLKREKDEI YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC
110 120 130 140 150
SSDSFNEDIA AFAKQVRSER PLFSSNPELD NLMIQAIQVL RFHLLELEKV
160 170 180 190 200
HDLCDNFCHR YITCLKGKMP IDLVIEDRDG GCREDFEDYP ASCPSLPDQN
210 220 230 240 250
NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL DTSVASPSSG
260 270 280 290 300
GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
310 320 330 340 350
DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET
360 370
QPHVAVRPPG SVGMSLNLEG EWHYL
Length:375
Mass (Da):41,115
Last modified:February 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C29818279800786
GO
Isoform 2 (identifier: Q99687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-286: S → SRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQ

Show »
Length:421
Mass (Da):46,175
Checksum:i3622AAB62D32561F
GO
Isoform 3 (identifier: Q99687-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-166: Missing.

Show »
Length:358
Mass (Da):39,052
Checksum:i7B9569CB90C91C8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNA8H0YNA8_HUMAN
Homeobox protein Meis3
MEIS3
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLU4H3BLU4_HUMAN
Homeobox protein Meis3
MEIS3
404Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMV2H0YMV2_HUMAN
Homeobox protein Meis3
MEIS3
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQJ9U3KQJ9_HUMAN
Homeobox protein Meis3
MEIS3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQV2U3KQV2_HUMAN
Homeobox protein Meis3
MEIS3
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLL0H0YLL0_HUMAN
Homeobox protein Meis3
MEIS3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 4MARR → LASQ in CAB95771 (PubMed:17974005).Curated4
Sequence conflicti1 – 4MARR → LASQ in CAH18472 (PubMed:17974005).Curated4
Sequence conflicti168 – 169KM → RP (PubMed:9049632).Curated2
Sequence conflicti202M → I (PubMed:9049632).Curated1
Sequence conflicti238D → V (PubMed:9049632).Curated1
Sequence conflicti260R → P (PubMed:9049632).Curated1
Sequence conflicti351Q → E (PubMed:9049632).Curated1
Sequence conflicti356 – 360VRPPG → FRAPA (PubMed:9049632).Curated5
Sequence conflicti364 – 370MSLNLEG → DEFGTRKE (PubMed:9049632).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012892150 – 166Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_012893286S → SRRSEAPVLPDVCLGLGSPS PGPRWARPWGSDCGRPGRQS DSCWWLQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289950 mRNA Translation: BAF82639.1
AL359938 mRNA Translation: CAB95771.1
CR749687 mRNA Translation: CAH18472.1
CH471126 Genomic DNA Translation: EAW57482.1
BC025404 mRNA Translation: AAH25404.1
BC069251 mRNA Translation: AAH69251.1
U68385 mRNA Translation: AAB19195.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33064.1 [Q99687-2]
CCDS46132.1 [Q99687-3]
CCDS74406.1 [Q99687-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001009813.1, NM_001009813.2 [Q99687-3]
NP_001287988.1, NM_001301059.1 [Q99687-1]
NP_064545.1, NM_020160.2 [Q99687-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000441740; ENSP00000388667; ENSG00000105419 [Q99687-3]
ENST00000558555; ENSP00000454073; ENSG00000105419 [Q99687-1]
ENST00000559524; ENSP00000452854; ENSG00000105419 [Q99687-2]
ENST00000561293; ENSP00000453307; ENSG00000105419 [Q99687-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56917

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56917

UCSC genome browser

More...
UCSCi
uc002pgs.5 human [Q99687-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289950 mRNA Translation: BAF82639.1
AL359938 mRNA Translation: CAB95771.1
CR749687 mRNA Translation: CAH18472.1
CH471126 Genomic DNA Translation: EAW57482.1
BC025404 mRNA Translation: AAH25404.1
BC069251 mRNA Translation: AAH69251.1
U68385 mRNA Translation: AAB19195.1
CCDSiCCDS33064.1 [Q99687-2]
CCDS46132.1 [Q99687-3]
CCDS74406.1 [Q99687-1]
RefSeqiNP_001009813.1, NM_001009813.2 [Q99687-3]
NP_001287988.1, NM_001301059.1 [Q99687-1]
NP_064545.1, NM_020160.2 [Q99687-2]

3D structure databases

SMRiQ99687
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121245, 3 interactors
IntActiQ99687, 24 interactors

PTM databases

iPTMnetiQ99687
PhosphoSitePlusiQ99687

Polymorphism and mutation databases

BioMutaiMEIS3
DMDMi59803105

Proteomic databases

jPOSTiQ99687
MassIVEiQ99687
MaxQBiQ99687
PeptideAtlasiQ99687
PRIDEiQ99687
ProteomicsDBi78398 [Q99687-1]
78399 [Q99687-2]
78400 [Q99687-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
56917

Genome annotation databases

EnsembliENST00000441740; ENSP00000388667; ENSG00000105419 [Q99687-3]
ENST00000558555; ENSP00000454073; ENSG00000105419 [Q99687-1]
ENST00000559524; ENSP00000452854; ENSG00000105419 [Q99687-2]
ENST00000561293; ENSP00000453307; ENSG00000105419 [Q99687-2]
GeneIDi56917
KEGGihsa:56917
UCSCiuc002pgs.5 human [Q99687-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56917

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEIS3
HGNCiHGNC:29537 MEIS3
HPAiHPA046699
neXtProtiNX_Q99687
OpenTargetsiENSG00000105419
PharmGKBiPA30742

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000161057
HOGENOMiHOG000253923
InParanoidiQ99687
KOiK16671
OMAiSGCREDL
OrthoDBi1126341at2759
PhylomeDBiQ99687
TreeFamiTF318093

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MEIS3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56917
PharosiQ99687

Protein Ontology

More...
PROi
PR:Q99687

Gene expression databases

BgeeiENSG00000105419 Expressed in 119 organ(s), highest expression level in myometrium
ExpressionAtlasiQ99687 baseline and differential
GenevisibleiQ99687 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEIS3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99687
Secondary accession number(s): A8K1N5
, Q6NT73, Q8TC66, Q9NPW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 15, 2005
Last modified: October 16, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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