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Entry version 165 (31 Jul 2019)
Sequence version 2 (10 May 2004)
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Protein

Monoglyceride lipase

Gene

MGLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).5 Publications

Miscellaneous

Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=110 µM for 2-arachidonoyglycerol1 Publication
  2. KM=15 µM for 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2-G)1 Publication
  1. Vmax=120 nmol/min/mg enzyme toward 2-arachidonoyglycerol1 Publication
  2. Vmax=89 nmol/min/mg enzyme toward 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2-G)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: triacylglycerol degradation

This protein is involved in the pathway triacylglycerol degradation, which is part of Glycerolipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway triacylglycerol degradation and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei122Nucleophile1 Publication1
Active sitei239Charge relay system1 Publication1
Active sitei269Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • lysophospholipase activity Source: ProtInc
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.23 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482883 Acyl chain remodeling of DAG and TAG
R-HSA-163560 Triglyceride catabolism
R-HSA-426048 Arachidonate production from DAG

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q99685

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00256

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

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ESTHERi
human-MGLL Monoglyceridelipase_lysophospholip

MEROPS protease database

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MEROPSi
S33.979

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000315

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monoglyceride lipase1 Publication (EC:3.1.1.235 Publications)
Short name:
MGLImported
Alternative name(s):
HU-K51 Publication
Lysophospholipase homolog
Lysophospholipase-like
Monoacylglycerol lipase1 Publication
Short name:
MAGL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGLLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17038 MGLL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609699 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99685

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi194Y → F: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol. 1 Publication1
Mutagenesisi201C → A: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol. 1 Publication1
Mutagenesisi208C → A: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol. 1 Publication1
Mutagenesisi242C → A: Reduced 1-monoacylglycerol lipase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
11343

Open Targets

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OpenTargetsi
ENSG00000074416

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30789

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4191

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1399

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGLL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117287

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001912651 – 303Monoglyceride lipaseAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphothreonineBy similarity1
Modified residuei58Nitrated tyrosineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99685

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99685

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99685

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99685

PeptideAtlas

More...
PeptideAtlasi
Q99685

PRoteomics IDEntifications database

More...
PRIDEi
Q99685

ProteomicsDB human proteome resource

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ProteomicsDBi
7025
78397 [Q99685-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99685

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99685

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adipose tissue, lung, liver, kidney, brain and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074416 Expressed in 246 organ(s), highest expression level in adipose tissue of abdominal region

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99685 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99685 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA011348
HPA011993
HPA011994

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ADRB2P075502EBI-721306,EBI-491169

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116471, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q99685, 6 interactors

Molecular INTeraction database

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MINTi
Q99685

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265052

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99685

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99685

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1455 Eukaryota
COG2267 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000003227

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99685

KEGG Orthology (KO)

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KOi
K01054

Database of Orthologous Groups

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OrthoDBi
1414461at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99685

TreeFam database of animal gene trees

More...
TreeFami
TF329184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR022742 Hydrolase_4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12146 Hydrolase_4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00111 ABHYDROLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00120 LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99685-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG
60 70 80 90 100
AGEHSGRYEE LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV
110 120 130 140 150
LQHVDSMQKD YPGLPVFLLG HSMGGAIAIL TAAERPGHFA GMVLISPLVL
160 170 180 190 200
ANPESATTFK VLAAKVLNLV LPNLSLGPID SSVLSRNKTE VDIYNSDPLI
210 220 230 240 250
CRAGLKVCFG IQLLNAVSRV ERALPKLTVP FLLLQGSADR LCDSKGAYLL
260 270 280 290 300
MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV SQRTATAGTA

SPP
Length:303
Mass (Da):33,261
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80E754F126EE64DE
GO
Isoform 2 (identifier: Q99685-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → METGPEDPSSM
     161-190: Missing.

Show »
Length:283
Mass (Da):31,149
Checksum:i5EE1BFA7CC9FBF26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFN3A0A0C4DFN3_HUMAN
Monoglyceride lipase
MGLL
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWX8E7EWX8_HUMAN
Monoglyceride lipase
MGLL
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4E0H7C4E0_HUMAN
Monoglyceride lipase
MGLL
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8Q3C9J8Q3_HUMAN
Monoglyceride lipase
MGLL
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAM4C9JAM4_HUMAN
Monoglyceride lipase
MGLL
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5K5H7C5K5_HUMAN
Monoglyceride lipase
MGLL
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C599H7C599_HUMAN
Monoglyceride lipase
MGLL
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITT3A0A3B3ITT3_HUMAN
Monoglyceride lipase
MGLL
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB39616 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH00551 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH06230 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG37910 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAG33116 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW79330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW79331 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144L → P in BAG52334 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451381M → METGPEDPSSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_045139161 – 190Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U67963 mRNA Translation: AAB39616.1 Different initiation.
AJ270950 mRNA Translation: CAC43316.1
AK091314 mRNA Translation: BAG52334.1
AK315529 mRNA Translation: BAG37910.1 Different initiation.
AK304844 mRNA Translation: BAH14267.1
CR456835 mRNA Translation: CAG33116.1 Different initiation.
AC023593 Genomic DNA No translation available.
AC117480 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79330.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79331.1 Different initiation.
BC000551 mRNA Translation: AAH00551.1 Different initiation.
BC006230 mRNA Translation: AAH06230.1 Different initiation.
BX640777 mRNA Translation: CAE45873.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43148.1 [Q99685-1]
CCDS58852.1 [Q99685-2]

NCBI Reference Sequences

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RefSeqi
NP_001003794.1, NM_001003794.2 [Q99685-1]
NP_001243514.1, NM_001256585.1 [Q99685-2]
NP_009214.1, NM_007283.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398104; ENSP00000381176; ENSG00000074416 [Q99685-1]
ENST00000434178; ENSP00000402798; ENSG00000074416 [Q99685-1]
ENST00000453507; ENSP00000404146; ENSG00000074416 [Q99685-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11343

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11343

UCSC genome browser

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UCSCi
uc003ejw.4 human [Q99685-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67963 mRNA Translation: AAB39616.1 Different initiation.
AJ270950 mRNA Translation: CAC43316.1
AK091314 mRNA Translation: BAG52334.1
AK315529 mRNA Translation: BAG37910.1 Different initiation.
AK304844 mRNA Translation: BAH14267.1
CR456835 mRNA Translation: CAG33116.1 Different initiation.
AC023593 Genomic DNA No translation available.
AC117480 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79330.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79331.1 Different initiation.
BC000551 mRNA Translation: AAH00551.1 Different initiation.
BC006230 mRNA Translation: AAH06230.1 Different initiation.
BX640777 mRNA Translation: CAE45873.1
CCDSiCCDS43148.1 [Q99685-1]
CCDS58852.1 [Q99685-2]
RefSeqiNP_001003794.1, NM_001003794.2 [Q99685-1]
NP_001243514.1, NM_001256585.1 [Q99685-2]
NP_009214.1, NM_007283.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HJUX-ray2.20A/B2-303[»]
3JW8X-ray2.10A/B1-303[»]
3JWEX-ray2.70A/B1-303[»]
3PE6X-ray1.35A1-303[»]
4UUQX-ray2.36A/B1-303[»]
5ZUNX-ray1.35A1-303[»]
6AX1X-ray2.26A/B1-303[»]
6BQ0X-ray2.00A/B1-303[»]
SMRiQ99685
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116471, 7 interactors
IntActiQ99685, 6 interactors
MINTiQ99685
STRINGi9606.ENSP00000265052

Chemistry databases

BindingDBiQ99685
ChEMBLiCHEMBL4191
GuidetoPHARMACOLOGYi1399
SwissLipidsiSLP:000000315

Protein family/group databases

ESTHERihuman-MGLL Monoglyceridelipase_lysophospholip
MEROPSiS33.979

PTM databases

iPTMnetiQ99685
PhosphoSitePlusiQ99685

Polymorphism and mutation databases

BioMutaiMGLL
DMDMi47117287

Proteomic databases

EPDiQ99685
jPOSTiQ99685
MaxQBiQ99685
PaxDbiQ99685
PeptideAtlasiQ99685
PRIDEiQ99685
ProteomicsDBi7025
78397 [Q99685-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398104; ENSP00000381176; ENSG00000074416 [Q99685-1]
ENST00000434178; ENSP00000402798; ENSG00000074416 [Q99685-1]
ENST00000453507; ENSP00000404146; ENSG00000074416 [Q99685-2]
GeneIDi11343
KEGGihsa:11343
UCSCiuc003ejw.4 human [Q99685-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11343
DisGeNETi11343

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MGLL
HGNCiHGNC:17038 MGLL
HPAiHPA011348
HPA011993
HPA011994
MIMi609699 gene
neXtProtiNX_Q99685
OpenTargetsiENSG00000074416
PharmGKBiPA30789

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1455 Eukaryota
COG2267 LUCA
GeneTreeiENSGT00390000011364
HOGENOMiHOG000003227
InParanoidiQ99685
KOiK01054
OrthoDBi1414461at2759
PhylomeDBiQ99685
TreeFamiTF329184

Enzyme and pathway databases

UniPathwayiUPA00256
BRENDAi3.1.1.23 2681
ReactomeiR-HSA-1482883 Acyl chain remodeling of DAG and TAG
R-HSA-163560 Triglyceride catabolism
R-HSA-426048 Arachidonate production from DAG
SABIO-RKiQ99685

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MGLL human
EvolutionaryTraceiQ99685

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11343

Protein Ontology

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PROi
PR:Q99685

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074416 Expressed in 246 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasiQ99685 baseline and differential
GenevisibleiQ99685 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGLL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99685
Secondary accession number(s): B3KRC2
, B7Z9D1, Q6IBG9, Q96AA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 31, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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