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Protein

Mitogen-activated protein kinase kinase kinase 5

Gene

MAP3K5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).18 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Activity regulationi

Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). Homophilic association of MAP3K5/ASK1 through the C-terminal coiled-coil domains and the heteromeric complex formation of MAP3K5/ASK1 with the reduced form of thioredoxin (TXN), constitutes an inactive form of the kinase (PubMed:17210579, PubMed:9564042). Upon ROS-induced dissociation of TXN from MAP3K5/ASK1, TRAF2 and TRAF6 are reciprocally recruited to MAP3K5/ASK1 and form the active MAP3K5/ASK1 signalosome, in which TRAF2 and TRAF6 appear to facilitate the active configuration of MAP3K5/ASK1 (PubMed:9774977, PubMed:10688666, PubMed:11920685). MAP3K5/ASK1 activity is also regulated through several phosphorylation and dephosphorylation events. Thr-838 is an activating phosphorylation site that is autophosphorylated and phosphorylated by MAP3K6/ASK2 and dephosphorylated by PPP5C (PubMed:11689443). Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2 (PubMed:11154276, PubMed:12697749, PubMed:15094778). Phosphorylation of Ser-966 induces association of MAP3K5/ASK1 with the 14-3-3 family proteins, which suppresses MAP3K5/ASK1 activity (PubMed:10411906, PubMed:14688258). Calcium/calmodulin-activated protein phosphatase calcineurin (PPP3CA) has been shown to directly dephosphorylate this site (PubMed:14749717). SOCS1 binds to ASK1 by recognizing phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells (PubMed:16407264). Also dephosphorylated and activated by PGAM5. Contains an N-terminal autoinhibitory domain. Once activated targeted for proteosomal degradation by RC3H2-mediated ubiquitination (PubMed:24448648).15 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei709ATP1
Active sitei803Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi686 – 694ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Host-virus interaction, Immunity, Innate immunity, Stress response
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2 2681
ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
SignaLinkiQ99683
SIGNORiQ99683

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)
Alternative name(s):
Apoptosis signal-regulating kinase 1
Short name:
ASK-1
MAPK/ERK kinase kinase 5
Short name:
MEK kinase 5
Short name:
MEKK 5
Gene namesi
Name:MAP3K5
Synonyms:ASK1, MAPKKK5, MEKK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000197442.9
HGNCiHGNC:6857 MAP3K5
MIMi602448 gene
neXtProtiNX_Q99683

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi709K → M: Loss of kinase activity. Inhibits activation of JNK and apoptosis mediated by TNFRSF6 and DAXX. 2 Publications1
Mutagenesisi709K → R: Loss of kinase activity. Abolishes DAXX-mediated apoptosis. Loss of RC3H2-mediated ubiquitination. 3 Publications1
Mutagenesisi966S → A: Enhanced induction of apoptosis, increased kinase activity, and loss of YWHAG binding. 2 Publications1
Mutagenesisi1033S → A: Enhanced induction of apoptosis and increased kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi4217
OpenTargetsiENSG00000197442
PharmGKBiPA30601

Chemistry databases

ChEMBLiCHEMBL5285
GuidetoPHARMACOLOGYi2080

Polymorphism and mutation databases

BioMutaiMAP3K5
DMDMi6685617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862491 – 1374Mitogen-activated protein kinase kinase kinase 5Add BLAST1374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83Phosphoserine; by PIM1, PKB/AKT1 and PKB/AKT23 Publications1
Modified residuei718Phosphotyrosine1 Publication1
Modified residuei813Phosphothreonine; by autocatalysis1 Publication1
Modified residuei838Phosphothreonine; by autocatalysis, MELK and MAP3K66 Publications1
Modified residuei842Phosphothreonine; by autocatalysis1 Publication1
Modified residuei958PhosphoserineCombined sources1
Modified residuei966Phosphoserine3 Publications1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources2 Publications1

Post-translational modificationi

Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5.13 Publications
Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99683
MaxQBiQ99683
PaxDbiQ99683
PeptideAtlasiQ99683
PRIDEiQ99683
ProteomicsDBi78395

PTM databases

CarbonylDBiQ99683
iPTMnetiQ99683
PhosphoSitePlusiQ99683

Expressioni

Tissue specificityi

Abundantly expressed in heart and pancreas.

Inductioni

By TNF. Inhibited by HIV-1 Nef.

Gene expression databases

BgeeiENSG00000197442 Expressed in 225 organ(s), highest expression level in primary visual cortex
CleanExiHS_MAP3K5
GenevisibleiQ99683 HS

Organism-specific databases

HPAiCAB007824
HPA063245
HPA064423

Interactioni

Subunit structurei

Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF (PubMed:15310755, PubMed:15701637, PubMed:17210579, PubMed:17389591). This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Interacts with SOCS1 which recognizes phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells. Interacts with the 14-3-3 family proteins such as YWHAB, YWHAE, YWHAQ, YWHAH, YWHAZ and SFN (PubMed:10411906, PubMed:15023544, PubMed:15094778). Interacts with ARRB2, BIRC2, DAB2IP, IGF1R, MAP3K6/ASK2, PGAM5, PIM1, PPP5C, SOCS1, STUB1, TRAF2, TRAF6 and TXN (PubMed:9564042,PubMed:9774977, PubMed:10688666, PubMed:11090355, PubMed:11689443, PubMed:12556535, PubMed:12813029, PubMed:15310755, PubMed:16038411, PubMed:16129676, PubMed:16407264, PubMed:17220297, PubMed:17724081, PubMed:18408005, PubMed:19590015, PubMed:19749799). Interacts with ERN1 in a TRAF2-dependent manner (PubMed:14749717). Interacts with calcineurin subunit PPP3R1 and with PPM1L (PubMed:17456047) (By similarity). Interacts (via N-terminus) with RAF1 and this interaction inhibits the proapoptotic function of MAP3K5 (PubMed:11427728). Interacts with DAB2IP (via N-terminus C2 domain); the interaction occurs in a TNF-alpha-dependent manner (PubMed:15310755). Interacts with DUSP13/DUSP13A; may positively regulate apoptosis (PubMed:20358250). Interacts with DAXX (PubMed:9743501). Interacts with RC3H2 (PubMed:24448648).By similarity28 Publications
(Microbial infection) Interacts with HIV-1 Nef; this interaction inhibits MAP3K5 signaling.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110381, 85 interactors
CORUMiQ99683
DIPiDIP-29516N
ELMiQ99683
IntActiQ99683, 42 interactors
MINTiQ99683
STRINGi9606.ENSP00000351908

Chemistry databases

BindingDBiQ99683

Structurei

Secondary structure

11374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99683
SMRiQ99683
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99683

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini680 – 938Protein kinasePROSITE-ProRule annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1245 – 1285Sequence analysisAdd BLAST41

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00920000149049
HOGENOMiHOG000293286
HOVERGENiHBG006305
InParanoidiQ99683
KOiK04426
OMAiTELHCKK
OrthoDBiEOG091G00SJ
PhylomeDBiQ99683
TreeFamiTF105115

Family and domain databases

InterProiView protein in InterPro
IPR025136 DUF4071
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13281 DUF4071, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q99683-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP
60 70 80 90 100
PGSFWNVESA AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA
110 120 130 140 150
SQGQLVVAES EALQSLREAC ETVGATLETL HFGKLDFGET TVLDRFYNAD
160 170 180 190 200
IAVVEMSDAF RQPSLFYHLG VRESFSMANN IILYCDTNSD SLQSLKEIIC
210 220 230 240 250
QKNTMCTGNY TFVPYMITPH NKVYCCDSSF MKGLTELMQP NFELLLGPIC
260 270 280 290 300
LPLVDRFIQL LKVAQASSSQ YFRESILNDI RKARNLYTGK ELAAELARIR
310 320 330 340 350
QRVDNIEVLT ADIVINLLLS YRDIQDYDSI VKLVETLEKL PTFDLASHHH
360 370 380 390 400
VKFHYAFALN RRNLPGDRAK ALDIMIPMVQ SEGQVASDMY CLVGRIYKDM
410 420 430 440 450
FLDSNFTDTE SRDHGASWFK KAFESEPTLQ SGINYAVLLL AAGHQFESSF
460 470 480 490 500
ELRKVGVKLS SLLGKKGNLE KLQSYWEVGF FLGASVLAND HMRVIQASEK
510 520 530 540 550
LFKLKTPAWY LKSIVETILI YKHFVKLTTE QPVAKQELVD FWMDFLVEAT
560 570 580 590 600
KTDVTVVRFP VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKKGIH
610 620 630 640 650
EWNFSASSVR GVSISKFEER CCFLYVLHNS DDFQIYFCTE LHCKKFFEMV
660 670 680 690 700
NTITEEKGRS TEEGDCESDL LEYDYEYDEN GDRVVLGKGT YGIVYAGRDL
710 720 730 740 750
SNQVRIAIKE IPERDSRYSQ PLHEEIALHK HLKHKNIVQY LGSFSENGFI
760 770 780 790 800
KIFMEQVPGG SLSALLRSKW GPLKDNEQTI GFYTKQILEG LKYLHDNQIV
810 820 830 840 850
HRDIKGDNVL INTYSGVLKI SDFGTSKRLA GINPCTETFT GTLQYMAPEI
860 870 880 890 900
IDKGPRGYGK AADIWSLGCT IIEMATGKPP FYELGEPQAA MFKVGMFKVH
910 920 930 940 950
PEIPESMSAE AKAFILKCFE PDPDKRACAN DLLVDEFLKV SSKKKKTQPK
960 970 980 990 1000
LSALSAGSNE YLRSISLPVP VLVEDTSSSS EYGSVSPDTE LKVDPFSFKT
1010 1020 1030 1040 1050
RAKSCGERDV KGIRTLFLGI PDENFEDHSA PPSPEEKDSG FFMLRKDSER
1060 1070 1080 1090 1100
RATLHRILTE DQDKIVRNLM ESLAQGAEEP KLKWEHITTL IASLREFVRS
1110 1120 1130 1140 1150
TDRKIIATTL SKLKLELDFD SHGISQVQVV LFGFQDAVNK VLRNHNIKPH
1160 1170 1180 1190 1200
WMFALDSIIR KAVQTAITIL VPELRPHFSL ASESDTADQE DLDVEDDHEE
1210 1220 1230 1240 1250
QPSNQTVRRP QAVIEDAVAT SGVSTLSSTV SHDSQSAHRS LNVQLGRMKI
1260 1270 1280 1290 1300
ETNRLLEELV RKEKELQALL HRAIEEKDQE IKHLKLKSQP IEIPELPVFH
1310 1320 1330 1340 1350
LNSSGTNTED SELTDWLRVN GADEDTISRF LAEDYTLLDV LYYVTRDDLK
1360 1370
CLRLRGGMLC TLWKAIIDFR NKQT
Length:1,374
Mass (Da):154,537
Last modified:May 1, 1997 - v1
Checksum:i265BDC65968AF985
GO
Isoform 2 (identifier: Q99683-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):69,839
Checksum:i7EFE3AD82F6AB9FF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0406931006G → R1 PublicationCorresponds to variant dbSNP:rs45626535Ensembl.1
Natural variantiVAR_0406941214I → T1 PublicationCorresponds to variant dbSNP:rs56379668Ensembl.1
Natural variantiVAR_0406951250I → V1 PublicationCorresponds to variant dbSNP:rs35551087Ensembl.1
Natural variantiVAR_0406961314T → I1 PublicationCorresponds to variant dbSNP:rs45599539Ensembl.1
Natural variantiVAR_0406971315D → N1 PublicationCorresponds to variant dbSNP:rs41288957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561821 – 753Missing in isoform 2. 1 PublicationAdd BLAST753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67156 mRNA Translation: AAC50894.1
D84476 mRNA Translation: BAA12684.2
AK294507 mRNA Translation: BAG57723.1
AL024508 Genomic DNA No translation available.
AL121933 Genomic DNA No translation available.
BC054503 mRNA Translation: AAH54503.1
BC088829 mRNA Translation: AAH88829.1
CCDSiCCDS5179.1 [Q99683-1]
RefSeqiNP_005914.1, NM_005923.3 [Q99683-1]
UniGeneiHs.186486

Genome annotation databases

EnsembliENST00000359015; ENSP00000351908; ENSG00000197442 [Q99683-1]
GeneIDi4217
KEGGihsa:4217
UCSCiuc003qhc.4 human [Q99683-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67156 mRNA Translation: AAC50894.1
D84476 mRNA Translation: BAA12684.2
AK294507 mRNA Translation: BAG57723.1
AL024508 Genomic DNA No translation available.
AL121933 Genomic DNA No translation available.
BC054503 mRNA Translation: AAH54503.1
BC088829 mRNA Translation: AAH88829.1
CCDSiCCDS5179.1 [Q99683-1]
RefSeqiNP_005914.1, NM_005923.3 [Q99683-1]
UniGeneiHs.186486

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLQX-ray2.30A/B659-951[»]
3VW6X-ray2.40A/B671-939[»]
4BF2X-ray2.11A/B660-977[»]
4BHNX-ray2.30A/B660-977[»]
4BIBX-ray2.43A/B660-977[»]
4BICX-ray2.62A/B660-977[»]
4BIDX-ray2.80A/B660-977[»]
4BIEX-ray2.36A/B660-977[»]
5ULMX-ray2.10A/B269-658[»]
5UORX-ray2.75A/B670-939[»]
5UOXX-ray2.50A/B670-940[»]
5UP3X-ray2.95A/B670-940[»]
5V19X-ray3.10A/B670-940[»]
5V24X-ray2.50A/B670-940[»]
5VILX-ray2.64A/B/C/D659-951[»]
5VIOX-ray2.84A/B/C/D659-951[»]
6EJLX-ray2.38C/D963-970[»]
ProteinModelPortaliQ99683
SMRiQ99683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110381, 85 interactors
CORUMiQ99683
DIPiDIP-29516N
ELMiQ99683
IntActiQ99683, 42 interactors
MINTiQ99683
STRINGi9606.ENSP00000351908

Chemistry databases

BindingDBiQ99683
ChEMBLiCHEMBL5285
GuidetoPHARMACOLOGYi2080

PTM databases

CarbonylDBiQ99683
iPTMnetiQ99683
PhosphoSitePlusiQ99683

Polymorphism and mutation databases

BioMutaiMAP3K5
DMDMi6685617

Proteomic databases

EPDiQ99683
MaxQBiQ99683
PaxDbiQ99683
PeptideAtlasiQ99683
PRIDEiQ99683
ProteomicsDBi78395

Protocols and materials databases

DNASUi4217
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359015; ENSP00000351908; ENSG00000197442 [Q99683-1]
GeneIDi4217
KEGGihsa:4217
UCSCiuc003qhc.4 human [Q99683-1]

Organism-specific databases

CTDi4217
DisGeNETi4217
EuPathDBiHostDB:ENSG00000197442.9
GeneCardsiMAP3K5
HGNCiHGNC:6857 MAP3K5
HPAiCAB007824
HPA063245
HPA064423
MIMi602448 gene
neXtProtiNX_Q99683
OpenTargetsiENSG00000197442
PharmGKBiPA30601
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00920000149049
HOGENOMiHOG000293286
HOVERGENiHBG006305
InParanoidiQ99683
KOiK04426
OMAiTELHCKK
OrthoDBiEOG091G00SJ
PhylomeDBiQ99683
TreeFamiTF105115

Enzyme and pathway databases

BRENDAi2.7.12.2 2681
ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
SignaLinkiQ99683
SIGNORiQ99683

Miscellaneous databases

ChiTaRSiMAP3K5 human
EvolutionaryTraceiQ99683
GeneWikiiASK1
GenomeRNAii4217
PROiPR:Q99683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197442 Expressed in 225 organ(s), highest expression level in primary visual cortex
CleanExiHS_MAP3K5
GenevisibleiQ99683 HS

Family and domain databases

InterProiView protein in InterPro
IPR025136 DUF4071
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13281 DUF4071, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM3K5_HUMAN
AccessioniPrimary (citable) accession number: Q99683
Secondary accession number(s): A6NIA0
, B4DGB2, Q5THN3, Q99461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 10, 2018
This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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