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Protein

Lysophosphatidic acid receptor 4

Gene

LPAR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors

Protein family/group databases

TCDBi9.A.14.13.9 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001577

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 4
Short name:
LPA receptor 4
Short name:
LPA-4
Alternative name(s):
G-protein coupled receptor 23
P2Y purinoceptor 9
Short name:
P2Y9
P2Y5-like receptor
Purinergic receptor 9
Gene namesi
Name:LPAR4
Synonyms:GPR23, LPA4, P2RY9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147145.12
HGNCiHGNC:4478 LPAR4
MIMi300086 gene
neXtProtiNX_Q99677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 155CytoplasmicSequence analysisAdd BLAST22
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 203ExtracellularSequence analysisAdd BLAST27
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 254CytoplasmicSequence analysisAdd BLAST30
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini276 – 294ExtracellularSequence analysisAdd BLAST19
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 370CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2846
MalaCardsiLPAR4
OpenTargetsiENSG00000147145
Orphaneti146 Differentiated thyroid carcinoma
PharmGKBiPA162394222

Chemistry databases

ChEMBLiCHEMBL5968
GuidetoPHARMACOLOGYi94

Polymorphism and mutation databases

BioMutaiLPAR4
DMDMi2495042

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700331 – 370Lysophosphatidic acid receptor 4Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ99677
PRIDEiQ99677
ProteomicsDBi78391

PTM databases

iPTMnetiQ99677
PhosphoSitePlusiQ99677

Expressioni

Tissue specificityi

High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.1 Publication

Gene expression databases

BgeeiENSG00000147145 Expressed in 122 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_LPAR4
ExpressionAtlasiQ99677 baseline and differential
GenevisibleiQ99677 HS

Organism-specific databases

HPAiHPA046563
HPA054951
HPA055571

Interactioni

Protein-protein interaction databases

BioGridi109105, 39 interactors
IntActiQ99677, 1 interactor
STRINGi9606.ENSP00000362398

Chemistry databases

BindingDBiQ99677

Structurei

3D structure databases

ProteinModelPortaliQ99677
SMRiQ99677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ99677
KOiK04275
OMAiSTTCFEG
OrthoDBiEOG091G0BRE
PhylomeDBiQ99677
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDRRFIDFQ FQDSNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF
60 70 80 90 100
ILGLITNSVS LFVFCFRMKM RSETAIFITN LAVSDLLFVC TLPFKIFYNF
110 120 130 140 150
NRHWPFGDTL CKISGTAFLT NIYGSMLFLT CISVDRFLAI VYPFRSRTIR
160 170 180 190 200
TRRNSAIVCA GVWILVLSGG ISASLFSTTN VNNATTTCFE GFSKRVWKTY
210 220 230 240 250
LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI GTNKKKVLKM
260 270 280 290 300
ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCFLERFAK IMYPITLCLA
310 320 330 340 350
TLNCCFDPFI YYFTLESFQK SFYINAHIRM ESLFKTETPL TTKPSLPAIQ
360 370
EEVSDQTTNN GGELMLESTF
Length:370
Mass (Da):41,895
Last modified:May 1, 1997 - v1
Checksum:i20857F52A3929E48
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GY74V9GY74_HUMAN
Lysophosphatidic acid receptor 4
LPAR4
45Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49V → A in AAH69996 (PubMed:15489334).Curated1
Sequence conflicti192F → L in AAB66322 (PubMed:9223435).Curated1
Sequence conflicti240I → V in AAH95538 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66578 Genomic DNA Translation: AAC51301.1
U90323 Genomic DNA Translation: AAB62087.1
U90322 mRNA Translation: AAB62088.1
AF005419 Genomic DNA Translation: AAB66322.1
AY301274 Genomic DNA Translation: AAP58404.1
AK314134 mRNA Translation: BAG36824.1
AL590083 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98596.1
BC069996 mRNA Translation: AAH69996.1
BC074722 mRNA Translation: AAH74722.1
BC095538 mRNA Translation: AAH95538.1
CCDSiCCDS14441.1
PIRiJC5549
RefSeqiNP_001264929.1, NM_001278000.1
NP_005287.1, NM_005296.2
XP_005262183.1, XM_005262126.3
XP_006724702.1, XM_006724639.3
XP_016884926.1, XM_017029437.1
XP_016884927.1, XM_017029438.1
UniGeneiHs.522701

Genome annotation databases

EnsembliENST00000435339; ENSP00000408205; ENSG00000147145
ENST00000614823; ENSP00000478261; ENSG00000147145
GeneIDi2846
KEGGihsa:2846
UCSCiuc010nme.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66578 Genomic DNA Translation: AAC51301.1
U90323 Genomic DNA Translation: AAB62087.1
U90322 mRNA Translation: AAB62088.1
AF005419 Genomic DNA Translation: AAB66322.1
AY301274 Genomic DNA Translation: AAP58404.1
AK314134 mRNA Translation: BAG36824.1
AL590083 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98596.1
BC069996 mRNA Translation: AAH69996.1
BC074722 mRNA Translation: AAH74722.1
BC095538 mRNA Translation: AAH95538.1
CCDSiCCDS14441.1
PIRiJC5549
RefSeqiNP_001264929.1, NM_001278000.1
NP_005287.1, NM_005296.2
XP_005262183.1, XM_005262126.3
XP_006724702.1, XM_006724639.3
XP_016884926.1, XM_017029437.1
XP_016884927.1, XM_017029438.1
UniGeneiHs.522701

3D structure databases

ProteinModelPortaliQ99677
SMRiQ99677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109105, 39 interactors
IntActiQ99677, 1 interactor
STRINGi9606.ENSP00000362398

Chemistry databases

BindingDBiQ99677
ChEMBLiCHEMBL5968
GuidetoPHARMACOLOGYi94
SwissLipidsiSLP:000001577

Protein family/group databases

TCDBi9.A.14.13.9 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ99677
PhosphoSitePlusiQ99677

Polymorphism and mutation databases

BioMutaiLPAR4
DMDMi2495042

Proteomic databases

PaxDbiQ99677
PRIDEiQ99677
ProteomicsDBi78391

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435339; ENSP00000408205; ENSG00000147145
ENST00000614823; ENSP00000478261; ENSG00000147145
GeneIDi2846
KEGGihsa:2846
UCSCiuc010nme.4 human

Organism-specific databases

CTDi2846
DisGeNETi2846
EuPathDBiHostDB:ENSG00000147145.12
GeneCardsiLPAR4
HGNCiHGNC:4478 LPAR4
HPAiHPA046563
HPA054951
HPA055571
MalaCardsiLPAR4
MIMi300086 gene
neXtProtiNX_Q99677
OpenTargetsiENSG00000147145
Orphaneti146 Differentiated thyroid carcinoma
PharmGKBiPA162394222
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFM0 Eukaryota
ENOG41115C6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG101917
InParanoidiQ99677
KOiK04275
OMAiSTTCFEG
OrthoDBiEOG091G0BRE
PhylomeDBiQ99677
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors

Miscellaneous databases

GeneWikiiLPAR4
GenomeRNAii2846
PROiPR:Q99677
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147145 Expressed in 122 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_LPAR4
ExpressionAtlasiQ99677 baseline and differential
GenevisibleiQ99677 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR4_HUMAN
AccessioniPrimary (citable) accession number: Q99677
Secondary accession number(s): B2RAC7
, O15132, Q502U9, Q6NSP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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