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Entry version 180 (22 Apr 2020)
Sequence version 4 (30 Nov 2010)
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Protein

Zinc finger protein 184

Gene

ZNF184

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12975 ZNF184

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602277 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99676

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7738

Open Targets

More...
OpenTargetsi
ENSG00000096654

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37557

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99676 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF184

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474431 – 751Zinc finger protein 184Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei117PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99676

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99676

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99676

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99676

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99676

PeptideAtlas

More...
PeptideAtlasi
Q99676

PRoteomics IDEntifications database

More...
PRIDEi
Q99676

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78390

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99676

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99676

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominant expression in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000096654 Expressed in Brodmann (1909) area 23 and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99676 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99676 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000096654 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113524, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q99676, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000211936

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99676 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99676

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 99KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162941

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99676

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
WIVEPSI

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99676

TreeFam database of animal gene trees

More...
TreeFami
TF350822

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99676-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR
60 70 80 90 100
DLFRDVTLEN YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD
110 120 130 140 150
WETRLENSVS APEPDISEEE LSPEVIVEKH KRDDSWSSNL LESWEYEGSL
160 170 180 190 200
ERQQANQQTL PKEIKVTEKT IPSWEKGPVN NEFGKSVNVS SNLVTQEPSP
210 220 230 240 250
EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH QRTHTGEKPY
260 270 280 290 300
KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH
310 320 330 340 350
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM
360 370 380 390 400
EHQKIHTGEK PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN
410 420 430 440 450
GPSTFIRHHM IHTGEKPYEC NECGKAFSQH SNLTQHQKTH TGEKPYDCAE
460 470 480 490 500
CGKSFSYWSS LAQHLKIHTG EKPYKCNECG KAFSYCSSLT QHRRIHTREK
510 520 530 540 550
PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI RSSSLAKHER
560 570 580 590 600
IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH
610 620 630 640 650
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT
660 670 680 690 700
FSQSSHLTQH QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC
710 720 730 740 750
NECRKTFSQS TYLIQHQRIH SGEKPFGCND CGKSFRYRSA LNKHQRLHPG

I
Length:751
Mass (Da):86,174
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i249DFB302C6BC97D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti286G → C in BAG35662 (PubMed:14702039).Curated1
Sequence conflicti295Q → R in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti359E → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti379 – 381QHQ → PHP in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti498R → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti526Q → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti533K → E in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti547 – 549KHE → QHQ in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti746R → K in AAC51180 (PubMed:9073517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04598927A → S3 PublicationsCorresponds to variant dbSNP:rs1883216Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK312804 mRNA Translation: BAG35662.1
AL021918 Genomic DNA No translation available.
BC022992 mRNA Translation: AAH22992.1
U66561 mRNA Translation: AAC51180.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4624.1

NCBI Reference Sequences

More...
RefSeqi
NP_001305820.1, NM_001318891.1
NP_001305821.1, NM_001318892.1
NP_001305822.1, NM_001318893.1
NP_001334761.1, NM_001347832.1
NP_009080.2, NM_007149.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000211936; ENSP00000211936; ENSG00000096654
ENST00000377419; ENSP00000366636; ENSG00000096654

Database of genes from NCBI RefSeq genomes

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GeneIDi
7738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7738

UCSC genome browser

More...
UCSCi
uc003nji.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312804 mRNA Translation: BAG35662.1
AL021918 Genomic DNA No translation available.
BC022992 mRNA Translation: AAH22992.1
U66561 mRNA Translation: AAC51180.1
CCDSiCCDS4624.1
RefSeqiNP_001305820.1, NM_001318891.1
NP_001305821.1, NM_001318892.1
NP_001305822.1, NM_001318893.1
NP_001334761.1, NM_001347832.1
NP_009080.2, NM_007149.2

3D structure databases

SMRiQ99676
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113524, 22 interactors
IntActiQ99676, 16 interactors
STRINGi9606.ENSP00000211936

PTM databases

iPTMnetiQ99676
PhosphoSitePlusiQ99676

Polymorphism and mutation databases

BioMutaiZNF184
DMDMi313104299

Proteomic databases

EPDiQ99676
jPOSTiQ99676
MassIVEiQ99676
MaxQBiQ99676
PaxDbiQ99676
PeptideAtlasiQ99676
PRIDEiQ99676
ProteomicsDBi78390

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
824 58 antibodies

The DNASU plasmid repository

More...
DNASUi
7738

Genome annotation databases

EnsembliENST00000211936; ENSP00000211936; ENSG00000096654
ENST00000377419; ENSP00000366636; ENSG00000096654
GeneIDi7738
KEGGihsa:7738
UCSCiuc003nji.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7738
DisGeNETi7738

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF184
HGNCiHGNC:12975 ZNF184
HPAiENSG00000096654 Low tissue specificity
MIMi602277 gene
neXtProtiNX_Q99676
OpenTargetsiENSG00000096654
PharmGKBiPA37557

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162941
HOGENOMiCLU_002678_44_5_1
InParanoidiQ99676
KOiK09228
OMAiWIVEPSI
OrthoDBi1318335at2759
PhylomeDBiQ99676
TreeFamiTF350822

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF184 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF184

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7738
PharosiQ99676 Tdark

Protein Ontology

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PROi
PR:Q99676
RNActiQ99676 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000096654 Expressed in Brodmann (1909) area 23 and 197 other tissues
ExpressionAtlasiQ99676 baseline and differential
GenevisibleiQ99676 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN184_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: April 22, 2020
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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