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Protein

Zinc finger protein 184

Gene

ZNF184

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 184
Gene namesi
Name:ZNF184
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096654.15
HGNCiHGNC:12975 ZNF184
MIMi602277 gene
neXtProtiNX_Q99676

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000096654
PharmGKBiPA37557

Polymorphism and mutation databases

BioMutaiZNF184
DMDMi313104299

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474431 – 751Zinc finger protein 184Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99676
MaxQBiQ99676
PaxDbiQ99676
PeptideAtlasiQ99676
PRIDEiQ99676
ProteomicsDBi78390

PTM databases

iPTMnetiQ99676
PhosphoSitePlusiQ99676

Expressioni

Tissue specificityi

Predominant expression in testis.

Gene expression databases

BgeeiENSG00000096654
CleanExiHS_ZNF184
ExpressionAtlasiQ99676 baseline and differential
GenevisibleiQ99676 HS

Organism-specific databases

HPAiHPA003226
HPA064793

Interactioni

Protein-protein interaction databases

BioGridi113524, 20 interactors
IntActiQ99676, 3 interactors
STRINGi9606.ENSP00000211936

Structurei

3D structure databases

ProteinModelPortaliQ99676
SMRiQ99676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 99KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri670 – 692C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri698 – 720C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri726 – 748C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148943
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ99676
KOiK09228
OMAiMEPSIPV
OrthoDBiEOG091G02KC
PhylomeDBiQ99676
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

Q99676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR
60 70 80 90 100
DLFRDVTLEN YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD
110 120 130 140 150
WETRLENSVS APEPDISEEE LSPEVIVEKH KRDDSWSSNL LESWEYEGSL
160 170 180 190 200
ERQQANQQTL PKEIKVTEKT IPSWEKGPVN NEFGKSVNVS SNLVTQEPSP
210 220 230 240 250
EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH QRTHTGEKPY
260 270 280 290 300
KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH
310 320 330 340 350
TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM
360 370 380 390 400
EHQKIHTGEK PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN
410 420 430 440 450
GPSTFIRHHM IHTGEKPYEC NECGKAFSQH SNLTQHQKTH TGEKPYDCAE
460 470 480 490 500
CGKSFSYWSS LAQHLKIHTG EKPYKCNECG KAFSYCSSLT QHRRIHTREK
510 520 530 540 550
PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI RSSSLAKHER
560 570 580 590 600
IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH
610 620 630 640 650
LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT
660 670 680 690 700
FSQSSHLTQH QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC
710 720 730 740 750
NECRKTFSQS TYLIQHQRIH SGEKPFGCND CGKSFRYRSA LNKHQRLHPG

I
Length:751
Mass (Da):86,174
Last modified:November 30, 2010 - v4
Checksum:i249DFB302C6BC97D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286G → C in BAG35662 (PubMed:14702039).Curated1
Sequence conflicti295Q → R in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti359E → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti379 – 381QHQ → PHP in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti498R → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti526Q → G in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti533K → E in AAC51180 (PubMed:9073517).Curated1
Sequence conflicti547 – 549KHE → QHQ in AAC51180 (PubMed:9073517).Curated3
Sequence conflicti746R → K in AAC51180 (PubMed:9073517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04598927A → S3 PublicationsCorresponds to variant dbSNP:rs1883216Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312804 mRNA Translation: BAG35662.1
AL021918 Genomic DNA No translation available.
BC022992 mRNA Translation: AAH22992.1
U66561 mRNA Translation: AAC51180.1
CCDSiCCDS4624.1
RefSeqiNP_001305820.1, NM_001318891.1
NP_001305821.1, NM_001318892.1
NP_001305822.1, NM_001318893.1
NP_001334761.1, NM_001347832.1
NP_009080.2, NM_007149.2
UniGeneiHs.158174
Hs.661037

Genome annotation databases

EnsembliENST00000211936; ENSP00000211936; ENSG00000096654
ENST00000377419; ENSP00000366636; ENSG00000096654
GeneIDi7738
KEGGihsa:7738
UCSCiuc003nji.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN184_HUMAN
AccessioniPrimary (citable) accession number: Q99676
Secondary accession number(s): B2R715, O60792, Q8TBA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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