UniProtKB - Q99666 (RGPD5_HUMAN)
Protein
RANBP2-like and GRIP domain-containing protein 5/6
Gene
RGPD5
moreOrganism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.
GO - Molecular functioni
- Ran GTPase binding Source: GO_Central
GO - Biological processi
- NLS-bearing protein import into nucleus Source: GO_Central
- positive regulation of GTPase activity Source: GOC
Enzyme and pathway databases
PathwayCommonsi | Q99666 |
Names & Taxonomyi
Protein namesi | Recommended name: RANBP2-like and GRIP domain-containing protein 5/6Alternative name(s): Ran-binding protein 2-like 1/2 Short name: RanBP2-like 1/2 Short name: RanBP2L1 Short name: RanBP2L2 Sperm membrane protein BS-63 |
Gene namesi | Name:RGPD5 Synonyms:RANBP2L1, RGP5, RGP7, RGPD7 AND Name:RGPD6 Synonyms:RANBP2L2, RGP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000015568.12 HostDB:ENSG00000183054.11 |
HGNCi | HGNC:32418, RGPD5 HGNC:32419, RGPD6 |
MIMi | 612708, gene 612709, gene 612710, gene |
neXtProti | NX_Q99666 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Nucleus
- nuclear pore Source: GO_Central
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000015568 |
PharmGKBi | PA142671074 |
Miscellaneous databases
Pharosi | Q99666, Tdark |
Polymorphism and mutation databases
BioMutai | RGPD5 |
DMDMi | 229463026 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204915 | 1 – 1765 | RANBP2-like and GRIP domain-containing protein 5/6Add BLAST | 1765 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99666 |
jPOSTi | Q99666 |
MassIVEi | Q99666 |
PaxDbi | Q99666 |
PeptideAtlasi | Q99666 |
PRIDEi | Q99666 |
ProteomicsDBi | 78386 [Q99666-1] 78387 [Q99666-2] |
PTM databases
iPTMneti | Q99666 |
PhosphoSitePlusi | Q99666 |
Expressioni
Tissue specificityi
Expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000015568, Expressed in testis and 213 other tissues |
ExpressionAtlasi | Q99666, baseline and differential |
Genevisiblei | Q99666, HS |
Organism-specific databases
HPAi | ENSG00000015568, Low tissue specificity ENSG00000183054, Low tissue specificity |
Interactioni
GO - Molecular functioni
- Ran GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123954, 51 interactors 609938, 5 interactors |
IntActi | Q99666, 36 interactors |
MINTi | Q99666 |
STRINGi | 9606.ENSP00000330842 |
Miscellaneous databases
RNActi | Q99666, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 59 | TPR 1Add BLAST | 34 | |
Repeati | 60 – 93 | TPR 2Add BLAST | 34 | |
Repeati | 648 – 681 | TPR 3Add BLAST | 34 | |
Domaini | 1036 – 1172 | RanBD1 1PROSITE-ProRule annotationAdd BLAST | 137 | |
Domaini | 1333 – 1469 | RanBD1 2PROSITE-ProRule annotationAdd BLAST | 137 | |
Domaini | 1702 – 1752 | GRIPPROSITE-ProRule annotationAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1261 – 1266 | Poly-Ser | 6 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00940000164065 |
HOGENOMi | CLU_022433_0_0_1 |
InParanoidi | Q99666 |
OrthoDBi | 201737at2759 |
PhylomeDBi | Q99666 |
TreeFami | TF314797 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR032023, GCC2_Rab_bind IPR000237, GRIP_dom IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF01465, GRIP, 1 hit PF16704, Rab_bind, 1 hit PF00638, Ran_BP1, 2 hits |
SMARTi | View protein in SMART SM00755, Grip, 1 hit SM00160, RanBD, 2 hits SM00028, TPR, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50913, GRIP, 1 hit PS50196, RANBD1, 2 hits PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q99666-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC
60 70 80 90 100
TYINVQERDP KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
160 170 180 190 200
FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVAHCHE AERNIALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LESDKSDWQA TNTDLLLAYA NLMLLTLSTR
260 270 280 290 300
DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK
310 320 330 340 350
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD
360 370 380 390 400
RLSQSGHMLL SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS
410 420 430 440 450
FLGSDDIGKI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA
460 470 480 490 500
LPGIRKWLKQ LFHRLPHETS RLETNAPESI CILDLEVFLL GVVYTSHLQL
510 520 530 540 550
KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI HRKAVPGNLA
560 570 580 590 600
KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI
610 620 630 640 650
GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA
660 670 680 690 700
HITFAMLDAV NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS
710 720 730 740 750
PEEQEECRNY LTKTRDYLIK IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM
760 770 780 790 800
QELEDYSEGG PLYKNGSLRN ADSEIKHSTP SPTKYSLSPS KSYKYSPETP
810 820 830 840 850
PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR WPTENYGPDS
860 870 880 890 900
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
910 920 930 940 950
SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGFQAQD
960 970 980 990 1000
ISGRKKGRGV IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE
1010 1020 1030 1040 1050
KLFSSRYGKM ANKANTSGDF EKDDDAYKTE DSDDIHFEPV VQMPEKVELV
1060 1070 1080 1090 1100
TGEEGEKVLY SQGVKLFRFD AEVRQWKERG LGNLKILKNE VNGKLRMLMR
1110 1120 1130 1140 1150
REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD AKLERLAAKF
1160 1170 1180 1190 1200
KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG
1210 1220 1230 1240 1250
LKDFKTFLTN DQTKVTEEEN KGSGTGAAGA SDTTIKPNAE NTGPTLEWDN
1260 1270 1280 1290 1300
YDLREDALDD SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS
1310 1320 1330 1340 1350
LSKSPAKLNQ SGTSVGTDEE SVVTQEEERD GQYFEPVVPL PDLVEVSSGE
1360 1370 1380 1390 1400
ENEQVVFSHR AEIYRYDKDV GQWKERGIGD IKILQNYDNK QVRIVMRRDQ
1410 1420 1430 1440 1450
VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV EHLAVRFKLQ
1460 1470 1480 1490 1500
DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAILEETT
1510 1520 1530 1540 1550
RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS
1560 1570 1580 1590 1600
SEKSKPFVFG NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK
1610 1620 1630 1640 1650
CELSKNSDIE QSSDSKVKNL SASFPTEESS INYTFKTPEK EPPLWHAEFT
1660 1670 1680 1690 1700
KEELVQKLRS TTKSADHLNG LLREIEATNA VLMEQIKLLK SEIRRLERNQ
1710 1720 1730 1740 1750
EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ LSPEEKGKLA
1760
AVAQDEEENA SRSSG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 | L → V in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 204 | N → H in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 214 | Y → H in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 229 | Q → R in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 257 | E → G in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 270 | K → E in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 451 | L → S in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 736 | P → S in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 784 | K → R in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 893 | A → G in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 905 | E → D in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 946 | F → L in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 1074 | R → S in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 1135 | D → H in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 1612 | S → P in AAB41848 (PubMed:10101573).Curated | 1 | |
Sequence conflicti | 1682 | L → P in AAB41848 (PubMed:10101573).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038968 | 868 – 904 | VATTG…GSSNT → EAAHRHFTIEKHGDSKWIIY RFTKQLCGTERARAKIS in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_038969 | 905 – 1765 | Missing in isoform 2. 1 PublicationAdd BLAST | 861 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64675 mRNA Translation: AAB41848.2 AL136868 mRNA Translation: CAB66802.1 AC013271 Genomic DNA Translation: AAY14902.1 AC123886 Genomic DNA Translation: AAY14839.1 AC108938 Genomic DNA Translation: AAY24132.1 AC109815 Genomic DNA No translation available. AB209082 mRNA Translation: BAD92319.1 |
CCDSi | CCDS2082.1 [Q99666-1] CCDS2083.1 [Q99666-2] CCDS42729.1 [Q99666-2] CCDS46388.1 [Q99666-1] |
RefSeqi | NP_001032955.1, NM_001037866.1 [Q99666-2] NP_001116835.1, NM_001123363.3 [Q99666-1] NP_005045.2, NM_005054.2 [Q99666-1] NP_115636.1, NM_032260.2 [Q99666-2] |
Genome annotation databases
Ensembli | ENST00000016946; ENSP00000016946; ENSG00000015568 [Q99666-1] ENST00000272454; ENSP00000272454; ENSG00000015568 [Q99666-2] ENST00000329516; ENSP00000330842; ENSG00000183054 [Q99666-1] ENST00000330331; ENSP00000330023; ENSG00000183054 [Q99666-2] ENST00000393283; ENSP00000376962; ENSG00000015568 [Q99666-2] |
GeneIDi | 729540 84220 |
KEGGi | hsa:729540 hsa:84220 |
UCSCi | uc002tfc.3, human [Q99666-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64675 mRNA Translation: AAB41848.2 AL136868 mRNA Translation: CAB66802.1 AC013271 Genomic DNA Translation: AAY14902.1 AC123886 Genomic DNA Translation: AAY14839.1 AC108938 Genomic DNA Translation: AAY24132.1 AC109815 Genomic DNA No translation available. AB209082 mRNA Translation: BAD92319.1 |
CCDSi | CCDS2082.1 [Q99666-1] CCDS2083.1 [Q99666-2] CCDS42729.1 [Q99666-2] CCDS46388.1 [Q99666-1] |
RefSeqi | NP_001032955.1, NM_001037866.1 [Q99666-2] NP_001116835.1, NM_001123363.3 [Q99666-1] NP_005045.2, NM_005054.2 [Q99666-1] NP_115636.1, NM_032260.2 [Q99666-2] |
3D structure databases
SMRi | Q99666 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123954, 51 interactors 609938, 5 interactors |
IntActi | Q99666, 36 interactors |
MINTi | Q99666 |
STRINGi | 9606.ENSP00000330842 |
PTM databases
iPTMneti | Q99666 |
PhosphoSitePlusi | Q99666 |
Polymorphism and mutation databases
BioMutai | RGPD5 |
DMDMi | 229463026 |
Proteomic databases
EPDi | Q99666 |
jPOSTi | Q99666 |
MassIVEi | Q99666 |
PaxDbi | Q99666 |
PeptideAtlasi | Q99666 |
PRIDEi | Q99666 |
ProteomicsDBi | 78386 [Q99666-1] 78387 [Q99666-2] |
Protocols and materials databases
Antibodypediai | 33171, 67 antibodies 58593, 9 antibodies |
DNASUi | 729540 84220 |
Genome annotation databases
Ensembli | ENST00000016946; ENSP00000016946; ENSG00000015568 [Q99666-1] ENST00000272454; ENSP00000272454; ENSG00000015568 [Q99666-2] ENST00000329516; ENSP00000330842; ENSG00000183054 [Q99666-1] ENST00000330331; ENSP00000330023; ENSG00000183054 [Q99666-2] ENST00000393283; ENSP00000376962; ENSG00000015568 [Q99666-2] |
GeneIDi | 729540 84220 |
KEGGi | hsa:729540 hsa:84220 |
UCSCi | uc002tfc.3, human [Q99666-1] |
Organism-specific databases
CTDi | 729540 84220 |
EuPathDBi | HostDB:ENSG00000015568.12 HostDB:ENSG00000183054.11 |
GeneCardsi | RGPD5 RGPD6 |
HGNCi | HGNC:32418, RGPD5 HGNC:32419, RGPD6 |
HPAi | ENSG00000015568, Low tissue specificity ENSG00000183054, Low tissue specificity |
MIMi | 612708, gene 612709, gene 612710, gene |
neXtProti | NX_Q99666 |
OpenTargetsi | ENSG00000015568 |
PharmGKBi | PA142671074 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0864, Eukaryota |
GeneTreei | ENSGT00940000164065 |
HOGENOMi | CLU_022433_0_0_1 |
InParanoidi | Q99666 |
OrthoDBi | 201737at2759 |
PhylomeDBi | Q99666 |
TreeFami | TF314797 |
Enzyme and pathway databases
PathwayCommonsi | Q99666 |
Miscellaneous databases
BioGRID-ORCSi | 729540, 691 hits in 800 CRISPR screens 84220, 23 hits in 96 CRISPR screens |
ChiTaRSi | RGPD5, human RGPD6, human |
GeneWikii | RGPD5 |
Pharosi | Q99666, Tdark |
PROi | PR:Q99666 |
RNActi | Q99666, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000015568, Expressed in testis and 213 other tissues |
ExpressionAtlasi | Q99666, baseline and differential |
Genevisiblei | Q99666, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR032023, GCC2_Rab_bind IPR000237, GRIP_dom IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF01465, GRIP, 1 hit PF16704, Rab_bind, 1 hit PF00638, Ran_BP1, 2 hits |
SMARTi | View protein in SMART SM00755, Grip, 1 hit SM00160, RanBD, 2 hits SM00028, TPR, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50913, GRIP, 1 hit PS50196, RANBD1, 2 hits PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGPD5_HUMAN | |
Accessioni | Q99666Primary (citable) accession number: Q99666 Secondary accession number(s): Q53QN2 Q9H0B2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM