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Entry version 180 (13 Feb 2019)
Sequence version 1 (01 May 1997)
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Protein

Interleukin-12 receptor subunit beta-2

Gene

IL12RB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • protein kinase binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99665

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-12 receptor subunit beta-2
Short name:
IL-12 receptor subunit beta-2
Short name:
IL-12R subunit beta-2
Short name:
IL-12R-beta-2
Short name:
IL-12RB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL12RB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000081985.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5972 IL12RB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601642 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99665

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 622ExtracellularSequence analysisAdd BLAST599
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 862CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi678Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications1
Mutagenesisi767Y → F: No loss of STAT4 activation. No loss of SOCS3 binding. 3 Publications1
Mutagenesisi800Y → F: Loss of STAT4 activation. Abolishes SOCS3 binding. 3 Publications1
Mutagenesisi801L → A: Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication1
Mutagenesisi802P → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication1
Mutagenesisi803S → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication1
Mutagenesisi804N → A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3595

Open Targets

More...
OpenTargetsi
ENSG00000081985

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29787

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL12RB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12229836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001092024 – 862Interleukin-12 receptor subunit beta-2Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei800Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99665

PeptideAtlas

More...
PeptideAtlasi
Q99665

PRoteomics IDEntifications database

More...
PRIDEi
Q99665

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78384
78385 [Q99665-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99665

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99665

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed at similar levels in both naive and activated T-cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maximum levels in Th1 cells between day 3 and day 8 of activation.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In vitro, up-regulated by IFN-alpha.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000081985 Expressed in 110 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99665 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99665 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA024168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109809, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-382 Interleukin-12-receptor complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q99665

Database of interacting proteins

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DIPi
DIP-6011N

Protein interaction database and analysis system

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IntActi
Q99665, 3 interactors

Molecular INTeraction database

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MINTi
Q99665

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99665

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99665

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 221Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini226 – 319Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini320 – 419Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini423 – 520Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini521 – 620Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni796 – 801Required for STAT4 binding6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi305 – 309WSXWS motif5
Motifi662 – 670Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi208 – 211Poly-Ser4
Compositional biasi750 – 753Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHXG Eukaryota
ENOG41116V2 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049086

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052059

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99665

KEGG Orthology (KO)

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KOi
K05064

Identification of Orthologs from Complete Genome Data

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OMAi
TWAKKYP

Database of Orthologous Groups

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OrthoDBi
144839at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99665

TreeFam database of animal gene trees

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TreeFami
TF338122

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF06328 Lep_receptor_Ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99665-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT
60 70 80 90 100
CSLKPRQGCF HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV
110 120 130 140 150
CKLACINSDE IQICGAEIFV GVAPEQPQNL SCIQKGEQGT VACTWERGRD
160 170 180 190 200
THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY LDFGINLTPE SPESNFTAKV
210 220 230 240 250
TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS RCTLYWRDEG
260 270 280 290 300
LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL
310 320 330 340 350
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV
360 370 380 390 400
SEARGKILHY QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA
410 420 430 440 450
NSKGSSLPTR INIMNLCEAG LLAPRQVSAN SEGMDNILVT WQPPRKDPSA
460 470 480 490 500
VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN VSALISENIK SYICYEIRVY
510 520 530 540 550
ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS WNSIPVQEQM
560 570 580 590 600
GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA
610 620 630 640 650
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV
660 670 680 690 700
FVLLAALRPQ WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE
710 720 730 740 750
DPEPLVISEV LHQVTPVFRH PPCSNWPQRE KGIQGHQASE KDMMHSASSP
760 770 780 790 800
PPPRALQAES RQLVDLYKVL ESRGSDPKPE NPACPWTVLP AGDLPTHDGY
810 820 830 840 850
LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL TFSCGDKLTL
860
DQLKMRCDSL ML
Length:862
Mass (Da):97,135
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C0E0D946B8DD58
GO
Isoform 2 (identifier: Q99665-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-659: VFVLLAALRP → RRHSCPWTGS
     660-862: Missing.

Show »
Length:659
Mass (Da):74,607
Checksum:i66A09C2666CCC64E
GO
Isoform 3 (identifier: Q99665-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-572: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):87,484
Checksum:i85F77F1E5D18E2C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTN7A0A0A0MTN7_HUMAN
Interleukin-12 receptor subunit bet...
IL12RB2
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5V0H0Y5V0_HUMAN
Interleukin-12 receptor subunit bet...
IL12RB2
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02127813M → V1 PublicationCorresponds to variant dbSNP:rs17129772Ensembl.1
Natural variantiVAR_021279149R → Q1 PublicationCorresponds to variant dbSNP:rs17129792Ensembl.1
Natural variantiVAR_014805185I → V. Corresponds to variant dbSNP:rs2307146Ensembl.1
Natural variantiVAR_019525201T → I. Corresponds to variant dbSNP:rs7526769Ensembl.1
Natural variantiVAR_019526313R → G1 Publication1
Natural variantiVAR_014806420G → R. Corresponds to variant dbSNP:rs2307148Ensembl.1
Natural variantiVAR_049169420G → S. Corresponds to variant dbSNP:rs2307148Ensembl.1
Natural variantiVAR_014807426Q → H2 PublicationsCorresponds to variant dbSNP:rs2307145Ensembl.1
Natural variantiVAR_014808465G → D1 PublicationCorresponds to variant dbSNP:rs2307153Ensembl.1
Natural variantiVAR_016097625A → V. Corresponds to variant dbSNP:rs2307154Ensembl.1
Natural variantiVAR_019527720H → R1 PublicationCorresponds to variant dbSNP:rs1242019108Ensembl.1
Natural variantiVAR_021280808L → R1 PublicationCorresponds to variant dbSNP:rs17838066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044784487 – 572Missing in isoform 3. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_011112650 – 659VFVLLAALRP → RRHSCPWTGS in isoform 2. 1 Publication10
Alternative sequenceiVSP_011113660 – 862Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U64198 mRNA Translation: AAB36675.1
AY640177 Genomic DNA Translation: AAT45456.1
CH471059 Genomic DNA Translation: EAX06499.1
AL358512 Genomic DNA No translation available.
AL389925 Genomic DNA No translation available.
BC104772 mRNA Translation: AAI04773.1
BC104774 mRNA Translation: AAI04775.1
BC143249 mRNA Translation: AAI43250.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS58006.1 [Q99665-2]
CCDS58007.1 [Q99665-3]
CCDS638.1 [Q99665-1]

NCBI Reference Sequences

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RefSeqi
NP_001245143.1, NM_001258214.1 [Q99665-2]
NP_001245144.1, NM_001258215.1 [Q99665-3]
NP_001245145.1, NM_001258216.1
NP_001306162.1, NM_001319233.1 [Q99665-2]
NP_001550.1, NM_001559.2 [Q99665-1]
XP_005270882.1, XM_005270825.2 [Q99665-1]
XP_005270884.1, XM_005270827.2 [Q99665-1]
XP_005270885.1, XM_005270828.3 [Q99665-1]
XP_006710680.1, XM_006710617.2 [Q99665-3]
XP_011539685.1, XM_011541383.2 [Q99665-1]
XP_016856692.1, XM_017001203.1 [Q99665-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.479347

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262345; ENSP00000262345; ENSG00000081985 [Q99665-1]
ENST00000371000; ENSP00000360039; ENSG00000081985 [Q99665-2]
ENST00000544434; ENSP00000442443; ENSG00000081985 [Q99665-3]
ENST00000648487; ENSP00000497959; ENSG00000081985 [Q99665-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3595

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3595

UCSC genome browser

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UCSCi
uc001ddu.3 human [Q99665-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64198 mRNA Translation: AAB36675.1
AY640177 Genomic DNA Translation: AAT45456.1
CH471059 Genomic DNA Translation: EAX06499.1
AL358512 Genomic DNA No translation available.
AL389925 Genomic DNA No translation available.
BC104772 mRNA Translation: AAI04773.1
BC104774 mRNA Translation: AAI04775.1
BC143249 mRNA Translation: AAI43250.1
CCDSiCCDS58006.1 [Q99665-2]
CCDS58007.1 [Q99665-3]
CCDS638.1 [Q99665-1]
RefSeqiNP_001245143.1, NM_001258214.1 [Q99665-2]
NP_001245144.1, NM_001258215.1 [Q99665-3]
NP_001245145.1, NM_001258216.1
NP_001306162.1, NM_001319233.1 [Q99665-2]
NP_001550.1, NM_001559.2 [Q99665-1]
XP_005270882.1, XM_005270825.2 [Q99665-1]
XP_005270884.1, XM_005270827.2 [Q99665-1]
XP_005270885.1, XM_005270828.3 [Q99665-1]
XP_006710680.1, XM_006710617.2 [Q99665-3]
XP_011539685.1, XM_011541383.2 [Q99665-1]
XP_016856692.1, XM_017001203.1 [Q99665-2]
UniGeneiHs.479347

3D structure databases

ProteinModelPortaliQ99665
SMRiQ99665
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109809, 4 interactors
ComplexPortaliCPX-382 Interleukin-12-receptor complex
CORUMiQ99665
DIPiDIP-6011N
IntActiQ99665, 3 interactors
MINTiQ99665
STRINGi9606.ENSP00000262345

PTM databases

iPTMnetiQ99665
PhosphoSitePlusiQ99665

Polymorphism and mutation databases

BioMutaiIL12RB2
DMDMi12229836

Proteomic databases

PaxDbiQ99665
PeptideAtlasiQ99665
PRIDEiQ99665
ProteomicsDBi78384
78385 [Q99665-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262345; ENSP00000262345; ENSG00000081985 [Q99665-1]
ENST00000371000; ENSP00000360039; ENSG00000081985 [Q99665-2]
ENST00000544434; ENSP00000442443; ENSG00000081985 [Q99665-3]
ENST00000648487; ENSP00000497959; ENSG00000081985 [Q99665-1]
GeneIDi3595
KEGGihsa:3595
UCSCiuc001ddu.3 human [Q99665-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3595
DisGeNETi3595
EuPathDBiHostDB:ENSG00000081985.10

GeneCards: human genes, protein and diseases

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GeneCardsi
IL12RB2
HGNCiHGNC:5972 IL12RB2
HPAiHPA024168
MIMi601642 gene
neXtProtiNX_Q99665
OpenTargetsiENSG00000081985
PharmGKBiPA29787

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHXG Eukaryota
ENOG41116V2 LUCA
GeneTreeiENSGT00940000159829
HOGENOMiHOG000049086
HOVERGENiHBG052059
InParanoidiQ99665
KOiK05064
OMAiTWAKKYP
OrthoDBi144839at2759
PhylomeDBiQ99665
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
SIGNORiQ99665

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IL12RB2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_12_receptor,_beta_2_subunit

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3595

Protein Ontology

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PROi
PR:Q99665

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000081985 Expressed in 110 organ(s), highest expression level in placenta
ExpressionAtlasiQ99665 baseline and differential
GenevisibleiQ99665 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF06328 Lep_receptor_Ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI12R2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99665
Secondary accession number(s): B1AN98
, B7ZKL9, F5H7L6, Q2M3V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: February 13, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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