Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oncostatin-M-specific receptor subunit beta

Gene

OSMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • growth factor binding Source: BHF-UCL

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • oncostatin-M-mediated signaling pathway Source: BHF-UCL
  • positive regulation of acute inflammatory response Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • response to cytokine Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q99650

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99650

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSMR
Synonyms:OSMRB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145623.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8507 OSMR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601743 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99650

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 740ExtracellularSequence analysisAdd BLAST713
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 979CytoplasmicSequence analysisAdd BLAST218

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyloidosis, primary localized cutaneous, 1 (PLCA1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
See also OMIM:105250
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043513618G → A in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750560EnsemblClinVar.1
Natural variantiVAR_065810647D → V in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906821EnsemblClinVar.1
Natural variantiVAR_043514691I → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750567EnsemblClinVar.1
Natural variantiVAR_065811694P → L in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906822EnsemblClinVar.1
Natural variantiVAR_065812697K → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906823EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9180

MalaCards human disease database

More...
MalaCardsi
OSMR
MIMi105250 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145623

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
353220 Familial primary localized cutaneous amyloidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32837

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSMR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025975928 – 979Oncostatin-M-specific receptor subunit betaAdd BLAST952

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi245 ↔ 255By similarity
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei826PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99650

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99650

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99650

PeptideAtlas

More...
PeptideAtlasi
Q99650

PRoteomics IDEntifications database

More...
PRIDEi
Q99650

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78379
78380 [Q99650-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99650

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99650

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99650

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated by oncostatin-M (PubMed:8999038). Up-regulated by IFNG/IFN-gamma (PubMed:15184896, PubMed:21261663). Up-regulated by bacterial lipopolysaccharides (LPS) (PubMed:15184896). Up-regulated by triacylated lipoprotein (Pam3Cys) (PubMed:21261663).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145623 Expressed in 200 organ(s), highest expression level in pericardium

CleanEx database of gene expression profiles

More...
CleanExi
HS_OSMR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99650 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99650 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017278

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
IL6STP401892EBI-2804080,EBI-1030834

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114617, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q99650, 12 interactors

Molecular INTeraction database

More...
MINTi
Q99650

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274276

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99650

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99650

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini335 – 428Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini433 – 528Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini529 – 623Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini625 – 736Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi415 – 419WSXWS motif5
Motifi770 – 778Box 1 motif9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCQ Eukaryota
ENOG410Y9XY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115294

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082088

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99650

KEGG Orthology (KO)

More...
KOi
K05057

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPCICFE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00RF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99650

TreeFam database of animal gene trees

More...
TreeFami
TF338122

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99650-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL
60 70 80 90 100
QWTVHNLPYH QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE
110 120 130 140 150
SELPLECATH FVRIKSLVDD AKFPEPNFWS NWSSWEEVSV QDSTGQDILF
160 170 180 190 200
VFPKDKLVEE GTNVTICYVS RNIQNNVSCY LEGKQIHGEQ LDPHVTAFNL
210 220 230 240 250
NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP KDFSCETEDF
260 270 280 290 300
KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ
310 320 330 340 350
DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI
360 370 380 390 400
MTWKVHSIRN NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY
410 420 430 440 450
MARVRCADAS HFWKWSEWSG QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT
460 470 480 490 500
LFWKPLSKLH ANGKILFYNV VVENLDKPSS SELHSIPAPA NSTKLILDRC
510 520 530 540 550
SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE GGFSLSWKPQ
560 570 580 590 600
PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR
610 620 630 640 650
IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST
660 670 680 690 700
ESQPGFIQGY HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI
710 720 730 740 750
VDNLKPESFY EFFITPFTSA GEGPSATFTK VTTPDEHSSM LIHILLPMVF
760 770 780 790 800
CVLLIMVMCY LKSQWIKETC YPDIPDPYKS SILSLIKFKE NPHLIIMNVS
810 820 830 840 850
DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL LPTEKNHSGP
860 870 880 890 900
GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN
910 920 930 940 950
YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA
960 970
VSLRLALPPP TENSSLSSIT LLDPGEHYC
Length:979
Mass (Da):110,509
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i179852CA3D90D9EF
GO
Isoform 2 (identifier: Q99650-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-342: VYLMNPFSVNFE → GETRVVTAHRGH
     343-979: Missing.

Show »
Length:342
Mass (Da):39,504
Checksum:i85C6A38D7B8CC73C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAD1H0YAD1_HUMAN
Oncostatin-M-specific receptor subu...
OSMR
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9E3H0Y9E3_HUMAN
Oncostatin-M-specific receptor subu...
OSMR
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8W9H0Y8W9_HUMAN
Oncostatin-M-specific receptor subu...
OSMR
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH63468 differs from that shown. Reason: Frameshift at positions 232 and 288.Curated
The sequence AAH63468 differs from that shown. Reason: Erroneous termination at position 216. Translated as Glu.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043512187H → Q. Corresponds to variant dbSNP:rs34675408Ensembl.1
Natural variantiVAR_028972210G → W1 PublicationCorresponds to variant dbSNP:rs17855841Ensembl.1
Natural variantiVAR_028973527E → K. Corresponds to variant dbSNP:rs10941412Ensembl.1
Natural variantiVAR_028974553D → N. Corresponds to variant dbSNP:rs2278329Ensembl.1
Natural variantiVAR_043513618G → A in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750560EnsemblClinVar.1
Natural variantiVAR_065810647D → V in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906821EnsemblClinVar.1
Natural variantiVAR_043514691I → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750567EnsemblClinVar.1
Natural variantiVAR_065811694P → L in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906822EnsemblClinVar.1
Natural variantiVAR_065812697K → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906823EnsemblClinVar.1
Natural variantiVAR_028975936P → S. Corresponds to variant dbSNP:rs3749737Ensembl.1
Natural variantiVAR_043515959P → R. Corresponds to variant dbSNP:rs34080825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021527331 – 342VYLMN…SVNFE → GETRVVTAHRGH in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021528343 – 979Missing in isoform 2. 1 PublicationAdd BLAST637

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U60805 mRNA Translation: AAC50946.1
BC010943 mRNA Translation: AAH10943.1
BC063468 mRNA Translation: AAH63468.1 Sequence problems.
BC125209 mRNA Translation: AAI25210.1
BC125210 mRNA Translation: AAI25211.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3928.1 [Q99650-1]
CCDS54847.1 [Q99650-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161827.1, NM_001168355.2 [Q99650-2]
NP_001310433.1, NM_001323504.1 [Q99650-2]
NP_001310434.1, NM_001323505.1 [Q99650-1]
NP_001310435.1, NM_001323506.1
NP_001310436.1, NM_001323507.1
NP_003990.1, NM_003999.2 [Q99650-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.120658
Hs.658389

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274276; ENSP00000274276; ENSG00000145623 [Q99650-1]
ENST00000502536; ENSP00000422023; ENSG00000145623 [Q99650-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9180

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9180

UCSC genome browser

More...
UCSCi
uc003jlm.2 human [Q99650-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60805 mRNA Translation: AAC50946.1
BC010943 mRNA Translation: AAH10943.1
BC063468 mRNA Translation: AAH63468.1 Sequence problems.
BC125209 mRNA Translation: AAI25210.1
BC125210 mRNA Translation: AAI25211.1
CCDSiCCDS3928.1 [Q99650-1]
CCDS54847.1 [Q99650-2]
RefSeqiNP_001161827.1, NM_001168355.2 [Q99650-2]
NP_001310433.1, NM_001323504.1 [Q99650-2]
NP_001310434.1, NM_001323505.1 [Q99650-1]
NP_001310435.1, NM_001323506.1
NP_001310436.1, NM_001323507.1
NP_003990.1, NM_003999.2 [Q99650-1]
UniGeneiHs.120658
Hs.658389

3D structure databases

ProteinModelPortaliQ99650
SMRiQ99650
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114617, 11 interactors
IntActiQ99650, 12 interactors
MINTiQ99650
STRINGi9606.ENSP00000274276

PTM databases

iPTMnetiQ99650
PhosphoSitePlusiQ99650
SwissPalmiQ99650

Polymorphism and mutation databases

BioMutaiOSMR
DMDMi74724833

Proteomic databases

EPDiQ99650
MaxQBiQ99650
PaxDbiQ99650
PeptideAtlasiQ99650
PRIDEiQ99650
ProteomicsDBi78379
78380 [Q99650-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274276; ENSP00000274276; ENSG00000145623 [Q99650-1]
ENST00000502536; ENSP00000422023; ENSG00000145623 [Q99650-2]
GeneIDi9180
KEGGihsa:9180
UCSCiuc003jlm.2 human [Q99650-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9180
DisGeNETi9180
EuPathDBiHostDB:ENSG00000145623.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OSMR
HGNCiHGNC:8507 OSMR
HPAiHPA017278
MalaCardsiOSMR
MIMi105250 phenotype
601743 gene
neXtProtiNX_Q99650
OpenTargetsiENSG00000145623
Orphaneti353220 Familial primary localized cutaneous amyloidosis
PharmGKBiPA32837

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFCQ Eukaryota
ENOG410Y9XY LUCA
GeneTreeiENSGT00940000160851
HOGENOMiHOG000115294
HOVERGENiHBG082088
InParanoidiQ99650
KOiK05057
OMAiGPCICFE
OrthoDBiEOG091G00RF
PhylomeDBiQ99650
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiQ99650
SIGNORiQ99650

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OSMR human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Oncostatin_M_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9180

Protein Ontology

More...
PROi
PR:Q99650

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145623 Expressed in 200 organ(s), highest expression level in pericardium
CleanExiHS_OSMR
ExpressionAtlasiQ99650 baseline and differential
GenevisibleiQ99650 HS

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSMR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99650
Secondary accession number(s): Q6P4E8, Q96QJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again