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Protein

Oncostatin-M-specific receptor subunit beta

Gene

OSMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.2 Publications

GO - Molecular functioni

  • cytokine receptor activity Source: InterPro
  • growth factor binding Source: BHF-UCL

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • oncostatin-M-mediated signaling pathway Source: BHF-UCL
  • positive regulation of acute inflammatory response Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • response to cytokine Source: BHF-UCL

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiQ99650
SIGNORiQ99650

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
Gene namesi
Name:OSMR
Synonyms:OSMRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145623.12
HGNCiHGNC:8507 OSMR
MIMi601743 gene
neXtProtiNX_Q99650

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 740ExtracellularSequence analysisAdd BLAST713
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 979CytoplasmicSequence analysisAdd BLAST218

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Amyloidosis, primary localized cutaneous, 1 (PLCA1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
See also OMIM:105250
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043513618G → A in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750560EnsemblClinVar.1
Natural variantiVAR_065810647D → V in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906821EnsemblClinVar.1
Natural variantiVAR_043514691I → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750567EnsemblClinVar.1
Natural variantiVAR_065811694P → L in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906822EnsemblClinVar.1
Natural variantiVAR_065812697K → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906823EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNETi9180
MalaCardsiOSMR
MIMi105250 phenotype
OpenTargetsiENSG00000145623
Orphaneti353220 Familial primary localized cutaneous amyloidosis
PharmGKBiPA32837

Polymorphism and mutation databases

BioMutaiOSMR
DMDMi74724833

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000025975928 – 979Oncostatin-M-specific receptor subunit betaAdd BLAST952

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi245 ↔ 255By similarity
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei826PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99650
MaxQBiQ99650
PaxDbiQ99650
PeptideAtlasiQ99650
PRIDEiQ99650
ProteomicsDBi78379
78380 [Q99650-2]

PTM databases

iPTMnetiQ99650
PhosphoSitePlusiQ99650
SwissPalmiQ99650

Expressioni

Tissue specificityi

Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).2 Publications

Inductioni

Activated by oncostatin-M (PubMed:8999038). Up-regulated by IFNG/IFN-gamma (PubMed:15184896, PubMed:21261663). Up-regulated by bacterial lipopolysaccharides (LPS) (PubMed:15184896). Up-regulated by triacylated lipoprotein (Pam3Cys) (PubMed:21261663).3 Publications

Gene expression databases

BgeeiENSG00000145623
CleanExiHS_OSMR
ExpressionAtlasiQ99650 baseline and differential
GenevisibleiQ99650 HS

Organism-specific databases

HPAiHPA017278

Interactioni

Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.1 Publication

GO - Molecular functioni

  • growth factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114617, 11 interactors
IntActiQ99650, 11 interactors
MINTiQ99650
STRINGi9606.ENSP00000274276

Structurei

3D structure databases

ProteinModelPortaliQ99650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 428Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini433 – 528Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini529 – 623Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini625 – 736Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi415 – 419WSXWS motif5
Motifi770 – 778Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCQ Eukaryota
ENOG410Y9XY LUCA
GeneTreeiENSGT00550000074436
HOGENOMiHOG000115294
HOVERGENiHBG082088
InParanoidiQ99650
KOiK05057
OMAiGPCICFE
OrthoDBiEOG091G00RF
PhylomeDBiQ99650
TreeFamiTF338122

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99650-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL
60 70 80 90 100
QWTVHNLPYH QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE
110 120 130 140 150
SELPLECATH FVRIKSLVDD AKFPEPNFWS NWSSWEEVSV QDSTGQDILF
160 170 180 190 200
VFPKDKLVEE GTNVTICYVS RNIQNNVSCY LEGKQIHGEQ LDPHVTAFNL
210 220 230 240 250
NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP KDFSCETEDF
260 270 280 290 300
KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ
310 320 330 340 350
DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI
360 370 380 390 400
MTWKVHSIRN NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY
410 420 430 440 450
MARVRCADAS HFWKWSEWSG QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT
460 470 480 490 500
LFWKPLSKLH ANGKILFYNV VVENLDKPSS SELHSIPAPA NSTKLILDRC
510 520 530 540 550
SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE GGFSLSWKPQ
560 570 580 590 600
PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR
610 620 630 640 650
IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST
660 670 680 690 700
ESQPGFIQGY HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI
710 720 730 740 750
VDNLKPESFY EFFITPFTSA GEGPSATFTK VTTPDEHSSM LIHILLPMVF
760 770 780 790 800
CVLLIMVMCY LKSQWIKETC YPDIPDPYKS SILSLIKFKE NPHLIIMNVS
810 820 830 840 850
DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL LPTEKNHSGP
860 870 880 890 900
GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN
910 920 930 940 950
YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA
960 970
VSLRLALPPP TENSSLSSIT LLDPGEHYC
Length:979
Mass (Da):110,509
Last modified:May 1, 1997 - v1
Checksum:i179852CA3D90D9EF
GO
Isoform 2 (identifier: Q99650-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-342: VYLMNPFSVNFE → GETRVVTAHRGH
     343-979: Missing.

Show »
Length:342
Mass (Da):39,504
Checksum:i85C6A38D7B8CC73C
GO

Sequence cautioni

The sequence AAH63468 differs from that shown. Reason: Frameshift at positions 232 and 288.Curated
The sequence AAH63468 differs from that shown. Reason: Erroneous termination at position 216. Translated as Glu.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043512187H → Q. Corresponds to variant dbSNP:rs34675408Ensembl.1
Natural variantiVAR_028972210G → W1 PublicationCorresponds to variant dbSNP:rs17855841Ensembl.1
Natural variantiVAR_028973527E → K. Corresponds to variant dbSNP:rs10941412Ensembl.1
Natural variantiVAR_028974553D → N. Corresponds to variant dbSNP:rs2278329Ensembl.1
Natural variantiVAR_043513618G → A in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750560EnsemblClinVar.1
Natural variantiVAR_065810647D → V in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906821EnsemblClinVar.1
Natural variantiVAR_043514691I → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs63750567EnsemblClinVar.1
Natural variantiVAR_065811694P → L in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906822EnsemblClinVar.1
Natural variantiVAR_065812697K → T in PLCA1. 1 PublicationCorresponds to variant dbSNP:rs387906823EnsemblClinVar.1
Natural variantiVAR_028975936P → S. Corresponds to variant dbSNP:rs3749737Ensembl.1
Natural variantiVAR_043515959P → R. Corresponds to variant dbSNP:rs34080825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021527331 – 342VYLMN…SVNFE → GETRVVTAHRGH in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_021528343 – 979Missing in isoform 2. 1 PublicationAdd BLAST637

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60805 mRNA Translation: AAC50946.1
BC010943 mRNA Translation: AAH10943.1
BC063468 mRNA Translation: AAH63468.1 Sequence problems.
BC125209 mRNA Translation: AAI25210.1
BC125210 mRNA Translation: AAI25211.1
CCDSiCCDS3928.1 [Q99650-1]
CCDS54847.1 [Q99650-2]
RefSeqiNP_001161827.1, NM_001168355.2 [Q99650-2]
NP_001310433.1, NM_001323504.1 [Q99650-2]
NP_001310434.1, NM_001323505.1 [Q99650-1]
NP_001310435.1, NM_001323506.1
NP_001310436.1, NM_001323507.1
NP_003990.1, NM_003999.2 [Q99650-1]
UniGeneiHs.120658
Hs.658389

Genome annotation databases

EnsembliENST00000274276; ENSP00000274276; ENSG00000145623 [Q99650-1]
ENST00000502536; ENSP00000422023; ENSG00000145623 [Q99650-2]
GeneIDi9180
KEGGihsa:9180
UCSCiuc003jlm.2 human [Q99650-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOSMR_HUMAN
AccessioniPrimary (citable) accession number: Q99650
Secondary accession number(s): Q6P4E8, Q96QJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 1997
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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