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Entry version 193 (16 Oct 2019)
Sequence version 1 (01 May 1997)
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Protein

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene

SDHC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: The heme is bound between the two transmembrane subunits SDHC and SDHD.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi127Iron (heme axial ligand); shared with SDHDBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07014-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.5.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99643

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00223

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.10.1.7 the prokaryotic succinate dehydrogenase (sdh) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Alternative name(s):
Integral membrane protein CII-3
QPs-1
Short name:
QPs1
Succinate dehydrogenase complex subunit C
Succinate-ubiquinone oxidoreductase cytochrome B large subunit
Short name:
CYBL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDHC
Synonyms:CYB560, SDH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10682 SDHC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602413 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 62Mitochondrial matrixBy similarityAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 92HelicalBy similarityAdd BLAST30
Topological domaini93 – 112Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei113 – 137HelicalBy similarityAdd BLAST25
Topological domaini138 – 144Mitochondrial matrixBy similarity7
Transmembranei145 – 166HelicalBy similarityAdd BLAST22
Topological domaini167 – 169Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Paragangliomas 3 (PGL3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
Related information in OMIM
Paraganglioma and gastric stromal sarcoma (PGGSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionGastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
Related information in OMIM

Organism-specific databases

DisGeNET

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DisGeNETi
6391

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SDHC

MalaCards human disease database

More...
MalaCardsi
SDHC
MIMi605373 phenotype
606864 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143252

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
97286 Carney-Stratakis syndrome
201 Cowden syndrome
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35607

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99643

Chemistry databases

Drug and drug target database

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DrugBanki
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
DB00139 Succinic acid
DB08689 UBIQUINONE-1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDHC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
5915811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000363430 – 169Succinate dehydrogenase cytochrome b560 subunit, mitochondrialAdd BLAST140

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q99643

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99643

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q99643

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99643

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99643

PeptideAtlas

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PeptideAtlasi
Q99643

PRoteomics IDEntifications database

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PRIDEi
Q99643

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78373 [Q99643-1]
78374 [Q99643-2]
78375 [Q99643-3]
78376 [Q99643-4]
78377 [Q99643-5]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q99643-1 [Q99643-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99643

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99643

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143252 Expressed in 183 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99643 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99643 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112292, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-561 Mitochondrial respiratory chain complex II

Protein interaction database and analysis system

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IntActi
Q99643, 10 interactors

Molecular INTeraction database

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MINTi
Q99643

STRING: functional protein association networks

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STRINGi
9606.ENSP00000356953

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99643

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0449 Eukaryota
COG2009 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000160253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99643

KEGG Orthology (KO)

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KOi
K00236

Identification of Orthologs from Complete Genome Data

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OMAi
IPGGIPC

Database of Orthologous Groups

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OrthoDBi
507784at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99643

TreeFam database of animal gene trees

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TreeFami
TF313317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034804 SQR/QFR_C/D
IPR018495 Succ_DH_cyt_bsu_CS
IPR014314 Succ_DH_cytb556
IPR000701 SuccDH_FuR_B_TM-su

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01127 Sdh_cyt, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000178 SDH_cyt_b560, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81343 SSF81343, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02970 succ_dehyd_cytB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01000 SDH_CYT_1, 1 hit
PS01001 SDH_CYT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99643-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALLLRHVG RHCLRAHFSP QLCIRNAVPL GTTAKEEMER FWNKNIGSNR
60 70 80 90 100
PLSPHITIYS WSLPMAMSIC HRGTGIALSA GVSLFGMSAL LLPGNFESYL
110 120 130 140 150
ELVKSLCLGP ALIHTAKFAL VFPLMYHTWN GIRHLMWDLG KGLKIPQLYQ
160
SGVVVLVLTV LSSMGLAAM
Length:169
Mass (Da):18,610
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF7CBD6D0CD49500
GO
Isoform 2 (identifier: Q99643-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-169: GVSLFGMSAL...VLSSMGLAAM → DVGPRKRPED...PAWEKFSLFV

Show »
Length:150
Mass (Da):16,650
Checksum:i971579A96F795D90
GO
Isoform 3 (identifier: Q99643-3) [UniParc]FASTAAdd to basket
Also known as: CII-3b

The sequence of this isoform differs from the canonical sequence as follows:
     27-60: Missing.

Show »
Length:135
Mass (Da):14,770
Checksum:i5F7A8BC812112D75
GO
Isoform 4 (identifier: Q99643-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-60: Missing.
     81-169: GVSLFGMSAL...VLSSMGLAAM → DVGPRKRPED...PAWEKFSLFV

Show »
Length:116
Mass (Da):12,810
Checksum:i36DFFD8CC2E6D4E8
GO
Isoform 5 (identifier: Q99643-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-59: Missing.

Show »
Length:116
Mass (Da):12,474
Checksum:iAC702AE33DD1F118
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBX6D6RBX6_HUMAN
Succinate dehydrogenase cytochrome ...
SDHC
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZU7A0A087WZU7_HUMAN
Succinate dehydrogenase cytochrome ...
SDHC
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413817 – 59Missing in isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_04138227 – 60Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_04138381 – 169GVSLF…GLAAM → DVGPRKRPEDSPAIPVWSGC PGSYCVVLYGAGSHVKKGGS QHHLPTHYYIHPSFCLSFLS PAWEKFSLFV in isoform 2 and isoform 4. 2 PublicationsAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U57877 mRNA Translation: AAB41838.1
D49737 mRNA Translation: BAA31998.1
AF039594
, AF039589, AF039590, AF039591, AF039592, AF039593 Genomic DNA Translation: AAC27993.1
AF081495 Genomic DNA Translation: AAC31940.1
AB201252 mRNA Translation: BAE46977.1
AB211234 mRNA Translation: BAE46978.1
AB211235 mRNA Translation: BAE46979.1
AB212048 mRNA Translation: BAE46980.1
AK294305 mRNA Translation: BAG57586.1
AL592295 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52600.1
CH471121 Genomic DNA Translation: EAW52604.1
BC020808 mRNA Translation: AAH20808.1
BC033626 mRNA Translation: AAH33626.1
BC066329 mRNA Translation: AAH66329.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1230.1 [Q99643-1]
CCDS41431.1 [Q99643-2]
CCDS41432.1 [Q99643-5]
CCDS44263.1 [Q99643-3]
CCDS60330.1 [Q99643-4]

NCBI Reference Sequences

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RefSeqi
NP_001030588.1, NM_001035511.1 [Q99643-2]
NP_001030589.1, NM_001035512.1 [Q99643-3]
NP_001030590.1, NM_001035513.1 [Q99643-5]
NP_001265101.1, NM_001278172.1 [Q99643-4]
NP_002992.1, NM_003001.3 [Q99643-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000342751; ENSP00000356952; ENSG00000143252 [Q99643-2]
ENST00000367975; ENSP00000356953; ENSG00000143252 [Q99643-1]
ENST00000392169; ENSP00000376009; ENSG00000143252 [Q99643-5]
ENST00000432287; ENSP00000390558; ENSG00000143252 [Q99643-3]
ENST00000513009; ENSP00000423260; ENSG00000143252 [Q99643-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6391

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6391

UCSC genome browser

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UCSCi
uc001gag.4 human [Q99643-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
TCA Cycle Gene Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57877 mRNA Translation: AAB41838.1
D49737 mRNA Translation: BAA31998.1
AF039594
, AF039589, AF039590, AF039591, AF039592, AF039593 Genomic DNA Translation: AAC27993.1
AF081495 Genomic DNA Translation: AAC31940.1
AB201252 mRNA Translation: BAE46977.1
AB211234 mRNA Translation: BAE46978.1
AB211235 mRNA Translation: BAE46979.1
AB212048 mRNA Translation: BAE46980.1
AK294305 mRNA Translation: BAG57586.1
AL592295 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52600.1
CH471121 Genomic DNA Translation: EAW52604.1
BC020808 mRNA Translation: AAH20808.1
BC033626 mRNA Translation: AAH33626.1
BC066329 mRNA Translation: AAH66329.1
CCDSiCCDS1230.1 [Q99643-1]
CCDS41431.1 [Q99643-2]
CCDS41432.1 [Q99643-5]
CCDS44263.1 [Q99643-3]
CCDS60330.1 [Q99643-4]
RefSeqiNP_001030588.1, NM_001035511.1 [Q99643-2]
NP_001030589.1, NM_001035512.1 [Q99643-3]
NP_001030590.1, NM_001035513.1 [Q99643-5]
NP_001265101.1, NM_001278172.1 [Q99643-4]
NP_002992.1, NM_003001.3 [Q99643-1]

3D structure databases

SMRiQ99643
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112292, 35 interactors
ComplexPortaliCPX-561 Mitochondrial respiratory chain complex II
IntActiQ99643, 10 interactors
MINTiQ99643
STRINGi9606.ENSP00000356953

Chemistry databases

DrugBankiDB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
DB00139 Succinic acid
DB08689 UBIQUINONE-1

Protein family/group databases

TCDBi3.D.10.1.7 the prokaryotic succinate dehydrogenase (sdh) family

PTM databases

iPTMnetiQ99643
PhosphoSitePlusiQ99643
SwissPalmiQ99643

Polymorphism and mutation databases

BioMutaiSDHC
DMDMi5915811

Proteomic databases

EPDiQ99643
jPOSTiQ99643
MassIVEiQ99643
MaxQBiQ99643
PaxDbiQ99643
PeptideAtlasiQ99643
PRIDEiQ99643
ProteomicsDBi78373 [Q99643-1]
78374 [Q99643-2]
78375 [Q99643-3]
78376 [Q99643-4]
78377 [Q99643-5]
TopDownProteomicsiQ99643-1 [Q99643-1]

Genome annotation databases

EnsembliENST00000342751; ENSP00000356952; ENSG00000143252 [Q99643-2]
ENST00000367975; ENSP00000356953; ENSG00000143252 [Q99643-1]
ENST00000392169; ENSP00000376009; ENSG00000143252 [Q99643-5]
ENST00000432287; ENSP00000390558; ENSG00000143252 [Q99643-3]
ENST00000513009; ENSP00000423260; ENSG00000143252 [Q99643-4]
GeneIDi6391
KEGGihsa:6391
UCSCiuc001gag.4 human [Q99643-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6391
DisGeNETi6391

GeneCards: human genes, protein and diseases

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GeneCardsi
SDHC
GeneReviewsiSDHC
HGNCiHGNC:10682 SDHC
MalaCardsiSDHC
MIMi602413 gene
605373 phenotype
606864 phenotype
neXtProtiNX_Q99643
OpenTargetsiENSG00000143252
Orphaneti97286 Carney-Stratakis syndrome
201 Cowden syndrome
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma
PharmGKBiPA35607

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0449 Eukaryota
COG2009 LUCA
GeneTreeiENSGT00390000000566
HOGENOMiHOG000160253
InParanoidiQ99643
KOiK00236
OMAiIPGGIPC
OrthoDBi507784at2759
PhylomeDBiQ99643
TreeFamiTF313317

Enzyme and pathway databases

UniPathwayiUPA00223
BioCyciMetaCyc:HS07014-MONOMER
BRENDAi1.3.5.1 2681
ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)
SIGNORiQ99643

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SDHC human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Succinate_dehydrogenase_complex_subunit_C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6391
PharosiQ99643

Protein Ontology

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PROi
PR:Q99643

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143252 Expressed in 183 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ99643 baseline and differential
GenevisibleiQ99643 HS

Family and domain databases

Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR034804 SQR/QFR_C/D
IPR018495 Succ_DH_cyt_bsu_CS
IPR014314 Succ_DH_cytb556
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000178 SDH_cyt_b560, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
TIGRFAMsiTIGR02970 succ_dehyd_cytB, 1 hit
PROSITEiView protein in PROSITE
PS01000 SDH_CYT_1, 1 hit
PS01001 SDH_CYT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC560_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99643
Secondary accession number(s): O75609
, Q3C259, Q3C2D8, Q3C2H4, Q5VTH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: October 16, 2019
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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