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Protein

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Gene

PKMYT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei139ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei233Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi238Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi251Magnesium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi116 – 124ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156711 Polo-like kinase mediated events
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q99640

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99640

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC:2.7.11.1)
Alternative name(s):
Myt1 kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKMYT1
Synonyms:MYT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127564.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29650 PKMYT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602474 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99640

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi238N → A: Loss of kinase activity. 1 Publication1
Mutagenesisi251D → A: Loss of kinase activity. 1 Publication1
Mutagenesisi486 – 488RNL → AAA: Loss of CDC2-CCNB1 interaction. 1 Publication3

Organism-specific databases

DisGeNET

More...
DisGeNETi
9088

Open Targets

More...
OpenTargetsi
ENSG00000127564

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA385

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3984

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2167

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKMYT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55976573

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865731 – 499Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei426Phosphoserine; by PLK11 Publication1
Modified residuei469PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei495Phosphothreonine; by PLK1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99640

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99640

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99640

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99640

PeptideAtlas

More...
PeptideAtlasi
Q99640

PRoteomics IDEntifications database

More...
PRIDEi
Q99640

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78372

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99640

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99640

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127564 Expressed in 139 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MYT1
HS_PKMYT1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99640 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99640 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA068860

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114544, 21 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q99640

Protein interaction database and analysis system

More...
IntActi
Q99640, 26 interactors

Molecular INTeraction database

More...
MINTi
Q99640

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262300

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99640

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1AX-ray1.70A75-362[»]
5VCVX-ray1.92A75-362[»]
5VCWX-ray2.25A/B75-362[»]
5VCXX-ray2.70A75-362[»]
5VCYX-ray1.56A75-362[»]
5VCZX-ray1.50A75-362[»]
5VD0X-ray2.13A75-362[»]
5VD1X-ray1.70A75-362[»]
5VD3X-ray1.80A75-362[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99640

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99640

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99640

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 359Protein kinasePROSITE-ProRule annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni398 – 499Interaction with PIN1Add BLAST102
Regioni437 – 499Interaction with CDC2-CCNB1Add BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi382 – 398Membrane-association motifAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 72Pro-richAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0601 Eukaryota
ENOG410XS1M LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293277

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053623

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99640

KEGG Orthology (KO)

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KOi
K06633

Database of Orthologous Groups

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OrthoDBi
1417203at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99640

TreeFam database of animal gene trees

More...
TreeFami
TF101087

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR016235 Tyr/Thr_kinase_Cdc2_inhib

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000567 TYPK_Myt1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99640-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLERPPALAM PMPTEGTPPP LSGTPIPVPA YFRHAEPGFS LKRPRGLSRS
60 70 80 90 100
LPPPPPAKGS IPISRLFPPR TPGWHQLQPR RVSFRGEASE TLQSPGYDPS
110 120 130 140 150
RPESFFQQSF QRLSRLGHGS YGEVFKVRSK EDGRLYAVKR SMSPFRGPKD
160 170 180 190 200
RARKLAEVGS HEKVGQHPCC VRLEQAWEEG GILYLQTELC GPSLQQHCEA
210 220 230 240 250
WGASLPEAQV WGYLRDTLLA LAHLHSQGLV HLDVKPANIF LGPRGRCKLG
260 270 280 290 300
DFGLLVELGT AGAGEVQEGD PRYMAPELLQ GSYGTAADVF SLGLTILEVA
310 320 330 340 350
CNMELPHGGE GWQQLRQGYL PPEFTAGLSS ELRSVLVMML EPDPKLRATA
360 370 380 390 400
EALLALPVLR QPRAWGVLWC MAAEALSRGW ALWQALLALL CWLWHGLAHP
410 420 430 440 450
ASWLQPLGPP ATPPGSPPCS LLLDSSLSSN WDDDSLGPSL SPEAVLARTV
460 470 480 490
GSTSTPRSRC TPRDALDLSD INSEPPRGSF PSFEPRNLLS LFEDTLDPT
Length:499
Mass (Da):54,521
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DF28A5965265567
GO
Isoform 2 (identifier: Q99640-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-499: SLSPEAVLAR...SLFEDTLDPT → GHPPCLACPP...AGAHPGMPWT

Note: No experimental confirmation available.
Show »
Length:480
Mass (Da):52,146
Checksum:iE3A040B3858812A6
GO
Isoform 3 (identifier: Q99640-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):53,542
Checksum:i0D60B306B464E780
GO
Isoform 4 (identifier: Q99640-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-73: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,284
Checksum:iCD5FC8DADE1E8E7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHV6A6NHV6_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
447Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L136I3L136_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DZM6B4DZM6_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
568Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3P0I3L3P0_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4K3I3L4K3_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1H7I3L1H7_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4Y0I3L4Y0_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2S4I3L2S4_HUMAN
Membrane-associated tyrosine- and t...
PKMYT1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD28540 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131E → A in BAG53500 (Ref. 4) Curated1
Sequence conflicti415G → D in AAB71843 (PubMed:9268380).Curated1
Sequence conflicti427L → F in AAB71843 (PubMed:9268380).Curated1
Sequence conflicti491L → M in AAB71843 (PubMed:9268380).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041034103E → Q1 PublicationCorresponds to variant dbSNP:rs55834293Ensembl.1
Natural variantiVAR_019928140R → C2 PublicationsCorresponds to variant dbSNP:rs4149796Ensembl.1
Natural variantiVAR_041035246R → H1 PublicationCorresponds to variant dbSNP:rs35192104Ensembl.1
Natural variantiVAR_041036351E → K1 PublicationCorresponds to variant dbSNP:rs56382954Ensembl.1
Natural variantiVAR_019929417P → R1 PublicationCorresponds to variant dbSNP:rs4149800Ensembl.1
Natural variantiVAR_019930445V → A1 PublicationCorresponds to variant dbSNP:rs10546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468461 – 9Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_0468475 – 73Missing in isoform 4. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_045699439 – 499SLSPE…TLDPT → GHPPCLACPPAGLHSPLRLS WPGLWGAPPPPGAGAHPGMP WT in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF014118 mRNA Translation: AAB71843.1
U56816 mRNA Translation: AAC50949.1
AK097642 mRNA Translation: BAG53500.1
AK098452 mRNA No translation available.
AK301926 mRNA Translation: BAG63346.1
AF549406 Genomic DNA Translation: AAN40703.1
AC004233 Genomic DNA Translation: AAC04478.1
AC004235 Genomic DNA Translation: AAC04477.1
CH471112 Genomic DNA Translation: EAW85439.1
CH471112 Genomic DNA Translation: EAW85440.1
AL713779 mRNA Translation: CAD28540.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10486.1 [Q99640-1]
CCDS45391.1 [Q99640-2]
CCDS58414.1 [Q99640-3]
CCDS58415.1 [Q99640-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001245379.1, NM_001258450.1 [Q99640-4]
NP_001245380.1, NM_001258451.1 [Q99640-3]
NP_004194.3, NM_004203.4 [Q99640-1]
NP_872629.1, NM_182687.2 [Q99640-2]
XP_011521036.1, XM_011522734.2 [Q99640-1]
XP_011521037.1, XM_011522735.2 [Q99640-3]
XP_011521038.1, XM_011522736.2 [Q99640-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.732385

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262300; ENSP00000262300; ENSG00000127564 [Q99640-1]
ENST00000440027; ENSP00000397739; ENSG00000127564 [Q99640-2]
ENST00000573944; ENSP00000459123; ENSG00000127564 [Q99640-3]
ENST00000574385; ENSP00000458943; ENSG00000127564 [Q99640-3]
ENST00000574730; ENSP00000460868; ENSG00000127564 [Q99640-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9088

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9088

UCSC genome browser

More...
UCSCi
uc002csm.4 human [Q99640-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014118 mRNA Translation: AAB71843.1
U56816 mRNA Translation: AAC50949.1
AK097642 mRNA Translation: BAG53500.1
AK098452 mRNA No translation available.
AK301926 mRNA Translation: BAG63346.1
AF549406 Genomic DNA Translation: AAN40703.1
AC004233 Genomic DNA Translation: AAC04478.1
AC004235 Genomic DNA Translation: AAC04477.1
CH471112 Genomic DNA Translation: EAW85439.1
CH471112 Genomic DNA Translation: EAW85440.1
AL713779 mRNA Translation: CAD28540.1 Sequence problems.
CCDSiCCDS10486.1 [Q99640-1]
CCDS45391.1 [Q99640-2]
CCDS58414.1 [Q99640-3]
CCDS58415.1 [Q99640-4]
RefSeqiNP_001245379.1, NM_001258450.1 [Q99640-4]
NP_001245380.1, NM_001258451.1 [Q99640-3]
NP_004194.3, NM_004203.4 [Q99640-1]
NP_872629.1, NM_182687.2 [Q99640-2]
XP_011521036.1, XM_011522734.2 [Q99640-1]
XP_011521037.1, XM_011522735.2 [Q99640-3]
XP_011521038.1, XM_011522736.2 [Q99640-3]
UniGeneiHs.732385

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1AX-ray1.70A75-362[»]
5VCVX-ray1.92A75-362[»]
5VCWX-ray2.25A/B75-362[»]
5VCXX-ray2.70A75-362[»]
5VCYX-ray1.56A75-362[»]
5VCZX-ray1.50A75-362[»]
5VD0X-ray2.13A75-362[»]
5VD1X-ray1.70A75-362[»]
5VD3X-ray1.80A75-362[»]
ProteinModelPortaliQ99640
SMRiQ99640
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114544, 21 interactors
ELMiQ99640
IntActiQ99640, 26 interactors
MINTiQ99640
STRINGi9606.ENSP00000262300

Chemistry databases

BindingDBiQ99640
ChEMBLiCHEMBL3984
GuidetoPHARMACOLOGYi2167

PTM databases

iPTMnetiQ99640
PhosphoSitePlusiQ99640

Polymorphism and mutation databases

BioMutaiPKMYT1
DMDMi55976573

Proteomic databases

EPDiQ99640
jPOSTiQ99640
MaxQBiQ99640
PaxDbiQ99640
PeptideAtlasiQ99640
PRIDEiQ99640
ProteomicsDBi78372

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9088
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262300; ENSP00000262300; ENSG00000127564 [Q99640-1]
ENST00000440027; ENSP00000397739; ENSG00000127564 [Q99640-2]
ENST00000573944; ENSP00000459123; ENSG00000127564 [Q99640-3]
ENST00000574385; ENSP00000458943; ENSG00000127564 [Q99640-3]
ENST00000574730; ENSP00000460868; ENSG00000127564 [Q99640-4]
GeneIDi9088
KEGGihsa:9088
UCSCiuc002csm.4 human [Q99640-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9088
DisGeNETi9088
EuPathDBiHostDB:ENSG00000127564.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PKMYT1
HGNCiHGNC:29650 PKMYT1
HPAiHPA068860
MIMi602474 gene
neXtProtiNX_Q99640
OpenTargetsiENSG00000127564
PharmGKBiPA385

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0601 Eukaryota
ENOG410XS1M LUCA
GeneTreeiENSGT00940000159427
HOGENOMiHOG000293277
HOVERGENiHBG053623
InParanoidiQ99640
KOiK06633
OrthoDBi1417203at2759
PhylomeDBiQ99640
TreeFamiTF101087

Enzyme and pathway databases

ReactomeiR-HSA-156711 Polo-like kinase mediated events
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint
SignaLinkiQ99640
SIGNORiQ99640

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PKMYT1 human
EvolutionaryTraceiQ99640

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PKMYT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9088

Protein Ontology

More...
PROi
PR:Q99640

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127564 Expressed in 139 organ(s), highest expression level in right testis
CleanExiHS_MYT1
HS_PKMYT1
ExpressionAtlasiQ99640 baseline and differential
GenevisibleiQ99640 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR016235 Tyr/Thr_kinase_Cdc2_inhib
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000567 TYPK_Myt1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPMYT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99640
Secondary accession number(s): B3KUN8
, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: January 16, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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