Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor 18

Gene

PRPF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the second step of pre-mRNA splicing.1 Publication

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 18
Alternative name(s):
PRP18 homolog
Short name:
hPRP18
Gene namesi
Name:PRPF18
Synonyms:HPRP18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165630.13
HGNCiHGNC:17351 PRPF18
MIMi604993 gene
neXtProtiNX_Q99633

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8559
OpenTargetsiENSG00000165630
PharmGKBiPA38449

Polymorphism and mutation databases

BioMutaiPRPF18
DMDMi37082244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585821 – 342Pre-mRNA-splicing factor 18Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99633
MaxQBiQ99633
PaxDbiQ99633
PeptideAtlasiQ99633
PRIDEiQ99633
ProteomicsDBi78369
78370 [Q99633-2]

PTM databases

iPTMnetiQ99633
PhosphoSitePlusiQ99633

Expressioni

Gene expression databases

BgeeiENSG00000165630 Expressed in 95 organ(s), highest expression level in testis
CleanExiHS_PRPF18
ExpressionAtlasiQ99633 baseline and differential
GenevisibleiQ99633 HS

Organism-specific databases

HPAiHPA037599
HPA047950

Interactioni

Subunit structurei

Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIHO434474EBI-2798416,EBI-1055615

Protein-protein interaction databases

BioGridi114129, 6 interactors
CORUMiQ99633
IntActiQ99633, 83 interactors
STRINGi9606.ENSP00000367835

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99633
SMRiQ99633
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99633

Family & Domainsi

Sequence similaritiesi

Belongs to the PRP18 family.Curated

Phylogenomic databases

eggNOGiKOG2808 Eukaryota
ENOG410XR90 LUCA
GeneTreeiENSGT00390000015073
HOGENOMiHOG000242389
HOVERGENiHBG053696
InParanoidiQ99633
KOiK12817
OMAiDICKHLL
OrthoDBiEOG091G0ID9
PhylomeDBiQ99633
TreeFamiTF315049

Family and domain databases

Gene3Di1.10.720.150, 1 hit
InterProiView protein in InterPro
IPR004098 Prp18
IPR014906 PRP4-like
IPR036285 PRP4-like_sf
PfamiView protein in Pfam
PF02840 Prp18, 1 hit
PF08799 PRP4, 1 hit
SMARTiView protein in SMART
SM00500 SFM, 1 hit
SUPFAMiSSF158230 SSF158230, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKIQ
60 70 80 90 100
PKEEDQKPLT SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE
110 120 130 140 150
TDYDAFQRLR KIEILTPEVN KGLRNDLKAA LDKIDQQYLN EIVGGQEPGE
160 170 180 190 200
EDTQNDLKVH EENTTIEELE ALGESLGKGD DHKDMDIITK FLKFLLGVWA
210 220 230 240 250
KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR NLPADIKESI
260 270 280 290 300
TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
310 320 330 340
HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL
Length:342
Mass (Da):39,860
Last modified:May 1, 1997 - v1
Checksum:i269D79E1E733CF6D
GO
Isoform 2 (identifier: Q99633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-259: Missing.
     286-342: Missing.

Note: No experimental confirmation available.
Show »
Length:47
Mass (Da):5,474
Checksum:i3A4FB4FF31181C8A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T9P7Q5T9P7_HUMAN
Pre-mRNA-splicing factor 18
PRPF18
249Annotation score:
Q5T9P8Q5T9P8_HUMAN
Pre-mRNA-splicing factor 18
PRPF18
167Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00832722 – 259Missing in isoform 2. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_008328286 – 342Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51990 mRNA Translation: AAB41490.1
AL157392 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86281.1
BC000794 mRNA Translation: AAH00794.1
BC002572 mRNA No translation available.
CCDSiCCDS7100.1 [Q99633-1]
RefSeqiNP_003666.1, NM_003675.3 [Q99633-1]
UniGeneiHs.660649
Hs.729158

Genome annotation databases

EnsembliENST00000378572; ENSP00000367835; ENSG00000165630 [Q99633-1]
GeneIDi8559
KEGGihsa:8559
UCSCiuc001imp.4 human [Q99633-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51990 mRNA Translation: AAB41490.1
AL157392 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86281.1
BC000794 mRNA Translation: AAH00794.1
BC002572 mRNA No translation available.
CCDSiCCDS7100.1 [Q99633-1]
RefSeqiNP_003666.1, NM_003675.3 [Q99633-1]
UniGeneiHs.660649
Hs.729158

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK4NMR-A60-122[»]
ProteinModelPortaliQ99633
SMRiQ99633
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114129, 6 interactors
CORUMiQ99633
IntActiQ99633, 83 interactors
STRINGi9606.ENSP00000367835

PTM databases

iPTMnetiQ99633
PhosphoSitePlusiQ99633

Polymorphism and mutation databases

BioMutaiPRPF18
DMDMi37082244

Proteomic databases

EPDiQ99633
MaxQBiQ99633
PaxDbiQ99633
PeptideAtlasiQ99633
PRIDEiQ99633
ProteomicsDBi78369
78370 [Q99633-2]

Protocols and materials databases

DNASUi8559
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378572; ENSP00000367835; ENSG00000165630 [Q99633-1]
GeneIDi8559
KEGGihsa:8559
UCSCiuc001imp.4 human [Q99633-1]

Organism-specific databases

CTDi8559
DisGeNETi8559
EuPathDBiHostDB:ENSG00000165630.13
GeneCardsiPRPF18
HGNCiHGNC:17351 PRPF18
HPAiHPA037599
HPA047950
MIMi604993 gene
neXtProtiNX_Q99633
OpenTargetsiENSG00000165630
PharmGKBiPA38449
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2808 Eukaryota
ENOG410XR90 LUCA
GeneTreeiENSGT00390000015073
HOGENOMiHOG000242389
HOVERGENiHBG053696
InParanoidiQ99633
KOiK12817
OMAiDICKHLL
OrthoDBiEOG091G0ID9
PhylomeDBiQ99633
TreeFamiTF315049

Miscellaneous databases

ChiTaRSiPRPF18 human
EvolutionaryTraceiQ99633
GenomeRNAii8559
PROiPR:Q99633
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165630 Expressed in 95 organ(s), highest expression level in testis
CleanExiHS_PRPF18
ExpressionAtlasiQ99633 baseline and differential
GenevisibleiQ99633 HS

Family and domain databases

Gene3Di1.10.720.150, 1 hit
InterProiView protein in InterPro
IPR004098 Prp18
IPR014906 PRP4-like
IPR036285 PRP4-like_sf
PfamiView protein in Pfam
PF02840 Prp18, 1 hit
PF08799 PRP4, 1 hit
SMARTiView protein in SMART
SM00500 SFM, 1 hit
SUPFAMiSSF158230 SSF158230, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRP18_HUMAN
AccessioniPrimary (citable) accession number: Q99633
Secondary accession number(s): Q5T9P9, Q9BUI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again