Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COP9 signalosome complex subunit 8

Gene

COPS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
Short name:
hCOP9
JAB1-containing signalosome subunit 8
Gene namesi
Name:COPS8
Synonyms:CSN8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000198612.10
HGNCiHGNC:24335 COPS8
MIMi616011 gene
neXtProtiNX_Q99627

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10920
OpenTargetsiENSG00000198612
PharmGKBiPA134968686

Polymorphism and mutation databases

BioMutaiCOPS8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001210072 – 209COP9 signalosome complex subunit 8Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99627
MaxQBiQ99627
PaxDbiQ99627
PeptideAtlasiQ99627
PRIDEiQ99627
ProteomicsDBi78367
78368 [Q99627-2]
TopDownProteomicsiQ99627-1 [Q99627-1]

PTM databases

iPTMnetiQ99627
PhosphoSitePlusiQ99627

Expressioni

Gene expression databases

BgeeiENSG00000198612 Expressed in 234 organ(s), highest expression level in secondary oocyte
CleanExiHS_COPS8
ExpressionAtlasiQ99627 baseline and differential
GenevisibleiQ99627 HS

Organism-specific databases

HPAiHPA036485

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (PubMed:18850735).3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116124, 72 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CPX-1871 COP9 signalosome variant 2
CORUMiQ99627
DIPiDIP-42075N
IntActiQ99627, 25 interactors
MINTiQ99627
STRINGi9606.ENSP00000346340

Structurei

3D structure databases

ProteinModelPortaliQ99627
SMRiQ99627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 179PCIPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the CSN8 family.Curated

Phylogenomic databases

eggNOGiKOG4414 Eukaryota
ENOG410XW9N LUCA
GeneTreeiENSGT00390000000977
HOGENOMiHOG000253954
HOVERGENiHBG051139
InParanoidiQ99627
KOiK12181
OMAiCETQELE
OrthoDBiEOG091G0O7O
PhylomeDBiQ99627
TreeFamiTF101150

Family and domain databases

InterProiView protein in InterPro
IPR033205 COP9_CSN8
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR13339 PTHR13339, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM
60 70 80 90 100
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE
110 120 130 140 150
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE
160 170 180 190 200
QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL

TDYVAFLEN
Length:209
Mass (Da):23,226
Last modified:May 1, 1997 - v1
Checksum:i203E236D8E304A8A
GO
Isoform 2 (identifier: Q99627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,909
Checksum:i3E7A1CA5C341955A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGT6E9PGT6_HUMAN
COP9 signalosome complex subunit 8
COPS8
173Annotation score:
F8WEF2F8WEF2_HUMAN
COP9 signalosome complex subunit 8
COPS8
64Annotation score:
H7C3S9H7C3S9_HUMAN
COP9 signalosome complex subunit 8
COPS8
83Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427151 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51205 mRNA Translation: AAB38529.1
AK289891 mRNA Translation: BAF82580.1
CR456994 mRNA Translation: CAG33275.1
AC105760 Genomic DNA Translation: AAY14978.1
CH471063 Genomic DNA Translation: EAW71097.1
CH471063 Genomic DNA Translation: EAW71098.1
BC003090 mRNA Translation: AAH03090.1
BC036499 mRNA Translation: AAH36499.1
BC080617 mRNA Translation: AAH80617.1
CCDSiCCDS2517.1 [Q99627-1]
CCDS42835.1 [Q99627-2]
RefSeqiNP_006701.1, NM_006710.4 [Q99627-1]
NP_937832.1, NM_198189.2 [Q99627-2]
UniGeneiHs.531713

Genome annotation databases

EnsembliENST00000354371; ENSP00000346340; ENSG00000198612 [Q99627-1]
ENST00000392008; ENSP00000375865; ENSG00000198612 [Q99627-2]
GeneIDi10920
KEGGihsa:10920
UCSCiuc002vwg.4 human [Q99627-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51205 mRNA Translation: AAB38529.1
AK289891 mRNA Translation: BAF82580.1
CR456994 mRNA Translation: CAG33275.1
AC105760 Genomic DNA Translation: AAY14978.1
CH471063 Genomic DNA Translation: EAW71097.1
CH471063 Genomic DNA Translation: EAW71098.1
BC003090 mRNA Translation: AAH03090.1
BC036499 mRNA Translation: AAH36499.1
BC080617 mRNA Translation: AAH80617.1
CCDSiCCDS2517.1 [Q99627-1]
CCDS42835.1 [Q99627-2]
RefSeqiNP_006701.1, NM_006710.4 [Q99627-1]
NP_937832.1, NM_198189.2 [Q99627-2]
UniGeneiHs.531713

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80H/P2-209[»]
4D18X-ray4.08H/P1-209[»]
4WSNX-ray5.50H/P/X/f/n/v1-209[»]
ProteinModelPortaliQ99627
SMRiQ99627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116124, 72 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CPX-1871 COP9 signalosome variant 2
CORUMiQ99627
DIPiDIP-42075N
IntActiQ99627, 25 interactors
MINTiQ99627
STRINGi9606.ENSP00000346340

PTM databases

iPTMnetiQ99627
PhosphoSitePlusiQ99627

Polymorphism and mutation databases

BioMutaiCOPS8

Proteomic databases

EPDiQ99627
MaxQBiQ99627
PaxDbiQ99627
PeptideAtlasiQ99627
PRIDEiQ99627
ProteomicsDBi78367
78368 [Q99627-2]
TopDownProteomicsiQ99627-1 [Q99627-1]

Protocols and materials databases

DNASUi10920
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354371; ENSP00000346340; ENSG00000198612 [Q99627-1]
ENST00000392008; ENSP00000375865; ENSG00000198612 [Q99627-2]
GeneIDi10920
KEGGihsa:10920
UCSCiuc002vwg.4 human [Q99627-1]

Organism-specific databases

CTDi10920
DisGeNETi10920
EuPathDBiHostDB:ENSG00000198612.10
GeneCardsiCOPS8
HGNCiHGNC:24335 COPS8
HPAiHPA036485
MIMi616011 gene
neXtProtiNX_Q99627
OpenTargetsiENSG00000198612
PharmGKBiPA134968686
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4414 Eukaryota
ENOG410XW9N LUCA
GeneTreeiENSGT00390000000977
HOGENOMiHOG000253954
HOVERGENiHBG051139
InParanoidiQ99627
KOiK12181
OMAiCETQELE
OrthoDBiEOG091G0O7O
PhylomeDBiQ99627
TreeFamiTF101150

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOPS8 human
GeneWikiiCOPS8
GenomeRNAii10920
PROiPR:Q99627
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198612 Expressed in 234 organ(s), highest expression level in secondary oocyte
CleanExiHS_COPS8
ExpressionAtlasiQ99627 baseline and differential
GenevisibleiQ99627 HS

Family and domain databases

InterProiView protein in InterPro
IPR033205 COP9_CSN8
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR13339 PTHR13339, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN8_HUMAN
AccessioniPrimary (citable) accession number: Q99627
Secondary accession number(s): A8K1H6, Q53QS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again