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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

SLC38A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.18.6.3 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
System N amino acid transporter 1
Gene namesi
Name:SLC38A3Imported
Synonyms:G17, NAT1, SN1, SNAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000188338.14
HGNCiHGNC:18044 SLC38A3
MIMi604437 gene
neXtProtiNX_Q99624

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10991
OpenTargetsiENSG00000188338
PharmGKBiPA38281

Chemistry databases

DrugBankiDB00174 L-Asparagine
DB00130 L-Glutamine
DB00117 L-Histidine

Polymorphism and mutation databases

BioMutaiSLC38A3
DMDMi52783419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938281 – 504Sodium-coupled neutral amino acid transporter 3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 275PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99624
PeptideAtlasiQ99624
PRIDEiQ99624
ProteomicsDBi78365

PTM databases

iPTMnetiQ99624
PhosphoSitePlusiQ99624

Expressioni

Gene expression databases

BgeeiENSG00000188338 Expressed in 104 organ(s), highest expression level in right lobe of liver
CleanExiHS_NAT1
HS_SLC38A3
ExpressionAtlasiQ99624 baseline and differential
GenevisibleiQ99624 HS

Organism-specific databases

HPAiHPA031871

Interactioni

Protein-protein interaction databases

BioGridi116187, 5 interactors
IntActiQ99624, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ99624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119147
HOVERGENiHBG059571
InParanoidiQ99624
KOiK13576
OMAiTTGNFSH
OrthoDBiEOG091G0GP8
PhylomeDBiQ99624

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ
60 70 80 90 100
KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL
110 120 130 140 150
FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT
160 170 180 190 200
LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI
210 220 230 240 250
ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT
260 270 280 290 300
GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ
410 420 430 440 450
EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH

GGNH
Length:504
Mass (Da):55,773
Last modified:May 1, 1997 - v1
Checksum:i86E7D205C6001C60
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Q4A0A087X1Q4_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A3
99Annotation score:
A0A087X175A0A087X175_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A3
104Annotation score:
A0A087WWS5A0A087WWS5_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A3
216Annotation score:
A0A087WVW8A0A087WVW8_HUMAN
Sodium-coupled neutral amino acid t...
SLC38A3
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → P in CAG33251 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA Translation: AAG15313.1
U49082 mRNA Translation: AAB47236.1
CR456970 mRNA Translation: CAG33251.1
AK313461 mRNA Translation: BAG36247.1
BX537382 mRNA Translation: CAD97624.1
AC002077 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65050.1
BC042875 mRNA Translation: AAH42875.1
CCDSiCCDS74940.1
RefSeqiNP_006832.1, NM_006841.5
XP_006713017.1, XM_006712954.2
UniGeneiHs.76460

Genome annotation databases

EnsembliENST00000614032; ENSP00000481301; ENSG00000188338
GeneIDi10991
KEGGihsa:10991
UCSCiuc032rmu.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244548 mRNA Translation: AAG15313.1
U49082 mRNA Translation: AAB47236.1
CR456970 mRNA Translation: CAG33251.1
AK313461 mRNA Translation: BAG36247.1
BX537382 mRNA Translation: CAD97624.1
AC002077 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65050.1
BC042875 mRNA Translation: AAH42875.1
CCDSiCCDS74940.1
RefSeqiNP_006832.1, NM_006841.5
XP_006713017.1, XM_006712954.2
UniGeneiHs.76460

3D structure databases

ProteinModelPortaliQ99624
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116187, 5 interactors
IntActiQ99624, 3 interactors

Chemistry databases

DrugBankiDB00174 L-Asparagine
DB00130 L-Glutamine
DB00117 L-Histidine

Protein family/group databases

TCDBi2.A.18.6.3 the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetiQ99624
PhosphoSitePlusiQ99624

Polymorphism and mutation databases

BioMutaiSLC38A3
DMDMi52783419

Proteomic databases

MaxQBiQ99624
PeptideAtlasiQ99624
PRIDEiQ99624
ProteomicsDBi78365

Protocols and materials databases

DNASUi10991
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614032; ENSP00000481301; ENSG00000188338
GeneIDi10991
KEGGihsa:10991
UCSCiuc032rmu.2 human

Organism-specific databases

CTDi10991
DisGeNETi10991
EuPathDBiHostDB:ENSG00000188338.14
GeneCardsiSLC38A3
HGNCiHGNC:18044 SLC38A3
HPAiHPA031871
MIMi604437 gene
neXtProtiNX_Q99624
OpenTargetsiENSG00000188338
PharmGKBiPA38281
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119147
HOVERGENiHBG059571
InParanoidiQ99624
KOiK13576
OMAiTTGNFSH
OrthoDBiEOG091G0GP8
PhylomeDBiQ99624

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRSiSLC38A3 human
GeneWikiiSLC38A3
GenomeRNAii10991
PROiPR:Q99624
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188338 Expressed in 104 organ(s), highest expression level in right lobe of liver
CleanExiHS_NAT1
HS_SLC38A3
ExpressionAtlasiQ99624 baseline and differential
GenevisibleiQ99624 HS

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS38A3_HUMAN
AccessioniPrimary (citable) accession number: Q99624
Secondary accession number(s): B2R8Q0, Q6IB34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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