Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prohibitin-2

Gene

PHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.1 PublicationBy similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amide binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8949664 Processing of SMDT1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99623

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prohibitin-2
Alternative name(s):
B-cell receptor-associated protein BAP37
D-prohibitin
Repressor of estrogen receptor activity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHB2Imported
Synonyms:BAPImported, REAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000215021.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30306 PHB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610704 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99623

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11331

Open Targets

More...
OpenTargetsi
ENSG00000215021

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671181

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138842 – 299Prohibitin-2Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei128PhosphotyrosineCombined sources1
Modified residuei147N6-acetyllysineBy similarity1
Modified residuei151PhosphoserineCombined sources1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei236N6-acetyllysineBy similarity1
Modified residuei250N6-acetyllysineCombined sources1
Modified residuei262N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99623

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99623

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99623

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99623

PeptideAtlas

More...
PeptideAtlasi
Q99623

PRoteomics IDEntifications database

More...
PRIDEi
Q99623

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78364

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q99623-1 [Q99623-1]
Q99623-2 [Q99623-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q99623

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q99623

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99623

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99623

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99623

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Levels of expression in fibroblasts decrease heterogeneously during cellular aging.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215021 Expressed in 234 organ(s), highest expression level in caecum

CleanEx database of gene expression profiles

More...
CleanExi
HS_PHB2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99623 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99623 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB014889
CAB026335
HPA039874

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033724EBI-358348,EBI-78473

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116459, 185 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q99623

Protein interaction database and analysis system

More...
IntActi
Q99623, 79 interactors

Molecular INTeraction database

More...
MINTi
Q99623

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441875

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99623

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99623

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 49Necessary for transcriptional repression1 PublicationAdd BLAST31
Regioni150 – 174Necessary for transcriptional repression1 PublicationAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili190 – 238Sequence analysisAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3090 Eukaryota
COG0330 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000205692

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004457

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99623

KEGG Orthology (KO)

More...
KOi
K17081

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELGTDYD

Database of Orthologous Groups

More...
OrthoDBi
1089994at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99623

TreeFam database of animal gene trees

More...
TreeFami
TF354230

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03401 SPFH_prohibitin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin

The PANTHER Classification System

More...
PANTHERi
PTHR23222 PTHR23222, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01145 Band_7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00679 PROHIBITIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00244 PHB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117892 SSF117892, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99623-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE ALSKNPGYIK
260 270 280 290
LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK
Length:299
Mass (Da):33,296
Last modified:July 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA887CC982BF85C80
GO
Isoform 2 (identifier: Q99623-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-240: Missing.

Show »
Length:261
Mass (Da):29,044
Checksum:iF698CB300517B30A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPX7J3KPX7_HUMAN
Prohibitin-2
PHB2
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY37F5GY37_HUMAN
Prohibitin-2
PHB2
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWA7F5GWA7_HUMAN
Prohibitin-2
PHB2
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3X6F5H3X6_HUMAN
Prohibitin-2
PHB2
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2D2F5H2D2_HUMAN
Prohibitin-2
PHB2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPZ5U3KPZ5_HUMAN
Prohibitin-2
PHB2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0C5F5H0C5_HUMAN
Prohibitin-2
PHB2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045311203 – 240Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U72511 mRNA Translation: AAC51639.1
AF150962 mRNA Translation: AAD38042.1
AF178980 mRNA Translation: AAF44345.1
AF126021 mRNA Translation: AAF17231.1
AK298217 mRNA Translation: BAG60487.1
U47924 Genomic DNA Translation: AAB51324.1
BC014766 mRNA Translation: AAH14766.1
BC110322 mRNA Translation: AAI10323.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53741.1 [Q99623-1]
CCDS58207.1 [Q99623-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001138303.1, NM_001144831.1 [Q99623-1]
NP_001254629.1, NM_001267700.1 [Q99623-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.504620

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000440277; ENSP00000412856; ENSG00000215021 [Q99623-2]
ENST00000535923; ENSP00000441875; ENSG00000215021 [Q99623-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11331

UCSC genome browser

More...
UCSCi
uc058kpb.1 human [Q99623-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72511 mRNA Translation: AAC51639.1
AF150962 mRNA Translation: AAD38042.1
AF178980 mRNA Translation: AAF44345.1
AF126021 mRNA Translation: AAF17231.1
AK298217 mRNA Translation: BAG60487.1
U47924 Genomic DNA Translation: AAB51324.1
BC014766 mRNA Translation: AAH14766.1
BC110322 mRNA Translation: AAI10323.1
CCDSiCCDS53741.1 [Q99623-1]
CCDS58207.1 [Q99623-2]
RefSeqiNP_001138303.1, NM_001144831.1 [Q99623-1]
NP_001254629.1, NM_001267700.1 [Q99623-2]
UniGeneiHs.504620

3D structure databases

ProteinModelPortaliQ99623
SMRiQ99623
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116459, 185 interactors
CORUMiQ99623
IntActiQ99623, 79 interactors
MINTiQ99623
STRINGi9606.ENSP00000441875

PTM databases

CarbonylDBiQ99623
iPTMnetiQ99623
PhosphoSitePlusiQ99623
SwissPalmiQ99623

Polymorphism and mutation databases

BioMutaiPHB2
DMDMi74752151

2D gel databases

OGPiQ99623

Proteomic databases

EPDiQ99623
jPOSTiQ99623
MaxQBiQ99623
PaxDbiQ99623
PeptideAtlasiQ99623
PRIDEiQ99623
ProteomicsDBi78364
TopDownProteomicsiQ99623-1 [Q99623-1]
Q99623-2 [Q99623-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11331
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000440277; ENSP00000412856; ENSG00000215021 [Q99623-2]
ENST00000535923; ENSP00000441875; ENSG00000215021 [Q99623-1]
GeneIDi11331
KEGGihsa:11331
UCSCiuc058kpb.1 human [Q99623-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11331
DisGeNETi11331
EuPathDBiHostDB:ENSG00000215021.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHB2
HGNCiHGNC:30306 PHB2
HPAiCAB014889
CAB026335
HPA039874
MIMi610704 gene
neXtProtiNX_Q99623
OpenTargetsiENSG00000215021
PharmGKBiPA142671181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiQ99623
KOiK17081
OMAiELGTDYD
OrthoDBi1089994at2759
PhylomeDBiQ99623
TreeFamiTF354230

Enzyme and pathway databases

ReactomeiR-HSA-8949664 Processing of SMDT1
SIGNORiQ99623

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHB2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PHB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11331

Protein Ontology

More...
PROi
PR:Q99623

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000215021 Expressed in 234 organ(s), highest expression level in caecum
CleanExiHS_PHB2
ExpressionAtlasiQ99623 baseline and differential
GenevisibleiQ99623 HS

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99623
Secondary accession number(s): B4DP75
, Q2YDA4, Q7KYU3, Q92978
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 1, 1997
Last modified: January 16, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again