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Protein

Cell division cycle-associated protein 3

Gene

CDCA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

SIGNORiQ99618
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 3
Alternative name(s):
Gene-rich cluster protein C8
Trigger of mitotic entry protein 1
Short name:
TOME-1
Gene namesi
Name:CDCA3
Synonyms:C8, GRCC8, TOME1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111665.11
HGNCiHGNC:14624 CDCA3
MIMi607749 gene
neXtProtiNX_Q99618

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi83461
OpenTargetsiENSG00000111665
PharmGKBiPA26276

Polymorphism and mutation databases

BioMutaiCDCA3
DMDMi74732787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877081 – 268Cell division cycle-associated protein 3Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei202PhosphothreonineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212PhosphothreonineBy similarity1

Post-translational modificationi

Ubiquitinated and degraded by the APC/C-Cdh1 complex.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99618
MaxQBiQ99618
PaxDbiQ99618
PeptideAtlasiQ99618
PRIDEiQ99618
ProteomicsDBi78361

PTM databases

iPTMnetiQ99618
PhosphoSitePlusiQ99618

Expressioni

Gene expression databases

BgeeiENSG00000111665 Expressed in 137 organ(s), highest expression level in oocyte
CleanExiHS_CDCA3
ExpressionAtlasiQ99618 baseline and differential
GenevisibleiQ99618 HS

Organism-specific databases

HPAiHPA026587

Interactioni

Subunit structurei

Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi123657, 44 interactors
IntActiQ99618, 34 interactors
STRINGi9606.ENSP00000442068

Structurei

3D structure databases

ProteinModelPortaliQ99618
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 120F-box-likeAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi258 – 260KEN box3

Domaini

The KEN box is required for the association with the APC/C-Cdh1 complex.By similarity

Phylogenomic databases

eggNOGiENOG410IQ4X Eukaryota
ENOG410Y54T LUCA
GeneTreeiENSGT00390000017343
HOGENOMiHOG000013100
HOVERGENiHBG053225
InParanoidiQ99618
OMAiGHDKENQ
OrthoDBiEOG091G0MF1
PhylomeDBiQ99618
TreeFamiTF101068

Family and domain databases

InterProiView protein in InterPro
IPR038832 CDCA3
PANTHERiPTHR34756 PTHR34756, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99618-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSAKSVPVT PARPPPHNKH LARVADPRSP SAGILRTPIQ VESSPQPGLP
60 70 80 90 100
AGEQLEGLKH AQDSDPRSPT LGIARTPMKT SSGDPPSPLV KQLSEVFETE
110 120 130 140 150
DSKSNLPPEP VLPPEAPLSS ELDLPLGTQL SVEEQMPPWN QTEFPSKQVF
160 170 180 190 200
SKEEARQPTE TPVASQSSDK PSRDPETPRS SGSMRNRWKP NSSKVLGRSP
210 220 230 240 250
LTILQDDNSP GTLTLRQGKR PSPLSENVSE LKEGAILGTG RLLKTGGRAW
260
EQGQDHDKEN QHFPLVES
Length:268
Mass (Da):28,998
Last modified:May 1, 1997 - v1
Checksum:i48933FA7FF57112C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDL1F8WDL1_HUMAN
Cell division cycle-associated prot...
CDCA3
219Annotation score:
J3KMY0J3KMY0_HUMAN
Cell division cycle-associated prot...
CDCA3
243Annotation score:
F5GX58F5GX58_HUMAN
Cell division cycle-associated prot...
CDCA3
182Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BG354576 mRNA No translation available.
U47924 Genomic DNA Translation: AAB51327.1
AK291421 mRNA Translation: BAF84110.1
CH471116 Genomic DNA Translation: EAW88728.1
CH471116 Genomic DNA Translation: EAW88729.1
BC002551 mRNA Translation: AAH02551.1
BC036512 mRNA Translation: AAH36512.1
CCDSiCCDS8565.1
RefSeqiNP_001284532.1, NM_001297603.2
NP_001284533.1, NM_001297604.2
NP_001317948.1, NM_001331019.1
NP_112589.1, NM_031299.6
UniGeneiHs.524216
Hs.709355

Genome annotation databases

EnsembliENST00000535406; ENSP00000446339; ENSG00000111665
ENST00000538862; ENSP00000442068; ENSG00000111665
GeneIDi83461
KEGGihsa:83461
UCSCiuc001qrg.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BG354576 mRNA No translation available.
U47924 Genomic DNA Translation: AAB51327.1
AK291421 mRNA Translation: BAF84110.1
CH471116 Genomic DNA Translation: EAW88728.1
CH471116 Genomic DNA Translation: EAW88729.1
BC002551 mRNA Translation: AAH02551.1
BC036512 mRNA Translation: AAH36512.1
CCDSiCCDS8565.1
RefSeqiNP_001284532.1, NM_001297603.2
NP_001284533.1, NM_001297604.2
NP_001317948.1, NM_001331019.1
NP_112589.1, NM_031299.6
UniGeneiHs.524216
Hs.709355

3D structure databases

ProteinModelPortaliQ99618
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123657, 44 interactors
IntActiQ99618, 34 interactors
STRINGi9606.ENSP00000442068

PTM databases

iPTMnetiQ99618
PhosphoSitePlusiQ99618

Polymorphism and mutation databases

BioMutaiCDCA3
DMDMi74732787

Proteomic databases

EPDiQ99618
MaxQBiQ99618
PaxDbiQ99618
PeptideAtlasiQ99618
PRIDEiQ99618
ProteomicsDBi78361

Protocols and materials databases

DNASUi83461
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535406; ENSP00000446339; ENSG00000111665
ENST00000538862; ENSP00000442068; ENSG00000111665
GeneIDi83461
KEGGihsa:83461
UCSCiuc001qrg.3 human

Organism-specific databases

CTDi83461
DisGeNETi83461
EuPathDBiHostDB:ENSG00000111665.11
GeneCardsiCDCA3
HGNCiHGNC:14624 CDCA3
HPAiHPA026587
MIMi607749 gene
neXtProtiNX_Q99618
OpenTargetsiENSG00000111665
PharmGKBiPA26276
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ4X Eukaryota
ENOG410Y54T LUCA
GeneTreeiENSGT00390000017343
HOGENOMiHOG000013100
HOVERGENiHBG053225
InParanoidiQ99618
OMAiGHDKENQ
OrthoDBiEOG091G0MF1
PhylomeDBiQ99618
TreeFamiTF101068

Enzyme and pathway databases

UniPathwayi
UPA00143

SIGNORiQ99618

Miscellaneous databases

GeneWikiiCDCA3
GenomeRNAii83461
PROiPR:Q99618
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111665 Expressed in 137 organ(s), highest expression level in oocyte
CleanExiHS_CDCA3
ExpressionAtlasiQ99618 baseline and differential
GenevisibleiQ99618 HS

Family and domain databases

InterProiView protein in InterPro
IPR038832 CDCA3
PANTHERiPTHR34756 PTHR34756, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDCA3_HUMAN
AccessioniPrimary (citable) accession number: Q99618
Secondary accession number(s): A8K5V6, D3DUS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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