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Protein

C-C motif chemokine 13

Gene

CCL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

Miscellaneous

This protein can bind heparin.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 13
Alternative name(s):
CK-beta-10
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
Short name:
MCP-4
NCC-1
Small-inducible cytokine A13
Cleaved into the following 3 chains:
Gene namesi
Name:CCL13
Synonyms:MCP4, NCC1, SCYA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181374.7
HGNCiHGNC:10611 CCL13
MIMi601391 gene
neXtProtiNX_Q99616

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6357
OpenTargetsiENSG00000181374
PharmGKBiPA35544

Polymorphism and mutation databases

BioMutaiCCL13
DMDMi3024128

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000000520117 – 98C-C motif chemokine 13, long chainAdd BLAST82
ChainiPRO_000000520222 – 98C-C motif chemokine 13, medium chainAdd BLAST77
ChainiPRO_000000520324 – 98C-C motif chemokine 13, short chainAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid; in short chain1 Publication1
Disulfide bondi34 ↔ 581 Publication
Disulfide bondi35 ↔ 741 Publication

Post-translational modificationi

One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ99616
PRIDEiQ99616
ProteomicsDBi78360

PTM databases

PhosphoSitePlusiQ99616

Miscellaneous databases

PMAP-CutDBiQ99616

Expressioni

Tissue specificityi

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Inductioni

By IL1/interleukin-1 and TNF.

Gene expression databases

BgeeiENSG00000181374 Expressed in 122 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_CCL13
ExpressionAtlasiQ99616 baseline and differential
GenevisibleiQ99616 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112260, 2 interactors
DIPiDIP-5874N
IntActiQ99616, 17 interactors
STRINGi9606.ENSP00000225844

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99616
SMRiQ99616
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99616

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEQZ Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
InParanoidiQ99616
KOiK16595
OMAiEKEICAD
OrthoDBiEOG091G14KV
PhylomeDBiQ99616
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS
60 70 80 90
YVITTSRCPQ KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT
Length:98
Mass (Da):10,986
Last modified:May 1, 1997 - v1
Checksum:i612688DFCD308873
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLQ9J3QLQ9_HUMAN
C-C motif chemokine 13
CCL13
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 98AHTLKT → LTP in CAB01111 (Ref. 12) Curated6

Mass spectrometryi

Molecular mass is 9314±30 Da from positions 17 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8760±30 Da from positions 22 - 98. Determined by MALDI. 1 Publication
Molecular mass is 8575±30 Da from positions 24 - 98. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0241695A → S. Corresponds to variant dbSNP:rs3136677Ensembl.1
Natural variantiVAR_04870629N → S. Corresponds to variant dbSNP:rs34566308Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46767 mRNA Translation: AAB38703.1
X98306 mRNA Translation: CAA66950.1
U59808 mRNA Translation: AAD09362.1
AJ001634 mRNA Translation: CAA04888.1
BT007385 mRNA Translation: AAP36049.1
AC002482 Genomic DNA Translation: AAB67307.1
CR450337 mRNA Translation: CAG29333.1
CH471147 Genomic DNA Translation: EAW80206.1
BC008621 mRNA Translation: AAH08621.1
Z77650 mRNA Translation: CAB01111.1
CCDSiCCDS11281.1
RefSeqiNP_005399.1, NM_005408.2
UniGeneiHs.414629

Genome annotation databases

EnsembliENST00000225844; ENSP00000225844; ENSG00000181374
GeneIDi6357
KEGGihsa:6357
UCSCiuc002hic.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL13 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46767 mRNA Translation: AAB38703.1
X98306 mRNA Translation: CAA66950.1
U59808 mRNA Translation: AAD09362.1
AJ001634 mRNA Translation: CAA04888.1
BT007385 mRNA Translation: AAP36049.1
AC002482 Genomic DNA Translation: AAB67307.1
CR450337 mRNA Translation: CAG29333.1
CH471147 Genomic DNA Translation: EAW80206.1
BC008621 mRNA Translation: AAH08621.1
Z77650 mRNA Translation: CAB01111.1
CCDSiCCDS11281.1
RefSeqiNP_005399.1, NM_005408.2
UniGeneiHs.414629

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RA4X-ray1.70A/B24-98[»]
ProteinModelPortaliQ99616
SMRiQ99616
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112260, 2 interactors
DIPiDIP-5874N
IntActiQ99616, 17 interactors
STRINGi9606.ENSP00000225844

PTM databases

PhosphoSitePlusiQ99616

Polymorphism and mutation databases

BioMutaiCCL13
DMDMi3024128

Proteomic databases

PaxDbiQ99616
PRIDEiQ99616
ProteomicsDBi78360

Protocols and materials databases

DNASUi6357
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225844; ENSP00000225844; ENSG00000181374
GeneIDi6357
KEGGihsa:6357
UCSCiuc002hic.3 human

Organism-specific databases

CTDi6357
DisGeNETi6357
EuPathDBiHostDB:ENSG00000181374.7
GeneCardsiCCL13
HGNCiHGNC:10611 CCL13
MIMi601391 gene
neXtProtiNX_Q99616
OpenTargetsiENSG00000181374
PharmGKBiPA35544
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEQZ Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
InParanoidiQ99616
KOiK16595
OMAiEKEICAD
OrthoDBiEOG091G14KV
PhylomeDBiQ99616
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiCCL13 human
EvolutionaryTraceiQ99616
GenomeRNAii6357
PMAP-CutDBiQ99616
PROiPR:Q99616
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181374 Expressed in 122 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_CCL13
ExpressionAtlasiQ99616 baseline and differential
GenevisibleiQ99616 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL13_HUMAN
AccessioniPrimary (citable) accession number: Q99616
Secondary accession number(s): O95689, Q6ICQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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