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Entry version 173 (07 Apr 2021)
Sequence version 3 (26 Feb 2008)
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Protein

Selenide, water dikinase 2

Gene

SEPHS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesizes selenophosphate from selenide and ATP.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei60Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63ATPBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei63Important for catalytic activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi120MagnesiumBy similarity1
Binding sitei138ATPBy similarity1
Metal bindingi161MagnesiumBy similarity1
Binding sitei161ATPBy similarity1
Metal bindingi316MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi118 – 120ATPBy similarity3
Nucleotide bindingi212 – 215ATP; shared with dimeric partnerBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Selenium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.9.3, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q99611

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2408557, Selenocysteine synthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Selenide, water dikinase 2 (EC:2.7.9.3By similarity)
Alternative name(s):
Selenium donor protein 2
Selenophosphate synthase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEPHS2
Synonyms:SPS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19686, SEPHS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606218, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99611

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22928

Open Targets

More...
OpenTargetsi
ENSG00000179918

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868765

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99611, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEPHS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172044671

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001276502 – 448Selenide, water dikinase 2Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99611

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99611

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99611

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99611

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99611

PeptideAtlas

More...
PeptideAtlasi
Q99611

PRoteomics IDEntifications database

More...
PRIDEi
Q99611

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78354

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99611

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99611

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000179918, Tissue enhanced (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116588, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q99611

Protein interaction database and analysis system

More...
IntActi
Q99611, 6 interactors

Molecular INTeraction database

More...
MINTi
Q99611

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418669

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99611, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3939, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000950

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99611

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSQNLAR

Database of Orthologous Groups

More...
OrthoDBi
1166567at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99611

TreeFam database of animal gene trees

More...
TreeFami
TF313811

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02195, SelD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf
IPR004536, SPS/SelD

The PANTHER Classification System

More...
PANTHERi
PTHR10256, PTHR10256, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55326, SSF55326, 1 hit
SSF56042, SSF56042, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00476, selD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q99611-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEASATGAC GEAMAAAEGS SGPAGLTLGR SFSNYRPFEP QALGLSPSWR
60 70 80 90 100
LTGFSGMKGU GCKVPQEALL KLLAGLTRPD VRPPLGRGLV GGQEEASQEA
110 120 130 140 150
GLPAGAGPSP TFPALGIGMD SCVIPLRHGG LSLVQTTDFF YPLVEDPYMM
160 170 180 190 200
GRIACANVLS DLYAMGITEC DNMLMLLSVS QSMSEEEREK VTPLMVKGFR
210 220 230 240 250
DAAEEGGTAV TGGQTVVNPW IIIGGVATVV CQPNEFIMPD SAVVGDVLVL
260 270 280 290 300
TKPLGTQVAV NAHQWLDNPE RWNKVKMVVS REEVELAYQE AMFNMATLNR
310 320 330 340 350
TAAGLMHTFN AHAATDITGF GILGHSQNLA KQQRNEVSFV IHNLPIIAKM
360 370 380 390 400
AAVSKASGRF GLLQGTSAET SGGLLICLPR EQAARFCSEI KSSKYGEGHQ
410 420 430 440
AWIVGIVEKG NRTARIIDKP RVIEVLPRGA TAAVLAPDSS NASSEPSS
Length:448
Mass (Da):47,305
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i309520C0CAE770F7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052345269P → A. Corresponds to variant dbSNP:rs1804600Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei60Selenocysteine1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43286 mRNA Translation: AAC50958.2
AC116348 Genomic DNA No translation available.
BC002381 mRNA Translation: AAH02381.3
BC016643 mRNA Translation: AAH16643.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42150.1

NCBI Reference Sequences

More...
RefSeqi
NP_036380.2, NM_012248.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000478753; ENSP00000418669; ENSG00000179918

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22928

Keywords - Coding sequence diversityi

Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43286 mRNA Translation: AAC50958.2
AC116348 Genomic DNA No translation available.
BC002381 mRNA Translation: AAH02381.3
BC016643 mRNA Translation: AAH16643.1
CCDSiCCDS42150.1
RefSeqiNP_036380.2, NM_012248.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116588, 17 interactors
CORUMiQ99611
IntActiQ99611, 6 interactors
MINTiQ99611
STRINGi9606.ENSP00000418669

PTM databases

iPTMnetiQ99611
PhosphoSitePlusiQ99611

Genetic variation databases

BioMutaiSEPHS2
DMDMi172044671

Proteomic databases

EPDiQ99611
jPOSTiQ99611
MassIVEiQ99611
MaxQBiQ99611
PaxDbiQ99611
PeptideAtlasiQ99611
PRIDEiQ99611
ProteomicsDBi78354

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
43619, 106 antibodies

The DNASU plasmid repository

More...
DNASUi
22928

Genome annotation databases

EnsembliENST00000478753; ENSP00000418669; ENSG00000179918
GeneIDi22928
KEGGihsa:22928

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22928
DisGeNETi22928

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SEPHS2
HGNCiHGNC:19686, SEPHS2
HPAiENSG00000179918, Tissue enhanced (intestine, liver)
MIMi606218, gene
neXtProtiNX_Q99611
OpenTargetsiENSG00000179918
PharmGKBiPA134868765

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3939, Eukaryota
GeneTreeiENSGT00390000000950
InParanoidiQ99611
OMAiHSQNLAR
OrthoDBi1166567at2759
PhylomeDBiQ99611
TreeFamiTF313811

Enzyme and pathway databases

BRENDAi2.7.9.3, 2681
PathwayCommonsiQ99611
ReactomeiR-HSA-2408557, Selenocysteine synthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22928, 334 hits in 966 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEPHS2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22928
PharosiQ99611, Tdark

Protein Ontology

More...
PROi
PR:Q99611
RNActiQ99611, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd02195, SelD, 1 hit
InterProiView protein in InterPro
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf
IPR004536, SPS/SelD
PANTHERiPTHR10256, PTHR10256, 1 hit
PfamiView protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 1 hit
SUPFAMiSSF55326, SSF55326, 1 hit
SSF56042, SSF56042, 1 hit
TIGRFAMsiTIGR00476, selD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99611
Secondary accession number(s): Q9BUQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 26, 2008
Last modified: April 7, 2021
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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