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Protein

Necdin

Gene

NDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).By similarity

Miscellaneous

Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous gene syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and possibly other genes within the chromosome region 15q11-q13.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processGrowth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and 13 signaling
SIGNORiQ99608

Names & Taxonomyi

Protein namesi
Recommended name:
Necdin
Gene namesi
Name:NDN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182636.5
HGNCiHGNC:7675 NDN
MIMi602117 gene
neXtProtiNX_Q99608

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4692
GeneReviewsiNDN
MalaCardsiNDN
MIMi176270 phenotype
OpenTargetsiENSG00000182636
Orphaneti177910 Prader-Willi syndrome due to imprinting mutation
98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
PharmGKBiPA31479

Polymorphism and mutation databases

BioMutaiNDN
DMDMi17380142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567401 – 321NecdinAdd BLAST321

Proteomic databases

EPDiQ99608
PaxDbiQ99608
PeptideAtlasiQ99608
PRIDEiQ99608
ProteomicsDBi78353

PTM databases

iPTMnetiQ99608
PhosphoSitePlusiQ99608

Expressioni

Tissue specificityi

Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.

Gene expression databases

BgeeiENSG00000182636
CleanExiHS_NDN
ExpressionAtlasiQ99608 baseline and differential
GenevisibleiQ99608 HS

Organism-specific databases

HPAiHPA074457

Interactioni

Subunit structurei

Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110772, 61 interactors
IntActiQ99608, 18 interactors
STRINGi9606.ENSP00000332643

Structurei

3D structure databases

ProteinModelPortaliQ99608
SMRiQ99608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 297MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG098101
InParanoidiQ99608
KOiK19482
OMAiRMIIWFP
OrthoDBiEOG091G0TJ0
PhylomeDBiQ99608
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR002190 MHD_dom
IPR030086 Necdin
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF10 PTHR11736:SF10, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q99608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQSKDLSD PNFAAEAPNS EVHSSPGVSE GVPPSATLAE PQSPPLGPTA
60 70 80 90 100
APQAAPPPQA PNDEGDPKAL QQAAEEGRAH QAPSAAQPGP APPAPAQLVQ
110 120 130 140 150
KAHELMWYVL VKDQKKMIIW FPDMVKDVIG SYKKWCRSIL RRTSLILARV
160 170 180 190 200
FGLHLRLTSL HTMEFALVKA LEPEELDRVA LSNRMPMTGL LLMILSLIYV
210 220 230 240 250
KGRGARESAV WNVLRILGLR PWKKHSTFGD VRKLITEEFV QMNYLKYQRV
260 270 280 290 300
PYVEPPEYEF FWGSRASREI TKMQIMEFLA RVFKKDPQAW PSRYREALEE
310 320
ARALREANPT AHYPRSSVSE D
Length:321
Mass (Da):36,086
Last modified:May 1, 1997 - v1
Checksum:i5068FE121308BFAF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065889318V → A1 PublicationCorresponds to variant dbSNP:rs114077338EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35139 mRNA Translation: AAB39469.1
AB007828 Genomic DNA Translation: BAA22660.1
AK312779 mRNA Translation: BAG35642.1
BC008750 mRNA Translation: AAH08750.1
CCDSiCCDS10014.1
RefSeqiNP_002478.1, NM_002487.2
UniGeneiHs.50130

Genome annotation databases

EnsembliENST00000331837; ENSP00000332643; ENSG00000182636
GeneIDi4692
KEGGihsa:4692

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNECD_HUMAN
AccessioniPrimary (citable) accession number: Q99608
Secondary accession number(s): B2R6Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1997
Last modified: July 18, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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