NDN

Functionⁱ

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).By similarity

Miscellaneous

Located in the Prader-Willi syndrome (PWS) chromosome region. Prader-Willi syndrome is a contiguous gene syndrome resulting from deletion of the paternal copies of the imprinted SNRPN gene, the necdin gene, and possibly other genes within the chromosome region 15q11-q13.

GO - Molecular functionⁱ

gamma-tubulin binding Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axonal fasciculation Source: Ensembl
axon extension Source: Ensembl
central nervous system development Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
genetic imprinting Source: Ensembl
glial cell migration Source: Ensembl
multicellular organismal homeostasis Source: Ensembl
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9630521
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9630521
neuron migration Source: Ensembl
neurotrophin TRK receptor signaling pathway Source: Ensembl
post-embryonic development Source: Ensembl
regulation of growth Source: UniProtKB-KW
respiratory system process Source: Ensembl
sensory perception of pain Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORⁱ	Q99608

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Necdin
Gene namesⁱ	Name:NDN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182636.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7675 NDN
MIMⁱ	602117 gene
neXtProtⁱ	NX_Q99608

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4692
GeneReviewsⁱ	NDN
MalaCards human disease database More...MalaCardsⁱ	NDN
MIMⁱ	176270 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000182636
Orphanetⁱ	177910 Prader-Willi syndrome due to imprinting mutation 98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15 177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1 177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
PharmGKBⁱ	PA31479

Polymorphism and mutation databases

BioMutaⁱ	NDN
DMDMⁱ	17380142

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000156740	1 – 321	NecdinAdd BLAST		321

Proteomic databases

EPDⁱ	Q99608
PaxDbⁱ	Q99608
PeptideAtlas More...PeptideAtlasⁱ	Q99608
PRIDEⁱ	Q99608
ProteomicsDBⁱ	78353

PTM databases

iPTMnetⁱ	Q99608
PhosphoSitePlusⁱ	Q99608

Expressionⁱ

Tissue specificityⁱ

Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.

Gene expression databases

Bgeeⁱ	ENSG00000182636 Expressed in 229 organ(s), highest expression level in metanephros
CleanExⁱ	HS_NDN
ExpressionAtlasⁱ	Q99608 baseline and differential
Genevisibleⁱ	Q99608 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074457

HPAⁱ

HPA074457

Interactionⁱ

Subunit structureⁱ

Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2 (By similarity).By similarity

GO - Molecular functionⁱ

gamma-tubulin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110772, 61 interactors
IntActⁱ	Q99608, 10 interactors
STRINGⁱ	9606.ENSP00000332643

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99608
SMRⁱ	Q99608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	98 – 297	MAGEPROSITE-ProRule annotationAdd BLAST		200

Phylogenomic databases

eggNOGⁱ	KOG4562 Eukaryota ENOG4111S70 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118824
HOGENOMⁱ	HOG000231161
HOVERGENⁱ	HBG098101
InParanoidⁱ	Q99608
KEGG Orthology (KO) More...KOⁱ	K19482
OMAⁱ	RMIIWFP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TJ0
PhylomeDBⁱ	Q99608
TreeFamⁱ	TF328505

Family and domain databases

InterProⁱ	View protein in InterPro IPR037445 MAGE IPR002190 MHD_dom IPR030086 Necdin
PANTHERⁱ	PTHR11736 PTHR11736, 1 hit PTHR11736:SF10 PTHR11736:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01454 MAGE, 1 hit
SMARTⁱ	View protein in SMART SM01373 MAGE, 1 hit
PROSITEⁱ	View protein in PROSITE PS50838 MAGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99608-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEQSKDLSD PNFAAEAPNS EVHSSPGVSE GVPPSATLAE PQSPPLGPTA 
        60         70         80         90        100
APQAAPPPQA PNDEGDPKAL QQAAEEGRAH QAPSAAQPGP APPAPAQLVQ 
       110        120        130        140        150
KAHELMWYVL VKDQKKMIIW FPDMVKDVIG SYKKWCRSIL RRTSLILARV 
       160        170        180        190        200
FGLHLRLTSL HTMEFALVKA LEPEELDRVA LSNRMPMTGL LLMILSLIYV 
       210        220        230        240        250
KGRGARESAV WNVLRILGLR PWKKHSTFGD VRKLITEEFV QMNYLKYQRV 
       260        270        280        290        300
PYVEPPEYEF FWGSRASREI TKMQIMEFLA RVFKKDPQAW PSRYREALEE 
       310        320 
ARALREANPT AHYPRSSVSE D

Length:321

Mass (Da):36,086

Last modified:May 1, 1997 - v1

Checksum:ⁱ5068FE121308BFAF

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065889	318	V → A1 PublicationCorresponds to variant dbSNP:rs114077338EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35139 mRNA Translation: AAB39469.1 AB007828 Genomic DNA Translation: BAA22660.1 AK312779 mRNA Translation: BAG35642.1 BC008750 mRNA Translation: AAH08750.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10014.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002478.1, NM_002487.2
UniGeneⁱ	Hs.50130

Genome annotation databases

Ensemblⁱ	ENST00000331837; ENSP00000332643; ENSG00000182636
GeneIDⁱ	4692
KEGGⁱ	hsa:4692

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99608	Necdin isoform A (Fragment)		HUMAN		321	UniRef100_Q99608
NDN isoform 1		PANTR		321
UPI0006C994CF		PANPA		205

Protein	Similar proteins		Species	Score	Length	Source
Q99608	Necdin isoform A (Fragment)		HUMAN		321	UniRef90_Q99608
NDN isoform 1		PANTR		321
NDN		CEREH		325
Uncharacterized protein		MUSPF		325
necdin		DELLE		325
+72

Protein	Similar proteins		Species	Score	Length	Source
Q99608	Necdin		MOUSE		325	UniRef50_P25233
Uncharacterized protein (Fragment)		NEOLE		328
Necdin homolog (Mouse)		RAT		325
Necdin		HETGA		325
necdin		MESAU		325
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35139 mRNA Translation: AAB39469.1 AB007828 Genomic DNA Translation: BAA22660.1 AK312779 mRNA Translation: BAG35642.1 BC008750 mRNA Translation: AAH08750.1
CCDSⁱ	CCDS10014.1
RefSeqⁱ	NP_002478.1, NM_002487.2
UniGeneⁱ	Hs.50130

3D structure databases

ProteinModelPortalⁱ	Q99608
SMRⁱ	Q99608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110772, 61 interactors
IntActⁱ	Q99608, 10 interactors
STRINGⁱ	9606.ENSP00000332643

PTM databases

iPTMnetⁱ	Q99608
PhosphoSitePlusⁱ	Q99608

Polymorphism and mutation databases

BioMutaⁱ	NDN
DMDMⁱ	17380142

Proteomic databases

EPDⁱ	Q99608
PaxDbⁱ	Q99608
PeptideAtlasⁱ	Q99608
PRIDEⁱ	Q99608
ProteomicsDBⁱ	78353

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4692
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000331837; ENSP00000332643; ENSG00000182636
GeneIDⁱ	4692
KEGGⁱ	hsa:4692

Organism-specific databases

CTDⁱ	4692
DisGeNETⁱ	4692
EuPathDBⁱ	HostDB:ENSG00000182636.5
GeneCardsⁱ	NDN
GeneReviewsⁱ	NDN
HGNCⁱ	HGNC:7675 NDN
HPAⁱ	HPA074457
MalaCardsⁱ	NDN
MIMⁱ	176270 phenotype 602117 gene
neXtProtⁱ	NX_Q99608
OpenTargetsⁱ	ENSG00000182636
Orphanetⁱ	177910 Prader-Willi syndrome due to imprinting mutation 98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15 177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1 177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
PharmGKBⁱ	PA31479
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4562 Eukaryota ENOG4111S70 LUCA
GeneTreeⁱ	ENSGT00760000118824
HOGENOMⁱ	HOG000231161
HOVERGENⁱ	HBG098101
InParanoidⁱ	Q99608
KOⁱ	K19482
OMAⁱ	RMIIWFP
OrthoDBⁱ	EOG091G0TJ0
PhylomeDBⁱ	Q99608
TreeFamⁱ	TF328505

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORⁱ	Q99608

Miscellaneous databases

GeneWikiⁱ	NDN_(gene)
GenomeRNAiⁱ	4692
Protein Ontology More...PROⁱ	PR:Q99608
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182636 Expressed in 229 organ(s), highest expression level in metanephros
CleanExⁱ	HS_NDN
ExpressionAtlasⁱ	Q99608 baseline and differential
Genevisibleⁱ	Q99608 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037445 MAGE IPR002190 MHD_dom IPR030086 Necdin
PANTHERⁱ	PTHR11736 PTHR11736, 1 hit PTHR11736:SF10 PTHR11736:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF01454 MAGE, 1 hit
SMARTⁱ	View protein in SMART SM01373 MAGE, 1 hit
PROSITEⁱ	View protein in PROSITE PS50838 MAGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NECD_HUMAN
Accessionⁱ	Q99608Primary (citable) accession number: Q99608 Secondary accession number(s): B2R6Z5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q99608 (NECD_HUMAN)

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Necdin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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GO - Biological processi

Enzyme and pathway databases

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Nucleus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Keywords - Coding sequence diversityi

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PTM databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ