UniProtKB - Q99607 (ELF4_HUMAN)
Protein
ETS-related transcription factor Elf-4
Gene
ELF4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity6 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 209 – 291 | ETSPROSITE-ProRule annotationAdd BLAST | 83 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- innate immune response Source: InterPro
- natural killer cell proliferation Source: UniProtKB
- NK T cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q99607 |
SIGNORi | Q99607 |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-4Alternative name(s): E74-like factor 4 Myeloid Elf-1-like factor |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3319, ELF4 |
MIMi | 300775, gene |
neXtProti | NX_Q99607 |
VEuPathDBi | HostDB:ENSG00000102034.16 |
Subcellular locationi
Nucleus
- PML body 1 Publication
Note: Accumulation into PML nuclear bodies is mediated by PML.
Nucleus
- nuclear body Source: HPA
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- PML body Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 25 – 26 | Breakpoint for translocation to form ELF4-ERG oncogene | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2000 |
MalaCardsi | ELF4 |
OpenTargetsi | ENSG00000102034 |
Orphaneti | 632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia |
PharmGKBi | PA27747 |
Miscellaneous databases
Pharosi | Q99607, Tbio |
Genetic variation databases
BioMutai | ELF4 |
DMDMi | 68052244 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204089 | 1 – 663 | ETS-related transcription factor Elf-4Add BLAST | 663 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 | |
Modified residuei | 641 | PhosphoserineCombined sources | 1 | |
Modified residuei | 648 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99607 |
jPOSTi | Q99607 |
MassIVEi | Q99607 |
MaxQBi | Q99607 |
PaxDbi | Q99607 |
PeptideAtlasi | Q99607 |
PRIDEi | Q99607 |
ProteomicsDBi | 78352 |
PTM databases
iPTMneti | Q99607 |
PhosphoSitePlusi | Q99607 |
Expressioni
Tissue specificityi
Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.2 Publications
Inductioni
By ponisterone A in erythroleukemia cells.1 Publication
Gene expression databases
Bgeei | ENSG00000102034, Expressed in bone marrow and 209 other tissues |
ExpressionAtlasi | Q99607, baseline and differential |
Genevisiblei | Q99607, HS |
Organism-specific databases
HPAi | ENSG00000102034, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter.
Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 108315, 9 interactors |
IntActi | Q99607, 5 interactors |
STRINGi | 9606.ENSP00000311280 |
Miscellaneous databases
RNActi | Q99607, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 206 | RUNX1-binding1 PublicationAdd BLAST | 120 |
Sequence similaritiesi
Belongs to the ETS family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000161870 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q99607 |
OMAi | DGTLCMA |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q99607 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR033070, Elf4 IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF170, PTHR11849:SF170, 1 hit |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q99607-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS
60 70 80 90 100
GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN
110 120 130 140 150
MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT
160 170 180 190 200
SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK
210 220 230 240 250
SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL
260 270 280 290 300
WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI
310 320 330 340 350
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK
360 370 380 390 400
PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV
410 420 430 440 450
PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA
460 470 480 490 500
STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA
510 520 530 540 550
PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM
560 570 580 590 600
VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS
610 620 630 640 650
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF
660
NPTSLIKMEP HDI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WU18 | A0A087WU18_HUMAN | ETS-related transcription factor El... | ELF4 | 662 | Annotation score: | ||
B1AL80 | B1AL80_HUMAN | ETS-related transcription factor El... | ELF4 | 76 | Annotation score: |
Sequence cautioni
The sequence AAC17452 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 293 – 294 | MP → IA in AAC17452 (PubMed:9524226).Curated | 2 | |
Sequence conflicti | 499 | P → L in AAC17452 (PubMed:9524226).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1 |
CCDSi | CCDS14617.1 |
RefSeqi | NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3 |
Genome annotation databases
Ensembli | ENST00000308167; ENSP00000311280; ENSG00000102034 ENST00000335997; ENSP00000338608; ENSG00000102034 |
GeneIDi | 2000 |
KEGGi | hsa:2000 |
UCSCi | uc004evd.5, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1 |
CCDSi | CCDS14617.1 |
RefSeqi | NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3 |
3D structure databases
SMRi | Q99607 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108315, 9 interactors |
IntActi | Q99607, 5 interactors |
STRINGi | 9606.ENSP00000311280 |
PTM databases
iPTMneti | Q99607 |
PhosphoSitePlusi | Q99607 |
Genetic variation databases
BioMutai | ELF4 |
DMDMi | 68052244 |
Proteomic databases
EPDi | Q99607 |
jPOSTi | Q99607 |
MassIVEi | Q99607 |
MaxQBi | Q99607 |
PaxDbi | Q99607 |
PeptideAtlasi | Q99607 |
PRIDEi | Q99607 |
ProteomicsDBi | 78352 |
Protocols and materials databases
Antibodypediai | 16200, 354 antibodies |
DNASUi | 2000 |
Genome annotation databases
Ensembli | ENST00000308167; ENSP00000311280; ENSG00000102034 ENST00000335997; ENSP00000338608; ENSG00000102034 |
GeneIDi | 2000 |
KEGGi | hsa:2000 |
UCSCi | uc004evd.5, human |
Organism-specific databases
CTDi | 2000 |
DisGeNETi | 2000 |
GeneCardsi | ELF4 |
HGNCi | HGNC:3319, ELF4 |
HPAi | ENSG00000102034, Low tissue specificity |
MalaCardsi | ELF4 |
MIMi | 300775, gene |
neXtProti | NX_Q99607 |
OpenTargetsi | ENSG00000102034 |
Orphaneti | 632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia |
PharmGKBi | PA27747 |
VEuPathDBi | HostDB:ENSG00000102034.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000161870 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q99607 |
OMAi | DGTLCMA |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q99607 |
TreeFami | TF318679 |
Enzyme and pathway databases
PathwayCommonsi | Q99607 |
SIGNORi | Q99607 |
Miscellaneous databases
BioGRID-ORCSi | 2000, 8 hits in 526 CRISPR screens |
ChiTaRSi | ELF4, human |
GeneWikii | ELF4 |
GenomeRNAii | 2000 |
Pharosi | Q99607, Tbio |
PROi | PR:Q99607 |
RNActi | Q99607, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102034, Expressed in bone marrow and 209 other tissues |
ExpressionAtlasi | Q99607, baseline and differential |
Genevisiblei | Q99607, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR033070, Elf4 IPR000418, Ets_dom IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF170, PTHR11849:SF170, 1 hit |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF4_HUMAN | |
Accessioni | Q99607Primary (citable) accession number: Q99607 Secondary accession number(s): D3DTG1, O60435 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM