UniProtKB - Q99607 (ELF4_HUMAN)

BLAST

>sp|Q99607|ELF4_HUMAN ETS-related transcription factor Elf-4 OS=Homo sapiens OX=9606 GN=ELF4 PE=1 SV=1
MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYSGLELDDVHNG
IITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDILDEKQIFSTSEML
PDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRK
TKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFK
LVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVI
EDEDESSEATAAPPQASTASVASASTTRRTSSRVSSRSAPQGKGSSSWEKPKIQHVGLQP
SASLELGPSLDEEIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHLGVAPVGSGSALTLQ
TIPLTTVLTNGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNASFQDSQVAAPGAP
LILSGLPQLLAGANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGP
LRSSSYVQGMVTGAPMEGLLVPEETLRELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLS
PPSRPTVGLTPVAELELSSGSGSLLMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEP
HDI

Align
Format
Add to basket Added to basket
History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 May 1997)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

ETS-related transcription factor Elf-4

Gene

ELF4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity6 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	209 – 291	ETSPROSITE-ProRule annotationAdd BLAST		83

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 14625302
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 14625302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
innate immune response Source: InterPro
natural killer cell proliferation Source: UniProtKB
NK T cell proliferation Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q99607

SIGNORⁱ

Q99607

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ETS-related transcription factor Elf-4 Alternative name(s): E74-like factor 4 Myeloid Elf-1-like factor
Gene namesⁱ	Name:ELF4Imported Synonyms:ELFRImported, MEFImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102034.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3319 ELF4
MIMⁱ	300775 gene
neXtProtⁱ	NX_Q99607

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	25 – 26	Breakpoint for translocation to form ELF4-ERG oncogene		2

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2000
MalaCards human disease database More...MalaCardsⁱ	ELF4
Open Targets More...OpenTargetsⁱ	ENSG00000102034
Orphanetⁱ	632 Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
PharmGKBⁱ	PA27747

Polymorphism and mutation databases

BioMutaⁱ	ELF4
DMDMⁱ	68052244

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204089	1 – 663	ETS-related transcription factor Elf-4Add BLAST		663

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	151	PhosphoserineCombined sources	1
Modified residueⁱ	188	PhosphoserineCombined sources	1
Modified residueⁱ	641	PhosphoserineCombined sources	1
Modified residueⁱ	648	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q99607
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99607
PaxDbⁱ	Q99607
PeptideAtlas More...PeptideAtlasⁱ	Q99607
PRIDEⁱ	Q99607
ProteomicsDBⁱ	78352

PTM databases

iPTMnetⁱ	Q99607
PhosphoSitePlusⁱ	Q99607

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.2 Publications

Inductionⁱ

By ponisterone A in erythroleukemia cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102034 Expressed in 192 organ(s), highest expression level in blood
CleanExⁱ	HS_ELF4
ExpressionAtlasⁱ	Q99607 baseline and differential
Genevisibleⁱ	Q99607 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058595 HPA060277

HPAⁱ

HPA058595
HPA060277

Interactionⁱ

Subunit structureⁱ

Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.2 Publications

Protein-protein interaction databases

BioGridⁱ	108315, 8 interactors
IntActⁱ	Q99607, 4 interactors
STRINGⁱ	9606.ENSP00000311280

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99607
SMRⁱ	Q99607
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	87 – 206	RUNX1-binding1 PublicationAdd BLAST		120

Sequence similaritiesⁱ

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3804 Eukaryota ENOG4111K4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118996
HOGENOMⁱ	HOG000049253
HOVERGENⁱ	HBG007183
InParanoidⁱ	Q99607
KEGG Orthology (KO) More...KOⁱ	K09428
OMAⁱ	SLFMAEP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B4I
PhylomeDBⁱ	Q99607
TreeFamⁱ	TF318679

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR033070 Elf4 IPR000418 Ets_dom IPR022084 TF_Elf_N IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11849:SF170 PTHR11849:SF170, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12310 Elf-1_N, 1 hit PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q99607-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS 
        60         70         80         90        100
GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN 
       110        120        130        140        150
MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT 
       160        170        180        190        200
SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK 
       210        220        230        240        250
SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL 
       260        270        280        290        300
WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI 
       310        320        330        340        350
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK 
       360        370        380        390        400
PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV 
       410        420        430        440        450
PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA 
       460        470        480        490        500
STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA 
       510        520        530        540        550
PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM 
       560        570        580        590        600
VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS 
       610        620        630        640        650
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF 
       660 
NPTSLIKMEP HDI

Length:663

Mass (Da):70,730

Last modified:May 1, 1997 - v1

Checksum:ⁱ1696085D31B09BC5

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WU18	A0A087WU18_HUMAN	ETS-related transcription factor El... ETS-related transcription factor Elf-4	ELF4	662	Annotation score:
B1AL80	B1AL80_HUMAN	ETS-related transcription factor El... ETS-related transcription factor Elf-4	ELF4	76	Annotation score:

Sequence cautionⁱ

The sequence AAC17452 differs from that shown. Reason: Frameshift at positions 334 and 412.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	293 – 294	MP → IA in AAC17452 (PubMed:9524226).Curated		2
Sequence conflictⁱ	499	P → L in AAC17452 (PubMed:9524226).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14617.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3
UniGeneⁱ	Hs.271940

Genome annotation databases

Ensemblⁱ	ENST00000308167; ENSP00000311280; ENSG00000102034 ENST00000335997; ENSP00000338608; ENSG00000102034
GeneIDⁱ	2000
KEGGⁱ	hsa:2000
UCSC genome browser More...UCSCⁱ	uc004evd.5 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Protein	Similar proteins		Species	Score	Length	Source
Q99607	ETS-related transcription factor Elf-4 (Fragment)		HUMAN		76	UniRef100_Q99607
ELF4 isoform 4 (Fragment)		PONAB		77
UPI0005D02A21		HUMAN		595

Protein	Similar proteins		Species	Score	Length	Source
Q99607	ETS-related transcription factor Elf-4 (Fragment)		HUMAN		76	UniRef90_Q99607
ELF4 isoform 4 (Fragment)		PONAB		77
E74 like ETS transcription factor 4		CALJA		663
E74 like ETS transcription factor 4		PANTR		663
Uncharacterized protein		PANPA		663
+19

Protein	Similar proteins		Species	Score	Length	Source
Q99607	ETS-related transcription factor Elf-4		MOUSE		655	UniRef50_Q99607
ETS-related transcription factor Elf-4 (Fragment)		HUMAN		76
ELF4 isoform 4 (Fragment)		PONAB		77
E74 like ETS transcription factor 4		CALJA		663
E74 like ETS transcription factor 4		SAIBB		663
+191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1
CCDSⁱ	CCDS14617.1
RefSeqⁱ	NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3
UniGeneⁱ	Hs.271940

3D structure databases

ProteinModelPortalⁱ	Q99607
SMRⁱ	Q99607
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108315, 8 interactors
IntActⁱ	Q99607, 4 interactors
STRINGⁱ	9606.ENSP00000311280

PTM databases

iPTMnetⁱ	Q99607
PhosphoSitePlusⁱ	Q99607

Polymorphism and mutation databases

BioMutaⁱ	ELF4
DMDMⁱ	68052244

Proteomic databases

EPDⁱ	Q99607
MaxQBⁱ	Q99607
PaxDbⁱ	Q99607
PeptideAtlasⁱ	Q99607
PRIDEⁱ	Q99607
ProteomicsDBⁱ	78352

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2000
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308167; ENSP00000311280; ENSG00000102034 ENST00000335997; ENSP00000338608; ENSG00000102034
GeneIDⁱ	2000
KEGGⁱ	hsa:2000
UCSCⁱ	uc004evd.5 human

Organism-specific databases

CTDⁱ	2000
DisGeNETⁱ	2000
EuPathDBⁱ	HostDB:ENSG00000102034.16
GeneCardsⁱ	ELF4
HGNCⁱ	HGNC:3319 ELF4
HPAⁱ	HPA058595 HPA060277
MalaCardsⁱ	ELF4
MIMⁱ	300775 gene
neXtProtⁱ	NX_Q99607
OpenTargetsⁱ	ENSG00000102034
Orphanetⁱ	632 Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
PharmGKBⁱ	PA27747
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3804 Eukaryota ENOG4111K4J LUCA
GeneTreeⁱ	ENSGT00760000118996
HOGENOMⁱ	HOG000049253
HOVERGENⁱ	HBG007183
InParanoidⁱ	Q99607
KOⁱ	K09428
OMAⁱ	SLFMAEP
OrthoDBⁱ	EOG091G0B4I
PhylomeDBⁱ	Q99607
TreeFamⁱ	TF318679

Enzyme and pathway databases

SIGNORⁱ	Q99607

SIGNORⁱ

Q99607

Miscellaneous databases

ChiTaRSⁱ	ELF4 human
GeneWikiⁱ	ELF4
GenomeRNAiⁱ	2000
Protein Ontology More...PROⁱ	PR:Q99607
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102034 Expressed in 192 organ(s), highest expression level in blood
CleanExⁱ	HS_ELF4
ExpressionAtlasⁱ	Q99607 baseline and differential
Genevisibleⁱ	Q99607 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR033070 Elf4 IPR000418 Ets_dom IPR022084 TF_Elf_N IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11849:SF170 PTHR11849:SF170, 1 hit
Pfamⁱ	View protein in Pfam PF12310 Elf-1_N, 1 hit PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELF4_HUMAN
Accessionⁱ	Q99607Primary (citable) accession number: Q99607 Secondary accession number(s): D3DTG1, O60435
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99607 (ELF4_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

ETS-related transcription factor Elf-4

ELF4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Sites

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ