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UniProtKB - Q99607 (ELF4_HUMAN)

Entry version 178 (25 May 2022)
Sequence version 1 (01 May 1997)
Previous versions | rss
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Protein

ETS-related transcription factor Elf-4

Gene

ELF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity).

Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity).

Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.

By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi209 – 291ETSPROSITE-ProRule annotationAdd BLAST83

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99607

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99607

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99607

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS-related transcription factor Elf-4
Alternative name(s):
E74-like factor 4
Myeloid Elf-1-like factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELF4Imported
Synonyms:ELFRImported, MEFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3319, ELF4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300775, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99607

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000102034

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei25 – 26Breakpoint for translocation to form ELF4-ERG oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		2000

MalaCards human disease database

More...MalaCardsi		ELF4

Open Targets

More...OpenTargetsi		ENSG00000102034

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27747

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99607, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELF4

Domain mapping of disease mutations (DMDM)

More...DMDMi		68052244

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002040891 – 663ETS-related transcription factor Elf-4Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei151PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99607

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99607

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99607

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99607

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99607

PeptideAtlas

More...PeptideAtlasi		Q99607

PRoteomics IDEntifications database

More...PRIDEi		Q99607

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78352

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99607

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99607

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ponisterone A in erythroleukemia cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102034, Expressed in bone marrow and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99607, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99607, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102034, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter.

Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108315, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q99607, 104 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311280

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99607, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99607

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99607

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 206RUNX1-binding1 PublicationAdd BLAST120
Regioni140 – 203DisorderedSequence analysisAdd BLAST64
Regioni302 – 353DisorderedSequence analysisAdd BLAST52
Regioni493 – 518DisorderedSequence analysisAdd BLAST26
Regioni582 – 605DisorderedSequence analysisAdd BLAST24
Regioni635 – 663DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi147 – 172Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi310 – 348Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3804, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027279_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99607

Identification of Orthologs from Complete Genome Data

More...OMAi		IVEQLPC

Database of Orthologous Groups

More...OrthoDBi		837296at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99607

TreeFam database of animal gene trees

More...TreeFami		TF318679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033070, Elf4
IPR000418, Ets_dom
IPR046328, ETS_fam
IPR022084, TF_Elf_N
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR11849, PTHR11849, 1 hit
PTHR11849:SF170, PTHR11849:SF170, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12310, Elf-1_N, 1 hit
PF00178, Ets, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00454, ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00413, ETS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00345, ETS_DOMAIN_1, 1 hit
PS00346, ETS_DOMAIN_2, 1 hit
PS50061, ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99607-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS 
        60         70         80         90        100
GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN 
       110        120        130        140        150
MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT 
       160        170        180        190        200
SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK 
       210        220        230        240        250
SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL 
       260        270        280        290        300
WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI 
       310        320        330        340        350
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK 
       360        370        380        390        400
PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV 
       410        420        430        440        450
PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA 
       460        470        480        490        500
STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA 
       510        520        530        540        550
PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM 
       560        570        580        590        600
VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS 
       610        620        630        640        650
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF 
       660 
NPTSLIKMEP HDI
Length:663
Mass (Da):70,730
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1696085D31B09BC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AL80B1AL80_HUMAN
ETS-related transcription factor El...
ELF4
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC17452 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293 – 294MP → IA in AAC17452 (PubMed:9524226).Curated2
Sequence conflicti499P → L in AAC17452 (PubMed:9524226).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U32645 mRNA Translation: AAB53693.1
AF000670 mRNA Translation: AAC17452.1 Frameshift.
AL136450, Z81363 Genomic DNA Translation: CAI42882.1
Z81363, AL136450 Genomic DNA Translation: CAI42371.1
CH471107 Genomic DNA Translation: EAX11813.1
CH471107 Genomic DNA Translation: EAX11814.1
BC017194 mRNA Translation: AAH17194.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14617.1

NCBI Reference Sequences

More...RefSeqi		NP_001120669.1, NM_001127197.1
NP_001412.1, NM_001421.3
XP_005262446.1, XM_005262389.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308167.10; ENSP00000311280.6; ENSG00000102034.18
ENST00000335997.11; ENSP00000338608.7; ENSG00000102034.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2000

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000308167.10; ENSP00000311280.6; NM_001421.4; NP_001412.1

UCSC genome browser

More...UCSCi		uc004evd.5, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32645 mRNA Translation: AAB53693.1
AF000670 mRNA Translation: AAC17452.1 Frameshift.
AL136450, Z81363 Genomic DNA Translation: CAI42882.1
Z81363, AL136450 Genomic DNA Translation: CAI42371.1
CH471107 Genomic DNA Translation: EAX11813.1
CH471107 Genomic DNA Translation: EAX11814.1
BC017194 mRNA Translation: AAH17194.1
CCDSiCCDS14617.1
RefSeqiNP_001120669.1, NM_001127197.1
NP_001412.1, NM_001421.3
XP_005262446.1, XM_005262389.3

3D structure databases

AlphaFoldDBiQ99607
SMRiQ99607
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108315, 10 interactors
IntActiQ99607, 104 interactors
STRINGi9606.ENSP00000311280

PTM databases

iPTMnetiQ99607
PhosphoSitePlusiQ99607

Genetic variation databases

BioMutaiELF4
DMDMi68052244

Proteomic databases

EPDiQ99607
jPOSTiQ99607
MassIVEiQ99607
MaxQBiQ99607
PaxDbiQ99607
PeptideAtlasiQ99607
PRIDEiQ99607
ProteomicsDBi78352

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16200, 369 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		2000

Genome annotation databases

EnsembliENST00000308167.10; ENSP00000311280.6; ENSG00000102034.18
ENST00000335997.11; ENSP00000338608.7; ENSG00000102034.18
GeneIDi2000
KEGGihsa:2000
MANE-SelectiENST00000308167.10; ENSP00000311280.6; NM_001421.4; NP_001412.1
UCSCiuc004evd.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2000
DisGeNETi2000

GeneCards: human genes, protein and diseases

More...GeneCardsi		ELF4
HGNCiHGNC:3319, ELF4
HPAiENSG00000102034, Tissue enhanced (bone)
MalaCardsiELF4
MIMi300775, gene
neXtProtiNX_Q99607
OpenTargetsiENSG00000102034
Orphaneti632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
PharmGKBiPA27747
VEuPathDBiHostDB:ENSG00000102034

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3804, Eukaryota
GeneTreeiENSGT00940000161870
HOGENOMiCLU_027279_1_0_1
InParanoidiQ99607
OMAiIVEQLPC
OrthoDBi837296at2759
PhylomeDBiQ99607
TreeFamiTF318679

Enzyme and pathway databases

PathwayCommonsiQ99607
SignaLinkiQ99607
SIGNORiQ99607

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2000, 16 hits in 730 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ELF4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ELF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2000
PharosiQ99607, Tbio

Protein Ontology

More...PROi		PR:Q99607
RNActiQ99607, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102034, Expressed in bone marrow and 210 other tissues
ExpressionAtlasiQ99607, baseline and differential
GenevisibleiQ99607, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033070, Elf4
IPR000418, Ets_dom
IPR046328, ETS_fam
IPR022084, TF_Elf_N
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR11849, PTHR11849, 1 hit
PTHR11849:SF170, PTHR11849:SF170, 1 hit
PfamiView protein in Pfam
PF12310, Elf-1_N, 1 hit
PF00178, Ets, 1 hit
PRINTSiPR00454, ETSDOMAIN
SMARTiView protein in SMART
SM00413, ETS, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345, ETS_DOMAIN_1, 1 hit
PS00346, ETS_DOMAIN_2, 1 hit
PS50061, ETS_DOMAIN_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99607
Secondary accession number(s): D3DTG1, O60435
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: May 1, 1997
Last modified: May 25, 2022
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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