UniProtKB - Q99607 (ELF4_HUMAN)
ETS-related transcription factor Elf-4
ELF4
Functioni
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity).
Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity).
Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
By similarity6 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 209 – 291 | ETSPROSITE-ProRule annotationAdd BLAST | 83 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- innate immune response Source: InterPro
- natural killer cell proliferation Source: UniProtKB
- NK T cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q99607 |
SignaLinki | Q99607 |
SIGNORi | Q99607 |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-4Alternative name(s): E74-like factor 4 Myeloid Elf-1-like factor |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3319, ELF4 |
MIMi | 300775, gene |
neXtProti | NX_Q99607 |
VEuPathDBi | HostDB:ENSG00000102034 |
Subcellular locationi
Nucleus
- PML body 1 Publication
Note: Accumulation into PML nuclear bodies is mediated by PML.
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- PML body Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 25 – 26 | Breakpoint for translocation to form ELF4-ERG oncogene | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2000 |
MalaCardsi | ELF4 |
OpenTargetsi | ENSG00000102034 |
Orphaneti | 632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia |
PharmGKBi | PA27747 |
Miscellaneous databases
Pharosi | Q99607, Tbio |
Genetic variation databases
BioMutai | ELF4 |
DMDMi | 68052244 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204089 | 1 – 663 | ETS-related transcription factor Elf-4Add BLAST | 663 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 | |
Modified residuei | 641 | PhosphoserineCombined sources | 1 | |
Modified residuei | 648 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99607 |
jPOSTi | Q99607 |
MassIVEi | Q99607 |
MaxQBi | Q99607 |
PaxDbi | Q99607 |
PeptideAtlasi | Q99607 |
PRIDEi | Q99607 |
ProteomicsDBi | 78352 |
PTM databases
iPTMneti | Q99607 |
PhosphoSitePlusi | Q99607 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000102034, Expressed in bone marrow and 210 other tissues |
ExpressionAtlasi | Q99607, baseline and differential |
Genevisiblei | Q99607, HS |
Organism-specific databases
HPAi | ENSG00000102034, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter.
Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 108315, 10 interactors |
IntActi | Q99607, 104 interactors |
STRINGi | 9606.ENSP00000311280 |
Miscellaneous databases
RNActi | Q99607, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 206 | RUNX1-binding1 PublicationAdd BLAST | 120 | |
Regioni | 140 – 203 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 302 – 353 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 493 – 518 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 582 – 605 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 635 – 663 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 147 – 172 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 310 – 348 | Polar residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000161870 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q99607 |
OMAi | IVEQLPC |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q99607 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR033070, Elf4 IPR000418, Ets_dom IPR046328, ETS_fam IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit PTHR11849:SF170, PTHR11849:SF170, 1 hit |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS
60 70 80 90 100
GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN
110 120 130 140 150
MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT
160 170 180 190 200
SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK
210 220 230 240 250
SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL
260 270 280 290 300
WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI
310 320 330 340 350
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK
360 370 380 390 400
PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV
410 420 430 440 450
PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA
460 470 480 490 500
STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA
510 520 530 540 550
PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM
560 570 580 590 600
VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS
610 620 630 640 650
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF
660
NPTSLIKMEP HDI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AL80 | B1AL80_HUMAN | ETS-related transcription factor El... | ELF4 | 76 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 293 – 294 | MP → IA in AAC17452 (PubMed:9524226).Curated | 2 | |
Sequence conflicti | 499 | P → L in AAC17452 (PubMed:9524226).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1 |
CCDSi | CCDS14617.1 |
RefSeqi | NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3 |
Genome annotation databases
Ensembli | ENST00000308167.10; ENSP00000311280.6; ENSG00000102034.18 ENST00000335997.11; ENSP00000338608.7; ENSG00000102034.18 |
GeneIDi | 2000 |
KEGGi | hsa:2000 |
MANE-Selecti | ENST00000308167.10; ENSP00000311280.6; NM_001421.4; NP_001412.1 |
UCSCi | uc004evd.5, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32645 mRNA Translation: AAB53693.1 AF000670 mRNA Translation: AAC17452.1 Frameshift. AL136450, Z81363 Genomic DNA Translation: CAI42882.1 Z81363, AL136450 Genomic DNA Translation: CAI42371.1 CH471107 Genomic DNA Translation: EAX11813.1 CH471107 Genomic DNA Translation: EAX11814.1 BC017194 mRNA Translation: AAH17194.1 |
CCDSi | CCDS14617.1 |
RefSeqi | NP_001120669.1, NM_001127197.1 NP_001412.1, NM_001421.3 XP_005262446.1, XM_005262389.3 |
3D structure databases
AlphaFoldDBi | Q99607 |
SMRi | Q99607 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108315, 10 interactors |
IntActi | Q99607, 104 interactors |
STRINGi | 9606.ENSP00000311280 |
PTM databases
iPTMneti | Q99607 |
PhosphoSitePlusi | Q99607 |
Genetic variation databases
BioMutai | ELF4 |
DMDMi | 68052244 |
Proteomic databases
EPDi | Q99607 |
jPOSTi | Q99607 |
MassIVEi | Q99607 |
MaxQBi | Q99607 |
PaxDbi | Q99607 |
PeptideAtlasi | Q99607 |
PRIDEi | Q99607 |
ProteomicsDBi | 78352 |
Protocols and materials databases
Antibodypediai | 16200, 369 antibodies from 30 providers |
DNASUi | 2000 |
Genome annotation databases
Ensembli | ENST00000308167.10; ENSP00000311280.6; ENSG00000102034.18 ENST00000335997.11; ENSP00000338608.7; ENSG00000102034.18 |
GeneIDi | 2000 |
KEGGi | hsa:2000 |
MANE-Selecti | ENST00000308167.10; ENSP00000311280.6; NM_001421.4; NP_001412.1 |
UCSCi | uc004evd.5, human |
Organism-specific databases
CTDi | 2000 |
DisGeNETi | 2000 |
GeneCardsi | ELF4 |
HGNCi | HGNC:3319, ELF4 |
HPAi | ENSG00000102034, Tissue enhanced (bone) |
MalaCardsi | ELF4 |
MIMi | 300775, gene |
neXtProti | NX_Q99607 |
OpenTargetsi | ENSG00000102034 |
Orphaneti | 632, Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia |
PharmGKBi | PA27747 |
VEuPathDBi | HostDB:ENSG00000102034 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000161870 |
HOGENOMi | CLU_027279_1_0_1 |
InParanoidi | Q99607 |
OMAi | IVEQLPC |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q99607 |
TreeFami | TF318679 |
Enzyme and pathway databases
PathwayCommonsi | Q99607 |
SignaLinki | Q99607 |
SIGNORi | Q99607 |
Miscellaneous databases
BioGRID-ORCSi | 2000, 16 hits in 730 CRISPR screens |
ChiTaRSi | ELF4, human |
GeneWikii | ELF4 |
GenomeRNAii | 2000 |
Pharosi | Q99607, Tbio |
PROi | PR:Q99607 |
RNActi | Q99607, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102034, Expressed in bone marrow and 210 other tissues |
ExpressionAtlasi | Q99607, baseline and differential |
Genevisiblei | Q99607, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR033070, Elf4 IPR000418, Ets_dom IPR046328, ETS_fam IPR022084, TF_Elf_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit PTHR11849:SF170, PTHR11849:SF170, 1 hit |
Pfami | View protein in Pfam PF12310, Elf-1_N, 1 hit PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF4_HUMAN | |
Accessioni | Q99607Primary (citable) accession number: Q99607 Secondary accession number(s): D3DTG1, O60435 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | May 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families