UniProtKB - Q99598 (TSNAX_HUMAN)
Protein
Translin-associated protein X
Gene
TSNAX
Organism
Homo sapiens (Human)
Status
Functioni
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 129 | Magnesium | 1 | |
Metal bindingi | 197 | Magnesium | 1 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- endoribonuclease activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- protein transporter activity Source: ProtInc
- RNA binding Source: UniProtKB
- sequence-specific DNA binding Source: GO_Central
- single-stranded DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-HSA-426486 Small interfering RNA (siRNA) biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Translin-associated protein XAlternative name(s): Translin-associated factor X |
Gene namesi | Name:TSNAX Synonyms:TRAX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000116918.13 |
HGNCi | HGNC:12380 TSNAX |
MIMi | 602964 gene |
neXtProti | NX_Q99598 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Nucleus
Other locations
Note: Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN.By similarity
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7257 |
OpenTargetsi | ENSG00000116918 |
PharmGKBi | PA37048 |
Polymorphism and mutation databases
BioMutai | TSNAX |
DMDMi | 6136057 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191686 | 1 – 290 | Translin-associated protein XAdd BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Sumoylated with SUMO1.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q99598 |
jPOSTi | Q99598 |
MaxQBi | Q99598 |
PaxDbi | Q99598 |
PeptideAtlasi | Q99598 |
PRIDEi | Q99598 |
ProteomicsDBi | 78351 |
PTM databases
iPTMneti | Q99598 |
PhosphoSitePlusi | Q99598 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116918 Expressed in 242 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q99598 baseline and differential |
Genevisiblei | Q99598 HS |
Organism-specific databases
HPAi | CAB034263 HPA031054 HPA031055 |
Interactioni
Subunit structurei
Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.5 Publications
Protein-protein interaction databases
BioGridi | 113108, 107 interactors |
DIPi | DIP-29463N |
STRINGi | 9606.ENSP00000355599 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PJA | X-ray | 3.00 | J/K/L | 1-290 | [»] | |
3QB5 | X-ray | 2.95 | K | 1-290 | [»] | |
ProteinModelPortali | Q99598 | |||||
SMRi | Q99598 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 73 – 208 | Interaction with C1D1 PublicationAdd BLAST | 136 |
Sequence similaritiesi
Belongs to the translin family.Curated
Phylogenomic databases
eggNOGi | KOG3066 Eukaryota COG2178 LUCA |
GeneTreei | ENSGT00940000153568 |
HOGENOMi | HOG000008075 |
HOVERGENi | HBG059067 |
InParanoidi | Q99598 |
OMAi | KAENVCY |
OrthoDBi | 1213910at2759 |
PhylomeDBi | Q99598 |
TreeFami | TF323633 |
Family and domain databases
Gene3Di | 1.20.58.190, 1 hit 1.20.58.200, 1 hit |
InterProi | View protein in InterPro IPR016069 Translin_C IPR002848 Translin_fam IPR016068 Translin_N IPR036081 Translin_sf |
PANTHERi | PTHR10741 PTHR10741, 1 hit |
Pfami | View protein in Pfam PF01997 Translin, 1 hit |
SUPFAMi | SSF74784 SSF74784, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99598-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK
110 120 130 140 150
IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK
160 170 180 190 200
QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5VVQ1 | Q5VVQ1_HUMAN | Translin-associated protein X | TSNAX | 163 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1 |
CCDSi | CCDS1596.1 |
RefSeqi | NP_005990.1, NM_005999.2 |
UniGenei | Hs.13318 |
Genome annotation databases
Ensembli | ENST00000366639; ENSP00000355599; ENSG00000116918 |
GeneIDi | 7257 |
KEGGi | hsa:7257 |
UCSCi | uc001huw.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1 |
CCDSi | CCDS1596.1 |
RefSeqi | NP_005990.1, NM_005999.2 |
UniGenei | Hs.13318 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PJA | X-ray | 3.00 | J/K/L | 1-290 | [»] | |
3QB5 | X-ray | 2.95 | K | 1-290 | [»] | |
ProteinModelPortali | Q99598 | |||||
SMRi | Q99598 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 113108, 107 interactors |
DIPi | DIP-29463N |
STRINGi | 9606.ENSP00000355599 |
PTM databases
iPTMneti | Q99598 |
PhosphoSitePlusi | Q99598 |
Polymorphism and mutation databases
BioMutai | TSNAX |
DMDMi | 6136057 |
Proteomic databases
EPDi | Q99598 |
jPOSTi | Q99598 |
MaxQBi | Q99598 |
PaxDbi | Q99598 |
PeptideAtlasi | Q99598 |
PRIDEi | Q99598 |
ProteomicsDBi | 78351 |
Protocols and materials databases
DNASUi | 7257 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000366639; ENSP00000355599; ENSG00000116918 |
GeneIDi | 7257 |
KEGGi | hsa:7257 |
UCSCi | uc001huw.4 human |
Organism-specific databases
CTDi | 7257 |
DisGeNETi | 7257 |
EuPathDBi | HostDB:ENSG00000116918.13 |
GeneCardsi | TSNAX |
HGNCi | HGNC:12380 TSNAX |
HPAi | CAB034263 HPA031054 HPA031055 |
MIMi | 602964 gene |
neXtProti | NX_Q99598 |
OpenTargetsi | ENSG00000116918 |
PharmGKBi | PA37048 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3066 Eukaryota COG2178 LUCA |
GeneTreei | ENSGT00940000153568 |
HOGENOMi | HOG000008075 |
HOVERGENi | HBG059067 |
InParanoidi | Q99598 |
OMAi | KAENVCY |
OrthoDBi | 1213910at2759 |
PhylomeDBi | Q99598 |
TreeFami | TF323633 |
Enzyme and pathway databases
Reactomei | R-HSA-426486 Small interfering RNA (siRNA) biogenesis |
Miscellaneous databases
ChiTaRSi | TSNAX human |
GeneWikii | TSNAX |
GenomeRNAii | 7257 |
PROi | PR:Q99598 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116918 Expressed in 242 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q99598 baseline and differential |
Genevisiblei | Q99598 HS |
Family and domain databases
Gene3Di | 1.20.58.190, 1 hit 1.20.58.200, 1 hit |
InterProi | View protein in InterPro IPR016069 Translin_C IPR002848 Translin_fam IPR016068 Translin_N IPR036081 Translin_sf |
PANTHERi | PTHR10741 PTHR10741, 1 hit |
Pfami | View protein in Pfam PF01997 Translin, 1 hit |
SUPFAMi | SSF74784 SSF74784, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TSNAX_HUMAN | |
Accessioni | Q99598Primary (citable) accession number: Q99598 Secondary accession number(s): B1APC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 13, 2019 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM