UniProtKB - Q99598 (TSNAX_HUMAN)

BLAST

>sp|Q99598|TSNAX_HUMAN Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1
MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLS
RDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAI
TTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRL
RVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVS
KKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS

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History
Entry version 158 (12 Sep 2018)
Sequence version 1 (01 May 1997)
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Protein

Translin-associated protein X

Gene

TSNAX

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	129	Magnesium		1
Metal bindingⁱ	197	Magnesium		1

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 9013868
metal ion binding Source: UniProtKB-KW
protein transporter activity
Source: ProtInc
Traceable author statementⁱ
- 9013868
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
multicellular organism development Source: UniProtKB-KW
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Spermatogenesis
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-426486 Small interfering RNA (siRNA) biogenesis

Reactomeⁱ

R-HSA-426486 Small interfering RNA (siRNA) biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Translin-associated protein X Alternative name(s): Translin-associated factor X
Gene namesⁱ	Name:TSNAX Synonyms:TRAX
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116918.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12380 TSNAX
MIMⁱ	602964 gene
neXtProtⁱ	NX_Q99598

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7257
Open Targets More...OpenTargetsⁱ	ENSG00000116918
PharmGKBⁱ	PA37048

Polymorphism and mutation databases

BioMutaⁱ	TSNAX
DMDMⁱ	6136057

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191686	1 – 290	Translin-associated protein XAdd BLAST		290

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	279	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylated with SUMO1.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q99598
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99598
PaxDbⁱ	Q99598
PeptideAtlas More...PeptideAtlasⁱ	Q99598
PRIDEⁱ	Q99598
ProteomicsDBⁱ	78351

PTM databases

iPTMnetⁱ	Q99598
PhosphoSitePlusⁱ	Q99598

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116918 Expressed in 242 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TSNAX
ExpressionAtlasⁱ	Q99598 baseline and differential
Genevisibleⁱ	Q99598 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034263 HPA031054 HPA031055

HPAⁱ

CAB034263
HPA031054
HPA031055

Interactionⁱ

Subunit structureⁱ

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AIMP1	Q12904	3	EBI-742638,EBI-1045802
BLOC1S5	Q8TDH9	5	EBI-742638,EBI-465861
CARD9	Q9H257	5	EBI-742638,EBI-751319
GADD45G	O95257	3	EBI-742638,EBI-448202
KLC3	Q6P597	5	EBI-742638,EBI-1643885
LDB2	O43679	3	EBI-742638,EBI-2865580
LZTS2	Q9BRK4	3	EBI-742638,EBI-741037
TCF12	Q99081	3	EBI-742638,EBI-722877
TSN	Q15631	11	EBI-742638,EBI-1044160
VPS28	Q9UK41-2	4	EBI-742638,EBI-12146727

Protein-protein interaction databases

BioGridⁱ	113108, 104 interactors
Database of interacting proteins More...DIPⁱ	DIP-29463N
IntActⁱ	Q99598, 106 interactors
Molecular INTeraction database More...MINTⁱ	Q99598
STRINGⁱ	9606.ENSP00000355599

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	34 – 75	Combined sources	42
Helixⁱ	83 – 108	Combined sources	26
Beta strandⁱ	109 – 111	Combined sources	3
Turnⁱ	114 – 116	Combined sources	3
Helixⁱ	117 – 119	Combined sources	3
Helixⁱ	121 – 139	Combined sources	19
Helixⁱ	145 – 150	Combined sources	6
Helixⁱ	184 – 207	Combined sources	24
Helixⁱ	213 – 231	Combined sources	19
Helixⁱ	232 – 234	Combined sources	3
Helixⁱ	237 – 263	Combined sources	27

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99598
SMRⁱ	Q99598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	73 – 208	Interaction with C1D1 PublicationAdd BLAST		136

Sequence similaritiesⁱ

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3066 Eukaryota COG2178 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014716
HOGENOMⁱ	HOG000008075
HOVERGENⁱ	HBG059067
InParanoidⁱ	Q99598
OMAⁱ	KAENVCY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JHU
PhylomeDBⁱ	Q99598
TreeFamⁱ	TF323633

Family and domain databases

Gene3Dⁱ	1.20.58.190, 1 hit 1.20.58.200, 1 hit
InterProⁱ	View protein in InterPro IPR016069 Translin_C IPR002848 Translin_fam IPR016068 Translin_N IPR036081 Translin_sf
PANTHERⁱ	PTHR10741 PTHR10741, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01997 Translin, 1 hit
SUPFAMⁱ	SSF74784 SSF74784, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q99598-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH 
        60         70         80         90        100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK 
       110        120        130        140        150
IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK 
       160        170        180        190        200
QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR 
       210        220        230        240        250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL 
       260        270        280        290
AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS

Length:290

Mass (Da):33,112

Last modified:May 1, 1997 - v1

Checksum:ⁱD38B0DD96B50C0B9

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5VVQ1	Q5VVQ1_HUMAN		Translin-associated protein X Translin-associated protein X	TSNAX	163	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1596.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005990.1, NM_005999.2
UniGeneⁱ	Hs.13318

Genome annotation databases

Ensemblⁱ	ENST00000366639; ENSP00000355599; ENSG00000116918
GeneIDⁱ	7257
KEGGⁱ	hsa:7257
UCSC genome browser More...UCSCⁱ	uc001huw.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99598	Translin-associated protein X		PONAB		290	UniRef100_Q99598
Translin-associated factor X, isoform CRA_c		HUMAN		290
Translin-associated factor X		PANTR		290
Uncharacterized protein		PANPA		290
Translin associated factor X		GORGO		290

Protein	Similar proteins		Species	Score	Length	Source
Q99598	Translin-associated protein X		PONAB		290	UniRef90_Q99598
Translin-associated protein X		MOUSE		290
Translin-associated protein X		RAT		290
Translin-associated factor X, isoform CRA_c		HUMAN		290
Translin-associated factor X		PANTR		290
+90

Protein	Similar proteins		Species	Score	Length	Source
Q99598	Translin-associated protein X		PONAB		290	UniRef50_Q99598
Translin-associated protein X		RAT		290
Translin-associated protein X		MOUSE		290
Translin-associated protein X		MACFA		290
Translin-associated factor X, isoform CRA_c		HUMAN		290
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1
CCDSⁱ	CCDS1596.1
RefSeqⁱ	NP_005990.1, NM_005999.2
UniGeneⁱ	Hs.13318

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3PJA	X-ray	3.00	J/K/L	1-290	[»]
	3QB5	X-ray	2.95	K	1-290	[»]
ProteinModelPortalⁱ	Q99598
SMRⁱ	Q99598
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113108, 104 interactors
DIPⁱ	DIP-29463N
IntActⁱ	Q99598, 106 interactors
MINTⁱ	Q99598
STRINGⁱ	9606.ENSP00000355599

PTM databases

iPTMnetⁱ	Q99598
PhosphoSitePlusⁱ	Q99598

Polymorphism and mutation databases

BioMutaⁱ	TSNAX
DMDMⁱ	6136057

Proteomic databases

EPDⁱ	Q99598
MaxQBⁱ	Q99598
PaxDbⁱ	Q99598
PeptideAtlasⁱ	Q99598
PRIDEⁱ	Q99598
ProteomicsDBⁱ	78351

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7257
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366639; ENSP00000355599; ENSG00000116918
GeneIDⁱ	7257
KEGGⁱ	hsa:7257
UCSCⁱ	uc001huw.4 human

Organism-specific databases

CTDⁱ	7257
DisGeNETⁱ	7257
EuPathDBⁱ	HostDB:ENSG00000116918.13
GeneCardsⁱ	TSNAX
HGNCⁱ	HGNC:12380 TSNAX
HPAⁱ	CAB034263 HPA031054 HPA031055
MIMⁱ	602964 gene
neXtProtⁱ	NX_Q99598
OpenTargetsⁱ	ENSG00000116918
PharmGKBⁱ	PA37048
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3066 Eukaryota COG2178 LUCA
GeneTreeⁱ	ENSGT00390000014716
HOGENOMⁱ	HOG000008075
HOVERGENⁱ	HBG059067
InParanoidⁱ	Q99598
OMAⁱ	KAENVCY
OrthoDBⁱ	EOG091G0JHU
PhylomeDBⁱ	Q99598
TreeFamⁱ	TF323633

Enzyme and pathway databases

Reactomeⁱ	R-HSA-426486 Small interfering RNA (siRNA) biogenesis

Reactomeⁱ

R-HSA-426486 Small interfering RNA (siRNA) biogenesis

Miscellaneous databases

ChiTaRSⁱ	TSNAX human
GeneWikiⁱ	TSNAX
GenomeRNAiⁱ	7257
Protein Ontology More...PROⁱ	PR:Q99598
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116918 Expressed in 242 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TSNAX
ExpressionAtlasⁱ	Q99598 baseline and differential
Genevisibleⁱ	Q99598 HS

Family and domain databases

Gene3Dⁱ	1.20.58.190, 1 hit 1.20.58.200, 1 hit
InterProⁱ	View protein in InterPro IPR016069 Translin_C IPR002848 Translin_fam IPR016068 Translin_N IPR036081 Translin_sf
PANTHERⁱ	PTHR10741 PTHR10741, 1 hit
Pfamⁱ	View protein in Pfam PF01997 Translin, 1 hit
SUPFAMⁱ	SSF74784 SSF74784, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSNAX_HUMAN
Accessionⁱ	Q99598Primary (citable) accession number: Q99598 Secondary accession number(s): B1APC6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 1, 1997
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99598 (TSNAX_HUMAN)

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Translin-associated protein X

TSNAX

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Other locations

Cytosol

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ