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UniProtKB - Q99598 (TSNAX_HUMAN)
Protein
Translin-associated protein X
Gene
TSNAX
Organism
Homo sapiens (Human)
Status
Functioni
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 129 | Magnesium | 1 | |
Metal bindingi | 197 | Magnesium | 1 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- endoribonuclease activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- production of siRNA involved in RNA interference Source: ComplexPortal
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99598 |
Reactomei | R-HSA-426486, Small interfering RNA (siRNA) biogenesis |
SignaLinki | Q99598 |
Names & Taxonomyi
Protein namesi | Recommended name: Translin-associated protein XAlternative name(s): Translin-associated factor X |
Gene namesi | Name:TSNAX Synonyms:TRAX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12380, TSNAX |
MIMi | 602964, gene |
neXtProti | NX_Q99598 |
VEuPathDBi | HostDB:ENSG00000116918 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Nucleus
Other locations
Note: Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN.By similarity
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- endoribonuclease complex Source: ComplexPortal
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7257 |
OpenTargetsi | ENSG00000116918 |
PharmGKBi | PA37048 |
Miscellaneous databases
Pharosi | Q99598, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4524025 |
Genetic variation databases
BioMutai | TSNAX |
DMDMi | 6136057 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191686 | 1 – 290 | Translin-associated protein XAdd BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Sumoylated with SUMO1.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q99598 |
jPOSTi | Q99598 |
MassIVEi | Q99598 |
MaxQBi | Q99598 |
PaxDbi | Q99598 |
PeptideAtlasi | Q99598 |
PRIDEi | Q99598 |
ProteomicsDBi | 78351 |
PTM databases
GlyGeni | Q99598, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99598 |
MetOSitei | Q99598 |
PhosphoSitePlusi | Q99598 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116918, Expressed in female gonad and 256 other tissues |
ExpressionAtlasi | Q99598, baseline and differential |
Genevisiblei | Q99598, HS |
Organism-specific databases
HPAi | ENSG00000116918, Low tissue specificity |
Interactioni
Subunit structurei
Ring-shaped heterooctamer of six TSN and two TSNAX subunits.
Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9.
Interacts with the homodimeric form of C1D following gamma-radiation.
Interacts with TSN and C1D in a mutually exclusive manner.
5 PublicationsProtein-protein interaction databases
BioGRIDi | 113108, 130 interactors |
ComplexPortali | CPX-890, C3PO endoribonuclease complex |
DIPi | DIP-29463N |
STRINGi | 9606.ENSP00000355599 |
Miscellaneous databases
RNActi | Q99598, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99598 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 73 – 208 | Interaction with C1D1 PublicationAdd BLAST | 136 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 27 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the translin family.Curated
Phylogenomic databases
eggNOGi | KOG3066, Eukaryota |
GeneTreei | ENSGT00940000153568 |
HOGENOMi | CLU_067225_1_0_1 |
InParanoidi | Q99598 |
OMAi | LMRLCIS |
OrthoDBi | 1213910at2759 |
PhylomeDBi | Q99598 |
TreeFami | TF323633 |
Family and domain databases
Gene3Di | 1.20.58.190, 1 hit 1.20.58.200, 1 hit |
InterProi | View protein in InterPro IPR016069, Translin_C IPR002848, Translin_fam IPR016068, Translin_N IPR036081, Translin_sf |
PANTHERi | PTHR10741, PTHR10741, 1 hit |
Pfami | View protein in Pfam PF01997, Translin, 1 hit |
SUPFAMi | SSF74784, SSF74784, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99598-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK
110 120 130 140 150
IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK
160 170 180 190 200
QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5VVQ1 | Q5VVQ1_HUMAN | Translin-associated protein X | TSNAX | 163 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1 |
CCDSi | CCDS1596.1 |
RefSeqi | NP_005990.1, NM_005999.2 |
Genome annotation databases
Ensembli | ENST00000366639; ENSP00000355599; ENSG00000116918 |
GeneIDi | 7257 |
KEGGi | hsa:7257 |
MANE-Selecti | ENST00000366639.9; ENSP00000355599.3; NM_005999.3; NP_005990.1 |
UCSCi | uc001huw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95073 mRNA Translation: CAA64469.1 AF271269, AF271267, AF271268 Genomic DNA Translation: AAK58640.1 AK313068 mRNA Translation: BAG35896.1 AL626763 Genomic DNA No translation available. AL445524 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69963.1 BC010376 mRNA Translation: AAH10376.1 BC011797 mRNA Translation: AAH11797.1 |
CCDSi | CCDS1596.1 |
RefSeqi | NP_005990.1, NM_005999.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PJA | X-ray | 3.00 | J/K/L | 1-290 | [»] | |
3QB5 | X-ray | 2.95 | K | 1-290 | [»] | |
SMRi | Q99598 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113108, 130 interactors |
ComplexPortali | CPX-890, C3PO endoribonuclease complex |
DIPi | DIP-29463N |
STRINGi | 9606.ENSP00000355599 |
Chemistry databases
ChEMBLi | CHEMBL4524025 |
PTM databases
GlyGeni | Q99598, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99598 |
MetOSitei | Q99598 |
PhosphoSitePlusi | Q99598 |
Genetic variation databases
BioMutai | TSNAX |
DMDMi | 6136057 |
Proteomic databases
EPDi | Q99598 |
jPOSTi | Q99598 |
MassIVEi | Q99598 |
MaxQBi | Q99598 |
PaxDbi | Q99598 |
PeptideAtlasi | Q99598 |
PRIDEi | Q99598 |
ProteomicsDBi | 78351 |
Protocols and materials databases
Antibodypediai | 34686, 152 antibodies from 26 providers |
DNASUi | 7257 |
Genome annotation databases
Ensembli | ENST00000366639; ENSP00000355599; ENSG00000116918 |
GeneIDi | 7257 |
KEGGi | hsa:7257 |
MANE-Selecti | ENST00000366639.9; ENSP00000355599.3; NM_005999.3; NP_005990.1 |
UCSCi | uc001huw.4, human |
Organism-specific databases
CTDi | 7257 |
DisGeNETi | 7257 |
GeneCardsi | TSNAX |
HGNCi | HGNC:12380, TSNAX |
HPAi | ENSG00000116918, Low tissue specificity |
MIMi | 602964, gene |
neXtProti | NX_Q99598 |
OpenTargetsi | ENSG00000116918 |
PharmGKBi | PA37048 |
VEuPathDBi | HostDB:ENSG00000116918 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3066, Eukaryota |
GeneTreei | ENSGT00940000153568 |
HOGENOMi | CLU_067225_1_0_1 |
InParanoidi | Q99598 |
OMAi | LMRLCIS |
OrthoDBi | 1213910at2759 |
PhylomeDBi | Q99598 |
TreeFami | TF323633 |
Enzyme and pathway databases
PathwayCommonsi | Q99598 |
Reactomei | R-HSA-426486, Small interfering RNA (siRNA) biogenesis |
SignaLinki | Q99598 |
Miscellaneous databases
BioGRID-ORCSi | 7257, 12 hits in 1052 CRISPR screens |
GeneWikii | TSNAX |
GenomeRNAii | 7257 |
Pharosi | Q99598, Tbio |
PROi | PR:Q99598 |
RNActi | Q99598, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116918, Expressed in female gonad and 256 other tissues |
ExpressionAtlasi | Q99598, baseline and differential |
Genevisiblei | Q99598, HS |
Family and domain databases
Gene3Di | 1.20.58.190, 1 hit 1.20.58.200, 1 hit |
InterProi | View protein in InterPro IPR016069, Translin_C IPR002848, Translin_fam IPR016068, Translin_N IPR036081, Translin_sf |
PANTHERi | PTHR10741, PTHR10741, 1 hit |
Pfami | View protein in Pfam PF01997, Translin, 1 hit |
SUPFAMi | SSF74784, SSF74784, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSNAX_HUMAN | |
Accessioni | Q99598Primary (citable) accession number: Q99598 Secondary accession number(s): B1APC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families