UniProtKB - Q99590 (SCAFB_HUMAN)
Protein
Protein SCAF11
Gene
SCAF11
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 82 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA processing Source: ProtInc
- RNA splicing Source: UniProtKB
- RNA splicing, via transesterification reactions Source: UniProtKB
- spliceosomal complex assembly Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q99590 |
SIGNORi | Q99590 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SCAF11Alternative name(s): CTD-associated SR protein 11 Renal carcinoma antigen NY-REN-40 SC35-interacting protein 1 SR-related and CTD-associated factor 11 SRSF2-interacting protein Serine/arginine-rich splicing factor 2-interacting protein Splicing factor, arginine/serine-rich 2-interacting protein Splicing regulatory protein 129 Short name: SRrp129 |
Gene namesi | Name:SCAF11 Synonyms:CASP11, SFRS2IP, SIP1, SRSF2IP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10784, SCAF11 |
MIMi | 603668, gene |
neXtProti | NX_Q99590 |
VEuPathDBi | HostDB:ENSG00000139218.17 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9169 |
OpenTargetsi | ENSG00000139218 |
PharmGKBi | PA35700 |
Miscellaneous databases
Pharosi | Q99590, Tdark |
Genetic variation databases
BioMutai | SCAF11 |
DMDMi | 251757337 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076314 | 1 – 1463 | Protein SCAF11Add BLAST | 1463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 331 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 338 | PhosphoserineCombined sources | 1 | |
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 401 | PhosphoserineCombined sources | 1 | |
Modified residuei | 402 | PhosphoserineCombined sources | 1 | |
Modified residuei | 405 | PhosphoserineCombined sources | 1 | |
Modified residuei | 410 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 | |
Modified residuei | 533 | PhosphoserineCombined sources | 1 | |
Modified residuei | 588 | PhosphoserineCombined sources | 1 | |
Cross-linki | 596 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 601 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Cross-linki | 610 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Cross-linki | 676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 687 | PhosphoserineCombined sources | 1 | |
Modified residuei | 694 | PhosphoserineCombined sources | 1 | |
Modified residuei | 723 | PhosphoserineCombined sources | 1 | |
Modified residuei | 726 | PhosphoserineCombined sources | 1 | |
Modified residuei | 769 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 771 | PhosphoserineCombined sources | 1 | |
Modified residuei | 776 | PhosphoserineCombined sources | 1 | |
Modified residuei | 796 | PhosphoserineCombined sources | 1 | |
Modified residuei | 798 | PhosphoserineCombined sources | 1 | |
Modified residuei | 802 | PhosphoserineCombined sources | 1 | |
Modified residuei | 807 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 816 | PhosphoserineCombined sources | 1 | |
Modified residuei | 963 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1122 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1126 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1151 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 1153 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1169 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1170 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99590 |
jPOSTi | Q99590 |
MassIVEi | Q99590 |
MaxQBi | Q99590 |
PaxDbi | Q99590 |
PeptideAtlasi | Q99590 |
PRIDEi | Q99590 |
ProteomicsDBi | 78343 [Q99590-1] 78344 [Q99590-2] |
PTM databases
GlyGeni | Q99590, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99590 |
PhosphoSitePlusi | Q99590 |
SwissPalmi | Q99590 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000139218, Expressed in tendon of biceps brachii and 254 other tissues |
ExpressionAtlasi | Q99590, baseline and differential |
Genevisiblei | Q99590, HS |
Organism-specific databases
HPAi | ENSG00000139218, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70.
1 PublicationProtein-protein interaction databases
BioGRIDi | 114610, 59 interactors |
IntActi | Q99590, 29 interactors |
MINTi | Q99590 |
STRINGi | 9606.ENSP00000358374 |
Miscellaneous databases
RNActi | Q99590, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 841 – 985 | Arg-richAdd BLAST | 145 | |
Compositional biasi | 1225 – 1285 | Pro-richAdd BLAST | 61 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 82 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0825, Eukaryota |
GeneTreei | ENSGT00950000183205 |
InParanoidi | Q99590 |
OMAi | ENSKSCM |
OrthoDBi | 1035398at2759 |
PhylomeDBi | Q99590 |
TreeFami | TF332183 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99590-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE
60 70 80 90 100
KEVGFPESCN HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV
110 120 130 140 150
QVKKQLRETK DKKNENSFEK QVSCHENSKS CIRRKAIVRE DLLSAKVCDL
160 170 180 190 200
KWIHRNSLYS ETGGKKNAAI KINKPQRSNW STNQCFRNFF SNMFSSVSHS
210 220 230 240 250
GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL PGIGRIGFIP
260 270 280 290 300
WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ
310 320 330 340 350
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG
360 370 380 390 400
NSNPSLSVPS SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS
410 420 430 440 450
SSNDSVDEET AESDTSPVLE KEHQPDVDSS NICTVQTHVE NQSANCLKSC
460 470 480 490 500
NEQIEESEKH TANYDTEERV GSSSSESCAQ DLPVLVGEEG EVKKLENTGI
510 520 530 540 550
EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD VCTVHLPNDF
560 570 580 590 600
PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL
610 620 630 640 650
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD
660 670 680 690 700
TFGNEDFNNI QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT
710 720 730 740 750
HIEQIQKHFS EDNNEMIPME CDSFCSDQNE SEVEPSVNAD LKQMNENSVT
760 770 780 790 800
HCSENNMPSS DLADEKVETV SQPSESPKDT IDKTKKPRTR RSRFHSPSTT
810 820 830 840 850
WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA RGRKKSRSQS
860 870 880 890 900
PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD
910 920 930 940 950
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK
960 970 980 990 1000
SSSFGRIDRD SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK
1010 1020 1030 1040 1050
NDIHLDADDP NSADKHRNDC PNWITEKINS GPDPRTRNPE KLKESHWEEN
1060 1070 1080 1090 1100
RNENSGNSWN KNFGSGWVSN RGRGRGNRGR GTYRSSFAYK DQNENRWQNR
1110 1120 1130 1140 1150
KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS GWTSASSWAV
1160 1170 1180 1190 1200
RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG
1210 1220 1230 1240 1250
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH
1260 1270 1280 1290 1300
PQLPLHLHTG VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ
1310 1320 1330 1340 1350
LQGIPSSSHV SNNMSTPVLP APTAAPGNTG MVQGPSSGNT SSSSHSKASN
1360 1370 1380 1390 1400
AAVKLAESKV SVAVEASADS SKTDKKLQIQ EKAAQEVKLA IKPFYQNKDI
1410 1420 1430 1440 1450
TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY KYSRKGSQKK
1460
TLEEPVSTEK NIG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VXG7 | F8VXG7_HUMAN | Protein SCAF11 | SCAF11 | 1,271 | Annotation score: | ||
A0A087WTB7 | A0A087WTB7_HUMAN | Protein SCAF11 | SCAF11 | 152 | Annotation score: | ||
A0A0A0MTP7 | A0A0A0MTP7_HUMAN | Protein SCAF11 | SCAF11 | 935 | Annotation score: | ||
F8W6K1 | F8W6K1_HUMAN | Protein SCAF11 | SCAF11 | 117 | Annotation score: | ||
A8MTP4 | A8MTP4_HUMAN | Protein SCAF11 | SCAF11 | 77 | Annotation score: | ||
A8MUK0 | A8MUK0_HUMAN | Protein SCAF11 | SCAF11 | 77 | Annotation score: | ||
A0A087WUE7 | A0A087WUE7_HUMAN | Protein SCAF11 | SCAF11 | 71 | Annotation score: |
Sequence cautioni
The sequence AAC39565 differs from that shown. Reason: Frameshift.Curated
The sequence AAC39565 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH40951 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH40951 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 584 | I → M in AAH40951 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 623 | D → G in AAH40951 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059722 | 657 | F → Y. Corresponds to variant dbSNP:rs7315731Ensembl. | 1 | |
Natural variantiVAR_059723 | 1261 | V → L. Corresponds to variant dbSNP:rs11574973Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037665 | 1 – 315 | Missing in isoform 2. 1 PublicationAdd BLAST | 315 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11251 mRNA Translation: CAA72121.1 AF030234 mRNA Translation: AAC39565.1 Sequence problems. AC000015 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57892.1 CH471111 Genomic DNA Translation: EAW57894.1 BC040951 mRNA Translation: AAH40951.1 Sequence problems. |
CCDSi | CCDS8748.2 [Q99590-1] |
PIRi | T09073 |
RefSeqi | NP_004710.2, NM_004719.2 [Q99590-1] XP_005269287.2, XM_005269230.2 [Q99590-1] XP_011537287.1, XM_011538985.1 [Q99590-1] |
Genome annotation databases
Ensembli | ENST00000369367; ENSP00000358374; ENSG00000139218 [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218 [Q99590-2] |
GeneIDi | 9169 |
KEGGi | hsa:9169 |
UCSCi | uc001row.4, human [Q99590-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11251 mRNA Translation: CAA72121.1 AF030234 mRNA Translation: AAC39565.1 Sequence problems. AC000015 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57892.1 CH471111 Genomic DNA Translation: EAW57894.1 BC040951 mRNA Translation: AAH40951.1 Sequence problems. |
CCDSi | CCDS8748.2 [Q99590-1] |
PIRi | T09073 |
RefSeqi | NP_004710.2, NM_004719.2 [Q99590-1] XP_005269287.2, XM_005269230.2 [Q99590-1] XP_011537287.1, XM_011538985.1 [Q99590-1] |
3D structure databases
SMRi | Q99590 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114610, 59 interactors |
IntActi | Q99590, 29 interactors |
MINTi | Q99590 |
STRINGi | 9606.ENSP00000358374 |
PTM databases
GlyGeni | Q99590, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99590 |
PhosphoSitePlusi | Q99590 |
SwissPalmi | Q99590 |
Genetic variation databases
BioMutai | SCAF11 |
DMDMi | 251757337 |
Proteomic databases
EPDi | Q99590 |
jPOSTi | Q99590 |
MassIVEi | Q99590 |
MaxQBi | Q99590 |
PaxDbi | Q99590 |
PeptideAtlasi | Q99590 |
PRIDEi | Q99590 |
ProteomicsDBi | 78343 [Q99590-1] 78344 [Q99590-2] |
Protocols and materials databases
Antibodypediai | 25285, 41 antibodies |
DNASUi | 9169 |
Genome annotation databases
Ensembli | ENST00000369367; ENSP00000358374; ENSG00000139218 [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218 [Q99590-2] |
GeneIDi | 9169 |
KEGGi | hsa:9169 |
UCSCi | uc001row.4, human [Q99590-1] |
Organism-specific databases
CTDi | 9169 |
DisGeNETi | 9169 |
GeneCardsi | SCAF11 |
HGNCi | HGNC:10784, SCAF11 |
HPAi | ENSG00000139218, Low tissue specificity |
MIMi | 603668, gene |
neXtProti | NX_Q99590 |
OpenTargetsi | ENSG00000139218 |
PharmGKBi | PA35700 |
VEuPathDBi | HostDB:ENSG00000139218.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0825, Eukaryota |
GeneTreei | ENSGT00950000183205 |
InParanoidi | Q99590 |
OMAi | ENSKSCM |
OrthoDBi | 1035398at2759 |
PhylomeDBi | Q99590 |
TreeFami | TF332183 |
Enzyme and pathway databases
PathwayCommonsi | Q99590 |
SIGNORi | Q99590 |
Miscellaneous databases
BioGRID-ORCSi | 9169, 39 hits in 878 CRISPR screens |
ChiTaRSi | SCAF11, human |
GeneWikii | SFRS2IP |
GenomeRNAii | 9169 |
Pharosi | Q99590, Tdark |
PROi | PR:Q99590 |
RNActi | Q99590, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139218, Expressed in tendon of biceps brachii and 254 other tissues |
ExpressionAtlasi | Q99590, baseline and differential |
Genevisiblei | Q99590, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCAFB_HUMAN | |
Accessioni | Q99590Primary (citable) accession number: Q99590 Secondary accession number(s): A6NEU9, A6NLW5, Q8IW59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | July 7, 2009 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot