UniProtKB - Q99590 (SCAFB_HUMAN)

BLAST

>sp|Q99590|SCAFB_HUMAN Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2
MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCN
HVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQVKKQLRETKDKKNENSFEK
QVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHRNSLYSETGGKKNAAIKINKPQRSNW
STNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEFIEASEISALIRQKRHELELSWFPDTL
PGIGRIGFIPWNVETEVLPLISSVLPRTIFPTSTISFEHFGTSCKGYALAHTQEGEEKKQ
TSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQSQRSPISDNSGCDAPGNSNPSLSVPS
SAESEKQTRQAPKRKSVRRGRKPPLLKKKLRSSVAAPEKSSSNDSVDEETAESDTSPVLE
KEHQPDVDSSNICTVQTHVENQSANCLKSCNEQIEESEKHTANYDTEERVGSSSSESCAQ
DLPVLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPLEKQDQISGLSQSEVKTD
VCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKITESSLVEITEHKDFTL
KTEELIESPKLESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIATCDTFGNEDFNNI
QDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPME
CDSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDT
IDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESA
RGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKD
SSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRD
SYSPRWKGRWANDGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDC
PNWITEKINSGPDPRTRNPEKLKESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGR
GTYRSSFAYKDQNENRWQNRKPLSGNSNSSGSESFKFVEQQSYKRKSEQEFSFDTPADRS
GWTSASSWAVRKTLPADVQNYYSRRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDG
SQLPINMMQPQMNVMQQQMNAQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQLPLHLHTG
VPLMQVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLP
APTAAPGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQIQ
EKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKY
KYSRKGSQKKTLEEPVSTEKNIG

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History
Entry version 140 (07 Nov 2018)
Sequence version 2 (07 Jul 2009)
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Protein

Protein SCAF11

Gene

SCAF11

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	41 – 82	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 9447963
RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963
RNA splicing, via transesterification reactions
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963
spliceosomal complex assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SCAF11 Alternative name(s): CTD-associated SR protein 11 Renal carcinoma antigen NY-REN-40 SC35-interacting protein 1 SR-related and CTD-associated factor 11 SRSF2-interacting protein Serine/arginine-rich splicing factor 2-interacting protein Splicing factor, arginine/serine-rich 2-interacting protein Splicing regulatory protein 129 Short name: SRrp129
Gene namesⁱ	Name:SCAF11 Synonyms:CASP11, SFRS2IP, SIP1, SRSF2IP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139218.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10784 SCAF11
MIMⁱ	603668 gene
neXtProtⁱ	NX_Q99590

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9169
Open Targets More...OpenTargetsⁱ	ENSG00000139218
PharmGKBⁱ	PA35700

Polymorphism and mutation databases

BioMutaⁱ	SCAF11
DMDMⁱ	251757337

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076314	1 – 1463	Protein SCAF11Add BLAST		1463

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	331	PhosphothreonineCombined sources	1
Modified residueⁱ	338	PhosphoserineCombined sources	1
Modified residueⁱ	341	PhosphoserineCombined sources	1
Modified residueⁱ	344	PhosphoserineCombined sources	1
Modified residueⁱ	400	PhosphoserineCombined sources	1
Modified residueⁱ	401	PhosphoserineCombined sources	1
Modified residueⁱ	402	PhosphoserineCombined sources	1
Modified residueⁱ	405	PhosphoserineCombined sources	1
Modified residueⁱ	410	PhosphothreonineCombined sources	1
Modified residueⁱ	413	PhosphoserineCombined sources	1
Modified residueⁱ	533	PhosphoserineCombined sources	1
Modified residueⁱ	588	PhosphoserineCombined sources	1
Cross-linkⁱ	596	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	601	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	608	PhosphoserineCombined sources	1
Cross-linkⁱ	610	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	614	PhosphoserineCombined sources	1
Cross-linkⁱ	676	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	676	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	680	PhosphoserineCombined sources	1
Modified residueⁱ	687	PhosphoserineCombined sources	1
Modified residueⁱ	694	PhosphoserineCombined sources	1
Modified residueⁱ	723	PhosphoserineCombined sources	1
Modified residueⁱ	726	PhosphoserineCombined sources	1
Modified residueⁱ	769	PhosphothreonineCombined sources	1
Modified residueⁱ	771	PhosphoserineCombined sources	1
Modified residueⁱ	776	PhosphoserineCombined sources	1
Modified residueⁱ	796	PhosphoserineCombined sources	1
Modified residueⁱ	798	PhosphoserineCombined sources	1
Modified residueⁱ	802	PhosphoserineCombined sources	1
Modified residueⁱ	807	PhosphothreonineCombined sources	1
Modified residueⁱ	816	PhosphoserineCombined sources	1
Modified residueⁱ	963	PhosphoserineCombined sources	1
Modified residueⁱ	1122	PhosphoserineCombined sources	1
Cross-linkⁱ	1126	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1127	PhosphoserineCombined sources	1
Modified residueⁱ	1151	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1153	PhosphothreonineCombined sources	1
Modified residueⁱ	1169	PhosphoserineCombined sources	1
Modified residueⁱ	1170	PhosphoserineCombined sources	1
Cross-linkⁱ	1178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99590
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99590
PaxDbⁱ	Q99590
PeptideAtlas More...PeptideAtlasⁱ	Q99590
PRIDEⁱ	Q99590
ProteomicsDBⁱ	78343 78344 [Q99590-2]

PTM databases

iPTMnetⁱ	Q99590
PhosphoSitePlusⁱ	Q99590
SwissPalmⁱ	Q99590

Miscellaneous databases

PMAP-CutDBⁱ	Q99590

PMAP-CutDBⁱ

Q99590

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000139218 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SFRS2IP HS_SIP1
ExpressionAtlasⁱ	Q99590 baseline and differential
Genevisibleⁱ	Q99590 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038862 HPA045456 HPA046345

HPAⁱ

HPA038862
HPA045456
HPA046345

Interactionⁱ

Subunit structureⁱ

Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70.1 Publication

Protein-protein interaction databases

BioGridⁱ	114610, 44 interactors
IntActⁱ	Q99590, 17 interactors
STRINGⁱ	9606.ENSP00000358374

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99590
SMRⁱ	Q99590
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	841 – 985	Arg-richAdd BLAST		145
Compositional biasⁱ	1225 – 1285	Pro-richAdd BLAST		61

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	41 – 82	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IMMV Eukaryota ENOG4111NG4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063661
HOVERGENⁱ	HBG101126
InParanoidⁱ	Q99590
OMAⁱ	CTEFIEV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05JH
PhylomeDBⁱ	Q99590
TreeFamⁱ	TF332183

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q99590-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE 
        60         70         80         90        100
KEVGFPESCN HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV 
       110        120        130        140        150
QVKKQLRETK DKKNENSFEK QVSCHENSKS CIRRKAIVRE DLLSAKVCDL 
       160        170        180        190        200
KWIHRNSLYS ETGGKKNAAI KINKPQRSNW STNQCFRNFF SNMFSSVSHS 
       210        220        230        240        250
GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL PGIGRIGFIP 
       260        270        280        290        300
WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ 
       310        320        330        340        350
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG 
       360        370        380        390        400
NSNPSLSVPS SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS 
       410        420        430        440        450
SSNDSVDEET AESDTSPVLE KEHQPDVDSS NICTVQTHVE NQSANCLKSC 
       460        470        480        490        500
NEQIEESEKH TANYDTEERV GSSSSESCAQ DLPVLVGEEG EVKKLENTGI 
       510        520        530        540        550
EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD VCTVHLPNDF 
       560        570        580        590        600
PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL 
       610        620        630        640        650
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD 
       660        670        680        690        700
TFGNEDFNNI QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT 
       710        720        730        740        750
HIEQIQKHFS EDNNEMIPME CDSFCSDQNE SEVEPSVNAD LKQMNENSVT 
       760        770        780        790        800
HCSENNMPSS DLADEKVETV SQPSESPKDT IDKTKKPRTR RSRFHSPSTT 
       810        820        830        840        850
WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA RGRKKSRSQS 
       860        870        880        890        900
PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD 
       910        920        930        940        950
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK 
       960        970        980        990       1000
SSSFGRIDRD SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK 
      1010       1020       1030       1040       1050
NDIHLDADDP NSADKHRNDC PNWITEKINS GPDPRTRNPE KLKESHWEEN 
      1060       1070       1080       1090       1100
RNENSGNSWN KNFGSGWVSN RGRGRGNRGR GTYRSSFAYK DQNENRWQNR 
      1110       1120       1130       1140       1150
KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS GWTSASSWAV 
      1160       1170       1180       1190       1200
RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG 
      1210       1220       1230       1240       1250
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH 
      1260       1270       1280       1290       1300
PQLPLHLHTG VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ 
      1310       1320       1330       1340       1350
LQGIPSSSHV SNNMSTPVLP APTAAPGNTG MVQGPSSGNT SSSSHSKASN 
      1360       1370       1380       1390       1400
AAVKLAESKV SVAVEASADS SKTDKKLQIQ EKAAQEVKLA IKPFYQNKDI 
      1410       1420       1430       1440       1450
TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY KYSRKGSQKK 
      1460 
TLEEPVSTEK NIG

Length:1,463

Mass (Da):164,652

Last modified:July 7, 2009 - v2

Checksum:ⁱ7170B88544BAF7D4

Isoform 2 (identifier: Q99590-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-315: Missing.

« Hide

        10         20         30         40         50
MTTPTRRSTR NTRAETASQS QRSPISDNSG CDAPGNSNPS LSVPSSAESE 
        60         70         80         90        100
KQTRQAPKRK SVRRGRKPPL LKKKLRSSVA APEKSSSNDS VDEETAESDT 
       110        120        130        140        150
SPVLEKEHQP DVDSSNICTV QTHVENQSAN CLKSCNEQIE ESEKHTANYD 
       160        170        180        190        200
TEERVGSSSS ESCAQDLPVL VGEEGEVKKL ENTGIEANVL CLESEISENI 
       210        220        230        240        250
LEKGGDPLEK QDQISGLSQS EVKTDVCTVH LPNDFPTCLT SESKVYQPVS 
       260        270        280        290        300
CPLSDLSENV ESVVNEEKIT ESSLVEITEH KDFTLKTEEL IESPKLESSE 
       310        320        330        340        350
GEIIQTVDRQ SVKSPEVQLL GHVETEDVEI IATCDTFGNE DFNNIQDSEN 
       360        370        380        390        400
NLLKNNLLNT KLEKSLEEKN ESLTEHPRST ELPKTHIEQI QKHFSEDNNE 
       410        420        430        440        450
MIPMECDSFC SDQNESEVEP SVNADLKQMN ENSVTHCSEN NMPSSDLADE 
       460        470        480        490        500
KVETVSQPSE SPKDTIDKTK KPRTRRSRFH SPSTTWSPNK DTPQEKKRPQ 
       510        520        530        540        550
SPSPRRETGK ESRKSQSPSP KNESARGRKK SRSQSPKKDI ARERRQSQSR 
       560        570        580        590        600
SPKRDTTRES RRSESLSPRR ETSRENKRSQ PRVKDSSPGE KSRSQSRERE 
       610        620        630        640        650
SDRDGQRRER ERRTRKWSRS RSHSRSPSRC RTKSKSSSFG RIDRDSYSPR 
       660        670        680        690        700
WKGRWANDGW RCPRGNDRYR KNDPEKQNEN TRKEKNDIHL DADDPNSADK 
       710        720        730        740        750
HRNDCPNWIT EKINSGPDPR TRNPEKLKES HWEENRNENS GNSWNKNFGS 
       760        770        780        790        800
GWVSNRGRGR GNRGRGTYRS SFAYKDQNEN RWQNRKPLSG NSNSSGSESF 
       810        820        830        840        850
KFVEQQSYKR KSEQEFSFDT PADRSGWTSA SSWAVRKTLP ADVQNYYSRR 
       860        870        880        890        900
GRNSSGPQSG WMKQEEETSG QDSSLKDQTN QQVDGSQLPI NMMQPQMNVM 
       910        920        930        940        950
QQQMNAQHQP MNIFPYPVGV HAPLMNIQRN PFNIHPQLPL HLHTGVPLMQ 
       960        970        980        990       1000
VATPTSVSQG LPPPPPPPPP SQQVNYIASQ PDGKQLQGIP SSSHVSNNMS 
      1010       1020       1030       1040       1050
TPVLPAPTAA PGNTGMVQGP SSGNTSSSSH SKASNAAVKL AESKVSVAVE 
      1060       1070       1080       1090       1100
ASADSSKTDK KLQIQEKAAQ EVKLAIKPFY QNKDITKEEY KEIVRKAVDK 
      1110       1120       1130       1140 
VCHSKSGEVN STKVANLVKA YVDKYKYSRK GSQKKTLEEP VSTEKNIG

Show »

Length:1,148

Mass (Da):128,875

Checksum:ⁱB57FD40EE5E4C48C

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VXG7	F8VXG7_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	1,271	Annotation score:
A8MTP4	A8MTP4_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	77	Annotation score:
A8MUK0	A8MUK0_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	77	Annotation score:
F8W6K1	F8W6K1_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	117	Annotation score:
A0A0A0MTP7	A0A0A0MTP7_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	935	Annotation score:
A0A087WTB7	A0A087WTB7_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	152	Annotation score:
A0A087WUE7	A0A087WUE7_HUMAN	Protein SCAF11 Protein SCAF11	SCAF11	71	Annotation score:

Sequence cautionⁱ

The sequence AAC39565 differs from that shown. Reason: Frameshift at position 62.Curated

The sequence AAC39565 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH40951 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence AAH40951 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	584	I → M in AAH40951 (PubMed:15489334).Curated		1
Sequence conflictⁱ	623	D → G in AAH40951 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059722	657	F → Y. Corresponds to variant dbSNP:rs7315731Ensembl.		1
Natural variantⁱVAR_059723	1261	V → L. Corresponds to variant dbSNP:rs11574973Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037665	1 – 315	Missing in isoform 2. 1 PublicationAdd BLAST		315

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11251 mRNA Translation: CAA72121.1 AF030234 mRNA Translation: AAC39565.1 Sequence problems. AC000015 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57892.1 CH471111 Genomic DNA Translation: EAW57894.1 BC040951 mRNA Translation: AAH40951.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8748.2 [Q99590-1]
PIRⁱ	T09073
NCBI Reference Sequences More...RefSeqⁱ	NP_004710.2, NM_004719.2 [Q99590-1] XP_005269287.2, XM_005269230.2 [Q99590-1] XP_011537287.1, XM_011538985.1 [Q99590-1]
UniGeneⁱ	Hs.210367

Genome annotation databases

Ensemblⁱ	ENST00000369367; ENSP00000358374; ENSG00000139218 [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218 [Q99590-2]
GeneIDⁱ	9169
KEGGⁱ	hsa:9169
UCSC genome browser More...UCSCⁱ	uc001row.4 human [Q99590-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99590	Protein SCAF11		HUMAN		1271	UniRef100_Q99590
SCAF11 isoform 6 (Fragment)		PANTR		118
Isoform 2 of Protein SCAF11		HUMAN		1148
Protein SCAF11 (Fragment)		HUMAN		117
UPI0005CFF027		HUMAN		1479

Protein	Similar proteins		Species	Score	Length	Source
Q99590	Protein SCAF11		HUMAN		1271	UniRef90_Q99590
SCAF11 isoform 6 (Fragment)		PANTR		118
Uncharacterized protein		MACMU		1520
Uncharacterized protein		Cebus capucinus imitator		1470
Uncharacterized protein		MACNE		1464
+72

Protein	Similar proteins		Species	Score	Length	Source
Q99590	Protein SCAF11		HUMAN		1271	UniRef50_Q99590
SCAF11 isoform 6 (Fragment)		PANTR		118
Uncharacterized protein		MACMU		1520
Uncharacterized protein		Cebus capucinus imitator		1470
Uncharacterized protein		CERAT		1464
+351

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11251 mRNA Translation: CAA72121.1 AF030234 mRNA Translation: AAC39565.1 Sequence problems. AC000015 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57892.1 CH471111 Genomic DNA Translation: EAW57894.1 BC040951 mRNA Translation: AAH40951.1 Sequence problems.
CCDSⁱ	CCDS8748.2 [Q99590-1]
PIRⁱ	T09073
RefSeqⁱ	NP_004710.2, NM_004719.2 [Q99590-1] XP_005269287.2, XM_005269230.2 [Q99590-1] XP_011537287.1, XM_011538985.1 [Q99590-1]
UniGeneⁱ	Hs.210367

3D structure databases

ProteinModelPortalⁱ	Q99590
SMRⁱ	Q99590
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114610, 44 interactors
IntActⁱ	Q99590, 17 interactors
STRINGⁱ	9606.ENSP00000358374

PTM databases

iPTMnetⁱ	Q99590
PhosphoSitePlusⁱ	Q99590
SwissPalmⁱ	Q99590

Polymorphism and mutation databases

BioMutaⁱ	SCAF11
DMDMⁱ	251757337

Proteomic databases

EPDⁱ	Q99590
MaxQBⁱ	Q99590
PaxDbⁱ	Q99590
PeptideAtlasⁱ	Q99590
PRIDEⁱ	Q99590
ProteomicsDBⁱ	78343 78344 [Q99590-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9169
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369367; ENSP00000358374; ENSG00000139218 [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218 [Q99590-2]
GeneIDⁱ	9169
KEGGⁱ	hsa:9169
UCSCⁱ	uc001row.4 human [Q99590-1]

Organism-specific databases

CTDⁱ	9169
DisGeNETⁱ	9169
EuPathDBⁱ	HostDB:ENSG00000139218.17
GeneCardsⁱ	SCAF11
H-InvDBⁱ	HIX0010567
HGNCⁱ	HGNC:10784 SCAF11
HPAⁱ	HPA038862 HPA045456 HPA046345
MIMⁱ	603668 gene
neXtProtⁱ	NX_Q99590
OpenTargetsⁱ	ENSG00000139218
PharmGKBⁱ	PA35700
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMMV Eukaryota ENOG4111NG4 LUCA
GeneTreeⁱ	ENSGT00530000063661
HOVERGENⁱ	HBG101126
InParanoidⁱ	Q99590
OMAⁱ	CTEFIEV
OrthoDBⁱ	EOG091G05JH
PhylomeDBⁱ	Q99590
TreeFamⁱ	TF332183

Miscellaneous databases

ChiTaRSⁱ	SCAF11 human
GeneWikiⁱ	SFRS2IP
GenomeRNAiⁱ	9169
PMAP-CutDBⁱ	Q99590
Protein Ontology More...PROⁱ	PR:Q99590
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139218 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SFRS2IP HS_SIP1
ExpressionAtlasⁱ	Q99590 baseline and differential
Genevisibleⁱ	Q99590 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCAFB_HUMAN
Accessionⁱ	Q99590Primary (citable) accession number: Q99590 Secondary accession number(s): A6NEU9, A6NLW5, Q8IW59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	July 7, 2009
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q99590 (SCAFB_HUMAN)

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Protein SCAF11

SCAF11

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ