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Protein

Protein S100-A13

Gene

S100A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 371Add BLAST14
Calcium bindingi64 – 752Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • fibroblast growth factor binding Source: UniProtKB
  • lipid binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cytokine secretion Source: UniProtKB
  • interleukin-1 alpha secretion Source: UniProtKB
  • mast cell degranulation Source: UniProtKB
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • regulation of cell shape Source: Ensembl
  • response to copper ion Source: Ensembl
  • response to electrical stimulus Source: Ensembl

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Copper, Lipid-binding, Metal-binding

Enzyme and pathway databases

SIGNORiQ99584

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A13
Alternative name(s):
S100 calcium-binding protein A13
Gene namesi
Name:S100A13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189171.14
HGNCiHGNC:10490 S100A13
MIMi601989 gene
neXtProtiNX_Q99584

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6284
OpenTargetsiENSG00000189171
PharmGKBiPA34902

Chemistry databases

DrugBankiDB01025 Amlexanox
DB00768 Olopatadine

Polymorphism and mutation databases

BioMutaiS100A13
DMDMi2493416

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440191 – 98Protein S100-A13Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99584
MaxQBiQ99584
PaxDbiQ99584
PeptideAtlasiQ99584
PRIDEiQ99584
ProteomicsDBi78342
TopDownProteomicsiQ99584

PTM databases

iPTMnetiQ99584
PhosphoSitePlusiQ99584

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000189171
CleanExiHS_S100A13
GenevisibleiQ99584 HS

Organism-specific databases

HPAiCAB025494
HPA019592

Interactioni

Subunit structurei

Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKHF2Q9H8W43EBI-721909,EBI-742388

GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112192, 20 interactors
IntActiQ99584, 9 interactors
MINTiQ99584
STRINGi9606.ENSP00000344822

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 3Combined sources3
Helixi8 – 24Combined sources17
Beta strandi26 – 28Combined sources3
Beta strandi32 – 34Combined sources3
Helixi35 – 45Combined sources11
Turni47 – 52Combined sources6
Beta strandi53 – 55Combined sources3
Helixi56 – 63Combined sources8
Beta strandi67 – 72Combined sources6
Helixi73 – 88Combined sources16
Helixi93 – 95Combined sources3

3D structure databases

ProteinModelPortaliQ99584
SMRiQ99584
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99584

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-handAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZIJ Eukaryota
ENOG410ZHGQ LUCA
GeneTreeiENSGT00530000063972
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiQ99584
OMAiLKFHEYW
OrthoDBiEOG091G103K
PhylomeDBiQ99584
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028487 S100A13
PANTHERiPTHR11639:SF57 PTHR11639:SF57, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

Q99584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL
60 70 80 90
KDVGSLDEKM KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK
Length:98
Mass (Da):11,471
Last modified:May 1, 1997 - v1
Checksum:i1D1BE57F3CD49E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99920 mRNA Translation: CAA68188.1
CR542149 mRNA Translation: CAG46946.1
BT006724 mRNA Translation: AAP35370.1
BX470102 Genomic DNA No translation available.
BC000632 mRNA Translation: AAH00632.1
BC068064 mRNA Translation: AAH68064.1
BC070291 mRNA Translation: AAH70291.1
AY987392 mRNA Translation: AAX89402.1
CCDSiCCDS30874.1
PIRiJC5064
RefSeqiNP_001019381.1, NM_001024210.1
NP_001019382.1, NM_001024211.1
NP_001019383.1, NM_001024212.1
NP_001019384.1, NM_001024213.1
NP_005970.1, NM_005979.2
XP_005245491.1, XM_005245434.3
XP_011508164.1, XM_011509862.2
XP_011508165.1, XM_011509863.2
XP_011508166.1, XM_011509864.1
XP_016857523.1, XM_017002034.1
XP_016857524.1, XM_017002035.1
XP_016857525.1, XM_017002036.1
UniGeneiHs.516505

Genome annotation databases

EnsembliENST00000339556; ENSP00000344822; ENSG00000189171
ENST00000392622; ENSP00000376398; ENSG00000189171
ENST00000392623; ENSP00000376399; ENSG00000189171
ENST00000440685; ENSP00000392767; ENSG00000189171
GeneIDi6284
KEGGihsa:6284
UCSCiuc001fcf.5 human

Similar proteinsi

Entry informationi

Entry nameiS10AD_HUMAN
AccessioniPrimary (citable) accession number: Q99584
Secondary accession number(s): Q52PI9, Q6FGF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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