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Protein

Protein FEV

Gene

FEV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18 – 19Breakpoint for insertion to form EWS-FEV fusion protein2

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 127ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: InterPro
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ99581

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FEV
Alternative name(s):
Fifth Ewing variant protein
PC12 ETS domain-containing transcription factor 1
Short name:
PC12 ETS factor 1
Short name:
Pet-1
Gene namesi
Name:FEV
Synonyms:PET1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163497.2
HGNCiHGNC:18562 FEV
MIMi607150 gene
neXtProtiNX_Q99581

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Sudden infant death syndrome (SIDS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionSIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
See also OMIM:272120
A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.1 Publication

Organism-specific databases

DisGeNETi54738
MIMi272120 phenotype
OpenTargetsiENSG00000163497
PharmGKBiPA134875093

Polymorphism and mutation databases

BioMutaiFEV
DMDMi74762701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442041 – 238Protein FEVAdd BLAST238

Proteomic databases

PaxDbiQ99581
PeptideAtlasiQ99581
PRIDEiQ99581
ProteomicsDBi78340

PTM databases

iPTMnetiQ99581
PhosphoSitePlusiQ99581

Expressioni

Tissue specificityi

In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.3 Publications

Gene expression databases

BgeeiENSG00000163497
CleanExiHS_FEV
GenevisibleiQ99581 HS

Organism-specific databases

HPAiHPA067679

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295727

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi49 – 57Combined sources9
Helixi60 – 62Combined sources3
Turni63 – 65Combined sources3
Beta strandi67 – 71Combined sources5
Beta strandi74 – 76Combined sources3
Helixi80 – 91Combined sources12
Helixi98 – 107Combined sources10
Turni108 – 112Combined sources5
Beta strandi113 – 116Combined sources4
Beta strandi123 – 126Combined sources4
Helixi128 – 134Combined sources7

3D structure databases

ProteinModelPortaliQ99581
SMRiQ99581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 238May mediate active transcriptional repressionAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 210Ala-richAdd BLAST79

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000234879
HOVERGENiHBG095796
InParanoidiQ99581
KOiK09437
OMAiCQPSTTE
OrthoDBiEOG091G0HJF
PhylomeDBiQ99581
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q99581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQSGASQPL LINMYLPDPV GDGLFKDGKN PSWGPLSPAV QKGSGQIQLW
60 70 80 90 100
QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK
110 120 130 140 150
LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA
160 170 180 190 200
AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPGP
210 220 230
AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
Length:238
Mass (Da):25,030
Last modified:May 1, 1997 - v1
Checksum:i057E4A76FBDD6E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08976 mRNA Translation: CAA70169.1
AC097468 Genomic DNA Translation: AAX88917.1
CH471063 Genomic DNA Translation: EAW70664.1
BC023511 mRNA Translation: AAH23511.1
CCDSiCCDS2428.1
RefSeqiNP_059991.1, NM_017521.2
UniGeneiHs.234759

Genome annotation databases

EnsembliENST00000295727; ENSP00000295727; ENSG00000163497
GeneIDi54738
KEGGihsa:54738
UCSCiuc002vji.1 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiFEV_HUMAN
AccessioniPrimary (citable) accession number: Q99581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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