UniProtKB - Q99578 (RIT2_HUMAN)
GTP-binding protein Rit2
RIT2
Functioni
Miscellaneous
Catalytic activityi
- EC:3.6.5.2By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 27 – 34 | GTPBy similarity | 8 | |
Nucleotide bindingi | 74 – 78 | GTPBy similarity | 5 | |
Nucleotide bindingi | 133 – 136 | GTPBy similarity | 4 |
GO - Molecular functioni
- calmodulin binding Source: ParkinsonsUK-UCL
- chromatin binding Source: Ensembl
- GDP binding Source: GO_Central
- GTPase activity Source: ParkinsonsUK-UCL
- GTP binding Source: ParkinsonsUK-UCL
- semaphorin receptor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- chemical synaptic transmission Source: ProtInc
- intracellular signal transduction Source: ParkinsonsUK-UCL
- maintenance of protein location in cell Source: ParkinsonsUK-UCL
- negative regulation of neuron projection development Source: Ensembl
- positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
- positive regulation of neuron projection development Source: ParkinsonsUK-UCL
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- Ras protein signal transduction Source: ParkinsonsUK-UCL
- regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
- regulation of Cdc42 protein signal transduction Source: ParkinsonsUK-UCL
- regulation of endocytosis Source: ParkinsonsUK-UCL
- regulation of protein phosphorylation Source: Ensembl
- small GTPase mediated signal transduction Source: UniProtKB
Keywordsi
Molecular function | Calmodulin-binding, Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99578 |
Reactomei | R-HSA-187706, Signalling to p38 via RIT and RIN |
SIGNORi | Q99578 |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein Rit2 (EC:3.6.5.2By similarity)Alternative name(s): Ras-like protein expressed in neurons Ras-like without CAAX protein 2 |
Gene namesi | Name:RIT2 Synonyms:RIN, ROC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10017, RIT2 |
MIMi | 609592, gene |
neXtProti | NX_Q99578 |
VEuPathDBi | HostDB:ENSG00000152214.12 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Plasma membrane
- Cell membrane 1 Publication
Note: Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393).1 Publication
Nucleus
- nucleus Source: ParkinsonsUK-UCL
Plasma Membrane
- plasma membrane Source: ParkinsonsUK-UCL
Other locations
- cell body Source: ParkinsonsUK-UCL
- cytoplasm Source: ParkinsonsUK-UCL
- dendritic tree Source: ParkinsonsUK-UCL
- membrane raft Source: ParkinsonsUK-UCL
- neuron projection Source: ParkinsonsUK-UCL
- synapse Source: GOC
Keywords - Cellular componenti
Cell membrane, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6014 |
OpenTargetsi | ENSG00000152214 |
PharmGKBi | PA35527 |
Miscellaneous databases
Pharosi | Q99578, Tbio |
Genetic variation databases
BioMutai | RIT2 |
DMDMi | 38258639 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082727 | 1 – 217 | GTP-binding protein Rit2Add BLAST | 217 |
Proteomic databases
MassIVEi | Q99578 |
PaxDbi | Q99578 |
PeptideAtlasi | Q99578 |
PRIDEi | Q99578 |
ProteomicsDBi | 78338 [Q99578-1] 78339 [Q99578-2] |
PTM databases
iPTMneti | Q99578 |
PhosphoSitePlusi | Q99578 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000152214, Expressed in cerebellar hemisphere and 108 other tissues |
ExpressionAtlasi | Q99578, baseline and differential |
Genevisiblei | Q99578, HS |
Organism-specific databases
HPAi | ENSG00000152214, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin.
Interacts with PLXNB3.
Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- calmodulin binding Source: ParkinsonsUK-UCL
- semaphorin receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 111946, 12 interactors |
IntActi | Q99578, 6 interactors |
STRINGi | 9606.ENSP00000321805 |
Miscellaneous databases
RNActi | Q99578, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000161402 |
HOGENOMi | CLU_041217_9_5_1 |
InParanoidi | Q99578 |
OMAi | RFLDYHD |
OrthoDBi | 1259506at2759 |
PhylomeDBi | Q99578 |
TreeFami | TF315072 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS
160 170 180 190 200
LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS
210
LWKKLKGSLK KKRENMT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EMR8 | K7EMR8_HUMAN | GTP-binding protein Rit2 | RIT2 | 169 | Annotation score: | ||
A0A3B3ITB4 | A0A3B3ITB4_HUMAN | GTP-binding protein Rit2 | RIT2 | 165 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | Q → L in AAM12636 (Ref. 4) Curated | 1 | |
Sequence conflicti | 76 | A → D in AAB42214 (PubMed:8824319).Curated | 1 | |
Sequence conflicti | 200 | S → C in AAH18060 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018102 | 143 – 153 | VSTEEGLSLAQ → PTLKEFGREEF in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_018103 | 154 – 217 | Missing in isoform 2. 1 PublicationAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U71204 mRNA Translation: AAB42214.1 Y07565 mRNA Translation: CAA68850.1 U78164 mRNA Translation: AAB64245.1 U78166 mRNA Translation: AAB64247.1 AF493922 mRNA Translation: AAM12636.1 AY563951 mRNA Translation: AAS75332.1 AK313823 mRNA Translation: BAG36558.1 CH471088 Genomic DNA Translation: EAX01432.1 BC018060 mRNA Translation: AAH18060.1 |
CCDSi | CCDS11921.1 [Q99578-1] CCDS62431.1 [Q99578-2] |
RefSeqi | NP_001259006.1, NM_001272077.1 [Q99578-2] NP_002921.1, NM_002930.3 [Q99578-1] |
Genome annotation databases
Ensembli | ENST00000326695; ENSP00000321805; ENSG00000152214 [Q99578-1] ENST00000589109; ENSP00000467217; ENSG00000152214 [Q99578-2] |
GeneIDi | 6014 |
KEGGi | hsa:6014 |
UCSCi | uc002lav.5, human [Q99578-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U71204 mRNA Translation: AAB42214.1 Y07565 mRNA Translation: CAA68850.1 U78164 mRNA Translation: AAB64245.1 U78166 mRNA Translation: AAB64247.1 AF493922 mRNA Translation: AAM12636.1 AY563951 mRNA Translation: AAS75332.1 AK313823 mRNA Translation: BAG36558.1 CH471088 Genomic DNA Translation: EAX01432.1 BC018060 mRNA Translation: AAH18060.1 |
CCDSi | CCDS11921.1 [Q99578-1] CCDS62431.1 [Q99578-2] |
RefSeqi | NP_001259006.1, NM_001272077.1 [Q99578-2] NP_002921.1, NM_002930.3 [Q99578-1] |
3D structure databases
SMRi | Q99578 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111946, 12 interactors |
IntActi | Q99578, 6 interactors |
STRINGi | 9606.ENSP00000321805 |
PTM databases
iPTMneti | Q99578 |
PhosphoSitePlusi | Q99578 |
Genetic variation databases
BioMutai | RIT2 |
DMDMi | 38258639 |
Proteomic databases
MassIVEi | Q99578 |
PaxDbi | Q99578 |
PeptideAtlasi | Q99578 |
PRIDEi | Q99578 |
ProteomicsDBi | 78338 [Q99578-1] 78339 [Q99578-2] |
Protocols and materials databases
Antibodypediai | 8862, 273 antibodies |
DNASUi | 6014 |
Genome annotation databases
Ensembli | ENST00000326695; ENSP00000321805; ENSG00000152214 [Q99578-1] ENST00000589109; ENSP00000467217; ENSG00000152214 [Q99578-2] |
GeneIDi | 6014 |
KEGGi | hsa:6014 |
UCSCi | uc002lav.5, human [Q99578-1] |
Organism-specific databases
CTDi | 6014 |
DisGeNETi | 6014 |
GeneCardsi | RIT2 |
HGNCi | HGNC:10017, RIT2 |
HPAi | ENSG00000152214, Tissue enriched (brain) |
MIMi | 609592, gene |
neXtProti | NX_Q99578 |
OpenTargetsi | ENSG00000152214 |
PharmGKBi | PA35527 |
VEuPathDBi | HostDB:ENSG00000152214.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000161402 |
HOGENOMi | CLU_041217_9_5_1 |
InParanoidi | Q99578 |
OMAi | RFLDYHD |
OrthoDBi | 1259506at2759 |
PhylomeDBi | Q99578 |
TreeFami | TF315072 |
Enzyme and pathway databases
PathwayCommonsi | Q99578 |
Reactomei | R-HSA-187706, Signalling to p38 via RIT and RIN |
SIGNORi | Q99578 |
Miscellaneous databases
BioGRID-ORCSi | 6014, 8 hits in 994 CRISPR screens |
ChiTaRSi | RIT2, human |
GeneWikii | RIT2 |
GenomeRNAii | 6014 |
Pharosi | Q99578, Tbio |
PROi | PR:Q99578 |
RNActi | Q99578, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152214, Expressed in cerebellar hemisphere and 108 other tissues |
ExpressionAtlasi | Q99578, baseline and differential |
Genevisiblei | Q99578, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIT2_HUMAN | |
Accessioni | Q99578Primary (citable) accession number: Q99578 Secondary accession number(s): B2R9L1 Q92964 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | May 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families