RIT2

Functionⁱ

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.By similarity

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	27 – 34	GTPBy similarity	8
Nucleotide bindingⁱ	74 – 78	GTPBy similarity	5
Nucleotide bindingⁱ	133 – 136	GTPBy similarity	4

GO - Molecular functionⁱ

calmodulin binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 8918462
chromatin binding Source: Ensembl
GTPase activity Source: ParkinsonsUK-UCL
GTP binding Source: ParkinsonsUK-UCL
semaphorin receptor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16122393

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 8918462
intracellular signal transduction
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21957239
maintenance of protein location in cell
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 21957239
negative regulation of neuron projection development Source: Ensembl
positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
positive regulation of neuron projection development
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 16157584
positive regulation of transcription by RNA polymerase II Source: Ensembl
Ras protein signal transduction Source: ParkinsonsUK-UCL
regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
regulation of Cdc42 protein signal transduction Source: ParkinsonsUK-UCL
regulation of endocytosis
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 21957239
small GTPase mediated signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 8824319

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187706 Signalling to p38 via RIT and RIN
SIGNORⁱ	Q99578

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GTP-binding protein Rit2 Alternative name(s): Ras-like protein expressed in neurons Ras-like without CAAX protein 2
Gene namesⁱ	Name:RIT2 Synonyms:RIN, ROC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152214.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10017 RIT2
MIMⁱ	609592 gene
neXtProtⁱ	NX_Q99578

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6014
Open Targets More...OpenTargetsⁱ	ENSG00000152214
PharmGKBⁱ	PA35527

Polymorphism and mutation databases

DMDMⁱ	38258639

DMDMⁱ

38258639

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082727	1 – 217	GTP-binding protein Rit2Add BLAST		217

Proteomic databases

PaxDbⁱ	Q99578
PeptideAtlas More...PeptideAtlasⁱ	Q99578
PRIDEⁱ	Q99578
ProteomicsDBⁱ	78338 78339 [Q99578-2]

PTM databases

iPTMnetⁱ	Q99578
PhosphoSitePlusⁱ	Q99578

Expressionⁱ

Tissue specificityⁱ

Neuron-specific.

Gene expression databases

Bgeeⁱ	ENSG00000152214 Expressed in 86 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_RIT2
ExpressionAtlasⁱ	Q99578 baseline and differential
Genevisibleⁱ	Q99578 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072174

HPAⁱ

HPA072174

Interactionⁱ

Subunit structureⁱ

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SLC6A3	Q01959	5	EBI-365914,EBI-6661445

With

Entry

#Exp.

IntAct

Notes

SLC6A3

Q01959

5

EBI-365914,EBI-6661445

GO - Molecular functionⁱ

calmodulin binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 8918462
semaphorin receptor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16122393

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111946, 10 interactors
IntActⁱ	Q99578, 3 interactors
STRINGⁱ	9606.ENSP00000321805

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99578
SMRⁱ	Q99578
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q99578
KEGG Orthology (KO) More...KOⁱ	K07833
OMAⁱ	RFLDYHD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	Q99578
TreeFamⁱ	TF315072

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q99578-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD 
        60         70         80         90        100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS 
       110        120        130        140        150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS 
       160        170        180        190        200
LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS 
       210 
LWKKLKGSLK KKRENMT

Length:217

Mass (Da):24,668

Last modified:May 1, 1997 - v1

Checksum:ⁱCD2A9ECE4AEAA792

GO

Isoform 2 (identifier: Q99578-2) [UniParc]FASTA Add to basket

Also known as: RIBA

The sequence of this isoform differs from the canonical sequence as follows:
143-153: VSTEEGLSLAQ → PTLKEFGREEF
154-217: Missing.

« Hide

        10         20         30         40         50
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD 
        60         70         80         90        100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS 
       110        120        130        140        150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQPTLKEFGR 

EEF

Show »

Length:153

Mass (Da):17,308

Checksum:ⁱ9820326EF5FCA223

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EMR8	K7EMR8_HUMAN		GTP-binding protein Rit2 GTP-binding protein Rit2	RIT2	169	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	39	Q → L in AAM12636 (Ref. 4) Curated	1
Sequence conflictⁱ	76	A → D in AAB42214 (PubMed:8824319).Curated	1
Sequence conflictⁱ	200	S → C in AAH18060 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018102	143 – 153	VSTEEGLSLAQ → PTLKEFGREEF in isoform 2. 1 PublicationAdd BLAST		11
Alternative sequenceⁱVSP_018103	154 – 217	Missing in isoform 2. 1 PublicationAdd BLAST		64

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71204 mRNA Translation: AAB42214.1 Y07565 mRNA Translation: CAA68850.1 U78164 mRNA Translation: AAB64245.1 U78166 mRNA Translation: AAB64247.1 AF493922 mRNA Translation: AAM12636.1 AY563951 mRNA Translation: AAS75332.1 AK313823 mRNA Translation: BAG36558.1 CH471088 Genomic DNA Translation: EAX01432.1 BC018060 mRNA Translation: AAH18060.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11921.1 [Q99578-1] CCDS62431.1 [Q99578-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001259006.1, NM_001272077.1 [Q99578-2] NP_002921.1, NM_002930.3 [Q99578-1]
UniGeneⁱ	Hs.464985

Genome annotation databases

Ensemblⁱ	ENST00000326695; ENSP00000321805; ENSG00000152214 [Q99578-1] ENST00000589109; ENSP00000467217; ENSG00000152214 [Q99578-2]
GeneIDⁱ	6014
KEGGⁱ	hsa:6014
UCSC genome browser More...UCSCⁱ	uc002lav.5 human [Q99578-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99578	RIT2 isoform 2		PANTR		217	UniRef100_Q99578
RIT2 isoform 2		PONAB		217
Uncharacterized protein		CERAT		217
Uncharacterized protein		RHIRO		217
Uncharacterized protein		PANPA		217
+7
Q99578-2	RIT2 isoform 1		PANTR		153	UniRef100_H2QEG5
Uncharacterized protein		PANPA		153
Uncharacterized protein		NOMLE		153
Ras like without CAAX 2		GORGO		153

Protein	Similar proteins		Species	Score	Length	Source
Q99578	GTP-binding protein Rit2		MOUSE		217	UniRef90_P70425
GTP-binding protein Rit2		RAT		217
GTP-binding protein Rit2		MYOBR		220
Uncharacterized protein		MUSPF		218
GTP-binding protein Rit2		Florida manatee		218
+78
Q99578-2	Ras like without CAAX 2		CHLSB		149	UniRef90_A0A0D9RZC6
RIT2 isoform 1		PANTR		153
Uncharacterized protein		PANPA		153
Uncharacterized protein		NOMLE		153
Ras like without CAAX 2		GORGO		153
+16

Protein	Similar proteins		Species	Score	Length	Source
Q99578	GTP-binding protein Rit2		MOUSE		217	UniRef50_P70425
GTP-binding protein Rit2		RAT		217
GTP-binding protein Rit2		MYOBR		220
Uncharacterized protein		MUSPF		218
GTP-binding protein Rit2		Florida manatee		218
+178
Q99578-2	Ras like without CAAX 2		CHLSB		149	UniRef50_A0A0D9RZC6
RIT2 isoform 1		PANTR		153
Uncharacterized protein		PANPA		153
Uncharacterized protein		NOMLE		153
Ras like without CAAX 2		GORGO		153
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71204 mRNA Translation: AAB42214.1 Y07565 mRNA Translation: CAA68850.1 U78164 mRNA Translation: AAB64245.1 U78166 mRNA Translation: AAB64247.1 AF493922 mRNA Translation: AAM12636.1 AY563951 mRNA Translation: AAS75332.1 AK313823 mRNA Translation: BAG36558.1 CH471088 Genomic DNA Translation: EAX01432.1 BC018060 mRNA Translation: AAH18060.1
CCDSⁱ	CCDS11921.1 [Q99578-1] CCDS62431.1 [Q99578-2]
RefSeqⁱ	NP_001259006.1, NM_001272077.1 [Q99578-2] NP_002921.1, NM_002930.3 [Q99578-1]
UniGeneⁱ	Hs.464985

3D structure databases

ProteinModelPortalⁱ	Q99578
SMRⁱ	Q99578
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111946, 10 interactors
IntActⁱ	Q99578, 3 interactors
STRINGⁱ	9606.ENSP00000321805

PTM databases

iPTMnetⁱ	Q99578
PhosphoSitePlusⁱ	Q99578

Polymorphism and mutation databases

DMDMⁱ	38258639

DMDMⁱ

38258639

Proteomic databases

PaxDbⁱ	Q99578
PeptideAtlasⁱ	Q99578
PRIDEⁱ	Q99578
ProteomicsDBⁱ	78338 78339 [Q99578-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6014
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326695; ENSP00000321805; ENSG00000152214 [Q99578-1] ENST00000589109; ENSP00000467217; ENSG00000152214 [Q99578-2]
GeneIDⁱ	6014
KEGGⁱ	hsa:6014
UCSCⁱ	uc002lav.5 human [Q99578-1]

Organism-specific databases

CTDⁱ	6014
DisGeNETⁱ	6014
EuPathDBⁱ	HostDB:ENSG00000152214.12
GeneCardsⁱ	RIT2
H-InvDBⁱ	HIX0014415
HGNCⁱ	HGNC:10017 RIT2
HPAⁱ	HPA072174
MIMⁱ	609592 gene
neXtProtⁱ	NX_Q99578
OpenTargetsⁱ	ENSG00000152214
PharmGKBⁱ	PA35527
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q99578
KOⁱ	K07833
OMAⁱ	RFLDYHD
OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	Q99578
TreeFamⁱ	TF315072

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187706 Signalling to p38 via RIT and RIN
SIGNORⁱ	Q99578

Miscellaneous databases

ChiTaRSⁱ	RIT2 human
GeneWikiⁱ	RIT2
GenomeRNAiⁱ	6014
Protein Ontology More...PROⁱ	PR:Q99578
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152214 Expressed in 86 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_RIT2
ExpressionAtlasⁱ	Q99578 baseline and differential
Genevisibleⁱ	Q99578 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIT2_HUMAN
Accessionⁱ	Q99578Primary (citable) accession number: Q99578 Secondary accession number(s): B2R9L1 , O15295, Q8TD69, Q8WVF6, Q92964
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q99578 (RIT2_HUMAN)

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GTP-binding protein Rit2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ