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Entry version 174 (16 Oct 2019)
Sequence version 2 (21 Feb 2001)
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Protein

Ribonucleases P/MRP protein subunit POP1

Gene

POP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processtRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6784531 tRNA processing in the nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP1 (EC:3.1.26.52 Publications)
Short name:
hPOP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POP1
Synonyms:KIAA0061
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30129 POP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602486 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99575

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anauxetic dysplasia 2 (ANXD2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive spondyloepimetaphyseal dysplasia characterized by severe short stature of prenatal onset, very short adult height (less than 1 meter), hypodontia, midface hypoplasia, and mild intellectual disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078770511D → Y in ANXD2. 1 PublicationCorresponds to variant dbSNP:rs1060505025EnsemblClinVar.1
Natural variantiVAR_078771582P → S in ANXD2. 2 PublicationsCorresponds to variant dbSNP:rs1060505023EnsemblClinVar.1
Natural variantiVAR_067755583G → E in ANXD2. 1 PublicationCorresponds to variant dbSNP:rs374828868EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
10940

MalaCards human disease database

More...
MalaCardsi
POP1
MIMi617396 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104356

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93347 Anauxetic dysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907403

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99575

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124451

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585131 – 1024Ribonucleases P/MRP protein subunit POP1Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei367PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99575

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99575

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99575

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99575

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99575

PeptideAtlas

More...
PeptideAtlasi
Q99575

PRoteomics IDEntifications database

More...
PRIDEi
Q99575

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78334

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99575

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99575

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99575

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104356 Expressed in 120 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99575 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99575 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066194

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:8918471, PubMed:16723659). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116140, 115 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q99575

Protein interaction database and analysis system

More...
IntActi
Q99575, 60 interactors

Molecular INTeraction database

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MINTi
Q99575

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385787

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99575

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3322 Eukaryota
ENOG410XT8N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017478

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013102

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99575

KEGG Orthology (KO)

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KOi
K01164

Identification of Orthologs from Complete Genome Data

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OMAi
EDNTPTV

Database of Orthologous Groups

More...
OrthoDBi
543991at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99575

TreeFam database of animal gene trees

More...
TreeFami
TF314236

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039182 Pop1
IPR009723 Pop1_N
IPR012590 POPLD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22731 PTHR22731, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06978 POP1, 2 hits
PF08170 POPLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNAKERKHA KKMRNQPTNV TLSSGFVADR GVKHHSGGEK PFQAQKQEPH
60 70 80 90 100
PGTSRQRQTR VNPHSLPDPE VNEQSSSKGM FRKKGGWKAG PEGTSQEIPK
110 120 130 140 150
YITASTFAQA RAAEISAMLK AVTQKSSNSL VFQTLPRHMR RRAMSHNVKR
160 170 180 190 200
LPRRLQEIAQ KEAEKAVHQK KEHSKNKCHK ARRCHMNRTL EFNRRQKKNI
210 220 230 240 250
WLETHIWHAK RFHMVKKWGY CLGERPTVKS HRACYRAMTN RCLLQDLSYY
260 270 280 290 300
CCLELKGKEE EILKALSGMC NIDTGLTFAA VHCLSGKRQG SLVLYRVNKY
310 320 330 340 350
PREMLGPVTF IWKSQRTPGD PSESRQLWIW LHPTLKQDIL EEIKAACQCV
360 370 380 390 400
EPIKSAVCIA DPLPTPSQEK SQTELPDEKI GKKRKRKDDG ENAKPIKKII
410 420 430 440 450
GDGTRDPCLP YSWISPTTGI IISDLTMEMN RFRLIGPLSH SILTEAIKAA
460 470 480 490 500
SVHTVGEDTE ETPHRWWIET CKKPDSVSLH CRQEAIFELL GGITSPAEIP
510 520 530 540 550
AGTILGLTVG DPRINLPQKK SKALPNPEKC QDNEKVRQLL LEGVPVECTH
560 570 580 590 600
SFIWNQDICK SVTENKISDQ DLNRMRSELL VPGSQLILGP HESKIPILLI
610 620 630 640 650
QQPGKVTGED RLGWGSGWDV LLPKGWGMAF WIPFIYRGVR VGGLKESAVH
660 670 680 690 700
SQYKRSPNVP GDFPDCPAGM LFAEEQAKNL LEKYKRRPPA KRPNYVKLGT
710 720 730 740 750
LAPFCCPWEQ LTQDWESRVQ AYEEPSVASS PNGKESDLRR SEVPCAPMPK
760 770 780 790 800
KTHQPSDEVG TSIEHPREAE EVMDAGCQES AGPERITDQE ASENHVAATG
810 820 830 840 850
SHLCVLRSRK LLKQLSAWCG PSSEDSRGGR RAPGRGQQGL TREACLSILG
860 870 880 890 900
HFPRALVWVS LSLLSKGSPE PHTMICVPAK EDFLQLHEDW HYCGPQESKH
910 920 930 940 950
SDPFRSKILK QKEKKKREKR QKPGRASSDG PAGEEPVAGQ EALTLGLWSG
960 970 980 990 1000
PLPRVTLHCS RTLLGFVTQG DFSMAVGCGE ALGFVSLTGL LDMLSSQPAA
1010 1020
QRGLVLLRPP ASLQYRFARI AIEV
Length:1,024
Mass (Da):114,709
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1DB872F3B940C02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RK39E5RK39_HUMAN
Ribonucleases P/MRP protein subunit...
POP1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057746127S → L. Corresponds to variant dbSNP:rs3824145Ensembl.1
Natural variantiVAR_057747460E → A. Corresponds to variant dbSNP:rs2306131Ensembl.1
Natural variantiVAR_078770511D → Y in ANXD2. 1 PublicationCorresponds to variant dbSNP:rs1060505025EnsemblClinVar.1
Natural variantiVAR_057748522K → N. Corresponds to variant dbSNP:rs17184326Ensembl.1
Natural variantiVAR_078771582P → S in ANXD2. 2 PublicationsCorresponds to variant dbSNP:rs1060505023EnsemblClinVar.1
Natural variantiVAR_067755583G → E in ANXD2. 1 PublicationCorresponds to variant dbSNP:rs374828868EnsemblClinVar.1
Natural variantiVAR_036232675E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057749994L → V. Corresponds to variant dbSNP:rs17856355Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK291434 mRNA Translation: BAF84123.1
CH471060 Genomic DNA Translation: EAW91776.1
X99302 mRNA Translation: CAA67684.1
D31765 mRNA Translation: BAA06543.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6277.1

NCBI Reference Sequences

More...
RefSeqi
NP_001139332.1, NM_001145860.1
NP_001139333.1, NM_001145861.1
NP_055844.2, NM_015029.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349693; ENSP00000339529; ENSG00000104356
ENST00000401707; ENSP00000385787; ENSG00000104356

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10940

UCSC genome browser

More...
UCSCi
uc003yij.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291434 mRNA Translation: BAF84123.1
CH471060 Genomic DNA Translation: EAW91776.1
X99302 mRNA Translation: CAA67684.1
D31765 mRNA Translation: BAA06543.1
CCDSiCCDS6277.1
RefSeqiNP_001139332.1, NM_001145860.1
NP_001139333.1, NM_001145861.1
NP_055844.2, NM_015029.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AHRelectron microscopy3.92B1-1024[»]
6AHUelectron microscopy3.66B1-1024[»]
SMRiQ99575
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116140, 115 interactors
CORUMiQ99575
IntActiQ99575, 60 interactors
MINTiQ99575
STRINGi9606.ENSP00000385787

PTM databases

iPTMnetiQ99575
PhosphoSitePlusiQ99575
SwissPalmiQ99575

Polymorphism and mutation databases

BioMutaiPOP1
DMDMi13124451

Proteomic databases

EPDiQ99575
jPOSTiQ99575
MassIVEiQ99575
MaxQBiQ99575
PaxDbiQ99575
PeptideAtlasiQ99575
PRIDEiQ99575
ProteomicsDBi78334

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10940

Genome annotation databases

EnsembliENST00000349693; ENSP00000339529; ENSG00000104356
ENST00000401707; ENSP00000385787; ENSG00000104356
GeneIDi10940
KEGGihsa:10940
UCSCiuc003yij.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10940
DisGeNETi10940

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POP1
HGNCiHGNC:30129 POP1
HPAiHPA066194
MalaCardsiPOP1
MIMi602486 gene
617396 phenotype
neXtProtiNX_Q99575
OpenTargetsiENSG00000104356
Orphaneti93347 Anauxetic dysplasia
PharmGKBiPA134907403

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3322 Eukaryota
ENOG410XT8N LUCA
GeneTreeiENSGT00390000017478
HOGENOMiHOG000013102
InParanoidiQ99575
KOiK01164
OMAiEDNTPTV
OrthoDBi543991at2759
PhylomeDBiQ99575
TreeFamiTF314236

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POP1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10940
PharosiQ99575

Protein Ontology

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PROi
PR:Q99575

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104356 Expressed in 120 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ99575 baseline and differential
GenevisibleiQ99575 HS

Family and domain databases

InterProiView protein in InterPro
IPR039182 Pop1
IPR009723 Pop1_N
IPR012590 POPLD_dom
PANTHERiPTHR22731 PTHR22731, 1 hit
PfamiView protein in Pfam
PF06978 POP1, 2 hits
PF08170 POPLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99575
Secondary accession number(s): A8K5W9, Q15037
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: October 16, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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