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UniProtKB - Q99574 (NEUS_HUMAN)

Entry version 183 (25 May 2022)
Sequence version 1 (01 May 1997)
Previous versions | rss
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Protein

Neuroserpin

Gene

SERPINI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).

May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

Curated5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei362 – 363Reactive bond1 Publication1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99574

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99574

Protein family/group databases

MEROPS protease database

More...MEROPSi		I04.025

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serpin I1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINI1
Synonyms:PI12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8943, SERPINI1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602445, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99574

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163536

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00852049S → P in FENIB; Syracuse; decreased protein stability; decreased proteinase inhibitor activity; increased tendency to form polymers. 2 PublicationsCorresponds to variant dbSNP:rs121909051EnsemblClinVar.1
Natural variantiVAR_00852152S → R in FENIB; Portland. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi161N → G: Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. 1 Publication1
Mutagenesisi162L → K: Increases protein stability and abolishes tendency to form polymers. No effect on inhibitory activity. 1 Publication1
Mutagenesisi163V → I: Increases protein stability and decreases tendency to form polymers. No effect on inhibitory activity. 1 Publication1
Mutagenesisi289E → A: Slightly decreases inhibitory activity. No effect on thermal stability. 1 Publication1
Mutagenesisi340S → A: Increases protein stability and decreases tendency to form polymers. No effect on inhibitory activity. 1 Publication1

Keywords - Diseasei

Disease variant, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		5274

MalaCards human disease database

More...MalaCardsi		SERPINI1
MIMi604218, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163536

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		530303, Progressive dementia with neuroserpin inclusion bodies

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35511

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99574, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SERPINI1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3183087

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003252117 – 410NeuroserpinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99574

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99574

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99574

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99574

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99574

PeptideAtlas

More...PeptideAtlasi		Q99574

PRoteomics IDEntifications database

More...PRIDEi		Q99574

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78333

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1559, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99574, 3 sites, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99574

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163536, Expressed in substantia nigra and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99574, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99574, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163536, Tissue enhanced (brain, choroid plexus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Has a tendency to form large polymers already at 41 and 45 degrees Celsius (in vitro).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111292, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q99574, 3 interactors

Molecular INTeraction database

More...MINTi		Q99574

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295777

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99574, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99574

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99574

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99574

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2392, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023330_0_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99574

Identification of Orthologs from Complete Genome Data

More...OMAi		KDVWRGL

Database of Orthologous Groups

More...OrthoDBi		1124079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99574

TreeFam database of animal gene trees

More...TreeFami		TF352620

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2

The PANTHER Classification System

More...PANTHERi		PTHR11461, PTHR11461, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00079, Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00093, SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56574, SSF56574, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00284, SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLGLFSLL VLQSMATGAT FPEEAIADLS VNMYNRLRAT GEDENILFSP 
        60         70         80         90        100
LSIALAMGMM ELGAQGSTQK EIRHSMGYDS LKNGEEFSFL KEFSNMVTAK 
       110        120        130        140        150
ESQYVMKIAN SLFVQNGFHV NEEFLQMMKK YFNAAVNHVD FSQNVAVANY 
       160        170        180        190        200
INKWVENNTN NLVKDLVSPR DFDAATYLAL INAVYFKGNW KSQFRPENTR 
       210        220        230        240        250
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE 
       260        270        280        290        300
ISMMLVLSRQ EVPLATLEPL VKAQLVEEWA NSVKKQKVEV YLPRFTVEQE 
       310        320        330        340        350
IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE 
       360        370        380        390        400
AAAVSGMIAI SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM 
       410
NTSGHDFEEL
Length:410
Mass (Da):46,427
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD966E9036BB21943
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDY5C9JDY5_HUMAN
Neuroserpin
SERPINI1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQU8C9JQU8_HUMAN
Neuroserpin
SERPINI1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5T9H7C5T9_HUMAN
Neuroserpin
SERPINI1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70K → E in AAH18043 (PubMed:15489334).Curated1
Sequence conflicti326S → Y in AAH18043 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00852049S → P in FENIB; Syracuse; decreased protein stability; decreased proteinase inhibitor activity; increased tendency to form polymers. 2 PublicationsCorresponds to variant dbSNP:rs121909051EnsemblClinVar.1
Natural variantiVAR_00852152S → R in FENIB; Portland. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z81326 mRNA Translation: CAB03626.1
AF248246, AF248244, AF248245 Genomic DNA Translation: AAG01089.1
AK290082 mRNA Translation: BAF82771.1
CR627434 mRNA Translation: CAH10520.1
CH471052 Genomic DNA Translation: EAW78571.1
CH471052 Genomic DNA Translation: EAW78572.1
CH471052 Genomic DNA Translation: EAW78573.1
BC018043 mRNA Translation: AAH18043.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3203.1

NCBI Reference Sequences

More...RefSeqi		NP_001116224.1, NM_001122752.1
NP_005016.1, NM_005025.4
XP_016862107.1, XM_017006618.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295777.9; ENSP00000295777.5; ENSG00000163536.13
ENST00000446050.7; ENSP00000397373.2; ENSG00000163536.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5274

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000446050.7; ENSP00000397373.2; NM_001122752.2; NP_001116224.1

UCSC genome browser

More...UCSCi		uc003ffa.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81326 mRNA Translation: CAB03626.1
AF248246, AF248244, AF248245 Genomic DNA Translation: AAG01089.1
AK290082 mRNA Translation: BAF82771.1
CR627434 mRNA Translation: CAH10520.1
CH471052 Genomic DNA Translation: EAW78571.1
CH471052 Genomic DNA Translation: EAW78572.1
CH471052 Genomic DNA Translation: EAW78573.1
BC018043 mRNA Translation: AAH18043.1
CCDSiCCDS3203.1
RefSeqiNP_001116224.1, NM_001122752.1
NP_005016.1, NM_005025.4
XP_016862107.1, XM_017006618.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F02X-ray1.80A/B17-362[»]
C/D363-410[»]
3F5NX-ray3.15A/B/C/D/E17-410[»]
3FGQX-ray2.09A/B17-400[»]
AlphaFoldDBiQ99574
SMRiQ99574
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111292, 8 interactors
IntActiQ99574, 3 interactors
MINTiQ99574
STRINGi9606.ENSP00000295777

Protein family/group databases

MEROPSiI04.025

PTM databases

GlyConnecti1559, 2 N-Linked glycans (1 site)
GlyGeniQ99574, 3 sites, 2 N-linked glycans (1 site)
iPTMnetiQ99574
PhosphoSitePlusiQ99574

Genetic variation databases

BioMutaiSERPINI1
DMDMi3183087

Proteomic databases

EPDiQ99574
jPOSTiQ99574
MassIVEiQ99574
MaxQBiQ99574
PaxDbiQ99574
PeptideAtlasiQ99574
PRIDEiQ99574
ProteomicsDBi78333

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		987, 475 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		5274

Genome annotation databases

EnsembliENST00000295777.9; ENSP00000295777.5; ENSG00000163536.13
ENST00000446050.7; ENSP00000397373.2; ENSG00000163536.13
GeneIDi5274
KEGGihsa:5274
MANE-SelectiENST00000446050.7; ENSP00000397373.2; NM_001122752.2; NP_001116224.1
UCSCiuc003ffa.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5274
DisGeNETi5274

GeneCards: human genes, protein and diseases

More...GeneCardsi		SERPINI1
HGNCiHGNC:8943, SERPINI1
HPAiENSG00000163536, Tissue enhanced (brain, choroid plexus)
MalaCardsiSERPINI1
MIMi602445, gene
604218, phenotype
neXtProtiNX_Q99574
OpenTargetsiENSG00000163536
Orphaneti530303, Progressive dementia with neuroserpin inclusion bodies
PharmGKBiPA35511
VEuPathDBiHostDB:ENSG00000163536

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2392, Eukaryota
GeneTreeiENSGT00940000158168
HOGENOMiCLU_023330_0_4_1
InParanoidiQ99574
OMAiKDVWRGL
OrthoDBi1124079at2759
PhylomeDBiQ99574
TreeFamiTF352620

Enzyme and pathway databases

PathwayCommonsiQ99574
SignaLinkiQ99574

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5274, 14 hits in 1076 CRISPR screens
EvolutionaryTraceiQ99574

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SERPINI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5274
PharosiQ99574, Tbio

Protein Ontology

More...PROi		PR:Q99574
RNActiQ99574, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163536, Expressed in substantia nigra and 239 other tissues
ExpressionAtlasiQ99574, baseline and differential
GenevisibleiQ99574, HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2
PANTHERiPTHR11461, PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079, Serpin, 1 hit
SMARTiView protein in SMART
SM00093, SERPIN, 1 hit
SUPFAMiSSF56574, SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284, SERPIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99574
Secondary accession number(s): A8K217, D3DNP1, Q6AHZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 25, 2022
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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